CN114632129A

CN114632129A - Traditional Chinese medicine for treating cough variant asthma in children and preparation method thereof

Info

Publication number: CN114632129A
Application number: CN202210280813.5A
Authority: CN
Inventors: 郭凯; 肖和印
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-03-25
Filing date: 2022-03-25
Publication date: 2022-06-17
Anticipated expiration: 2042-03-25
Also published as: CN114632129B

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating cough variant asthma in children and a preparation method and application thereof; herba schizonepetae and radix sileris are used as monarch drugs, and the emphasis is on dispelling wind and eliminating evil. Ephedra, dahurian angelica root, cicada slough and uncaria are ministerial, and dahurian angelica root is good at dispelling wind-cold evil; the ephedra herb relieves exterior syndrome, dissipates cold, disperses and lowers lung qi, can effectively relieve bronchial smooth muscle spasm, and plays the roles of relieving spasm and cough; cicada slough is good at dispelling wind from inside and outside, gambir plant can extinguish wind and stop convulsions, and the combination of the two herbs can also calm liver wood, so both inside and outside wind are considered; dark plum, Chinese magnoliavine fruit, starwort root, aster and stemona root are used as assistant drugs, dark plum is sour and astringent in taste and is good at astringing lung and astringing; fructus Schisandrae chinensis is acidic, and has effects in astringing lung, promoting fluid production, and nourishing lung yin; radix Asteris and radix Stemonae have effects of moistening lung, lowering adverse qi, and radix Stellariae has sweet taste and cool nature, and has effects of clearing heat and cooling blood to dissipate lung heat; the rhizoma atractylodis macrocephalae is fried for ensuring that the rhizoma atractylodis macrocephalae can invigorate the spleen and replenish qi, can protect the qi of the spleen and the stomach and eliminate pathogenic factors without damaging vital qi; the medicines are matched to play a good effect together.

Description

Traditional Chinese medicine for treating cough variant asthma in children and preparation method thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating cough variant asthma in children and a preparation method thereof.

Background

Cough Variant Asthma (CVA), a specific manifestation of asthma, is a relatively common clinical disease in pediatrics. It is clinically characterized by chronic cough as the main symptom, and is accompanied by symptoms of allergic rhinitis and allergic conjunctivitis, such as nasal obstruction, watery nasal discharge, sneeze, and eye malaxation. It usually manifests as persistent or repeated cough for more than 1 month, often accompanied by persistent cough at night or early morning, little phlegm and aggravation after exercise.

The CVA of children can be developed at any age, and the CVA can be developed in all seasons of the year as children before school age are common. CVA has complex etiology and is influenced by both genetic and environmental factors, and allergic constitutions are closely related to the disease. Modern medicine considers the interaction between constitutions and causes of CVA as the cause. Its pathogenesis is consistent with that of bronchial asthma, and it is also an airway allergic reaction, which is chronic nonspecific inflammation, which is indirectly manifested as airway hyperreactivity.

At present, leukotriene regulator, glucocorticoid, beta 2 receptor agonist, anticholinergic drug, theophylline, antihistamine drug, immunomodulator, desensitization therapy and the like are mostly used in western medicine for treating the cough variant asthma in children, so that the symptoms of cough and the like can be relieved, but the side effect of each drug is obvious after long-term application.

The ancient books do not have the disease name of cough variant asthma, the disease belongs to the category of cough of traditional Chinese medicine, the progress of treating the cough variant asthma of children by the traditional Chinese medicine is relatively quick in recent years, and most students consider that the disease mechanism is caused by wind, wind evil attacks the lung, evil attacks lung collaterals, lung qi fails to disperse, and airway spasm is caused. Su Wen-Feng Lun cloud: for wind syndrome, the primary treatment of all diseases is wind dispelling, spasm relieving and cough relieving.

Disclosure of Invention

The Minkening granule of the invention is a prescription improvement of the inventor on the basis of self-prepared prescription of the Qufengningfei powder, the original prescription of the Qufengningfei powder is an proved prescription of the Xiaozhou Xiao and professor of the Tanjin Hospital of China Chinese medical science academy, wherein the traditional Chinese medicines are as follows: herba Schizonepetae, radix Saposhnikoviae, radix Angelicae Dahuricae, periostracum Cicadae, ramulus Uncariae cum uncis, mume fructus, fructus Schisandrae chinensis, radix Asteris preparata, radix Stemonae preparata, radix Stellariae, parched Atractylodis rhizoma, and rhizoma picrorhizae.

Professor Xiao He Ying considers that the disease is mainly responsible for lung, liver and spleen, its external cause is mainly caused by pathogenic wind attacking the lung, its internal cause is mainly internal stirring of liver wind, and its central cause in later stage of disease is mainly caused by lung-spleen deficiency.

The lung powder for dispelling wind and relieving cough is used for treating children cough variant asthma in pediatrics of the hospital, years of clinical medication experience exists, and the inventor repeatedly searches, adds ephedra herb and rhizoma picrorhizae on the basis of the formula, and prepares the Minkening granules after preparing the granules, and clinical application of the powder achieves better treatment effect than the original formula.

The Minkening granular prescription medicine comprises the following components: 6-10g of schizonepeta, 6-10g of divaricate saposhnikovia root, 3-6g of ephedra herb, 6-10g of dahurian angelica root, 3-6g of cicada slough, 6-10g of uncaria, 6-10g of dark plum fruit, 3-6g of Chinese magnoliavine fruit, 6-10g of aster, 3-6g of sessile stemona root, 6-10g of starwort root and 6-10g of largehead atractylodes rhizome. Has the effects of dispelling pathogenic wind, dispersing lung qi, relieving spasm and relieving cough. Mainly treats cough variant asthma, upper airway cough syndrome, cough after infection, allergic cough and other respiratory system diseases taking cough as main symptom.

In the formula, herba schizonepetae and divaricate saposhnikovia root are used as monarch drugs, and the emphasis is on dispelling wind and eliminating evil. Ephedra, dahurian angelica root, cicada slough and uncaria are ministerial, and dahurian angelica root is good at dispelling wind-cold evil; the ephedra herb relieves exterior syndrome, dissipates cold, disperses and lowers lung qi, can effectively relieve bronchial smooth muscle spasm, and plays the roles of relieving spasm and cough; cicada slough is good at dispelling internal and external wind, gambir plant can extinguish wind and stop convulsion, and liver wood can be calmed when the two medicines are used together, so both internal and external wind are considered; the smoked plums, the schisandra chinensis, the starwort roots, the aster tataricus and the stemona roots are used as adjuvant medicines, the smoked plums are sour and astringent in taste and are good at astringing lung and astringing, and the smoked plums are matched with the divaricate saposhnikovia roots, can expel wind and relieve spasm, astringe lung and promote fluid production and are commonly used for treating allergic diseases such as asthma and the like; fructus Schisandrae chinensis has acidic taste, and can astringe lung, promote fluid production, and nourish lung yin, and when used together with mume fructus, can soften liver and control yang; the aster and radix stemonae not only moisten lung and descend the adverse rise of qi, but also have the effects of relieving cough and reducing phlegm, and the starwort root is sweet in taste and cool in nature and can clear heat and cool blood to dissipate lung heat; the rhizoma atractylodis macrocephalae is fried for ensuring that the rhizoma atractylodis macrocephalae can invigorate the spleen and replenish qi, can protect the qi of the spleen and the stomach and eliminate pathogenic factors without damaging vital qi; the medicines are matched to play a role in cold and heat, and the medicines are scattered and received, so that the pathogenic qi can be removed, the spleen and the stomach can be protected, the symptoms and root causes can be treated, and the good effect can be achieved.

The ephedra, the schisandra and the stemona root relieve the airway spasm; fructus mume, radix Saposhnikoviae, and periostracum Cicadae have antiallergic effect and can regulate immunity; the modern pharmacological action of the formula is consistent with the pathogenesis of cough variant asthma.

The basic research of the schoolteaching of Show and seal for treating chronic cough such as cough variant asthma is proved by a series of clinical research, and is the subject of the Hodgkin Hospital in Chinese medical science institute in 2012 and the characteristic project of the capital Committee in Beijing City science and drug addition in 2018 and 2020.

The prescription has the advantages of obvious clinical curative effect, convenient administration and high compliance, improves the life quality of children patients, relieves the psychological pressure of parents, has lower incidence of adverse reaction and higher safety, can be prepared into preparations in hospitals for popularization and development, and has long-term economic and social benefits.

In order to illustrate the improvement of the formula of the self-prepared formula of the powder for dispelling wind and calming lung, the inventor describes the improvement by the following treatment groups and comparative examples 1-3:

the treatment group is a scheme of increasing ephedra and reducing rhizoma picrorhizae on the basis of an original formula, the comparative example 1 is a scheme of dispersing the original formula for dispelling wind and calming the lung, the comparative example 2 is a scheme of increasing bitter apricot seeds and reducing rhizoma picrorhizae, and the comparative example 3 is a scheme of increasing earthworms and reducing rhizoma picrorhizae. The hypoxanthine contained in Lumbricus has effect in relaxing bronchus and relieving spasm of bronchial smooth muscle, and the semen Armeniacae amarum also has effect in relaxing bronchial smooth muscle and relieving spasm of bronchial smooth muscle. The ephedra, the earthworm and the bitter apricot kernel are all commonly used traditional Chinese medicines for relieving the spasm of bronchial smooth muscle, relaxing the air passage and relieving cough and asthma. The inventor combines a large amount of clinical use experience and screens the selection of the traditional Chinese medicine by animal and clinical experiments.

TABLE 1 composition of groups

	Treatment group	Comparative example 1	Comparative example 2	Comparative example 3
					Schizonepeta (share)	10	10	10	10
Ledebouriella root (copies)	10	10	10	10
					Radix Angelicae Dahuricae (in parts)	10	10	10	10
Cicada slough (share)	6	6	6	6
					Uncaria (share)	10	10	10	10
Dark plum (share)	10	10	10	10
					Schisandra chinensis (share)	6	6	6	6
Aster (share)	10	10	10	10
					Stemona root (share)	6	6	6	6
Radix Stellariae (root of starwort)	10	10	10	10
					Atractylodis rhizoma (parts)	10	10	10	10
Chinese ephedra (share)	6	0	0	0
					Picrorhiza rhizome (share)	0	3	0	0
Earthworm (share)	0	0	5	0
					Bitter apricot kernel (parts)	0	0	0	5

(I) clinical data:

all cases are 150 children who meet cough variant asthma western medicine diagnosis standards and Chinese medicine syndrome differentiation typing and are diagnosed in 2021 years from department of pediatrics in Tanjin Hospital, Chinesemedicine academy of sciences, 5 groups of the children are 30 according to a random digital table method, and 5 groups of the children are respectively: control group, treatment group, comparative examples 1-3.

(1) Criteria for diagnosis and typing

Western diagnostic criteria:

refer to 2016 edition "guidelines for the diagnosis and treatment of bronchial asthma in children" for the diagnosis of cough variant asthma.

The cough lasts for more than 4 weeks, and the cough is usually cured or aggravated at exercise, night and/or in the early morning, and is mainly dry cough; without wheezing.

② no infection symptom clinically or ineffective antibiotic treatment for a long time;

③ the anti-asthma medicine is effective in diagnosis and treatment;

fourthly, eliminating chronic cough caused by other reasons;

positive bronchus excitation test and/or maximum expiratory flow (PEF) daily variation rate (continuously monitored for 2 weeks) is more than or equal to 13 percent;

sixthly, the individual or the first and second relatives have the history of allergic diseases or have positive allergen detection.

The above items (i) - (iv) are the basic conditions for diagnosis.

The traditional Chinese medicine syndrome differentiation and typing standard is as follows:

refer to cough chapter "practical TCM pediatrics" and "TCM pediatrics clinical practice and treatment guideline" children cough variant asthma ", and make it by literature research and expert consensus.

Wind attacking the lung: repeated cough with sudden changes in climate, rapid onset of paroxysmal cough or rapid onset of cough with symptoms of sneezing and nasal discharge, cough with little or no sputum, itching throat and chest distress.

(2) Inclusion criteria

The method accords with the cough variant asthma western medicine diagnosis standard;

② the standard of differentiation and typing of the syndrome of pathogenic wind attacking the lung is satisfied;

the age is more than or equal to 3 years and less than or equal to 14 years;

fourthly, the patient can complete the treatment course;

fifthly, the parents agree with the information.

(3) Exclusion criteria

The patients who do not accord with western medicine diagnosis and Chinese medicine syndrome differentiation and typing;

② patients with serious wheezing symptoms;

③ those with serious primary diseases such as gravity, liver, kidney, hematopoietic system, etc.;

fourthly, the children patients who can not take the traditional Chinese medicine or the children patients who have the traditional Chinese medicine allergy history.

(4) Method of treatment

Treatment medication:

the control group is orally taken by adopting montelukast sodium tablets and procaterol hydrochloride tablets; the treatment group adopts the traditional Chinese medicine formula granules of the invention in example 1 (dispelling wind and calming lung powder + ephedra-rhizoma picrorhizae) for oral administration, the traditional Chinese medicine formula granules of the dispelling wind and calming lung powder in comparative example 1 for oral administration, the traditional Chinese medicine formula granules of the dispelling wind and calming lung powder + X-rhizoma picrorhizae in comparative example 2 for oral administration, and the traditional Chinese medicine formula granules of the dispelling wind and calming lung powder + Y-rhizoma picrorhizae in comparative example 3 for oral administration. (X, Y use bitter apricot seed and earthworm separately)

The montelukast sodium tablet and the procaterol hydrochloride tablet are orally taken according to the instruction or are in compliance with medical requirements.

The treatment groups and comparative examples 1-3 are decocted with water, and administered with 1 dose daily and 2 times daily, each dose is 100 ml.

The course of administration is as follows:

7 days is 1 course of treatment, and 2 courses of treatment are continued.

TABLE 2 integral comparison of syndromes before and after treatment

Item	Group of	N	Mean value before treatment	Mean value after 2 weeks of treatment
					Number of coughs	Control group	30	4.22±1.34	1.25±1.00*#
	Treatment group	30	4.31±1.62	1.36±1.23*#
						Comparative example 1	30	4.25±1.45	2.15±1.35*
	Comparative example 2	30	4.16±1.69	2.26±1.38*
						Comparative example 3	30	4.36±1.87	2.13±1.55*
Degree of cough	Control group	30	4.02±1.01	1.11±1.02*#
						Treatment group	30	4.11±1.52	1.28±0.84*#
	Comparative example 1	30	3.98±1.88	2.12±1.21*
						Comparative example 2	30	4.12±0.97	1.98±1.36*
	Comparative example 3	30	4.15±1.95	1.88±0.80*
					Expectoration	Control group	30	3.56±1.66	1.86±1.21*#
	Treatment group	30	3.44±1.87	1.65±1.10*#
						Comparative example 1	30	3.55±1.64	2.69±1.21*
	Comparative example 2	30	3.64±1.10	2.07±0.85*
						Comparative example 3	30	3.55±1.79	2.01±1.18*
Sneezing	Control group	30	2.36±1.27	0.88±0.82*#
						Treatment group	30	2.52±1.41	0.98±0.66*#
	Comparative example 1	30	2.65±1.30	1.99±0.98*
						Comparative example 2	30	2.65±1.34	2.01±1.36*
	Comparative example 3	30	2.83±1.58	1.85±1.28*
					Running nose	Control group	30	3.65±1.21	2.21±1.24*
	Treatment group	30	3.58±1.55	1.99±1.15*#
						Comparative example 1	30	3.67±1.28	2.69±1.48*
	Comparative example 2	30	3.52±1.59	2.36±1.37*
						Comparative example 3	30	3.61±1.54	2.68±1.55*

*: the differences were statistically significant (P < 0.05)

#: the difference was statistically significant (P < 0.05)

Clinical treatment results show that the traditional Chinese medicine syndrome integrals (cough frequency, cough degree, expectoration, sneezing and rhinorrhea) of each group after treatment are obviously reduced compared with those before treatment, and the difference has statistical significance (P is less than 0.05); compared between the groups two weeks after treatment, the difference between the treatment group and the inventor's previous powder group (comparative example 1) for dispelling wind and calming lung is statistically significant (P < 0.05).

It can be seen from the experiment that compared with comparative examples 2 and 3, in which the ephedra herb is added, the treatment group with the ephedra herb is obviously improved in the aspects of cough frequency, cough degree, expectoration, sneeze, rhinorrhea and the like.

(II) animal experiment:

the cough relieving effect of the invention on mice with cough caused by ammonia water is researched:

60 mice, the average weight of 20.10 +/-1.56 g, are randomly divided into 4 groups, 15 mice in each group are respectively administrated with the medicaments of the treatment group, the comparative example 2 group and the comparative example 3 group for intragastric administration, and the model group is administrated with distilled water for intragastric administration, and the administration amount is as follows: 0.3ml/10g body weight, once daily, for one week. 1 hour after the last dose, mice were given an ultrasonic nebulizer to spray ammonia for 20 seconds, after which the latency for the first cough to occur was recorded and the number of coughs within three minutes was recorded.

TABLE 3 antitussive effect on mice with cough caused by ammonia water

Group of	N	Incubation period (seconds)	Cough frequency of 3min
				Model set	15	19.12±3.26	16.26±5.98
Treatment group	15	35.21±2.56*＆#	8.36±3.65*＆#
				Comparative example 2	15	25.32±3.54	12.36±1.24
Comparative example 3	15	26.39±5.21	13.22±1.52

The treatment groups and the comparative examples 2 and 3 have the effect of prolonging the cough latency of the mice caused by ammonia water and reducing the cough frequency. The treatment groups had more excellent effects of extending the latent period and reducing the number of coughs than the comparative example 2 and the comparative example 3 groups, and the difference was significant (P < 0.05) in the treatment groups compared to the other groups.

*: the differences were statistically significant compared to the model group (P < 0.05)

And: the difference was statistically significant (P < 0.05)

#: the difference was statistically significant (P < 0.05)

The specific embodiment is as follows:

reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.

Example 1

Prescription: 6-10g of schizonepeta, 6-10g of divaricate saposhnikovia root, 3-6g of ephedra herb, 6-10g of dahurian angelica root, 3-6g of cicada slough, 6-10g of uncaria, 6-10g of dark plum fruit, 3-6g of Chinese magnoliavine fruit, 6-10g of aster, 3-6g of sessile stemona root, 6-10g of starwort root and 6-10g of largehead atractylodes rhizome.

The preparation method comprises the following steps: decocting the above 12 materials with 10 times of water for 3 times, each time for 2 hr, filtering, concentrating the filtrate at 60 deg.C under reduced pressure, concentrating the extractive solution until the relative density is 1.10 (60 deg.C), adding 95% ethanol to adjust the mass fraction concentration of the extractive solution to 70%, stirring, refrigerating overnight, filtering, collecting supernatant, recovering ethanol at 80 deg.C under reduced pressure, concentrating until the relative density is 1.30(60 deg.C), drying under reduced pressure to obtain extract powder, adding xylitol and sucralose, mixing well, granulating, drying, and packaging.

Example 2

Prescription: 10g of schizonepeta, 10g of divaricate saposhnikovia root, 6g of ephedra, 10g of dahurian angelica root, 6g of cicada slough, 10g of uncaria, 10g of dark plum fruit, 6g of Chinese magnoliavine fruit, 10g of aster, 6g of sessile stemona root, 10g of starwort root and 10g of largehead atractylodes rhizome.

The preparation method is the same as example 1.

Example 3

Prescription: 6g of herba schizonepetae, 6g of radix sileris, 3g of ephedra, 6g of angelica dahurica, 3g of cicada slough, 6g of uncaria, 6g of dark plum fruit, 3g of schisandra chinensis, 6g of aster, 3g of radix stemonae, 6g of starwort root and 6g of bighead atractylodes rhizome.

The preparation method is the same as that of example 1.

Typical treatment cases are:

infant male, 6 years old, chief complaints at first visit: repeated cough for 2 months and aggravation for 5 days. The infant patient is diagnosed with cold in the hospital 2 months before fever and cough, the fever is subsided after treatment, the nasal obstruction and the rhinorrhoea are improved, but the cough is not continuous, the cough is aggravated in the morning and at night or after exercise, and the paroxysmal cough is caused, the lung heat cough and asthma of the infant, the orange-shell mixture, the azithromycin and other medicines are used in sequence, the effect is not obvious, the lung function examination is perfected, the airway hyperreactivity is shown, and the measurement result of the exhaled nitric oxide is as follows: 96PPB, considering cough variant asthma, is orally taken as 'Montelukast', and is treated by 'budesonide and salbutamol sulfate' through aerosol inhalation, so that the cough is relieved, but symptoms are recovered after the medicine is stopped, and the patient can turn to the Xiaozhou teaching for treatment. The symptoms are as follows: cough in children, marked by paroxysmal cough and white phlegm at morning, night or after exercise. Emaciation, lusterless complexion, multiple white spots, red tongue with whitish and thick coating, and peeling off of the coating at the tip of the tongue. And (3) diagnosis: cough-variant asthma is characterized by the onset of disease due to spleen deficiency, hyperactivity of the liver, wind-pathogen attack, and latent phlegm. The prescription of the medicine for treating the cough is used for treating the cough, and 7 doses of the medicine are decocted with water for oral administration. The sick children are advised to eat light diet and temporarily avoid eating hair. Follow-up after 1 month, no cough after the infant medicine, and the measurement result of the nitric oxide in the exhaled air: 8PPB, down to the normal range. According to the language: the children suffering from the disease are red in tongue and stripped of tongue fur at the tip of the tongue due to spleen deficiency and liver hyperactivity, wind evil attacking the lung to cause phlegm, cough for a long time and yin consumption and fluid impairment. The wiry, thready and rapid left pulse is marked by liver-blood deficiency, exuberance of liver fire, liver fire attacking the lung and cough. The treatment of allergic cough emphasizes the pathogenicity of pathogenic wind, grasps the essence of chronic cough and asthma, relieves pathogenic wind, nourishes the qi of spleen and lung, and recovers the function of lung to disperse and descend, so all symptoms are eliminated.

Claims

1. The traditional Chinese medicine for treating cough variant asthma is characterized by comprising the following raw materials in parts by weight: 6-10g of schizonepeta, 6-10g of divaricate saposhnikovia root, 3-6g of ephedra herb, 6-10g of dahurian angelica root, 3-6g of cicada slough, 6-10g of uncaria, 6-10g of dark plum fruit, 3-6g of Chinese magnoliavine fruit, 6-10g of aster, 3-6g of sessile stemona root, 6-10g of starwort root and 6-10g of largehead atractylodes rhizome.

2. The traditional Chinese medicine for treating cough variant asthma according to claim 1, wherein the raw materials and the dosage are as follows: 10g of schizonepeta, 10g of divaricate saposhnikovia root, 6g of ephedra, 10g of dahurian angelica root, 6g of cicada slough, 10g of uncaria, 10g of dark plum fruit, 6g of Chinese magnoliavine fruit, 10g of aster, 6g of sessile stemona root, 10g of starwort root and 10g of largehead atractylodes rhizome.

3. The traditional Chinese medicine for treating cough variant asthma according to claim 1, wherein the raw materials and the dosage are as follows: 6g of herba schizonepetae, 6g of radix sileris, 3g of ephedra, 6g of angelica dahurica, 3g of cicada slough, 6g of uncaria, 6g of dark plum fruit, 3g of schisandra chinensis, 6g of aster, 3g of radix stemonae, 6g of starwort root and 6g of bighead atractylodes rhizome.

4. The method of preparing a traditional Chinese medicine for treating cough variant asthma as claimed in any one of claims 1 to 3, comprising the steps of: taking 12 kinds of herba schizonepetae, radix sileris, ephedra, angelica dahurica, cicada slough, uncaria, dark plum fruit, schisandra chinensis, aster, radix stemonae, starwort root and bighead atractylodes rhizome according to the specified dosage, adding 6-10 times of water for decoction and extraction for 3 times, each time for 2 hours, filtering, concentrating the filtrate at 60 ℃ under reduced pressure, concentrating the extract until the relative density is 1.10 (60 ℃), adding 95% ethanol to adjust the mass fraction concentration of the extract to 70%, uniformly stirring, refrigerating overnight, filtering, taking supernatant fluid, recovering ethanol under reduced pressure at 80 ℃, concentrating until the relative density is 1.30(60 ℃), drying under reduced pressure to obtain extract powder, adding appropriate auxiliary materials, uniformly mixing, granulating, drying and subpackaging to obtain the Chinese medicinal composition.

5. Use of a traditional Chinese medicine according to claims 1-3 in the preparation of a medicament for the treatment of cough variant asthma.