CN114600893A - Flupirouron floating granule and preparation method and application thereof - Google Patents
Flupirouron floating granule and preparation method and application thereof Download PDFInfo
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- CN114600893A CN114600893A CN202210396085.4A CN202210396085A CN114600893A CN 114600893 A CN114600893 A CN 114600893A CN 202210396085 A CN202210396085 A CN 202210396085A CN 114600893 A CN114600893 A CN 114600893A
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- diflubenzuron
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- 239000008187 granular material Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000005893 Diflubenzuron Substances 0.000 claims abstract description 30
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229940019503 diflubenzuron Drugs 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000945 filler Substances 0.000 claims abstract description 12
- 239000011521 glass Substances 0.000 claims abstract description 9
- 239000011324 bead Substances 0.000 claims abstract description 8
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000006229 carbon black Substances 0.000 claims abstract description 7
- 229940005574 sodium gluconate Drugs 0.000 claims abstract description 7
- 235000012207 sodium gluconate Nutrition 0.000 claims abstract description 7
- 239000000176 sodium gluconate Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 10
- 230000002013 molluscicidal effect Effects 0.000 claims description 9
- 239000012752 auxiliary agent Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000004898 kneading Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- 239000008202 granule composition Substances 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000011812 mixed powder Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 15
- 238000009792 diffusion process Methods 0.000 abstract description 12
- 241000237858 Gastropoda Species 0.000 abstract description 10
- 241000534460 Ampullaria Species 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 6
- 239000000575 pesticide Substances 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 2
- 238000005507 spraying Methods 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 8
- 241000124008 Mammalia Species 0.000 description 3
- 241000209094 Oryza Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 239000003750 molluscacide Substances 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000004563 wettable powder Substances 0.000 description 3
- 241000570011 Pomacea canaliculata Species 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- -1 pyridylurea compound Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- FMHDHIYHKKVRJU-UHFFFAOYSA-N (2-carbamoylphenyl) hypochlorite Chemical compound NC(=O)C1=CC=CC=C1OCl FMHDHIYHKKVRJU-UHFFFAOYSA-N 0.000 description 1
- JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical compound NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 description 1
- 239000005760 Difenoconazole Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 239000005956 Metaldehyde Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000565675 Oncomelania Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- GKKDCARASOJPNG-UHFFFAOYSA-N metaldehyde Chemical compound CC1OC(C)OC(C)OC(C)O1 GKKDCARASOJPNG-UHFFFAOYSA-N 0.000 description 1
- NYQXIOZBHWFCBU-UHFFFAOYSA-N n-phenylpyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC1=CC=CC=C1 NYQXIOZBHWFCBU-UHFFFAOYSA-N 0.000 description 1
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 description 1
- 229960001920 niclosamide Drugs 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- HCJLVWUMMKIQIM-UHFFFAOYSA-M sodium;2,3,4,5,6-pentachlorophenolate Chemical compound [Na+].[O-]C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl HCJLVWUMMKIQIM-UHFFFAOYSA-M 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a diflubenzuron floating granule as well as a preparation method and application thereof, wherein the diflubenzuron floating granule comprises the following components in percentage by mass: 20% of pyrifluazuron, 7% of diffusant 1, 7% of diffusant 2, 3% of filler 1, 35% of carrier, and the balance of filler 2, wherein the diffusant 1 is YUS-FS1, the diffusant 2 is YUS-CH8100, the filler 1 is white carbon black, the carrier is glass floating beads, and the filler 2 is sodium gluconate. The pyrifluazuron floating granule prepared by the invention is applied to a paddy field system, can effectively prevent and control snail organisms such as paddy field ampullaria gigas and the like, is safe to non-target aquatic organisms and environment-friendly, and has excellent diffusion performance, so that the pesticide can be uniformly dispersed on the water surface no matter the pesticide is applied on the surface or applied on the spot, the uniformity is good, and the prevention effect is stable. The effect of point application and surface application of the diflubenzuron floating granule is close to that of the traditional spraying method, so that the method has the advantages of labor saving and convenience.
Description
Technical Field
The invention belongs to the technical field of molluscacidal, and particularly relates to a diflubenzuron floating granule as well as a preparation method and application thereof.
Background
The freshwater snails such as oncomelania, ampullaria gigas and the like are intermediate hosts of a plurality of parasites, and the killing of the freshwater snails can effectively reduce and control the occurrence of parasitic diseases. Molluscicides fall into two broad categories: botanical drugs and pure chemically synthesized drugs. Among them, one kind of plant medicine has the advantages of good effect, easy degradation, low toxicity to environment and non-target organisms, but has the disadvantages of high production difficulty, high use cost and short lasting period; the other kind of pure chemical synthetic medicine, such as niclosamide, has good molluscicidal effect and small side effect on mammals such as human beings, but has high toxicity on non-target aquatic animals and is easy to cause serious loss on agricultural fishery production, and other chemical synthetic medicines, such as metaldehyde, sodium pentachlorophenate, bromoacetamide, nicotinanilide and chlorosalicylamide, cannot be popularized and used on a large scale due to the defects of medium toxicity on mammals, overhigh toxicity on mammals, sensitization in use, serious climbing in application, poor stability in storage process and the like.
The pyridylurea compound is a newly synthesized compound with molluscicidal activity, is also called as pirirourea, is an N-pyridine-3-N '-4' -chlorphenyl urea compound, has the advantages of good molluscicidal effect and safety to non-target organisms, particularly aquatic organisms, but no mature product can be used at present, and great difficulty is caused to molluscicidal work. Therefore, the development of new dosage forms of piriurea appears to be very necessary.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a diflubenzuron floating granule and a preparation method and application thereof, which specifically adopt the following technical scheme:
the diflubenzuron floating granule comprises the following components in percentage by mass: 20% of pyrifluazuron, 7% of dispersing agent 1, 7% of dispersing agent 2, 3% of filler 1, 35% of carrier and the balance of filler 2.
Wherein the diffusant 1 is YUS-FS1, the diffusant 2 is YUS-CH8100, the filler 1 is white carbon black, the carrier is glass floating beads, and the filler 2 is sodium gluconate.
The existing piriurea products, such as the piriurea sulfate wettable powder, have good control effect and no obvious harm to fishes, but the wettable powder easily generates more dust during processing to cause air pollution, and the suspension rate is unstable when the wettable powder is used, so that the spray head of a sprayer is easily blocked. The pyrifluazuron floating granule has excellent diffusion performance, the medicament can be uniformly dispersed on the water surface no matter applied on the surface or applied on the spot, the uniformity is good, the control effect is close, and the control effect is stable.
The invention also provides a preparation method of the pyrifluazuron floating granule, which comprises the following steps:
(1) putting 20% of raw pirluuron, 28% of sodium gluconate and 3% of white carbon black into a double-helix conical mixer by mass percent, and uniformly mixing;
(2) transferring the mixture obtained in the step (1) to a jet mill for crushing, and transferring the crushed mixture to a double-helix conical mixer;
(3) adding 35% of glass floating beads into a double-helix conical mixer, and uniformly mixing the glass floating beads with the mixture crushed in the step (2);
(4) adding a proper amount of water into a reaction kettle, then respectively adding 7% of YUS-FS1 and 7% of YUS-CH8100, and uniformly stirring and mixing to obtain an auxiliary agent solution;
(5) respectively putting the mixed powder obtained in the step (3) and the auxiliary agent liquid obtained in the step (4) into a high-speed mixer for kneading, transferring the kneaded mixture into a storage tank of a granulator for extrusion granulation to obtain a wet granule mixture;
(6) and (3) putting the wet granule mixture into a vibrating fluidized bed dryer, wherein the moisture content of the dried granules is less than or equal to 1.0%, and sieving the dried granules by using a vibrating screen to obtain the 20% pyrifluazuron floating granules.
Preferably, the mixing time in step (1) is more than or equal to 20 min.
Preferably, the rotational speed of the classifying wheel of the jet mill in the step (2) is 1800 rpm.
Preferably, the mixing time in step (3) is more than or equal to 30 min.
Preferably, the stirring time in the step (4) is more than or equal to 15 min.
Preferably, the kneading time in step (5) is 5min or more.
Preferably, step (6) is specifically operative to: preheating a dryer of the vibratory fluidized bed in advance, setting the temperature of an air inlet to be 80 ℃ and the temperature of an air outlet to be 75-66 ℃, putting wet granules into the vibratory fluidized bed, drying for 3min, wherein the moisture content of the dried granules is less than or equal to 1.0%, and sieving the dried granules by a vibrating sieve.
The pyrifluazuron floating granule prepared by the invention is applied as a molluscicide.
The invention has the beneficial effects that: the pyrifluazuron floating granule prepared by the invention is applied to a paddy field system, can effectively prevent and control snail organisms such as paddy field ampullaria gigas and the like, is safe to non-target aquatic organisms and environment-friendly, and has excellent diffusion performance, so that the pesticide can be uniformly dispersed on the water surface no matter the pesticide is applied on the surface or applied on the spot, the uniformity is good, and the prevention effect is stable. The effect of point application and surface application of the diflubenzuron floating granule is close to that of the traditional spraying method, so that the method has the advantages of labor saving and convenience.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described in the following embodiments to fully understand the objects, aspects and effects of the present invention. It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
Example 1
Preparing 200kg of diflubenzuron floating granules:
(1) 41.24kg of 97% pyrifluazuron original drug, YUS-FS14kg, YUS-CH810014kg, 6kg of white carbon black, 70kg of glass float and 54.76kg of sodium gluconate are weighed.
(2) 41.24kg of raw piriurea, 54.76kg of sodium gluconate and 6kg of white carbon black are put into a double-helix conical mixer to be mixed for 20 min.
(3) And (3) starting the jet mill, setting the rotating speed of a grading wheel of the jet mill to be 1800rpm, starting a bottom valve of the double-helix conical mixer, sucking the mixture obtained in the step (2) into the jet mill for crushing, and injecting the crushed mixture into the double-helix conical mixer.
(4) And (3) adding 70kg of glass floating beads into a double-helix conical mixer, uniformly mixing with the mixture subjected to airflow crushing in the step (3), and mixing for 30 min.
(5) Adding 16kg of water into a reaction kettle, starting stirring, then adding 14kg of YUS-FS1 and 14kg of YUS-CH8100 into the reaction kettle, and stirring until the auxiliary agent is completely and uniformly dispersed for 15 min.
(6) And (3) respectively putting the mixed powder obtained in the step (4) and the auxiliary agent liquid obtained in the step (5) into a high-speed mixer for kneading for 5min, transferring the kneaded mixture into a storage tank above a granulator for extrusion granulation to obtain wet granular materials.
(7) Preheating a vibrating fluidized bed dryer in advance, setting the air inlet temperature to be 80 ℃ and the air outlet temperature to be 75-66 ℃, putting wet granular materials into the vibrating fluidized bed, drying for 3min, and sieving the dried granules through a vibrating screen to obtain the diflubenzuron floating granules, wherein the moisture content of the dried granules is less than or equal to 1.0%.
Example 2
The diffusion speed and distance test of the diflubenzuron floating granule is as follows:
the method comprises the steps of putting water into a water tank with the length of 3 meters and the width of 2 meters till the water depth is 5cm, taking 10g of the diflubenzuron floating granules prepared in the embodiment 1, starting timing after the diflubenzuron floating granules are put into the water tank at a position 10cm away from one end of the water tank, measuring the diffusion distance of the diflubenzuron floating granules (the distance when the diflubenzuron floating granules are not diffused in the water tank is the diffusion distance), and calculating the diffusion speed.
The diffusion distance of the diflubenzuron floating granule is shown in table 1:
TABLE 1 Difenoconazole Floating granule diffusion distance
The diffusion rate of the diflubenzuron floating granule is shown in table 2:
TABLE 2 rate of diffusion of diflubenzuron floating granules
It can be seen that the diflubenzuron floating granule has good diffusivity and a large diffusion range.
Example 3
The control effect test of the pyrifluazuron floating granule comprises the following steps:
(1) the test method comprises the following steps: the molluscicide is used for preventing and treating ampullaria gigas (GB/T17980.81-2004) in pesticide field efficacy test guidelines.
(2) Test subjects and crops: pomacea canaliculata and rice.
(3) Cell preparation: the depth of the water layer of the rice field is kept to be 5cm, and the water retention time is equal to the last investigation time. The small area is surrounded by a net with the height of 80cm, a small ridge is built, independent irrigation and drainage are carried out to prevent water from mixing, and a sidewalk is reserved. And (4) inserting rice in 25 clusters per square meter in the cell before snail release, and releasing snails after inserting for 1 week. Each cell is lightly placed with ampullaria gigas of uniform size to form snails, and the density is controlled to be 10 per square meter.
(4) The test dosage and treatment number of the 20% diflubenzuron floating granule are shown in Table 3
Table 320% Coniro urea Floating granule test dosage and treatment number
Wherein, the surface application means that the medicament is uniformly scattered in the whole cell; point application refers to spreading the medicament in the midpoint of the cell.
(5) Cell area, repetition and spiral: 2m per cell24 replicates and 20 ampullaria gigas of uniform size per cell.
(6) Investigation time, number of times and method: the test was conducted for 2 total surveys: sampling and investigating for 1 time 3 and 7 days after the drug administration; the method comprises the following steps: during investigation, the number of live and dead snails can be detected in the cell, and after 7 days of drug administration, the number of live and dead snails can be detected by finding out all the bred snails (the number is less than the original number and calculated according to the escape).
(7) The test results are shown in table 4:
TABLE 4 mortality of Pomacea canaliculata with 20% of the amount tested
As can be seen from Table 4, 7 days after the administration, the 20% diflubenzuron floating granule is 0.25g a.i./m2The control effect of the surface application and the point application is 96.25 percent; when the dosage of the 20% pyrifluazuron floating granule reaches 0.5g a.i./m2When the composition is applied on the surface, the control effect of the composition is 98.75 percent and 100.00 percent, and the diflubenzuron floating granules have excellent control effect on the ampullaria gigas.
While the present invention has been described in considerable detail and with particular reference to a few illustrative embodiments thereof, it is not intended to be limited to any such details or embodiments or any particular embodiments, but it is to be construed as effectively covering the intended scope of the invention by providing a broad, potential interpretation of such claims in view of the prior art with reference to the appended claims. Furthermore, the foregoing describes the invention in terms of embodiments foreseen by the inventor for which an enabling description was available, notwithstanding that insubstantial modifications of the invention, not presently foreseen, may nonetheless represent equivalent modifications thereto.
Claims (10)
1. The diflubenzuron floating granule is characterized by comprising the following components in percentage by mass: 20% of pyrifluazuron, 7% of dispersing agent 1, 7% of dispersing agent 2, 3% of filler 1, 35% of carrier and the balance of filler 2.
2. The pyrifluazuron floating granule is characterized in that the diffusant 1 is YUS-FS1, the diffusant 2 is YUS-CH8100, the filler 1 is white carbon black, the carrier is glass floating beads and the filler 2 is sodium gluconate.
3. A preparation method of a diflubenzuron floating granule is characterized by comprising the following steps:
(1) putting 20% of raw pirluuron, 28% of sodium gluconate and 3% of white carbon black into a double-helix conical mixer by mass percent, and uniformly mixing;
(2) transferring the mixture obtained in the step (1) to a jet mill for crushing, and transferring the crushed mixture to a double-helix conical mixer;
(3) adding 35% of glass floating beads into the double-helix conical mixer, and uniformly mixing the glass floating beads with the mixture crushed in the step (2);
(4) adding a proper amount of water into a reaction kettle, then respectively adding 7% of YUS-FS1 and 7% of YUS-CH8100, and uniformly stirring and mixing to obtain an auxiliary agent solution;
(5) respectively putting the mixed powder obtained in the step (3) and the auxiliary agent liquid obtained in the step (4) into a high-speed mixer for kneading, transferring the kneaded mixture into a storage tank of a granulator for extrusion granulation to obtain a wet granule mixture;
(6) and (3) putting the wet granule mixture into a vibrating fluidized bed dryer, wherein the moisture content of the dried granules is less than or equal to 1.0%, and sieving the dried granules by using a vibrating screen to obtain the 20% pyrifluazuron floating granules.
4. The preparation method of diflubenzuron floating granules according to claim 3, characterized in that the mixing time in step (1) is not less than 20 min.
5. The preparation method of diflubenzuron floating granules according to the claim 3, characterized in that the rotation speed of the grading wheel of the air flow pulverizer in the step (2) is 1800 rpm.
6. The preparation method of diflubenzuron floating granules according to claim 3, characterized in that the mixing time in step (3) is more than or equal to 30 min.
7. The preparation method of the diflubenzuron floating granule as claimed in claim 3, characterized in that the stirring time in the step (4) is not less than 15 min.
8. The preparation method of diflubenzuron floating granules according to claim 3, characterized in that the kneading time in step (5) is not less than 5 min.
9. The preparation method of the diflubenzuron floating granule according to the claim 3, characterized in that the step (6) is specifically operated as follows: preheating a dryer of the vibratory fluidized bed in advance, setting the temperature of an air inlet to be 80 ℃ and the temperature of an air outlet to be 75-66 ℃, putting wet granules into the vibratory fluidized bed, drying for 3min, wherein the moisture content of the dried granules is less than or equal to 1.0%, and sieving the dried granules by a vibrating sieve.
10. Use of a diflubenzuron floating granule as described in claims 1-2 as a molluscicidal drug.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018170A1 (en) * | 1993-02-05 | 1994-08-18 | Smithkline Beecham Plc | Use of phenyl heteroaryl ureas as 5ht2c receptor antagonists and urea compounds |
| CN106172464A (en) * | 2016-07-27 | 2016-12-07 | 江苏擎宇化工科技有限公司 | A kind of water surface floating granule of self-diffusion type and preparation method thereof |
| CN109645019A (en) * | 2017-10-11 | 2019-04-19 | 中国疾病预防控制中心寄生虫病预防控制所 | The purposes of pyridine carbamide compounds with ovicidal trait |
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- 2022-04-15 CN CN202210396085.4A patent/CN114600893A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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