CN114588025A - Chemical pharmaceutical granulation machine - Google Patents

Chemical pharmaceutical granulation machine Download PDF

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Publication number
CN114588025A
CN114588025A CN202210209437.0A CN202210209437A CN114588025A CN 114588025 A CN114588025 A CN 114588025A CN 202210209437 A CN202210209437 A CN 202210209437A CN 114588025 A CN114588025 A CN 114588025A
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China
Prior art keywords
fixed
plate
sliding
granulation machine
extrusion
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Granted
Application number
CN202210209437.0A
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Chinese (zh)
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CN114588025B (en
Inventor
宋平
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Dalian Deyuansheng Technology Group Co ltd
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B11/00Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/22Extrusion presses; Dies therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B11/00Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/34Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00General characteristics or adaptations
    • A61J2200/20Extrusion means, e.g. for producing pharmaceutical forms

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the field of pharmacy, in particular to a chemical pharmaceutical granulation machine which has good extrusion forming effect; the chemical pharmaceutical granulation machine comprises a forming pipe fixed on a support main frame and an extrusion column sliding in the forming pipe, wherein a blanking pipe I is fixed on the forming pipe, an installation plate is fixed on the support main frame, and a backstop mechanism assisting in extrusion molding is fixed on the installation plate; the forming tubes are provided with a plurality of extrusion columns which are all fixedly connected on the front frame; the rear blocking mechanism comprises a square column sliding on the mounting plate, a supporting arm rod is fixed at the front end of the square column, a baffle is connected at the front end of the supporting arm rod, and a spring I is arranged at the front end of the square column and the mounting plate; still including fixing the spacing seat at the square column front end, sliding connection has on the mounting panel to be used for with spacing gliding stop gear of seat, is fixed with the rib on the front truck, rib and stop gear sliding connection.

Description

Chemical pharmaceutical granulation machine
Technical Field
The invention relates to the field of pharmacy, in particular to a chemical pharmacy granulation machine.
Background
When the medicine is prepared, the medicinal materials are generally crushed and then uniformly mixed according to the proportion to prepare medicinal powder, but the medicinal powder is inconvenient to eat, so that the medicinal powder needs to be granulated or filled in capsules, and a patient can conveniently and quantitatively eat the medicinal powder.
When the medicinal powder is granulated, granulation equipment is generally needed, but the existing granulation equipment has poor extrusion forming effect and influences the use.
Disclosure of Invention
The invention aims to provide a chemical pharmaceutical granulator which is good in extrusion forming effect.
The purpose of the invention is realized by the following technical scheme:
the utility model provides a chemical industry pharmacy granulation machine, is including fixing the forming tube on supporting the body frame, slides the extrusion post in the forming tube, is fixed with blanking pipe I on the forming tube, is fixed with the mounting panel on supporting the body frame, is fixed with supplementary extrusion's backstop mechanism on the mounting panel.
The forming pipe is provided with a plurality of extruding columns which are fixedly connected on the front frame.
Backstop mechanism is including sliding the square column on the mounting panel, and the front end of square column is fixed with a boom bar, and the front end of boom bar is connected with the baffle, and the front end of square column is equipped with spring I with the mounting panel.
Still including fixing the spacing seat at the square column front end, sliding connection has on the mounting panel to be used for with spacing gliding stop gear of seat, is fixed with the rib on the front truck, rib and stop gear sliding connection.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a chemical pharmaceutical granulation machine;
FIGS. 2 and 3 are schematic structural views of the support frame and the forming tube;
FIG. 4 is a schematic structural view of the mounting plate in connection with the backstop mechanism and the spacing mechanism;
FIG. 5 is a schematic structural view of the rear stop mechanism;
FIG. 6 is a schematic structural view of a spacing mechanism;
FIG. 7 is a schematic view of the construction of the squeeze post and the front frame;
fig. 8 is a schematic view of an embodiment of the regulation of the amount of the pressed powder;
FIG. 9 is a schematic view of the structure of the quantitative lower plate;
FIG. 10 is a schematic view showing the structure of the quantitative upper plate and the down pipe II.
In the figure:
a support main frame 101; a forming tube 102; a guide plate 103; a blanking pipe I104; a tablet guide plate 105; a powder guide plate 106; a mounting plate 107; a baffle 201; an arm support lever 202; a pulling plate 203; a trace 204; a slide plate 205; a spring II 206 square column 207; a spring I208; a limiting seat 209; a cross frame 301; a card board 302; a spring III 303; a control mount 304; a front frame 401; an extrusion column 402; ribs 403; a transverse push plate 404; a quantitative lower plate 501; a leak hole I502; a quantitative spring I503; an adjustment plate 601; an adjusting screw 602; a blanking pipe II 603; a quantitative upper plate 604; a quantitative spring II 605; a leak hole II 606; a container 607.
Detailed Description
As shown in fig. 1-10:
the utility model provides a chemical industry pharmacy granulation machine, is including supporting body frame 101, forming tube 102, mounting panel 107 and extrusion post 402, and forming tube 102 fixes on supporting body frame 101, and extrusion post 402 slides in forming tube 102, and blanking pipe I104 fixes on forming tube 102, and mounting panel 107 is fixed on supporting body frame 101, is fixed with the backstop mechanism of supplementary extrusion on the mounting panel 107.
When the medicine granule is being made, add powder to blanking pipe I104 in, the powder falls into forming tube 102 through blanking pipe I104 in, control extrusion post 402 is backward moved in forming tube 102, and the fender mechanism forms and extrudees the powder after the cooperation to make the powder by extrusion and obtain the granule, extrusion is effectual.
Furthermore, a plurality of forming tubes 102 are provided, and a plurality of extrusion columns 402 are fixed on the front frame 401.
The forming pipes 102 are arranged, so that the powder can be simultaneously adjusted into the forming pipes 102, the front frame 401 drives the extrusion columns 402 to move backwards in the forming pipes 102 by controlling the telescopic rod arranged between the front frame 401 and the supporting main frame 101 to contract, and the rear stop mechanism is matched to extrude the powder, so that the powder is extruded and formed into particles; thereby improving the efficiency of the pharmaceutical particles.
As shown in fig. 1-10:
the rear stop mechanism comprises a baffle plate 201, a support arm rod 202, a square column 207 and a spring I208; the square column 207 slides on the mounting plate 107, the arm rod 202 is fixed at the front end of the square column 207, the baffle 201 is fixed at the front end of the arm rod 202, and the spring I208 is arranged between the front end of the square column 207 and the mounting plate 107.
The rear end formed in the forming tube 102 through the baffle 201 is blocked, and the medicinal powder in the forming tube 102 is extruded and formed by matching with the extrusion column 402 which slides backwards;
with the continuous backward movement of the extrusion column 402, the square column 207 extrudes the spring I208 and moves backward on the mounting plate 107, so that the baffle plate 201 slides out of the forming tube 102, the formed medicine grains slide out of the forming tube 102 at the same time, then the telescopic rod is controlled to extend rapidly, so that the extrusion column 402 is separated from the medicine grains suddenly, the medicine grains fall downwards under the influence of self gravity, the extruded spring I208 pushes the square column 207 to slide back, and the baffle plate 201 slides into the initial position in the forming tube 102 to prepare for next extrusion.
As shown in fig. 1-10:
still include spacing seat 209, have rib 403 and stop gear, spacing seat 209 is fixed at the front end of square column 207 for with spacing seat 209 gliding stop gear sliding connection on mounting panel 107, rib 403 is fixed on preceding frame 401, rib 403 and stop gear sliding connection.
In order to ensure that the medicine granules can fall freely after the extrusion column 402 is separated, after the extrusion column 402 extrudes the medicine granules to slide out of the forming tube 102, the limiting seat 209 on the square column 207 slides through the limiting mechanism, the telescopic rod is controlled to extend rapidly, so that after the extrusion column 402 is separated from the medicine granules suddenly, the extruded spring I208 pushes the square column 207 to slide back, so that when the limiting seat 209 slides to the limiting mechanism, the limiting seat 209 is limited by the limiting mechanism and stops moving, so that the baffle 201 stops moving forward, the medicine granules have enough time to fall freely and are not influenced by the back-sliding baffle 201;
the extrusion column 402 is driven by the front frame 401 to slide back, and simultaneously the ribs 403 are driven to move forward until the ribs on the ribs 403 slide with the limiting mechanism, so that the limitation of the limiting mechanism on the limiting seat 209 is removed, the elastic force of the spring I208 continues to push the square column 207 to slide back, and the baffle 201 slides into the initial position in the forming tube 102 to prepare for next extrusion.
As shown in fig. 1-10:
the device also comprises a pulling plate 203, a linkage rod 204, a sliding plate 205 and a spring II 206;
the pull plate 203 is fixed on the baffle 201, the sliding plate 205 slides on the arm rod 202, the linkage rod 204 is rotatably connected between the pull plate 203 and the sliding plate 205, and the spring II 206 is arranged between the limiting seat 209 and the sliding plate 205.
In order to further ensure that the medicine particles can fall freely after the extrusion column 402 is separated, the telescopic rod is controlled to extend rapidly, so that after the extrusion column 402 is separated from the medicine particles suddenly, the limiting seat 209 is limited by the limiting mechanism and stops moving, the elastic force of the spring II 206 pushes the sliding plate 205 to slide forwards, then the pull plate 203 is pushed by the linkage rod 204, the baffle plate 201 rotates on the support arm rod 202, and the medicine particles attached to the baffle plate 201 are thrown downwards by the rotating baffle plate 201, so that the medicine particles are further ensured to be separated from the baffle plate 201;
after the limit of the limiting mechanism on the limiting seat 209 is released, the elastic force of the spring I208 continuously pushes the square column 207 to slide back, the pull plate 203 on the baffle plate 201 is firstly contacted with the forming tube 102, so that the guide rotation of the baffle plate 201 is formed, and then the baffle plate 201 can be aligned to the forming tube 102 and slide in;
and the supporting arm rod 202 can be tightly supported through the pulling plate 203, so that the baffle 201 is effectively prevented from rotating too much and sliding into the forming tube 102.
As shown in fig. 1-10:
the limiting mechanism comprises a cross frame 301, a clamping plate 302, a spring III 303 and a control seat 304; crossbearer 301 slides on mounting panel 107, and a plurality of cardboard 302 are all fixed at crossbearer 301's lower extreme, a plurality of cardboard 302 respectively with a plurality of spacing seats 209 sliding connection, control seat 304 is fixed in crossbearer 301's upper end, control seat 304 and rib 403 sliding connection, spring III 303 sets up between crossbearer 301 and mounting panel 107.
After the extrusion column 402 extrudes the medicine grains to slide out of the forming tube 102, when the medicine grains continue to move successively, the limiting seat 209 on the square column 207 is contacted with the clamping plate 302 and extrudes the clamping plate 302, so that the clamping plate 302 extrudes the spring III 303 through the cross frame 301 and moves upwards until the limiting seat 209 slides over the clamping plate 302, the telescopic rod is controlled to extend rapidly, and after the extrusion column 402 is suddenly separated from the medicine grains, the backward-sliding limiting seat 209 is tightly propped on the clamping plate 302 to form limiting brake on the limiting seat 209, so that the medicine grains can fall off in enough time;
along with the extrusion post 402 is driven by the front frame 401 to slide back, the ribs 403 are driven to move forward at the same time, until the ribs on the ribs 403 are in contact with the control seat 304, the extrusion control seat 304 drives the clamping plate 302 to slide upwards, so that the clamping plate 302 is separated from the limiting seat 209, the limiting brake on the limiting seat 209 is released, the elastic force of the spring I208 continues to push the square post 207 to slide back, and the baffle 201 slides into the initial position in the forming tube 102 to prepare for next extrusion.
As shown in fig. 1-10:
a guide plate 103 is disposed above the rear end of the forming tube 102.
Through the arrangement of the guide plate 103, the guide plate 103 is in contact with the pull plate 203 on the baffle 201 in advance to form guide rotation of the baffle 201, so that the baffle 201 is prevented from having no rotation space and influencing the sliding of the baffle 201 into the forming tube 102.
As shown in fig. 1-10:
the front frame 401 is provided with a transmission shaft which is in transmission connection with a plurality of extrusion columns 402.
Through installing the motor at preceding frame 401 and transmitting the transmission shaft, make a plurality of extrusion posts 402 of transmission shaft simultaneous transmission, make when extrusion post 402 extrudees powder, be the rotation state to the extrusion end face that forms extrusion post 402 stirs to the drive of powder, powder can evenly distributed when the extrusion, ensures that powder when extrusion, the shape is unified.
As shown in fig. 1-10:
the tablet guide plate 105 is obliquely fixed on the support main frame 101 below the forming tube 102.
The dropped medicine particles are received by the medicine particle guide plate 105, and are intensively guided to the rear end of the device through the inclination angle of the medicine particle guide plate for centralized collection.
As shown in fig. 1-10:
the medicine granule guide plate 105 is provided with a screening long hole, and the lower end of the medicine granule guide plate 105 is obliquely fixed with a medicine powder guide plate 106.
Through the setting of screening slot hole, when the medicine grain is not moulded or has other quality problems, contain powder in the medicine grain that drops, along with the medicine grain messenger of gliding along medicine grain baffle 105, powder will pass the screening slot hole, fall to powder baffle 106 on to the formation is concentrated the collection to powder in the device the place ahead through powder baffle 106.
As shown in fig. 1-10:
a plurality of blanking pipes II 603 are connected into the blanking pipes I104, and a containing box 607 is fixed at the upper end of each blanking pipe II 603.
The containing box 607 is used for containing medicine powder, so that the medicine powder slides into the blanking pipe I104 through the blanking pipe II 603 and falls into the forming pipe 102.
As shown in fig. 1-10:
the quantitative feeding device is characterized by further comprising a transverse push plate 404, a quantitative lower plate 501, a leakage hole I502, a quantitative spring I503, a quantitative upper plate 604, a quantitative spring II 605 and a leakage hole II 606, wherein the quantitative lower plate 501 slides in the blanking pipe I104, the quantitative lower plate 501 is provided with the leakage hole I502, the quantitative spring I503 is arranged between the front end of the quantitative lower plate 501 and the blanking pipe I104, the quantitative upper plate 604 slides in the blanking pipe II 603, the leakage hole II 606 is arranged on the quantitative upper plate 604, the quantitative spring II 605 is arranged between the front end of the quantitative upper plate 604 and the blanking pipe II 603, and the transverse push plate 404 is fixed on the ridge 403.
When the extrusion column 402 is positioned at the forefront to be extruded, the transverse push plate 404 fixed on the rib 403 is positioned at the forefront and is positioned in contact with the quantitative lower plate 501, the quantitative lower plate 501 is positioned at the forefront end in the blanking pipe I104 under the action of a quantitative spring I503, the leak hole I502 is positioned in the blanking pipe I104, and the forming pipe 102 is communicated with the blanking pipe II 603, so that the medicine powder in the blanking pipe II 603 falls into the forming pipe 102;
meanwhile, the quantitative upper plate 604 is positioned at the foremost end in the blanking pipe II 603 under the action of the quantitative spring II 605, and the leakage hole II 606 is not positioned in the blanking pipe II 603, so that the blanking pipe II 603 is separated, and the medicinal powder in the containing box 607 cannot flow into the blanking pipe I104;
with the backward movement of the extrusion column 402, the horizontal push plate 404 moves backward, the quantitative lower plate 501 contacts with the horizontal push plate 404 firstly, so that the quantitative lower plate 501 is pushed to move backward, the leakage hole I502 slides out of the blanking pipe I104 to form a partition of the blanking pipe I104, the horizontal push plate 404 continues to move backward to contact with the quantitative upper plate 604 and extrude the quantitative upper plate 604 to move backward, the leakage hole II 606 on the quantitative upper plate 604 gradually slides into the blanking pipe II 603, and the medicine powder in the container 607 flows onto the quantitative lower plate 501 in the blanking pipe I104 through the leakage hole II 606 until the space above the quantitative lower plate 501 is filled with the medicine powder;
after the medicine particles are formed, the extrusion column 402 moves forwards, the quantitative lower plate 501 and the quantitative upper plate 604 are pushed forwards by elasticity at the same time, before the quantitative upper plate 604 is separated from the transverse push plate 404, the quantitative upper plate 604 firstly separates the blanking pipe II 603, so that quantitative medicine powder between the quantitative lower plate 501 and the quantitative upper plate 604 is formed, the leakage hole I502 slides into the blanking pipe I104 along with the forward movement of the quantitative lower plate 501, the quantitative medicine powder falls into the forming pipe 102, the quantitative medicine powder is extruded into the medicine particles along with the forward movement of the next extrusion column 402, and the actions are repeated simultaneously to form the same volume of the medicine powder extruded each time, so that the content of the medicine particles extruded and formed in the same manner are the same.
As shown in fig. 1-10:
the blanking pipe blanking device further comprises an adjusting plate 601 and an adjusting screw 602, a plurality of blanking pipes II 603 are fixed on the adjusting plate 601, the adjusting plate 601 is in threaded connection with the adjusting screw 602, and the adjusting screw 602 rotates on the mounting plate 107.
Through rotating adjusting screw 602, adjusting screw 602 screw thread transmission regulating plate 601 goes up and down, drives blanking pipe II 603 then and goes up and down in blanking pipe I104 to change the interval between ration hypoplastron 501 and the ration upper plate 604, thereby form the regulation to the volume of ration powder, collection device can adapt to the pelletization of the powder of different volumes.

Claims (10)

1. The utility model provides a chemical industry pharmacy granulation machine which characterized in that: the extrusion forming device comprises a forming pipe (102) fixed on a supporting main frame (101) and an extrusion column (402) sliding in the forming pipe (102), wherein a blanking pipe I (104) is fixed on the forming pipe (102), a mounting plate (107) is fixed on the supporting main frame (101), and a rear stop mechanism for assisting extrusion forming is fixed on the mounting plate (107).
2. The chemical pharmaceutical granulation machine of claim 1, wherein: the forming pipe (102) is provided with a plurality of extruding columns (402) which are fixedly connected on the front frame (401).
3. The chemical pharmaceutical granulation machine according to claim 2, wherein: the rear stop mechanism comprises a square column (207) sliding on the mounting plate (107), a support arm rod (202) is fixed to the front end of the square column (207), a baffle plate (201) is connected to the front end of the support arm rod (202), and a spring I (208) is arranged at the front end of the square column (207) and the mounting plate (107).
4. The chemical pharmaceutical granulation machine according to claim 3, wherein: the square column fixing device is characterized by further comprising a limiting seat (209) fixed at the front end of the square column (207), a limiting mechanism used for sliding with the limiting seat (209) is connected onto the mounting plate (107) in a sliding mode, ribs (403) are fixed on the front frame (401), and the ribs (403) are connected with the limiting mechanism in a sliding mode.
5. The chemical pharmaceutical granulation machine according to claim 4, wherein: the device is characterized by further comprising a pulling plate (203) fixed on the baffle (201), a sliding plate (205) sliding on the support arm rod (202), a linkage rod (204) rotatably connected between the pulling plate (203) and the sliding plate (205), and a spring II (206) arranged between the limiting seat (209) and the sliding plate (205).
6. The chemical pharmaceutical granulation machine of claim 5, wherein: stop gear is including sliding crossbearer (301) on mounting panel (107), and the lower extreme of crossbearer (301) is equipped with a plurality of cardboard (302), a plurality of cardboard (302) respectively with a plurality of spacing seat (209) sliding connection, the upper end of crossbearer (301) is equipped with control seat (304), control seat (304) and rib (403) sliding connection are equipped with spring III (303) between crossbearer (301) and mounting panel (107).
7. The chemical pharmaceutical granulation machine according to claim 6, wherein: a guide plate (103) is arranged above the rear end of the forming pipe (102).
8. The chemical pharmaceutical granulation machine according to claim 2, wherein: the front frame (401) is rotatably provided with a transmission shaft, and the transmission shaft is in transmission connection with a plurality of extrusion columns (402).
9. The chemical pharmaceutical granulation machine of claim 1, wherein: a medicine particle guide plate (105) is obliquely fixed on the supporting main frame (101) below the forming tube (102).
10. The chemical pharmaceutical granulation machine of claim 9, wherein: the medicine granule guide plate (105) is provided with a screening long hole, and the lower end of the medicine granule guide plate (105) is obliquely fixed with a medicine powder guide plate (106).
CN202210209437.0A 2022-03-03 2022-03-03 Chemical pharmaceutical granulation machine Active CN114588025B (en)

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CN202210209437.0A CN114588025B (en) 2022-03-03 2022-03-03 Chemical pharmaceutical granulation machine

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Application Number Priority Date Filing Date Title
CN202210209437.0A CN114588025B (en) 2022-03-03 2022-03-03 Chemical pharmaceutical granulation machine

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CN114588025B CN114588025B (en) 2023-09-08

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CN112895198A (en) * 2021-01-13 2021-06-04 李传八 Polyethylene granulation process
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CN214810635U (en) * 2021-06-03 2021-11-23 武汉华源晨泰健康生物科技有限公司 Wet granulation device for medicinal powder
CN215504390U (en) * 2021-06-24 2022-01-14 成都慧德医药科技有限公司 A pelletization device for production of hydrochloric acid glucosamine piece
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CN112895198A (en) * 2021-01-13 2021-06-04 李传八 Polyethylene granulation process
CN214448798U (en) * 2021-03-29 2021-10-22 海南涛生医药科技研究院有限公司 Powder measurement compression piece device
CN214810635U (en) * 2021-06-03 2021-11-23 武汉华源晨泰健康生物科技有限公司 Wet granulation device for medicinal powder
CN215504390U (en) * 2021-06-24 2022-01-14 成都慧德医药科技有限公司 A pelletization device for production of hydrochloric acid glucosamine piece
CN114052276A (en) * 2021-10-08 2022-02-18 赵勇 Feed granulator capable of improving particle compactness through pressure

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