CN114616239A - 嵌合抗原受体和其中表达有嵌合抗原受体的t细胞 - Google Patents
嵌合抗原受体和其中表达有嵌合抗原受体的t细胞 Download PDFInfo
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Abstract
本发明公开了嵌合抗原受体和其中表达有嵌合抗原受体的T细胞，具体公开了靶向CD3的嵌合抗原受体，该嵌合抗原受体包括CD3结合结构域；铰链区和跨膜结构域；共刺激结构域；信号转导结构域。本发明还公开了编码嵌合抗原受体的核酸分子、表达载体，宿主细胞和包含其的药物组合物和试剂盒。本发明的嵌合抗原受体可用于免疫治疗和抗移植排异反应中，具有巨大的市场应用价值。
Description
PCT国内申请，说明书已公开。
Claims (45)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2019/111651 | 2019-10-17 | ||
| CN2019111651 | 2019-10-17 | ||
| PCT/CN2020/121674 WO2021073626A1 (zh) | 2019-10-17 | 2020-10-16 | 嵌合抗原受体和其中表达有嵌合抗原受体的t细胞 |
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| Publication Number | Publication Date |
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| CN114616239A true CN114616239A (zh) | 2022-06-10 |
| CN114616239B CN114616239B (zh) | 2023-08-11 |
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| CN202080072781.9A Active CN114616239B (zh) | 2019-10-17 | 2020-10-16 | 嵌合抗原受体和其中表达有嵌合抗原受体的t细胞 |
Country Status (2)
| Country | Link |
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| CN (1) | CN114616239B (zh) |
| WO (1) | WO2021073626A1 (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102958942A (zh) * | 2009-12-29 | 2013-03-06 | 新兴产品开发西雅图有限公司 | 异二聚体结合蛋白及其应用 |
| CN107249602A (zh) * | 2015-02-27 | 2017-10-13 | 美商生物细胞基因治疗有限公司 | 靶向血液恶性肿瘤之嵌合抗原受体（car）、其组合物及使用方法 |
| WO2018161064A1 (en) * | 2017-03-03 | 2018-09-07 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
| CN109777782A (zh) * | 2019-02-15 | 2019-05-21 | 北京门罗生物科技有限公司 | 一种通用型car-t细胞及其制备方法和用途 |
-
2020
- 2020-10-16 WO PCT/CN2020/121674 patent/WO2021073626A1/zh active Application Filing
- 2020-10-16 CN CN202080072781.9A patent/CN114616239B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102958942A (zh) * | 2009-12-29 | 2013-03-06 | 新兴产品开发西雅图有限公司 | 异二聚体结合蛋白及其应用 |
| CN107249602A (zh) * | 2015-02-27 | 2017-10-13 | 美商生物细胞基因治疗有限公司 | 靶向血液恶性肿瘤之嵌合抗原受体（car）、其组合物及使用方法 |
| WO2018161064A1 (en) * | 2017-03-03 | 2018-09-07 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
| CN109777782A (zh) * | 2019-02-15 | 2019-05-21 | 北京门罗生物科技有限公司 | 一种通用型car-t细胞及其制备方法和用途 |
Non-Patent Citations (2)
| Title |
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| XIUYAN WANG ET AL.: ""Clinical manufacturing of CAR T cells: foundation of a promising therapy"", 《 MOLECULAR THERAPY-ONCOLYTICS》 * |
| 耿兴超 等: ""抗CD3单克隆抗体对食蟹猴免疫功能及相关基因表达的影响"", 《中国药学杂志》 * |
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| WO2021073626A1 (zh) | 2021-04-22 |
| CN114616239B (zh) | 2023-08-11 |
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