CN114573836B - Hydrogel and method for producing same - Google Patents
Hydrogel and method for producing same Download PDFInfo
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- CN114573836B CN114573836B CN202210215389.6A CN202210215389A CN114573836B CN 114573836 B CN114573836 B CN 114573836B CN 202210215389 A CN202210215389 A CN 202210215389A CN 114573836 B CN114573836 B CN 114573836B
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 51
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 66
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 21
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 19
- 229920002678 cellulose Polymers 0.000 claims abstract description 19
- 239000001913 cellulose Substances 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 238000000227 grinding Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000007790 solid phase Substances 0.000 claims abstract description 8
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims description 30
- 239000008247 solid mixture Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- 238000004132 cross linking Methods 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- 230000004580 weight loss Effects 0.000 claims description 8
- 239000000084 colloidal system Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000012043 crude product Substances 0.000 claims description 5
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 238000003892 spreading Methods 0.000 claims description 4
- 230000007480 spreading Effects 0.000 claims description 4
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- 239000003431 cross linking reagent Substances 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 3
- 150000002334 glycols Chemical class 0.000 abstract description 2
- 229960004106 citric acid Drugs 0.000 description 17
- 239000002245 particle Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 239000007787 solid Substances 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 208000008589 Obesity Diseases 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000002641 glycemic effect Effects 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000036186 satiety Effects 0.000 description 3
- 235000019627 satiety Nutrition 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000004260 weight control Methods 0.000 description 3
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 229960002303 citric acid monohydrate Drugs 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000012674 dispersion polymerization Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011802 pulverized particle Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- -1 solubilization Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2301/08—Cellulose derivatives
- C08J2301/26—Cellulose ethers
- C08J2301/28—Alkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2471/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2471/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C08K5/092—Polycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the field of preparation of hydrogels, in particular to a hydrogel and a production method thereof. The production method of the hydrogel comprises the following steps: mixing water, polyethylene glycol compound, citric acid and cellulose compound, grinding to form completely melted semisolid mixture, and performing solid phase polymerization. By adopting citric acid as a crosslinking agent and polyethylene glycol compounds as auxiliary crosslinking agents, and changing the mixing mode of preparing hydrogel from solution mixing to semi-solid phase mixing, the production time is shortened, and the production efficiency is greatly improved; the water consumption is reduced, the energy is saved, the environment is protected, the performance of the prepared hydrogel is improved, the medium uptake ratio is improved, and the elastic modulus is not obviously reduced.
Description
Technical Field
The invention relates to the field of preparation of hydrogels, in particular to a hydrogel and a production method thereof.
Background
Hydrogels (hydrogels) are a class of extremely hydrophilic three-dimensional network structure gels that swell rapidly in water and in this swollen state can hold large volumes of water without dissolution. In the prior art, a fiber compound is generally used as a substrate, and reacts with a cross-linking agent to prepare hydrogel. In addition, citric acid is usually used as a cross-linking agent in the preparation process, and the reaction system is aqueous solution for solution dispersion polymerization, but the concentration of the fiber compound is usually 4-6% relative to the weight of water due to low solubility of the fiber compound. The dissolution rate is very slow, typically taking tens of hours; and the water solvent needs to be removed at a later stage, so that a large amount of energy is required. And the properties of hydrogels prepared using the above-described crosslinkers and methods are not particularly excellent.
Disclosure of Invention
The present invention provides a hydrogel and a method for producing the same, which aims to improve the above problems.
The invention is realized in the following way:
in a first aspect, an embodiment of the present invention provides a method for producing a hydrogel, including: mixing water, polyethylene glycol compound, citric acid and cellulose compound, grinding to form completely melted semisolid mixture, and performing solid phase polymerization.
Further, in a preferred embodiment of the present invention, the method comprises: mixing and stirring purified water, citric acid and polyethylene glycol compound at 20-60deg.C for dissolving, slowly and uniformly adding cellulose compound into the solution, stirring, and grinding with colloid mill to obtain completely melted semisolid mixture.
Further, in a preferred embodiment of the present invention, the mass ratio of the water, the citric acid, the polyethylene glycol compound and the cellulose compound is 6 to 12:0.008-0.012:0.08-0.14:1.
further, in a preferred embodiment of the present invention, the cellulose-based compound comprises sodium carboxymethyl cellulose.
Further, in a preferred embodiment of the present invention, the polyethylene glycol compound includes polyethylene glycol 4000 and polyethylene glycol 6000.
Further, in a preferred embodiment of the present invention, the solid phase polymerization reaction comprises: drying the semi-solid mixture at 40-100 ℃ until the drying weight loss is not more than 15%, and then carrying out crosslinking reaction at 100-140 ℃.
Further, in a preferred embodiment of the present invention, the production method further comprises: spreading the semi-solid mixture into a baking tray, drying at 40-100 ℃ until the drying weight loss is not more than 15%, crushing, crosslinking at 100-140 ℃ for 3-4 hours to form a crosslinked crude product, and cleaning and drying.
Further, in a preferred embodiment of the invention, the crushed material has a diameter of 100-1000 microns.
Further, in a preferred embodiment of the present invention, the drying process includes: drying at 65-85deg.C for 24-30 hr, and drying at 40-50deg.C until the drying weight loss is less than 10%.
In a second aspect, embodiments of the present invention provide a hydrogel, which is prepared by the method for producing a hydrogel as described above.
The beneficial effects of the invention are as follows: according to the embodiment of the invention, citric acid is used as a crosslinking agent and polyethylene glycol compounds are used as auxiliary crosslinking agents, and the mixing mode of preparing hydrogel is changed from solution mixing to semi-solid phase mixing, so that the production time is shortened, and the production efficiency is greatly improved; the water consumption is reduced, the energy is saved, the environment is protected, the performance of the prepared hydrogel is improved, the medium uptake ratio is improved, and the elastic modulus is not obviously reduced.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The following provides a specific description of a hydrogel and a method for producing the same.
First, the present invention provides a method for producing a hydrogel, comprising:
mixing water, polyethylene glycol compound, citric acid and cellulose compound, grinding to form completely melted semisolid mixture, and performing solid phase polymerization. In particular, the method comprises the steps of,
adding purified water, citric acid and polyethylene glycol compound into a low-shear normal-pressure mixing container at 20-60 ℃, stirring and dissolving to form a solution, slowly and uniformly adding the cellulose compound into the solution, and stirring for 15-30min to ensure that the cellulose compound is uniformly dispersed in the water without obvious large bulk or powdery materials. The mixture is then poured into a colloid mill and ground multiple times (e.g., 2 times) using the colloid mill to obtain a fully melted semi-solid mixture.
The fully melted semi-solid mixture was: the cellulose compound and water are completely adhered, and no solid-liquid separation phenomenon exists between the cellulose compound and the water; the semi-solid mixture is in a uniform state, and the surface is flat and smooth; the color is nearly colorless and transparent, and no granular object exists.
The cellulose compound can be a cellulose compound known in the prior art, and the sodium carboxymethyl cellulose is selected in the embodiment of the invention because the sodium carboxymethyl cellulose has higher water solubility, so that the water consumption can be properly reduced, and the semisolid mixing formation is promoted more favorably.
Polyethylene glycols may be used as the polyethylene glycols known in the art, such as polyethylene glycol 4000 and polyethylene glycol 6000.
The citric acid used is citric acid monohydrate, but non-hydrated citric acid may also be used.
The mass ratio of the water to the citric acid to the polyethylene glycol to the cellulose is 6-12:0.008-0.012:0.08-0.14:1. the performance of the formed hydrogel can be better improved by adopting the proportion, and the elastic modulus is not obviously reduced while the medium uptake ratio is improved.
Then spreading the completely melted semi-solid mixture into a stainless steel baking pan (thickness not exceeding 30 mm), and then placing the stainless steel baking pan into an oven for baking, specifically, baking at 40-100 ℃ for 30-40 hours, for example, at 40-100 ℃ for 30-40 hours, 31 hours, 32 hours, 33 hours, 34 hours, 35 hours, 36 hours, 37 hours, 38 hours, 39 hours, 40 hours, and the like, at 40-100 ℃ for 30-40 hours. And the weight loss after drying is not more than 15 percent, and the middle part of the drying is turned once.
And then crushing the dried hard and crisp solid, specifically, shearing the dried hard and crisp solid into small pieces with the diameter of about 5cm by using a coarse grinder, crushing the small pieces by using a fine grinder, sieving the small pieces and collecting particles with the diameter of 100-1000 micrometers (20-150 meshes).
Then, the above-mentioned pulverized particles are placed in a crosslinking reactor, and placed at a temperature of 100 to 140 ℃, for example, at a temperature of 100 ℃, 105 ℃, 110 ℃, 115 ℃, 120 ℃, 125 ℃, 130 ℃, 135 ℃, 140 ℃ or the like, and any value between 100 to 140 ℃ is subjected to a crosslinking reaction for about 3 to 4 hours, for example, any value between 3 hours, 3.5 hours, 4 hours or the like, to obtain a crosslinked raw product.
Transferring the above crosslinked crude product to a cleaning tank, washing with 150-200 times of purified water to remove by-products and unreacted raw materials, and filtering. The solid obtained by filtration is placed in a tray and dried by ventilation, the thickness is 40mm, and the drying is carried out for 24-30 hours at 65-85 ℃, for example, the drying temperature is any value between 65-85 ℃ such as 65 ℃, 66 ℃, 67 ℃, 68 ℃, 69 ℃, 70 ℃, 71 ℃, 72 ℃, 73 ℃, 74 ℃, 75 ℃, 76 ℃, 77 ℃, 78 ℃, 79 ℃,80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃ and 85 ℃ and the drying time is any value between 24-30 hours such as 24 hours, 25 hours, 26 hours, 27 hours, 28 hours, 29 hours and 30 hours. And then drying at 40-50 ℃ until the drying weight loss is less than 10%. For example, the temperature may be any value between 40 and 50℃such as 40℃41℃42℃43℃44℃45℃46℃47℃48℃49℃50 ℃. And then finishing, and collecting particles with 20-150 meshes.
The embodiment of the invention provides a hydrogel, which is prepared by the production method of the hydrogel.
The hydrogels of the present invention may be used in methods of treating obesity, reducing food or calorie intake, or achieving or maintaining satiety. The hydrogels of the present invention may also be used to improve glycemic control, treat or prevent diabetes, or assist in weight control. The product can be taken alone or together with liquid or food.
The hydrogels of the present invention may be used as pharmaceutical compositions, which may include hydrogels as active components, optionally in combination with pharmaceutically acceptable excipients or carriers. The pharmaceutical composition can be used for oral administration to treat obesity, enhance satiety, improve glycemic control, treat or prevent diabetes or assist in weight control.
The hydrogel can be used as a pharmaceutical composition, wherein the hydrogel is used as an inactive ingredient, plays roles of slow release, dispersion, solubilization, coating and the like in the composition, and is suitable for different purposes. The pharmaceutical composition can be used for oral administration to treat obesity, enhance satiety, improve glycemic control, treat or prevent diabetes or assist in weight control.
Relevant assays for hydrogels provided by embodiments of the present invention include yield, media uptake ratio, elastic modulus, moisture content, and tap density. The detection method of each item is as follows:
1. tap density (DT, g/ml) determination method:
40.0+ -0.1 g of test particles (M, g) were weighed accurately, poured into a dry 100ml graduated glass cylinder, shaken or tapped until the readings were no longer changed (the difference between 2 readings was less than 2%),record the final vibration mass (V) f ，ml)。
DT＝M/V f 。
2. Media Uptake Ratio (MUR) determination method:
6 dry sintered glass funnels were washed clean with 40ml of purified water, placed on a stand, the funnels were sucked dry with filter paper, weighed, and the weight of the empty device (W tare )。
Accurately weighing 0.250+ -0.005 g of test particles (W in ) Put into a 100ml beaker, put 40.0.+ -. 0.1g of purified water, gently shake to obtain suspension, gently stir for 30 minutes to obtain suspension. The suspension was poured into a funnel and drained for 10 minutes until no water drops were present, blotted dry with filter paper and weighed to an accuracy of 0.1g (W fin )。MUR＝(W fin -W tare -W in )/W in . 3 parts in parallel and averaged.
3. Modulus of elasticity
The samples were measured by an extensometer and averaged in 3 replicates.
The hydrogel and the production method thereof provided by the invention are specifically described below with reference to specific examples.
Examples 1 to 4
The operations of examples 1-4 and comparative examples 1-5 are substantially identical, except that the mass ratio of polyethylene glycol compound, the citric acid and the cellulose compound is different, and the specific operations are as follows:
(1) 300kg of purified water, 300g of citric acid monohydrate and Xkg polyethylene glycol 4000 (the specific dosage is shown in table 1) are added into a low-shear normal-pressure mixing container at the temperature of 40 ℃, 30kg of CMC-Na is slowly and uniformly added into the solution after stirring and dissolving, and stirring is carried out for 15min, so that CMC-Na is uniformly dispersed in water and has no obvious big bulk or powdery materials. Pouring the mixture into a colloid mill, grinding for 2 times by using the colloid mill at the rotating speed of 2900r/min to obtain a fully melted semi-solid mixture.
(2) Spreading the fully melted semi-solid mixture into a stainless steel baking pan (thickness not exceeding 30 mm);
(3) Drying in an oven at 80deg.C for 40 hr until the loss on drying is not more than 15%, and turning over once in the middle.
(4) Cutting the dried hard and crisp solid into small pieces of about 5cm by a coarse grinder, grinding by a fine grinder, sieving, and collecting particles with the diameter of 100-1000 micrometers (20-150 meshes).
(5) And (3) placing the crushed particles into a crosslinking reactor, and placing the particles into a 140 ℃ oven for crosslinking reaction for about 3 hours to obtain crosslinked cellulose crude product particles.
(6) Transferring the crude product particles to a cleaning tank, washing with 200 times of purified water to remove byproducts and unreacted raw materials, and filtering; the solid obtained by filtration was placed in a tray and dried by aeration, 40mm in thickness, and dried at 85℃for 28 hours. Drying at 50deg.C until the drying weight is less than 10%, and total drying time is about 60 hr; finishing, collecting particles with 20-150 meshes, and weighing Zkg.
The yield was calculated: z/30 x 100%.
Comparative example 6: hydrogels were prepared with reference to the production method of the above examples, except that polyethylene glycol 4000 was replaced with an equimolar amount of sorbitol as in example 1.
The hydrogels prepared in examples and comparative examples were then examined separately, and the results of the examination are shown in table 1.
TABLE 1
As can be seen from the above table, in comparative example 1, which is a hydrogel formed by using only citric acid as a crosslinking agent, the medium uptake ratio was only 32MUR and the elastic modulus was 1.62Kpa, but when citric acid and polyethylene glycol were used in combination, the medium uptake ratio was increased, and the elastic modulus was not significantly reduced, thereby improving the properties of the formed hydrogel. If the ratio of the citric acid to the polyethylene glycol is within the range defined by the invention, the hydrogel has higher medium uptake ratio under the condition that the elastic modulus of the hydrogel is not obviously reduced, and the performance is further improved. If the combination of citric acid and polyethylene glycol is changed as the crosslinking agent, for example, the combination of citric acid and sorbitol is changed, the yield of the hydrogel is greatly reduced, and the medium uptake ratio is also lower than 50MUR, which indicates that the performance of the hydrogel is reduced. Further, the embodiment of the invention is verified that the performance of the hydrogel can be effectively improved by specifically matching the citric acid and the polyethylene glycol.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, and various modifications and variations may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. A method for producing a hydrogel, comprising: mixing water, polyethylene glycol compound, citric acid and cellulose compound, grinding to form completely melted semi-solid mixture, and performing solid phase polymerization reaction; the mass ratio of the water to the citric acid to the polyethylene glycol to the cellulose is 10:0.01:0.12-0.14:1.
2. the method for producing a hydrogel according to claim 1, comprising: mixing and stirring purified water, citric acid and polyethylene glycol compound at 20-60deg.C for dissolving, slowly and uniformly adding cellulose compound into the solution, stirring, and grinding with colloid mill to obtain completely melted semisolid mixture.
3. The method of producing a hydrogel according to claim 1 or 2, wherein the cellulose-based compound comprises sodium carboxymethyl cellulose.
4. The method of producing a hydrogel according to claim 1 or 2, wherein the polyethylene glycol-based compound comprises polyethylene glycol 4000 and polyethylene glycol 6000.
5. The method for producing a hydrogel according to claim 1, wherein the solid phase polymerization reaction comprises: drying the semi-solid mixture at 40-100 ℃ until the drying weight loss is not more than 15%, and then carrying out crosslinking reaction at 100-140 ℃.
6. The method for producing a hydrogel according to claim 5, further comprising: spreading the semi-solid mixture into a baking tray, drying at 40-100 ℃ until the drying weight loss is not more than 15%, crushing, crosslinking at 100-140 ℃ for 3-4 hours to form a crosslinked crude product, and cleaning and drying.
7. The method of producing a hydrogel according to claim 6, wherein the crushed material has a diameter of 100 to 1000 microns.
8. The method of producing a hydrogel according to claim 6, wherein the drying process comprises: drying at 65-85deg.C for 24-30 hr, and drying at 40-50deg.C until the drying weight loss is less than 10%.
9. A hydrogel, characterized in that it is prepared by the method for producing a hydrogel according to any one of claims 1 to 8.
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