CN114715527B - HPV detection kit and detection method convenient for storing HPV samples - Google Patents

HPV detection kit and detection method convenient for storing HPV samples Download PDF

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Publication number
CN114715527B
CN114715527B CN202210410037.6A CN202210410037A CN114715527B CN 114715527 B CN114715527 B CN 114715527B CN 202210410037 A CN202210410037 A CN 202210410037A CN 114715527 B CN114715527 B CN 114715527B
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sampling
hpv
circular
side wall
cavity
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CN114715527A (en
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陈祖翼
冉静
李琼瑶
闵迅
黄健
鄢仁晴
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Affiliated Hospital of Zunyi Medical University
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Affiliated Hospital of Zunyi Medical University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/04—Partitions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to the technical field of HPV sample storage and detection, and discloses an HPV detection kit and a detection method convenient for HPV sample storage; the HPV detection kit comprises an external protection box body convenient to carry, a storage device arranged in the external protection box body, and an integrated sampling assembly arranged in the storage device and used for collecting and storing samples; the external protection box body comprises an end cover A, an end cover B, a first circular tube side wall and a second circular tube side wall which are round in shape; the side walls of the first circular tube and the second circular tube are buckled to form a closed cylindrical cavity; the storage device comprises a plurality of independent disc storage devices; s1, taking out an integrated sampling assembly; s2, taking out the sampler; s3, sampling and packaging; the invention can optimize the sampling operation method of HPV detection, improve the operability of detection and effectively avoid cross infection of the sample obtained by detection.

Description

HPV detection kit and detection method convenient for storing HPV samples
Technical Field
The invention relates to the technical field of HPV sample storage and detection, in particular to an HPV detection kit and an HPV detection method convenient for HPV sample storage.
Background
HPV is short for human papilloma virus, has certain carcinogenicity, is the cause of cervical cancer of females, and can be used for judging whether HPV is infected by carrying out HPV detection; in general, HPV is detected for DNA or mRNA, and a common sampling method is to brush the surface of cervical canal with a small brush and then send to examine the level of HPV and the type of HPV.
When taking a sample to the inspector, traditional sampling device and storage test tube are separately, need place the brush head that the sample was accomplished into the test tube after the sample to with the brush holder rupture, the problem that prior art exists is that the operation that adopts the brush head to get into cervical portion position and brush the sample is extremely inconvenient, and the operation is difficult, causes the discomfort easily with the inspector.
In addition, when the sample is placed in the protection box body after the sampling is finished, the protection device provided by the prior art cannot better protect the sample on one hand, and cross infection is easy to occur, so that the detection result is influenced; on the other hand, the protection box body storing a large amount of detection samples is inconvenient for medical staff to carry.
Disclosure of Invention
The invention solves the technical problems that: the HPV detection kit and the detection method are convenient for storing HPV samples, the sampling operation of HPV detection is optimized, the operability of detection is improved, and cross infection of the detected samples is effectively avoided.
The technical scheme of the invention is as follows: an HPV detection kit convenient for storing HPV samples comprises an external protection box body convenient to carry, a storage device arranged in the external protection box body, and an integrated sampling assembly arranged in the storage device and used for collecting and storing samples;
the outer protection box body comprises an end cover A and an end cover B which are round in shape, a first circular tube side wall arranged between the end cover A and the end cover B and positioned at the upper half part, and a second circular tube side wall arranged between the end cover A and the end cover B and positioned at the lower half part;
the first circular tube side wall and the second circular tube side wall are semicircular side walls with the same diameter and wall thickness; the side walls of the first circular tube and the second circular tube are buckled to form a closed cylindrical cavity;
the storage device comprises a plurality of independent disc storage devices which are uniformly clamped in the cylindrical cavity;
the independent disc storage device comprises a circular cavity and a plurality of rotary endless belts which are arranged in the circular cavity and the central axis of which coincides with the central axis of the circular cavity;
annular placing cavities uniformly arranged in the circular cavities are formed between the adjacent rotating endless belts; an electric rotating shaft penetrating through the circular cavity and connected with the rotating ring belt is arranged between the end cover A and the end cover B;
the outer side walls of the rotating ring are respectively sleeved with a rotating clamping belt; arc-shaped clamping grooves for clamping the integrated sampling assembly are uniformly formed in the rotating clamping belt;
an annular groove for connecting the rotary clamping belt is formed in the circular cavity;
the rotary clamping belt can rotate in the annular groove and drives the integrated sampling assembly to rotate through the arc clamping groove;
the integrated sampling assembly comprises a sampling tube movably clamped in the arc-shaped clamping groove and a sampler movably arranged in the sampling tube;
the sampler comprises an operation part and a sampling part;
the operation part comprises a sliding sleeve movably arranged in the sampling tube and a handheld part fixed at one end of the sliding sleeve; the inner wall of the sliding sleeve is uniformly provided with sliding grooves;
the sampling part comprises a cylindrical sampling tube, a sliding column and a wave sampling groove, wherein one end of the cylindrical sampling tube is arranged in the sliding sleeve in a sliding way, the sliding column is uniformly arranged on the outer side wall of the cylindrical sampling tube and is in sliding connection with the sliding groove, the wave sampling groove is uniformly arranged on the outer side wall of the cylindrical sampling tube and axially extends along the cylindrical sampling tube, a hemispherical sampling head is arranged at the other end of the sliding sleeve, and a clamping piece is arranged at the bottoms of the hemispherical sampling head and the sampling tube;
the sliding sleeve is characterized in that a scraping ring capable of being meshed with the wave sampling groove is arranged at the joint of the lower end of the sliding sleeve and the cylindrical sampling tube.
Further, a taking and placing structure is arranged in the annular placing cavity in the circular cavity;
the picking and placing structure comprises a picking and placing opening which is arranged on one side wall of the circular cavity and communicated with the annular placing cavity, a sliding baffle which is movably arranged on the picking and placing opening, and a pop-up picking and placing structure which is arranged on the other side wall of the circular cavity and corresponds to the picking and placing opening;
the setting of the taking and placing structure is convenient for the quick taking and placing of the integrated sampling assembly; through rotating the sliding baffle, taking and placing the integrated sampling assembly from the taking and placing port; after opening and getting and putting the mouth, pop out and get and put the structure and can utilize the spring to release integral type sampling assembly, be convenient for take.
Further, the ejecting, taking and placing structure comprises a pressing plate, a spring, a wedge-shaped cushion block and a pressing buckle, wherein one end of the spring is arranged on the side wall of the circular cavity, the other end of the spring is connected with the pressing plate, the wedge-shaped cushion block is arranged on one side of the spring, and the pressing buckle is arranged between the wedge-shaped cushion block and the pressing plate;
the integrated sampling assembly rotates to be contacted with the pressing plate through the wedge-shaped cushion block, the spring is compressed, and the integrated sampling assembly can be ejected after the taking and placing opening is opened; when the integrated sampling assembly is placed, the compression pressing plate and the pressing buckle enable the spring to shrink and lock, and the integrated sampling assembly can be placed continuously.
Further, a round central baffle plate is arranged in the middle of the round cavity; the central partition separates the rotating endless belt from the middle; the rotating clamping bands are arranged on the rotating ring bands on two sides of the central partition plate;
the setting of center baffle can carry out effective dilatation to the storage capacity of circular cavity, improves the storage volume of integral type sampling subassembly.
Further, the first circular tube side wall comprises a plurality of movable protective covers which are uniformly and movably arranged on the first circular tube side wall;
one end of the movable protective cover is movably hinged with the side wall of the first circular tube, and the other end of the movable protective cover is connected with the side wall of the first circular tube through a buckle; the movable protective cover is convenient to open and close quickly due to the arrangement of the buckle, convenient to operate and high in practicability.
Further, upper semicircular partition plates are arranged on two sides of the movable protective cover;
a lower semicircular baffle corresponding to the upper semicircular baffle is uniformly arranged in the side wall of the second circular tube;
the upper semicircular baffle plate and the lower semicircular baffle plate are buckled to separate the cylindrical cavity into a plurality of sealed circular protection cavities; through setting up a plurality of circular protection cavity body, can keep apart the protection to strorage device, effectively avoid taking place cross infection between the sample.
Further, semiconductor refrigerating sheets are uniformly arranged on the inner side wall of the circular protection cavity;
a power supply control module electrically connected with the semiconductor refrigerating sheet is arranged in the end cover A; the semiconductor refrigerating sheet can provide good temperature conditions for detecting samples, ensures that the samples do not deteriorate, and is beneficial to ensuring the reliability of sample detection.
Further, an anti-rolling frame lifting ring in a U shape is movably arranged between the end cover A and the end cover B; the end parts of the rolling-prevention frame lifting rings are connected with rotary dampers arranged at the centers of the end cover A and the end cover B; the anti-rolling frame lifting ring is convenient to carry on one hand, and on the other hand, the anti-rolling frame lifting ring can prevent the external protection box body from rolling when being horizontally placed.
A detection method of an HPV detection kit for facilitating HPV sample storage comprises the following steps:
s1, taking out integrated sampling assembly
Firstly, opening an external protection box body, enabling an electric rotating shaft to rotate a rotary ring belt, and taking out an integrated sampling assembly from an arc clamping groove;
s2, taking out sampler
Then pinching the handheld part to pull along the axial direction of the sampler, sliding and elongating the inner wall of the sliding sleeve and the outer wall of the cylindrical sampling tube, and simultaneously sliding and elongating the inner wall of the sampling tube and the outer wall of the sliding sleeve until the clamping piece is finally pulled open, so that the operation part and the sampling part are separated;
s3, sampling and packaging
Then enabling the hemispherical sampling head and the cylindrical sampling tube to enter an HPV detection sampling part, and slightly rotating the handheld part to enable the wave sampling groove to sample; then the sampling part is retracted to the sampling tube; the hand-held part is pressed down to enable the scraping ring to scrape the sample in the wave sampling groove into the sampling tube; and then placing the shortened integrated sampling assembly into a circular cavity, and closing the external protection box body.
The beneficial effects of the invention are as follows: the invention provides an HPV detection kit convenient for storing HPV samples, wherein an integrated sampling assembly is arranged inside the HPV detection kit; the device can effectively avoid cross infection between samples by arranging the independent disc storage devices in the cylindrical cavity; the integrated sampling assembly is conveniently stored in the independent disc storage device through the rotation arrangement of the rotary clamping belt and the arc clamping groove, and the device has the characteristics of high tightness and strong protection; the arrangement of the upper semicircular partition plate and the lower semicircular partition plate can effectively isolate a plurality of independent spaces, and the semiconductor refrigerating sheet is utilized to independently control the temperature of the plurality of independent spaces, so that only one circular protection cavity is required to be opened when the semiconductor refrigerating sheet is taken and placed, and the contact between samples in other independent spaces and the external environment is effectively avoided.
The invention also provides an integrated sampling assembly for collecting and storing HPV samples, which is characterized in that compared with the traditional brush sampling, the integrated sampling assembly is provided with a cylindrical sampling tube, a wave sampling groove and a hemispherical sampling head to improve the convenience of sampling and reduce the discomfort of a detected person; the traditional brushing sampling method is improved into a mode that a rotary cylindrical sampling tube is sampled by using a wave sampling groove, so that sampling operation of HPV detection is optimized, and the operability of detection is improved.
Drawings
FIG. 1 is a schematic view showing the overall structure of embodiment 1 of the present invention;
FIG. 2 is a schematic view of the circular cavity of embodiment 1 of the present invention;
FIG. 3 is a schematic view showing the structure of a free-standing disk storage unit according to embodiment 1 of the present invention;
FIG. 4 is a schematic structural view of an integral sampling assembly according to embodiment 1 of the present invention;
FIG. 5 is a schematic view of the pick-and-place structure according to embodiment 1 of the present invention;
FIG. 6 is an enlarged view of part of the pick-and-place structure of embodiment 1 of the present invention;
FIG. 7 is a schematic view of the semiconductor refrigeration sheet, roll cage bail structure of embodiment 3 of the present invention;
wherein, 1-external protective case, 10-end cap A, 11-end cap B, 12-first round tube sidewall, 120-removable protective cap, 121-upper semi-round partition, 13-second round tube sidewall, 130-lower semi-round partition, 14-cylindrical cavity, 140-round protective cavity, 15-buckle, 16-semiconductor refrigeration tablet, 17-roll-off rack bail, 18-rotary damper, 2-storage device, 20-free-standing disc storage device, 200-round cavity, 201-rotating ring belt, 202-annular placement cavity, 203-rotating cartridge, 204-arcuate clamping groove, 205-annular groove, 206-central partition, 207-electrical rotating shaft, 21-pick-and-place structure, 210-pick-and-place port, 211-sliding baffle, 212-pressing plate, 213-spring, 214-wedge block, 215-pressing buckle, 3-integral sampling assembly, 30-storage device, 31-sampling device, 310-operating portion, 3101-sliding sleeve, 3102-hand-holding portion, 3-sliding chute, 4-scraping ring, 311-annular groove, 205-annular groove, 206-central partition, 207-electrical rotating shaft, 3101-3113-hemispherical sampling head, 3103-3113-hemispherical sampling head.
Detailed Description
Example 1
The HPV detection kit convenient for storing HPV samples as shown in FIG. 1 comprises an external protection box body 1 convenient to carry, a storage device 2 arranged inside the external protection box body 1, and an integrated sampling assembly 3 arranged inside the storage device 2 and used for collecting and storing samples;
the outer protection box body 1 comprises an end cover A10 and an end cover B11 which are circular in shape, a first circular tube side wall 12 arranged between the end cover A10 and the end cover B11 and positioned at the upper half part, and a second circular tube side wall 13 arranged between the end cover A10 and the end cover B11 and positioned at the lower half part;
the first circular tube side wall 12 and the second circular tube side wall 13 are semicircular side walls with the same diameter and wall thickness; the first circular tube side wall 12 and the second circular tube side wall 13 are buckled to form a closed cylindrical cavity 14;
the storage device 2 comprises 5 independent disc storage devices 20 which are uniformly clamped in the cylindrical cavity 14;
as shown in fig. 2, the free-standing disc storage device 20 includes a circular cavity 200, and 5 rotating endless belts 201 disposed in the circular cavity 200 and having central axes coincident with the central axes of the circular cavity 200;
an annular placing cavity 202 uniformly arranged in the circular cavity 200 is formed between the adjacent rotating endless belts 201; an electric rotating shaft 207 penetrating through the circular cavity 200 and connected with the rotating ring belt 201 is arranged between the end cover A10 and the end cover B11;
as shown in fig. 3, the outer side walls of the rotary endless belt 201 are respectively sleeved with a rotary clamping belt 203; the rotating clamping belt 203 is uniformly provided with arc-shaped clamping grooves 204 for clamping the integrated sampling assembly 3;
an annular groove 205 for connecting the rotary clamping belt 203 is arranged in the circular cavity 200;
the rotary clamping belt 203 can rotate in the annular groove 205 and drive the integrated sampling assembly 3 to rotate through the arc clamping groove 204;
as shown in fig. 4, the integral sampling assembly 3 includes a sampling tube 30 movably clamped in the arc-shaped clamping groove 204, and a sampler 31 movably disposed in the sampling tube 30;
the sampler 31 includes an operation unit 310 and a sampling unit 311;
the operation part 310 includes a sliding sleeve 3101 movably disposed in the sample tube 30, and a hand-held part 3102 fixed to one end of the sliding sleeve 3101; a sliding groove 3103 is uniformly formed in the inner wall of the sliding sleeve 3101;
the sampling part 311 comprises a cylindrical sampling tube 3110 with one end slidably arranged in a sliding sleeve 3101, a sliding column 3111 uniformly arranged on the outer side wall of the cylindrical sampling tube 3110 and slidably connected with a sliding chute 3103, a wave sampling groove 3112 uniformly arranged on the outer side wall of the cylindrical sampling tube 3110 and axially extending along the cylindrical sampling tube 3110, a hemispherical sampling head 3113 arranged at the other end of the sliding sleeve 3101, and a clamping piece 3114 arranged at the bottoms of the hemispherical sampling head 3113 and the sampling tube 30;
a scraping ring 3104 capable of being meshed with the wave sampling groove 3112 is arranged at the joint of the lower end of the sliding sleeve 3101 and the cylindrical sampling tube 3110.
As shown in fig. 5, a picking and placing structure 21 is disposed in the annular placing cavity 202 in the circular cavity 200;
the picking and placing structure 21 includes a picking and placing opening 210 disposed on one side wall of the circular cavity 200 and communicated with the annular placing cavity 202, a sliding baffle 211 movably disposed on the picking and placing opening 210, and a pop-up picking and placing structure disposed on the other side wall of the circular cavity 200 and corresponding to the picking and placing opening 210.
As shown in fig. 6, the ejecting, picking and placing structure includes a pressing plate 212, a spring 213 with one end disposed on a sidewall of the circular cavity 200 and the other end connected to the pressing plate 212, a wedge-shaped pad 214 disposed on one side of the spring 213, and a pressing buckle 215 disposed between the wedge-shaped pad 214 and the pressing plate 212.
As shown in fig. 5, a circular center baffle 206 is disposed in the middle of the circular cavity 200; the center spacer 206 separates the rotating endless belt 201 from the middle; the rotary clamping bands 203 are arranged on the rotary annular bands 201 at two sides of the central partition plate 206.
Wherein, the electric rotating shaft 207 and the push buckle 215 are all made of the prior art, and the specific product type can be selected by those skilled in the art according to the needs.
Example 2
A detection method of HPV detection kit for facilitating HPV sample storage according to embodiment 1 comprises the following steps:
s1, taking out integrated sampling assembly 3
Firstly, opening the external protection box body 1, rotating the rotary ring belt 201 by the electric rotating shaft 207, and taking out the integrated sampling assembly 3 from the arc-shaped clamping groove 204;
s2, taking out the sampler 31
Then, the hand-held part 3102 is pinched and pulled along the axial direction of the sampler 31, the inner wall of the sliding sleeve 3101 and the outer wall of the cylindrical sampling tube 3110 are in sliding extension, and meanwhile, the inner wall of the sampling tube 30 and the outer wall of the sliding sleeve 3101 are in sliding extension until the clamping piece 3114 is finally pulled out, so that the operation part 310 and the sampling part 311 are separated;
s3, sampling and packaging
Then, the hemispherical sampling head 3113 and the cylindrical sampling tube 3110 are put into the HPV detection sampling section, and the wave sampling tank 3112 is sampled by slightly rotating the hand-held section 3102; then the sampling part 311 is retracted to the sampling tube 30; the sample in the wave sampling groove 3112 is scraped into the sampling tube 30 by the scraping ring 3104 by pressing the hand-held portion 3102; the shortened integrated sampling assembly 3 is then placed into the circular cavity 200, closing the external protection cartridge 1.
Example 3
Unlike example 1, the following is:
as shown in fig. 7, the first circular tube sidewall 12 includes a plurality of movable protecting covers 120 uniformly and movably disposed on the first circular tube sidewall 12;
one end of the movable protecting cover 120 is movably hinged with the first circular tube side wall 12, and the other end of the movable protecting cover 120 is connected with the first circular tube side wall 12 through a buckle 15.
Upper semicircular partition plates 121 are arranged on two sides of the movable protective cover 120;
a lower semicircular baffle 130 corresponding to the upper semicircular baffle 121 is uniformly arranged in the second circular tube side wall 13;
the upper semi-circular partition plate 121 and the lower semi-circular partition plate 130 are buckled to divide the cylindrical cavity 14 into 5 sealed circular protection cavities 140.
The inner side wall of the circular protection cavity 140 is uniformly provided with semiconductor refrigerating sheets 16;
the end cap a10 is internally provided with a power control module electrically connected with the semiconductor refrigerating sheet 16.
An anti-rolling frame lifting ring 17 with a U shape is movably arranged between the end cover A10 and the end cover B11; the ends of the roll cage bails 17 are connected to rotary dampers 18 provided in the centers of the end caps a10, B11.
The power control module and the semiconductor refrigerating sheet 16 are all made of the prior art, and specific product types can be selected by those skilled in the art according to requirements.

Claims (9)

1. The HPV detection kit convenient for storing HPV samples is characterized by comprising an external protection box body (1) convenient to carry, a storage device (2) arranged inside the external protection box body (1), and an integrated sampling assembly (3) arranged inside the storage device (2) and used for collecting and storing samples;
the external protection box body (1) comprises an end cover A (10) and an end cover B (11) which are circular in shape, a first circular tube side wall (12) which is arranged between the end cover A (10) and the end cover B (11) and is positioned at the upper half part, and a second circular tube side wall (13) which is arranged between the end cover A (10) and the end cover B (11) and is positioned at the lower half part;
the first circular tube side wall (12) and the second circular tube side wall (13) are semicircular side walls with the same diameter and wall thickness; the first circular tube side wall (12) and the second circular tube side wall (13) are buckled to form a closed cylindrical cavity (14);
the storage device (2) comprises a plurality of independent disc storage devices (20) which are uniformly clamped in the cylindrical cavity (14);
the independent disc storage device (20) comprises a circular cavity (200), and a plurality of rotary endless belts (201) which are arranged in the circular cavity (200) and the central axis of which coincides with the central axis of the circular cavity (200);
annular placing cavities (202) uniformly arranged in the circular cavities (200) are formed between the adjacent rotating endless belts (201); an electric rotating shaft (207) penetrating through the circular cavity (200) and connected with the rotating endless belt (201) is arranged between the end cover A (10) and the end cover B (11);
the outer side walls of the rotary endless belts (201) are respectively sleeved with a rotary clamping belt (203); arc-shaped clamping grooves (204) for clamping the integrated sampling assembly (3) are uniformly formed in the rotating clamping belt (203);
an annular groove (205) for connecting the rotary clamping belt (203) is arranged in the circular cavity (200);
the rotary clamping belt (203) can rotate in the annular groove (205) and drives the integrated sampling assembly (3) to rotate through the arc clamping groove (204);
the integrated sampling assembly (3) comprises a sampling tube (30) movably clamped in the arc-shaped clamping groove (204), and a sampler (31) movably arranged in the Chu Yangguan (30);
the sampler (31) comprises an operation part (310) and a sampling part (311);
the operation part (310) comprises a sliding sleeve (3101) movably arranged in the sampling tube (30), and a hand-held part (3102) fixed at one end of the sliding sleeve (3101); a sliding groove (3103) is uniformly formed in the inner wall of the sliding sleeve (3101);
the sampling part (311) comprises a cylindrical sampling tube (3110) with one end arranged in a sliding sleeve (3101) in a sliding way, a sliding column (3111) which is uniformly arranged on the outer side wall of the cylindrical sampling tube (3110) and is in sliding connection with a sliding groove (3103), a wave sampling groove (3112) which is uniformly arranged on the outer side wall of the cylindrical sampling tube (3110) and axially extends along the cylindrical sampling tube (3110), a hemispherical sampling head (3113) which is arranged at the other end of the sliding sleeve (3101), and a clamping piece (3114) which is arranged at the bottoms of the hemispherical sampling head (3113) and the Chu Yangguan (30);
a scraping ring (3104) which can be meshed with the wave sampling groove (3112) is arranged at the joint of the lower end of the sliding sleeve (3101) and the cylindrical sampling tube (3110).
2. The HPV detection kit for facilitating HPV sample storage according to claim 1, wherein a pick-and-place structure (21) is provided in an annular placement cavity (202) in the circular cavity (200);
the picking and placing structure (21) comprises a picking and placing opening (210) which is arranged on one side wall of the circular cavity (200) and communicated with the annular placing cavity (202), a sliding baffle (211) which is movably arranged on the picking and placing opening (210), and a pop-up picking and placing structure which is arranged on the other side wall of the circular cavity (200) and corresponds to the picking and placing opening (210).
3. The HPV detection kit for facilitating HPV sample storage according to claim 2, wherein the pop-up pick-and-place structure comprises a pressing plate (212), a spring (213) having one end disposed on a side wall of the circular cavity (200) and the other end connected to the pressing plate (212), a wedge-shaped pad (214) disposed on one side of the spring (213), and a pressing buckle (215) disposed between the wedge-shaped pad (214) and the pressing plate (212).
4. The HPV detection kit for facilitating HPV sample storage according to claim 1, wherein a circular center spacer (206) is provided in the middle of the circular cavity (200); the central partition (206) separates the rotating endless belt (201) from the middle; the rotary clamping bands (203) are arranged on the rotary annular bands (201) on two sides of the central partition plate (206).
5. An HPV detection kit for facilitating storage of HPV samples according to claim 1, wherein the first circular tube side wall (12) comprises a plurality of movable protective caps (120) uniformly movably disposed on the first circular tube side wall (12);
one end of the movable protective cover (120) is movably hinged with the first circular tube side wall (12), and the other end of the movable protective cover (120) is connected with the first circular tube side wall (12) through a buckle (15).
6. The HPV detection kit for facilitating HPV sample storage according to claim 5, wherein the movable protective cover (120) is provided with upper semicircular partitions (121) on both sides;
a lower semicircular baffle plate (130) corresponding to the upper semicircular baffle plate (121) is uniformly arranged in the second circular tube side wall (13);
the upper semicircular baffle plate (121) and the lower semicircular baffle plate (130) are buckled to separate the cylindrical cavity (14) into a plurality of sealed circular protection cavities (140).
7. The HPV detection kit for facilitating HPV sample storage according to claim 6, wherein the inner side wall of the circular protection cavity (140) is uniformly provided with semiconductor refrigerating sheets (16);
the end cover A (10) is internally provided with a power control module which is electrically connected with the semiconductor refrigerating sheet (16).
8. The HPV detection kit convenient for storing HPV samples according to claim 1 is characterized in that an anti-rolling frame lifting ring (17) in a U shape is movably arranged between the end cover A (10) and the end cover B (11); the ends of the rolling-prevention frame lifting rings (17) are connected with rotary dampers (18) arranged at the centers of the end cover A (10) and the end cover B (11).
9. The detection method of an HPV detection kit for facilitating HPV sample storage according to any one of claims 1 to 8, comprising the steps of:
s1, taking out an integrated sampling component (3)
Firstly, opening an external protection box body (1), rotating a rotary ring belt (201) by an electric rotating shaft (207), and taking out an integrated sampling assembly (3) from an arc-shaped clamping groove (204);
s2, take out sampler (31)
Then pinching the hand-held part (3102) to pull along the axial direction of the sampler (31), sliding and elongating the inner wall of the sliding sleeve (3101) and the outer wall of the cylindrical sampling tube (3110), and simultaneously sliding and elongating the inner wall of the sampling tube (30) and the outer wall of the sliding sleeve (3101) until the clamping piece (3114) is finally pulled open, so that the operation part (310) and the sampling part (311) are separated;
s3, sampling and packaging
Then, a hemispherical sampling head (3113) and a cylindrical sampling tube (3110) are put into an HPV detection sampling part, and a wave sampling groove (3112) is used for sampling by slightly rotating a handheld part (3102); then, the sampling part (311) is retracted to the sampling tube (30); the scraping ring (3104) scrapes the sample in the wave sampling groove (3112) into the sampling tube (30) by pressing down the hand-held part (3102); and then the shortened integrated sampling assembly (3) is placed into the circular cavity (200), and the external protection box body (1) is closed.
CN202210410037.6A 2022-04-19 2022-04-19 HPV detection kit and detection method convenient for storing HPV samples Active CN114715527B (en)

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CN207703506U (en) * 2018-01-20 2018-08-07 深圳市惠安生物科技有限公司 A kind of feces sampler
CN109717909A (en) * 2019-03-08 2019-05-07 上海领因生物科技有限公司 Integral sampling device and integrated sampling swab
CN209639990U (en) * 2019-01-10 2019-11-15 江苏医药职业学院 A kind of collector for feces examination
CN209751108U (en) * 2019-01-30 2019-12-10 赵鲁文 Clinical sampling device of gynaecology
CN209950217U (en) * 2019-03-04 2020-01-17 安徽冠东电子科技有限公司 Biological sample low temperature storage device and access arrangement
CN111226906A (en) * 2020-01-15 2020-06-05 青岛大学附属医院 Conveniently get procreation medical science of putting and use low temperature save set
CN114313566A (en) * 2022-01-12 2022-04-12 张国栋 A sample case for AIDS detects

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001033359A (en) * 1999-07-16 2001-02-09 Soichi Nakagawa Tool for sampling specimen
CN2479496Y (en) * 2001-07-06 2002-02-27 北京倍爱康生物技术有限公司 Disposable shit collector
CN207703506U (en) * 2018-01-20 2018-08-07 深圳市惠安生物科技有限公司 A kind of feces sampler
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