CN114686005A - Blend of collagen and levorotatory polylactic acid - Google Patents

Blend of collagen and levorotatory polylactic acid Download PDF

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Publication number
CN114686005A
CN114686005A CN202210348266.XA CN202210348266A CN114686005A CN 114686005 A CN114686005 A CN 114686005A CN 202210348266 A CN202210348266 A CN 202210348266A CN 114686005 A CN114686005 A CN 114686005A
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parts
collagen
polylactic acid
blend
weight
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于景堂
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Shanghai Yifei Medical Technology Co ltd
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Shanghai Yifei Medical Technology Co ltd
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85Polyesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a blend of collagen and levorotatory polylactic acid. Comprises the following components in parts by weight: 40-50 parts of collagen, 30-35 parts of levorotatory polylactic acid, 16-20 parts of hyaluronic acid, 8-10 parts of xanthan gum, 0.5-1 part of jaceosidin, 0.3-0.6 part of anthocyanin, 0.2-0.4 part of lycopene, 0.2-0.4 part of taxol, 0.2-0.6 part of catechin, 0.4-0.6 part of lipid carotenoid, 0.2-0.4 part of soybean phospholipid and 0.1-0.3 part of pheophytin. The invention abandons the conventional single-component scheme, adopts the blending of collagen and levorotatory polylactic acid, and introduces other components to form a compound scheme, thereby obtaining a brand-new composition formula. The blend not only obviously improves the biological performance, but also has good stability and is comprehensively superior to the single-component efficacy of collagen or levorotatory polylactic acid. The invention has reasonable formula, good technical effect and outstanding technical advantages.

Description

Blend of collagen and levorotatory polylactic acid
Technical Field
The invention relates to the technical field of medical cosmetology, in particular to a blend of collagen and levorotatory polylactic acid.
Background
Polylactic acid is also classified into dextrorotatory polylactic acid (PDLA), levorotatory polylactic acid (PLLA), racemic polylactic acid (PDLLA), and optically inactive polylactic acid (Meso-PLA) because lactic acid has an asymmetric carbon atom in its molecule and is optically active. PLLA is an important biodegradable high molecular material, and has the characteristics of no toxicity, no irritation, biodegradability, absorption, high strength, good plasticity and easy processing and forming. The degradation period is 2-12 months. PLLA has many uses, mainly used in the medical field of surgical suture, dentistry, ophthalmology, medicinal controlled release system, artificial skin, artificial blood vessel, bone and soft tissue defect part filler, bioabsorbable scaffold, etc.
Collagen is a biological macromolecule, a main component in the connective tissue of animals, and is also a functional protein with the largest content and the widest distribution in mammals, accounting for 25-30 percent of the total protein, and even reaching more than 80 percent of certain organisms. Collagen has good biocompatibility, biodegradability and bioactivity, and thus is widely used in the fields of food, medicine, tissue engineering, cosmetics, and the like. In the prior art, collagen and L-polylactic acid respectively have certain biological properties, but the overall efficacy of the collagen and the L-polylactic acid still needs to be improved.
Disclosure of Invention
The invention aims to provide a blend of collagen and levorotatory polylactic acid aiming at the technical defects of the prior art so as to solve the technical problem of low biological performance of a single-component preparation.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
the blend of the collagen and the levorotatory polylactic acid comprises the following components in parts by weight: 40-50 parts of collagen, 30-35 parts of levorotatory polylactic acid, 16-20 parts of hyaluronic acid, 8-10 parts of xanthan gum, 0.5-1 part of jaceosidin, 0.3-0.6 part of anthocyanin, 0.2-0.4 part of lycopene, 0.2-0.4 part of taxol, 0.2-0.6 part of catechin, 0.4-0.6 part of lipid carotenoid, 0.2-0.4 part of soybean phospholipid and 0.1-0.3 part of pheophytin.
Preferably, the blend further comprises 0.2 to 0.4 parts by weight of lecithin.
Preferably, the blend also comprises 0.8-1 weight part of glyceroglycolipid.
Preferably, the blend also comprises 0.1 to 0.3 weight part of dithio-aminopropionic acid.
Preferably, the blend also comprises 0.2-0.4 weight part of glucoside.
Preferably, the blend consists of the following ingredients in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid and 0.2 part of pheophytin.
Preferably, the blend consists of the following ingredients in parts by weight: 45 parts of collagen, 32 parts of levorotatory polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin, 0.3 part of lecithin, 0.9 part of glyceroglycolipid, 0.2 part of dithio-amino propionic acid and 0.3 part of glucoside.
The invention provides a blend of collagen and levorotatory polylactic acid. The technical scheme abandons the conventional single-component scheme, adopts the blending of collagen and L-polylactic acid, and introduces other components to form a compounding scheme, thereby obtaining a brand-new composition formula. The blend not only obviously improves the biological performance, but also has good stability and is comprehensively superior to the single-component efficacy of collagen or levorotatory polylactic acid. The invention has reasonable formula, good technical effect and outstanding technical advantages.
Detailed Description
Hereinafter, specific embodiments of the present invention will be described in detail. Well-known structures or functions may not be shown in detail in the following embodiments in order to avoid unnecessarily obscuring the details. Approximating language, as used herein in the following examples, may be applied to identify quantitative representations that could permissibly vary in number without resulting in a change in the basic function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
Example 1
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid and 0.2 part of pheophytin.
Example 2
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 45 parts of collagen, 32 parts of levorotatory polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin, 0.3 part of lecithin, 0.9 part of glyceroglycolipid, 0.2 part of dithio-amino propionic acid and 0.3 part of glucoside.
Example 3
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 40 parts of collagen, 30 parts of L-polylactic acid, 16 parts of hyaluronic acid, 8 parts of xanthan gum, 0.5 part of jaceosidin, 0.3 part of anthocyanin, 0.2 part of lycopene, 0.2 part of taxol, 0.2 part of catechin, 0.4 part of lipid carotenoid, 0.2 part of soybean phospholipid and 0.1 part of pheophytin.
Example 4
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 50 parts of collagen, 35 parts of L-polylactic acid, 20 parts of hyaluronic acid, 10 parts of xanthan gum, 1 part of jaceosidin, 0.6 part of anthocyanin, 0.4 part of lycopene, 0.4 part of taxol, 0.6 part of catechin, 0.6 part of lipid carotenoid, 0.4 part of soybean phospholipid and 0.3 part of pheophytin.
Example 5
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of brown cyanidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin, 0.2 part of lecithin and 0.4 part of glucoside.
Example 6
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: a blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of brown cyanidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin, 0.9 part of glyceroglycolipid and 0.3 part of dithio-amino propionic acid.
Example 7
A blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: a blend of collagen and levorotatory polylactic acid comprises the following components in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of brown cyanidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin and 0.3 part of glucoside.
The embodiments of the present invention have been described in detail, but the description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.

Claims (7)

1. The blend of the collagen and the levorotatory polylactic acid is characterized by comprising the following components in parts by weight: 40-50 parts of collagen, 30-35 parts of levorotatory polylactic acid, 16-20 parts of hyaluronic acid, 8-10 parts of xanthan gum, 0.5-1 part of jaceosidin, 0.3-0.6 part of anthocyanin, 0.2-0.4 part of lycopene, 0.2-0.4 part of taxol, 0.2-0.6 part of catechin, 0.4-0.6 part of lipid carotenoid, 0.2-0.4 part of soybean phospholipid and 0.1-0.3 part of pheophytin.
2. The blend of collagen and L-polylactic acid according to claim 1, further comprising 0.2-0.4 weight part of lecithin.
3. The blend of collagen and L-polylactic acid according to claim 1, further comprising 0.8-1 weight part of glyceroglycolipid.
4. The blend of collagen and L-polylactic acid according to claim 1, further comprising 0.1-0.3 weight part of dithio amino propionic acid.
5. The blend of collagen and L-polylactic acid according to claim 1, further comprising 0.2-0.4 weight parts of glucoside.
6. The blend of collagen and L-polylactic acid according to claim 1, which is prepared from the following components in parts by weight: 45 parts of collagen, 32 parts of L-polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid and 0.2 part of pheophytin.
7. The blend of collagen and L-polylactic acid according to claim 1, which is prepared from the following components in parts by weight: 45 parts of collagen, 32 parts of levorotatory polylactic acid, 18 parts of hyaluronic acid, 9 parts of xanthan gum, 0.8 part of jaceosidin, 0.5 part of anthocyanin, 0.3 part of lycopene, 0.3 part of taxol, 0.4 part of catechin, 0.5 part of lipid carotenoid, 0.3 part of soybean phospholipid, 0.2 part of pheophytin, 0.3 part of lecithin, 0.9 part of glyceroglycolipid, 0.2 part of dithio-amino propionic acid and 0.3 part of glucoside.
CN202210348266.XA 2022-04-01 2022-04-01 Blend of collagen and levorotatory polylactic acid Pending CN114686005A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115887760A (en) * 2022-11-21 2023-04-04 娜罗曼苏(杭州)医疗生物科技有限公司 Preparation process of L-polylactic acid for injection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258470A (en) * 2014-05-13 2015-01-07 山东省医疗器械研究所 Mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and preparation method of mixed gel
CN105233332A (en) * 2015-09-30 2016-01-13 苏州蔻美新材料有限公司 Polylactic acid-polyvinyl alcohol absorbable surgical suture and preparation method thereof
CN109331224A (en) * 2018-09-21 2019-02-15 陈炯锋 A kind of gel and its preparation method and application
CN111110623A (en) * 2019-06-28 2020-05-08 青岛华澳现代医疗美容有限公司 Self-repairing small needle nutrient solution formula
CN113413330A (en) * 2021-06-29 2021-09-21 玉本妍(南京)医疗科技有限公司 Compounding method and compounding preparation of collagen and levorotatory polylactic acid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258470A (en) * 2014-05-13 2015-01-07 山东省医疗器械研究所 Mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and preparation method of mixed gel
CN105233332A (en) * 2015-09-30 2016-01-13 苏州蔻美新材料有限公司 Polylactic acid-polyvinyl alcohol absorbable surgical suture and preparation method thereof
CN109331224A (en) * 2018-09-21 2019-02-15 陈炯锋 A kind of gel and its preparation method and application
CN111110623A (en) * 2019-06-28 2020-05-08 青岛华澳现代医疗美容有限公司 Self-repairing small needle nutrient solution formula
CN113413330A (en) * 2021-06-29 2021-09-21 玉本妍(南京)医疗科技有限公司 Compounding method and compounding preparation of collagen and levorotatory polylactic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115887760A (en) * 2022-11-21 2023-04-04 娜罗曼苏(杭州)医疗生物科技有限公司 Preparation process of L-polylactic acid for injection

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