CN114632556A - Universal fluid control system and control method - Google Patents
Universal fluid control system and control method Download PDFInfo
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- CN114632556A CN114632556A CN202011479942.4A CN202011479942A CN114632556A CN 114632556 A CN114632556 A CN 114632556A CN 202011479942 A CN202011479942 A CN 202011479942A CN 114632556 A CN114632556 A CN 114632556A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0642—Filling fluids into wells by specific techniques
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Abstract
The invention discloses a universal fluid control system, which comprises a shell, a power module, an air pump, a valve body, a gas-liquid exchange container, a controller and an interface component, wherein the power module, the air pump, the valve body, the gas-liquid exchange container and the controller are used for supplying power to the system; the valve body comprises an air inlet, a first air outlet and a second air outlet, the air inlet is connected with the air pump to introduce air, and the first air outlet is connected with the interface component; the gas-liquid exchange container is internally provided with a space for containing liquid and is simultaneously communicated with the second gas outlet and the interface component, and the controller is used for controlling the gas inlet to be selectively switched to be communicated with the first gas outlet or the second gas outlet. The invention integrates air pressure control and hydraulic control together by adopting a high-precision universal gas-liquid control module, realizes the multipurpose application of a single system, can be compatible with air pressure control and hydraulic control at the same time, and can be used for replacing control system equipment needing liquid or gas, such as a liquid drop generating instrument, an injection pump, an infusion pump, a micro-fluidic system and the like.
Description
Technical Field
The invention relates to the technical field of fluid control, in particular to a universal fluid control system and a control method.
Background
Microfluidics (Microfluidics), which refers to the science and technology involved in systems using microchannels (tens to hundreds of microns in size) to process or manipulate tiny fluids (nanoliters to attoliters in volume), is an emerging interdiscipline of chemistry, fluid physics, microelectronics, new materials, biology and biomedical engineering. Because of their miniaturization, integration, etc., microfluidic devices are commonly referred to as microfluidic chips, also known as Lab-on-a-chips (Lab-on-a-chips) and micro-Total Analytical systems (micro-Total Analytical systems).
The fields of medical detection, biological detection, chemical experiments and the like often require fine control and operation of various gases or liquids, and the regulation and control mode can be adjusted by a pressure controller/pressure-driven pump or an injection pump. According to the conventional method, a set of special control system and a special operation flow are required to be designed for each application of gas or liquid, other applications cannot be compatible, the application range of equipment is limited, the same equipment cannot simultaneously complete fine control of the gas and the liquid, and scientific research cost is increased.
Disclosure of Invention
In view of the defects in the prior art, the invention provides a universal fluid control system and a control method, which can simultaneously and finely control liquid and gas, improve the compatibility of equipment, expand application scenes and save cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
a universal fluid control system comprises a shell, a power supply module for supplying power to the system, an air pump, a valve body, a gas-liquid exchange container, a controller and an interface assembly for connecting a microfluidic chip or an injection pump; the valve body comprises an air inlet, a first air outlet and a second air outlet, the air inlet is connected with the air pump to introduce air, and the first air outlet is connected with the interface component; the gas-liquid exchange container is internally provided with a space for containing liquid and is simultaneously communicated with the second gas outlet and the interface component, and the controller is used for controlling the gas inlet to be selectively switched to be communicated with the first gas outlet or the second gas outlet.
As one of the embodiments, the universal fluid control system further comprises a pressure sensor group comprising a first sensor and a second pressure sensor; the first sensor is connected between the first gas outlet and the interface component to detect a gas output pressure of the first gas outlet; the second pressure sensor is connected between the gas-liquid exchange container and the interface assembly to detect the liquid output pressure of the gas-liquid exchange container; the controller is also used for adjusting the air pressure output of the valve body according to the detection results of the first sensor and the second pressure sensor.
In one embodiment, the valve body is an electromagnetic proportional valve.
In one embodiment, the fluid control system further includes a liquid pump connected to the gas-liquid exchange container to replenish liquid in the gas-liquid exchange container.
As one embodiment, the interface assembly includes a clamp fixed on the surface of the housing for clamping the microfluidic chip or the syringe pump, and an interface for connecting a gas-liquid inlet of the microfluidic chip or the syringe pump.
As one embodiment, the clamp includes a bottom plate and a cover plate, the bottom plate is provided with a groove for embedding the microfluidic chip or the syringe pump, the cover plate is rotatably connected with the bottom plate and is used for arranging the microfluidic chip or the syringe pump in the groove, and the interface is convexly arranged in the groove.
In one embodiment, the surface of the housing is provided with a plurality of sets of mounting holes at different positions, and the bottom plate is selectively fixed on one set of the mounting holes.
Another object of the present invention is to provide a general fluid control method, including:
starting the air pump, and introducing air pressure to the valve body;
judging the fluid output requirement;
when only the air pressure needs to be output, the valve body is controlled to be switched to the first air outlet to be conducted, the pressure of the first air outlet is detected, and the input pressure of the air pump is adjusted in real time;
when liquid needs to be output, the control valve body is switched to the second air outlet to be communicated, air pressure is injected into the gas-liquid exchange container filled with the liquid, the pressure between the gas-liquid exchange container and the interface assembly is detected, and the pressure of the air pump is adjusted in real time.
As one embodiment, the general fluid control method further includes: detecting the liquid amount in the gas-liquid exchange container, and supplementing the liquid into the gas-liquid exchange container when needed.
As one embodiment, the general fluid control method further includes: and installing the corresponding interface assembly on the shell according to the model of the microfluidic chip or the injection pump.
The invention integrates air pressure control and hydraulic control together by adopting a high-precision universal gas-liquid control module, realizes the multipurpose application of a single system, can be compatible with air pressure control and hydraulic control at the same time, and can be used for replacing control system equipment needing liquid or gas, such as a liquid drop generating instrument, an injection pump, an infusion pump, a micro-fluidic system and the like. The application of a single system in the liquid or gas control field with various requirements can be realized by matching the universal interface and the clamp.
Drawings
FIG. 1 is a schematic perspective view of a universal fluid control system according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of the internal structure of a universal fluid control system according to an embodiment of the present invention;
FIG. 3 is a block diagram of a generic fluid control system according to an embodiment of the invention;
FIG. 4 is an exploded view of an interface module according to an embodiment of the present invention;
fig. 5 is a flowchart of a general fluid control method according to an embodiment of the invention.
Detailed Description
In the present invention, the terms "disposed", "provided" and "connected" are to be understood in a broad sense. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meanings of the above terms in the present invention can be understood by those of ordinary skill in the art according to specific situations.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Moreover, some of the above terms may be used in other meanings besides orientation or positional relationship, for example, the term "upper" may also be used in some cases to indicate a certain attaching or connecting relationship. The specific meanings of these terms in the present invention can be understood by those skilled in the art as appropriate.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1 to 3, the general fluid control system according to the embodiment of the present invention mainly includes a housing 1, a power module 2 for supplying power to the system, an air pump 3, a valve body 4, a gas-liquid exchange container 5, a controller 6, and an interface assembly 7 for connecting a microfluidic chip or an injection pump. The valve body 4 comprises an air inlet 41, a first air outlet 42 and a second air outlet 43, the air inlet 41 is connected with the air pump 3 to introduce air, and the first air outlet 42 is connected with the interface component 7; a space for containing liquid is arranged in the gas-liquid exchange container 5, the second gas outlet 43 and the interface component 7 are communicated at the same time, and the controller 6 is used for controlling the gas inlet 41 to be selectively switched to be communicated with the first gas outlet 42 or the second gas outlet 43.
The power module 2 is electrically connected with the air pump 3, the valve body 4 and the controller 6 which are arranged in the shell 1 and used for supplying power to the whole system. In an initial state, the controller 6 controls the air inlet 41 to be communicated with the first air outlet 42, the air pump 3 introduces high-pressure air to the valve body 4, the air enters from the air inlet 41 and enters the micro-fluidic chip or the injection pump from the interface component 7 through the first air outlet 42, and therefore air pressure control is achieved; when liquid control is needed, the controller 6 controls the gas inlet 41 to be communicated with the second gas outlet 43, the first gas outlet 42 does not discharge gas, gas enters from the gas-liquid exchange container 5, and liquid in the gas-liquid exchange container 5 is output to the interface component 7 at stable pressure, so that the control process of the liquid is realized, and the control of the gas and the liquid by using the same control system is realized.
In order to better ensure the control accuracy of the system, as shown in fig. 3, the general fluid control system further includes a pressure sensor group 8, and the pressure sensor group 8 includes a first sensor 81 and a second pressure sensor 82, wherein the first sensor 81 is connected between the first gas outlet 42 and the interface component 7 to detect the gas output pressure of the first gas outlet 42, and the second pressure sensor 8 is connected between the gas-liquid exchange container 5 and the interface component 7 to detect the liquid output pressure of the gas-liquid exchange container 5, so that the controller 6 can precisely adjust the gas pressure output of the valve body 4 according to the detection results of the first sensor 81 and the second pressure sensor 8, thereby achieving precise control of the gas pressure and the hydraulic pressure.
Here, the valve body 4 is preferably an electromagnetic proportional valve, and high-precision air pressure control can be realized. The general fluid control system also has a liquid pump 9, and the liquid pump 9 is connected to the gas-liquid exchange container 5 to replenish the liquid in the gas-liquid exchange container 5, if necessary.
As shown in fig. 4, the interface assembly 7 of the present embodiment specifically includes a clamp 71 and an interface 72, the clamp 71 is fixed on the surface of the housing 1 and is used for clamping the microfluidic chip or the syringe pump, and the interface 72 is used for connecting a gas-liquid inlet of the microfluidic chip or the syringe pump. It will be appreciated that the gas and liquid outlet lines of the system may be common or separate and need only be connected to the ports 72 of the desired port assembly 7 at the same time.
Further, the clamp 71 includes a bottom plate 711 and a cover plate 712, the bottom plate 711 is provided with a groove 7110 for embedding the microfluidic chip or the syringe pump, the cover plate 712 is rotatably connected with the bottom plate 711, and is used for arranging the microfluidic chip or the syringe pump in the groove 7110 therein, and the interface 72 is convexly arranged in the groove 7110.
In addition, in order to realize the detachable connection of the clamp 71 to adapt to different clamps according to different application scenarios, a plurality of sets of mounting holes 10 with different positions are formed on the surface of the housing 1, and the bottom plate 711 is selectively fixed on one set of the mounting holes 10, so that the compatibility of the system is improved.
In addition, an interactive panel D such as a touch screen can be arranged on the surface of the shell 1, the system state can be displayed in real time, a control interface is provided, interactive control with the system is achieved, and the device is convenient and practical.
As shown in fig. 5, an embodiment of the present invention further provides a general fluid control method, including:
s01, starting the air pump 3, and introducing air pressure to the valve body 4;
s02, judging the fluid output requirement;
s03, when only the air pressure needs to be output, the valve body 4 is controlled to be switched to the first air outlet 42 to be conducted, the pressure of the first air outlet 42 is detected, and the input pressure of the air pump 3 is adjusted in real time;
and S04, when liquid needs to be output, the control valve body 4 is switched to the second air outlet 43 to be conducted, air pressure is injected into the gas-liquid exchange container 5 filled with the liquid, the pressure between the gas-liquid exchange container 5 and the interface component 7 is detected, and the pressure of the air pump 3 is adjusted in real time.
In step S04, when the liquid is to be discharged, the liquid amount in the gas-liquid exchange container 5 is detected, and the liquid may be replenished into the gas-liquid exchange container 5 as needed.
In different application scenarios, the general fluid control system further comprises: according to the model of the micro-fluidic chip or the injection pump, the corresponding interface assembly 7 is mounted on the housing 1, specifically, the bottom plate 711 of the clamp 71 is selectively fixed on one set of mounting holes 10, so that the interface 72 is connected with the internal gas and liquid output pipelines in a precise alignment manner. Specifically, when the microfluidic chip or the syringe pump is mounted, the cover plate 712 may be rotated to open the microfluidic chip or the syringe pump, and the microfluidic chip or the syringe pump may be fixed in the groove 7110, so as to precisely assemble the interface 72 with the microfluidic chip or the syringe pump, and finally the cover plate 712 is rotated to fix the microfluidic chip or the syringe pump in the bottom plate 711.
The invention integrates air pressure control and hydraulic control together by adopting a high-precision universal gas-liquid control module, realizes the multipurpose application of a single system, can be compatible with air pressure control and hydraulic control at the same time, and can be used for replacing control system equipment needing liquid or gas, such as a liquid drop generating instrument, an injection pump, an infusion pump, a micro-fluidic system and the like. The application of a single system in the liquid or gas control field with various requirements can be realized by matching the universal interface and the clamp.
The foregoing is directed to embodiments of the present application and it is noted that numerous modifications and adaptations may be made by those skilled in the art without departing from the principles of the present application and are intended to be within the scope of the present application.
Claims (10)
1. A universal fluid control system is characterized by comprising a shell (1), a power supply module (2) for supplying power to the system, an air pump (3), a valve body (4), a gas-liquid exchange container (5), a controller (6) and an interface component (7) for connecting a micro-fluidic chip or an injection pump; the valve body (4) comprises an air inlet (41), a first air outlet (42) and a second air outlet (43), the air inlet (41) is connected with the air pump (3) to introduce air, and the first air outlet (42) is connected with the interface component (7); a space for containing liquid is arranged in the gas-liquid exchange container (5), the second gas outlet (43) and the interface component (7) are communicated at the same time, and the controller (6) is used for controlling the gas inlet (41) to be selectively switched to be communicated with the first gas outlet (42) or the second gas outlet (43).
2. The universal fluid control system according to claim 1, further comprising a pressure sensor set (8), said pressure sensor set (8) comprising a first sensor (81) and a second pressure sensor (82); the first sensor (81) is connected between the first gas outlet (42) and the interface assembly (7) to detect a gas output pressure of the first gas outlet (42); the second pressure sensor (8) is connected between the gas-liquid exchange container (5) and the interface component (7) to detect the liquid output pressure of the gas-liquid exchange container (5); the controller (6) is also used for adjusting the air pressure output of the valve body (4) according to the detection results of the first pressure sensor (81) and the second pressure sensor (8).
3. Universal fluid control system according to claim 1, characterized in that the valve body (4) is a solenoid proportional valve.
4. The universal fluid control system according to claim 1, further comprising a liquid pump (9), said liquid pump (9) being connected to said gas-liquid exchange vessel (5) to replenish liquid into said gas-liquid exchange vessel (5).
5. The universal fluid control system according to any one of claims 1 to 4, wherein the interface assembly (7) comprises a clamp (71) and an interface (72), the clamp (71) is fixed on the surface of the housing (1) and used for clamping the microfluidic chip or the injection pump, and the interface (72) is used for connecting a gas-liquid inlet of the microfluidic chip or the injection pump.
6. The universal fluid control system according to claim 5, wherein the clamp (71) comprises a bottom plate (711) and a cover plate (712), the bottom plate (711) is provided with a groove (7110) for embedding a micro-fluidic chip or a syringe pump, the cover plate (712) is rotatably connected with the bottom plate (711) and is used for arranging the micro-fluidic chip or the syringe pump cover in the groove (7110), and the interface (72) is convexly arranged in the groove (7110).
7. The universal fluid control system according to claim 5, wherein said housing (1) defines a plurality of sets of differently positioned mounting holes (10) on a surface thereof, and said base plate (711) is selectively fixed to one of said sets of mounting holes (10).
8. A universal fluid control method, comprising:
starting the air pump (3) and introducing air pressure to the valve body (4);
judging the fluid output requirement;
when only the air pressure needs to be output, the valve body (4) is controlled to be switched to the first air outlet (42) to be conducted, the pressure of the first air outlet (42) is detected, and the inlet pressure of the air pump (3) is adjusted in real time;
when liquid needs to be output, the control valve body (4) is switched to the second air outlet (43) to be conducted, air pressure is injected into the gas-liquid exchange container (5) filled with the liquid, the pressure between the gas-liquid exchange container (5) and the interface assembly (7) is detected, and the pressure of the air pump (3) is adjusted in real time.
9. The universal fluid control method according to claim 8, further comprising: the amount of liquid in the gas-liquid exchange container (5) is detected, and the liquid is replenished into the gas-liquid exchange container (5) when necessary.
10. The universal fluid control method according to claim 8 or 9, further comprising: and according to the type of the micro-fluidic chip or the injection pump, a corresponding interface assembly (7) is installed on the shell (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202011479942.4A CN114632556A (en) | 2020-12-15 | 2020-12-15 | Universal fluid control system and control method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011479942.4A CN114632556A (en) | 2020-12-15 | 2020-12-15 | Universal fluid control system and control method |
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| CN114632556A true CN114632556A (en) | 2022-06-17 |
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| CN202011479942.4A Pending CN114632556A (en) | 2020-12-15 | 2020-12-15 | Universal fluid control system and control method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115970780A (en) * | 2023-03-21 | 2023-04-18 | 浙江扬清芯片技术有限公司 | General type switching device and multifunctional microfluidic research and development platform with selectable modules |
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| CN115970780A (en) * | 2023-03-21 | 2023-04-18 | 浙江扬清芯片技术有限公司 | General type switching device and multifunctional microfluidic research and development platform with selectable modules |
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