CN114673935A - Injection water distribution system for drug manufacturing - Google Patents

Injection water distribution system for drug manufacturing Download PDF

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Publication number
CN114673935A
CN114673935A CN202210270649.XA CN202210270649A CN114673935A CN 114673935 A CN114673935 A CN 114673935A CN 202210270649 A CN202210270649 A CN 202210270649A CN 114673935 A CN114673935 A CN 114673935A
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China
Prior art keywords
water
pipe
injection
injection water
temperature
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Granted
Application number
CN202210270649.XA
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Chinese (zh)
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CN114673935B (en
Inventor
李建平
董齐新
刘炳立
邱彦
鲜中华
郝田贵
于坤义
孙美华
金晓山
殷晓静
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Beijing Shuangji Pharmaceutical Co ltd
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Beijing Shuangji Pharmaceutical Co ltd
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Priority to CN202210270649.XA priority Critical patent/CN114673935B/en
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/08Pipe-line systems for liquids or viscous products
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/08Pipe-line systems for liquids or viscous products
    • F17D1/14Conveying liquids or viscous products by pumping
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D3/00Arrangements for supervising or controlling working operations
    • F17D3/01Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D5/00Protection or supervision of installations

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Accessories For Mixers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The application relates to an injection water distribution system for drug production, which belongs to the field of pharmacy and comprises a heating tank, a water storage tank, a water delivery pipe and a water return pipe, wherein a loop is formed; the low-temperature medium circulation device comprises a heat exchanger and a low-temperature liquid supply device, wherein a high-temperature medium flow pipeline and a low-temperature medium flow pipeline are arranged in the heat exchanger, and the low-temperature liquid supply device is communicated with a water inlet of the low-temperature medium flow pipeline; a high-temperature liquid feeding pipe is arranged at a water inlet of the high-temperature medium flowing pipeline and is communicated with the three-way valve through a communicating pipe; the water outlet of the high-temperature medium flowing pipeline is communicated with the mixer. This application has the waste that reduces the injection water, practices thrift manufacturing cost's effect.

Description

Injection water distribution system for drug manufacturing
Technical Field
The application relates to the field of pharmacy, in particular to an injection water distribution system for medicine production.
Background
In the production of pharmaceutical enterprises, water for injection is commonly used, wherein the water for injection refers to water which meets the requirements of Chinese pharmacopoeia water for injection, and the preparation, storage and distribution of the water for injection can prevent the breeding and pollution of microorganisms.
Because the temperature reduction of the injection water is a continuous process, a part of injection water which is not reduced to a specific temperature is generated in the process, the part of injection water cannot be directly used, and the water temperature of the main pipeline cannot be directly and circularly returned to the main pipeline to cause the water temperature change of the main pipeline, so that the part of injection water is directly discharged, and great waste is caused.
Disclosure of Invention
In order to reduce the waste of injection water and save the production cost, the application provides an injection water distribution system for pharmaceutical production.
The application provides an injection water distribution system for drug manufacturing adopts following technical scheme:
an injection water distribution system for medicine production comprises a heating tank, a water storage tank, a water feeding pipe and a water return pipe which are communicated together and form a loop, wherein an injection water using point is arranged on the water return pipe, the injection water using point comprises an injection water discharging pipe, a mixer, an injection water discharging pipe and an injection water discharging valve which are sequentially arranged, the injection water discharging pipe is communicated with the water return pipe, a temperature detection element is arranged on the injection water discharging pipe, and a three-way valve is arranged between the injection water discharging pipe and the injection water discharging valve;
One interface of the three-way valve is communicated with the injection water outlet pipe, and the other interface of the three-way valve is communicated with the injection water discharge valve;
the injection water distribution system for medicine production further comprises a heat exchanger and a low-temperature liquid supply device, wherein a high-temperature medium flow pipeline and a low-temperature medium flow pipeline are arranged inside the heat exchanger, and the low-temperature liquid supply device is communicated with a water inlet of the low-temperature medium flow pipeline through a low-temperature liquid supply pipeline;
a high-temperature liquid feeding pipe is arranged at a water inlet of the high-temperature medium flowing pipeline and communicated with the rest of connectors in the three-way valve through a communicating pipe; and the water outlet of the high-temperature medium flowing pipeline is communicated with the mixer through a high-temperature liquid discharge pipe.
By adopting the technical scheme, when injection water needs to be distributed, the water flows into the injection water discharge pipe from the water return pipe and flows into the injection water outlet pipe along the injection water discharge pipe and the mixer, the temperature detection element on the injection water outlet pipe detects the temperature of the water entering the injection water outlet pipe, when the temperature of the water is higher than the required temperature, the three-way valve communicates the injection water outlet pipe with the communicating pipe, so that the water flows into the heat exchanger along the communicating pipe to be cooled, the cooled water is sent into the mixer to be mixed with the newly entering injection water discharge pipe, and the three-way valve communicates the injection water outlet pipe with the injection water discharge valve until the temperature of the water meets the requirement, so that the injection water is discharged from the injection water discharge valve.
Optionally, a water outlet of the low-temperature medium flow pipeline is communicated with the low-temperature liquid supply device through a low-temperature liquid return pipeline.
By adopting the technical scheme, the liquid flowing through the low-temperature medium flow pipeline can flow back to the interior of the low-temperature liquid supply device for repeated use.
Optionally, the quantity of injection water service point is a plurality of, the play water end of high temperature liquid discharge pipe is provided with the reposition of redundant personnel calandria, the reposition of redundant personnel calandria includes trunk line and the shunt tubes that quantity and injection water service point quantity are the same that are linked together with the high temperature liquid discharge pipe, one-to-one between shunt tubes and the injection water service point, shunt tubes one end with the trunk line is linked together, the other end of shunt tubes is linked together with the blender in the injection water service point that corresponds, all installs the stop valve on the every shunt tubes.
Through adopting above-mentioned technical scheme, can set up a plurality of injection water use points in order to collocate the demand to the injection water in the different medicine production processes at the back flow.
Optionally, a delivery pump is installed on the high-temperature liquid feeding pipe.
Through adopting above-mentioned technical scheme, can be better send into the inside of high temperature medium flow line with high temperature injection water.
Optionally, the injection water outlet pipe is provided with a flow velocity detection element.
By adopting the technical scheme, the flow velocity of the injection water can be detected.
Optionally, the medium flowing direction inside the high temperature medium flowing pipeline is opposite to the medium flowing direction inside the low temperature medium flowing pipeline.
By adopting the technical scheme, heat exchange can be better carried out between the flowing medium in the high-temperature medium flowing pipeline and the flowing medium in the low-temperature medium flowing pipeline.
Optionally, a conductivity sensor is installed on the water supply pipe.
By adopting the technical scheme, the conductivity of the injection water can be monitored.
Optionally, the heating tank is provided with a water replenishing pipe communicated with the heating tank, and the water replenishing pipe is provided with a water replenishing valve.
Through adopting above-mentioned technical scheme, when the water yield in the heating jar is not enough, can carry out the moisturizing for in the heating jar through the moisturizing pipe.
Optionally, the injection water distribution system for pharmaceutical production further comprises a water inlet pipe communicated with the water return pipe, and the water inlet pipe is provided with a stop valve.
Through adopting above-mentioned technical scheme, can control the intercommunication or the disconnection between inlet tube and the wet return through the stop valve, be convenient for maintain injection water distribution system.
In summary, the present application includes at least one of the following beneficial technical effects:
1. when the temperature of the injection water in the injection water outlet pipe is higher than the required temperature, the injection water can be cooled, the temperature of the paper injection water is reduced to the required temperature, and then the paper injection water can be finally discharged through the injection water discharge valve, so that the waste of the injection water is reduced, and the production cost is saved.
2. A plurality of injection water use points can be arranged on the return pipe to match the requirements of different medicines for injection water in the production process.
Drawings
Fig. 1 is a schematic diagram of a water injection dispensing system for pharmaceutical manufacturing according to an embodiment of the present application.
Description of reference numerals: 1. a heating tank; 11. a water replenishing pipe; 12. a water replenishing valve; 2. a water storage tank; 3. a water supply pipe; 31. a conductivity sensor; 32. a valve; 4. a water return pipe; 41. a first delivery pump; 42. a first shut-off valve; 5. a water inlet pipe; 51. a second stop valve; 6. point of use of injection water; 61. an injection water discharge pipe; 62. a mixer; 63. an injection water outlet pipe; 631. a flow rate sensor; 632. a temperature sensor; 64. an injection water discharge valve; 7. a temperature adjusting unit; 71. a heat exchanger; 711. a high temperature medium flow line; 712. a cryogenic medium flow line; 72. a cryogenic liquid supply tank; 73. a shunt calandria; 731. a main pipeline; 732. a shunt tube; 733. a third stop valve; 74. a cryogenic liquid supply conduit; 75. a second delivery pump; 76. a low-temperature liquid return pipeline; 77. a high-temperature liquid discharge pipe; 78. a high temperature liquid feed pipe; 79. a communicating pipe; 8. an electric three-way valve; 9. and a third delivery pump.
Detailed Description
The present application is described in further detail below with reference to fig. 1.
The embodiment of the application discloses an injection water distribution system for medicine production.
Referring to fig. 1, the injection water distribution system for pharmaceutical production includes a heating tank 1 and a water storage tank 2, a water outlet of the heating tank 1 is communicated with a water inlet of the water storage tank 2 through a water supply pipe 3, and a water inlet of the heating tank 1 is communicated with a water outlet of the water storage tank 2 through a water return pipe 4. A loop with the inside communicated is formed among the heating tank 1, the water storage tank 2, the water feeding pipe 3 and the water return pipe 4. A conductivity sensor 31 is installed on the water feeding pipe 3, and the conductivity sensor 31 is used to detect the conductivity of the water flowing through the water feeding pipe 3.
A valve 32 is arranged between the water feeding pipe 3 and the water inlet of the water storage tank 2, and the valve 32 is used for controlling the connection or disconnection between the water feeding pipe 3 and the water storage tank 2. When the valve 32 is opened, the water storage tank 2 is communicated with the water feeding pipe 3, and when the valve 32 is closed, the water storage tank 2 is disconnected from the water feeding pipe 3.
The heating tank 1 is also provided with a water replenishing pipe 11 communicated with the inside of the heating tank 1, and the water replenishing pipe 11 is provided with a water replenishing valve 12. One end of the water replenishing pipe 11 far away from the heating tank 1 is communicated with a water replenishing water source. When water needs to be supplied to the inside of the heating tank 1, the water supply valve 12 is opened to communicate the water supply pipe 11 with the inside of the heating tank 1, and water can be supplied to the inside of the heating tank 1 along the water supply pipe 11.
A first transfer pump 41 and a first shut-off valve 42 are installed on the return pipe 4, and the first transfer pump 41 is used to pump the water in the water storage tank 2 into the return pipe 4 and to make the water in the water storage tank 2 flow to the heating tank 1 along the return pipe 4.
The injection water distribution system for medicine production further comprises a water inlet pipe 5, one end of the water inlet pipe 5 is communicated with the water return pipe 4, and the other end of the water inlet pipe 5 is communicated with a water source. The connection point of the water inlet pipe 5 and the water return pipe 4 is located between the first cut-off valve 42 and the first transfer pump 41. A second shut-off valve 51 is mounted on the inlet pipe 5.
A plurality of injection water use points 6 communicated with the water return pipe 4 are further arranged on the water return pipe 4, the injection water use points 6 comprise an injection water discharge pipe 61 communicated with the water return pipe 4, a mixer 62, an injection water outlet pipe 63 and an injection water discharge valve 64, and the injection water discharge pipe 61, the mixer 62, the injection water outlet pipe 63 and the injection water discharge valve 64 are sequentially communicated.
When the water in the return pipe 4 is discharged through the injection water using point 6, the injection water first enters the injection water discharging pipe 61 and is fed into the mixer 62 along the injection water discharging pipe 61, and the injection water flowing through the mixer 62 flows into the injection water discharging pipe 63 and is finally discharged through the injection water discharging valve 64.
A flow rate sensor 631 and a temperature sensor 632 are mounted on the injection water outlet pipe 63, and the flow rate sensor 631 is used for detecting the flow rate of water flowing through the injection water outlet pipe 63; the temperature sensor 632 is used to detect the temperature of water flowing through the injection water outlet pipe 63.
The water injection distribution system for pharmaceutical production further comprises a temperature regulating unit 7, wherein the temperature regulating unit 7 comprises a heat exchanger 71, a cryogenic liquid supply tank 72 and a shunt drain pipe 73. The inside of the heat exchanger 71 is provided with a high temperature medium flow line 711 and a low temperature medium flow line 712 for performing heat exchange, wherein the medium flow direction inside the low temperature medium flow line 712 is opposite to the medium flow direction inside the high temperature medium flow line 711. The water inlet of the low-temperature medium flow pipeline 712 is communicated with the water outlet of the low-temperature liquid supply tank 72 through a low-temperature liquid supply pipeline 74, a second delivery pump 75 is installed on the low-temperature liquid supply pipeline 74, and the second delivery pump 75 is used for delivering the liquid in the low-temperature liquid supply pipeline 74 into the low-temperature medium flow pipeline 712. The outlet of the cryogenic medium flow line 712 communicates with the inlet of the cryogenic liquid supply tank 72 via the cryogenic liquid return line 76. The liquid flowing through the cryogenic medium flow line 712 is finally returned to the interior of the cryogenic liquid supply tank 72 along the cryogenic liquid return line 76.
The shunt canalisation 73 comprises a main conduit 731 and the same number of shunt tubes 732 as there are injection water usage points 6. There is a one-to-one correspondence between the shunt tubes 732 and the injection water points of use 6. One end of the shunt tube 732 is communicated with the main tube 731, and the other end of the shunt tube 732 is communicated with the mixer 62 in the corresponding injection water using point 6. A third shut-off valve 733 is installed at each shunt tube 732.
The outlet of the high temperature medium flow line 711 is connected to the main line 731 via a high temperature liquid discharge pipe 77. The high temperature liquid feed pipe 78 is connected to the water inlet of the high temperature medium flow pipe 711.
The injection water outlet pipe 63 of each injection water use point 6 is communicated with the high-temperature liquid feeding pipe 78 through a communicating pipe 79. The connection position of the communicating pipe 79 and the injection water outlet pipe 63 is connected through an electric three-way valve 8. One of the ports of the electric three-way valve 8 is connected with the water outlet end of the injection water outlet pipe 63, one port is communicated with the injection water discharge valve 64, and the other port is communicated with the communicating pipe 79.
A third transfer pump 9 is installed between the high-temperature liquid feed pipe 78 and the high-temperature medium flow pipe 711, and the third transfer pump 9 is used for feeding the liquid flowing into the high-temperature liquid feed pipe 78 into the high-temperature medium flow pipe 711.
The implementation principle of an injection water distribution system for drug production in the embodiment of the application is as follows: when it is desired to dispense injection water, water first flows from return pipe 4 into injection water discharge pipe 61, mixer 62 and injection water outlet pipe 63 of injection water point of use 6. The temperature sensor 632 and the flow rate sensor 631 on the injection water outlet pipe 63 detect the flow rate and the temperature of water, when the temperature of the water is higher than the required temperature, the electric three-way valve 8 communicates the injection water outlet pipe 63 with the communicating pipe 79, so that the water is sent into the heat exchanger 71 along the communicating pipe 79 to be cooled, the cooled water is sent back to the mixer 62 to be mixed, and after the temperature meets the requirement, the electric three-way valve 8 communicates the injection water outlet pipe 63 with the injection water discharge valve 64, so that the injection water is discharged from the injection water discharge valve 64.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (9)

1. The utility model provides an injection water distribution system for pharmaceutical production, is including intercommunication together and heating jar (1), water storage tank (2), flow pipe (3) and wet return (4) that form the loop, be provided with injection water use point (6) on wet return (4), its characterized in that: the injection water using point (6) comprises an injection water discharge pipe (61), a mixer (62), an injection water outlet pipe (63) and an injection water discharge valve (64) which are sequentially arranged, the injection water discharge pipe (61) is communicated with the water return pipe (4), a temperature detection element is mounted on the injection water outlet pipe (63), and a three-way valve is arranged between the injection water outlet pipe (63) and the injection water discharge valve (64);
One interface of the three-way valve is communicated with the injection water outlet pipe (63), and the other interface of the three-way valve is communicated with the injection water discharge valve (64);
the injection water distribution system for medicine production further comprises a heat exchanger (71) and a low-temperature liquid supply device, wherein a high-temperature medium flow pipeline (711) and a low-temperature medium flow pipeline (712) are arranged inside the heat exchanger (71), and the low-temperature liquid supply device is communicated with a water inlet of the low-temperature medium flow pipeline (712) through a low-temperature liquid supply pipeline (74);
a high-temperature liquid feeding pipe (78) is arranged at a water inlet of the high-temperature medium flowing pipeline (711), and the high-temperature liquid feeding pipe (78) is communicated with the rest of connectors in the three-way valve through a communicating pipe (79); the water outlet of the high-temperature medium flowing pipeline (711) is communicated with the mixer (62) through a high-temperature liquid discharge pipe (77).
2. A system for dispensing injectable water for pharmaceutical production as defined in claim 1 wherein: and a water outlet of the low-temperature medium flowing pipeline (712) is communicated with the low-temperature liquid supply device through a low-temperature liquid return pipeline (76).
3. A water-for-injection dispensing system for use in the manufacture of a medicament as claimed in claim 1, wherein: the quantity of injection water usage point (6) is a plurality of, the play water end of high temperature liquid discharge pipe (77) is provided with reposition of redundant personnel calandria (73), reposition of redundant personnel calandria (73) include trunk line (731) and the shunt tubes (732) that quantity is the same with injection water usage point (6) quantity that are linked together with high temperature liquid discharge pipe (77), one-to-one between shunt tubes (732) and the injection water usage point (6), shunt tubes (732) one end with trunk line (731) is linked together, the other end of shunt tubes (732) is linked together with blender (62) in the injection water usage point (6) that correspond, all installs the stop valve on every shunt tubes (732).
4. A system for dispensing injectable water for pharmaceutical production as defined in claim 1 wherein: and a delivery pump is arranged on the high-temperature liquid feeding pipe (78).
5. A water-for-injection dispensing system for use in the manufacture of a medicament as claimed in claim 1, wherein: and a flow velocity detection element is arranged on the injection water outlet pipe (63).
6. A water-for-injection dispensing system for use in the manufacture of a medicament as claimed in claim 1, wherein: the medium flow direction inside the high-temperature medium flow pipe (711) is opposite to the medium flow direction inside the low-temperature medium flow pipe (712).
7. A water-for-injection dispensing system for use in the manufacture of a medicament as claimed in claim 1, wherein: and the water supply pipe (3) is provided with a conductivity sensor (31).
8. A water-for-injection dispensing system for use in the manufacture of a medicament as claimed in claim 1, wherein: the heating tank (1) is provided with a water replenishing pipe (11) communicated with the heating tank (1), and the water replenishing pipe (11) is provided with a water replenishing valve (12).
9. The injection water distribution system for pharmaceutical production according to claim 1, further comprising a water inlet pipe (5) communicated with the water return pipe (4), wherein the water inlet pipe (5) is provided with a stop valve.
CN202210270649.XA 2022-03-18 2022-03-18 Injection water distribution system for drug production Active CN114673935B (en)

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CN114673935B CN114673935B (en) 2024-01-30

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102538067A (en) * 2010-12-07 2012-07-04 上海熊猫机械(集团)有限公司 Heat supply equipment
CN105498019A (en) * 2014-09-24 2016-04-20 上海奥星制药技术装备有限公司 Bicirculating system of water for injection
CN206300520U (en) * 2016-12-07 2017-07-04 杨凌金海生物技术有限公司 A kind of water for injection system
CN207404831U (en) * 2017-10-23 2018-05-25 上海奥星制药技术装备有限公司 low-temperature injection water system
CN110143632A (en) * 2019-04-10 2019-08-20 上海凯贤流体科技有限公司 A kind of water for injection cooling system based on how colod-application point
CN111442191A (en) * 2020-04-02 2020-07-24 上海奥星制药技术装备有限公司 Injection water taking system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102538067A (en) * 2010-12-07 2012-07-04 上海熊猫机械(集团)有限公司 Heat supply equipment
CN105498019A (en) * 2014-09-24 2016-04-20 上海奥星制药技术装备有限公司 Bicirculating system of water for injection
CN206300520U (en) * 2016-12-07 2017-07-04 杨凌金海生物技术有限公司 A kind of water for injection system
CN207404831U (en) * 2017-10-23 2018-05-25 上海奥星制药技术装备有限公司 low-temperature injection water system
CN110143632A (en) * 2019-04-10 2019-08-20 上海凯贤流体科技有限公司 A kind of water for injection cooling system based on how colod-application point
CN111442191A (en) * 2020-04-02 2020-07-24 上海奥星制药技术装备有限公司 Injection water taking system

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