CN114728944A - 血管紧张素ii受体拮抗剂与nep抑制剂的复合物及其制备方法 - Google Patents
血管紧张素ii受体拮抗剂与nep抑制剂的复合物及其制备方法 Download PDFInfo
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- CN114728944A CN114728944A CN202080076793.9A CN202080076793A CN114728944A CN 114728944 A CN114728944 A CN 114728944A CN 202080076793 A CN202080076793 A CN 202080076793A CN 114728944 A CN114728944 A CN 114728944A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract
提供了一系列具有双重作用的超分子络合物(复合物),该超分子络合物(复合物)包含具有血管紧张素II受体(AT1)阻断作用的化合物、脑啡肽酶抑制剂(NEPi)、药学上可接受的阳离子。
Description
PCT国内申请,说明书已公开。
Claims (12)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN2019110926076 | 2019-11-11 | ||
CN201911092607 | 2019-11-11 | ||
PCT/CN2020/127415 WO2021093697A1 (zh) | 2019-11-11 | 2020-11-09 | 血管紧张素ii受体拮抗剂与nep抑制剂的复合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN114728944A true CN114728944A (zh) | 2022-07-08 |
CN114728944B CN114728944B (zh) | 2023-09-15 |
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CN202080076793.9A Active CN114728944B (zh) | 2019-11-11 | 2020-11-09 | 血管紧张素ii受体拮抗剂与nep抑制剂的复合物及其制备方法 |
Country Status (2)
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CN (1) | CN114728944B (zh) |
WO (1) | WO2021093697A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115443272B (zh) * | 2020-08-17 | 2023-11-17 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的心衰应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105982891A (zh) * | 2015-01-30 | 2016-10-05 | 王召印 | 阿利沙坦脂和脑啡肽酶抑制剂或其前药的药物组合物 |
WO2017125031A1 (zh) * | 2016-01-20 | 2017-07-27 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105963296B (zh) * | 2015-03-12 | 2020-01-21 | 深圳信立泰药业股份有限公司 | 一种含有阿利沙坦酯或其盐或其水解产物或其水解产物盐的药物组合物及其用途 |
CN106146472A (zh) * | 2015-04-15 | 2016-11-23 | 苏州朗科生物技术有限公司 | 一种双重作用的阿利沙坦复合物 |
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2020
- 2020-11-09 WO PCT/CN2020/127415 patent/WO2021093697A1/zh active Application Filing
- 2020-11-09 CN CN202080076793.9A patent/CN114728944B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105982891A (zh) * | 2015-01-30 | 2016-10-05 | 王召印 | 阿利沙坦脂和脑啡肽酶抑制剂或其前药的药物组合物 |
WO2017125031A1 (zh) * | 2016-01-20 | 2017-07-27 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
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CN114728944B (zh) | 2023-09-15 |
WO2021093697A1 (zh) | 2021-05-20 |
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