CN114616259A - pH响应性破膜高分子材料及其制备方法与应用 - Google Patents

pH响应性破膜高分子材料及其制备方法与应用 Download PDF

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CN114616259A
CN114616259A CN202180005804.9A CN202180005804A CN114616259A CN 114616259 A CN114616259 A CN 114616259A CN 202180005804 A CN202180005804 A CN 202180005804A CN 114616259 A CN114616259 A CN 114616259A
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polymeric material
material according
polymer material
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alkyl
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CN114616259B (zh
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熊梦华
鲍燕
黄良琪
王晓川
刘明冬
梁阳彬
王均
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South China University of Technology SCUT
Sun Yat Sen Memorial Hospital Sun Yat Sen University
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Abstract

本发明提供了一种pH响应性破膜高分子材料及其制备方法与应用。该pH响应性破膜高分子材料具有式(I)所示结构。该高分子材料在正常生理pH下，呈疏水电中性，可自组装成PEG为壳层的纳米颗粒，与细胞膜的相互作用弱；当pH降低，可以质子化，形成疏水结构域和阳离子结构域组成的两亲性结构，与细胞膜具有强相互作用并且具有强破膜活性，因而可以高效、高选择性杀伤肿瘤细胞或细菌。
Figure DDA0003585641650000011

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN202180005804.9A 2020-06-30 2021-06-28 pH响应性破膜高分子材料及其制备方法与应用 Active CN114616259B (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650307A (zh) * 2015-01-28 2015-05-27 华南理工大学 基于PDEAEMA的pH敏感五嵌段线性聚合物及胶束
CN109265680A (zh) * 2018-09-21 2019-01-25 中国科学院理化技术研究所 一种pH响应的ε-聚赖氨酸及其制备方法和应用
JP2019108473A (ja) * 2017-12-19 2019-07-04 国立大学法人山形大学 自立性高分子薄膜及びその製造方法、並びに、自立性高分子前駆体薄膜、それからなる密閉容器及び内包剤の放出方法
WO2020092633A1 (en) * 2018-10-30 2020-05-07 Vanderbilt University Graft copolymers, methods of forming graft copolymers, and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650307A (zh) * 2015-01-28 2015-05-27 华南理工大学 基于PDEAEMA的pH敏感五嵌段线性聚合物及胶束
JP2019108473A (ja) * 2017-12-19 2019-07-04 国立大学法人山形大学 自立性高分子薄膜及びその製造方法、並びに、自立性高分子前駆体薄膜、それからなる密閉容器及び内包剤の放出方法
CN109265680A (zh) * 2018-09-21 2019-01-25 中国科学院理化技术研究所 一种pH响应的ε-聚赖氨酸及其制备方法和应用
WO2020092633A1 (en) * 2018-10-30 2020-05-07 Vanderbilt University Graft copolymers, methods of forming graft copolymers, and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHUNHUI LUO 等: "Pathway-dependent re-assembly of dual-responsive ABC terpolymer in water", 《SOFT MATTER》 *
JESSALYN J. BALJON 等: "The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome", 《BIOMATER. SCI.》 *
XIAO-FEI XU 等: "Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance", 《MACROMOLECULES》 *

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