CN114569904A - Ultrasonic colpitis noninvasive treatment and vaginal flora regulation and control device - Google Patents
Ultrasonic colpitis noninvasive treatment and vaginal flora regulation and control device Download PDFInfo
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
- A61M2210/1475—Vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N7/00—Ultrasound therapy
- A61N2007/0043—Ultrasound therapy intra-cavitary
Abstract
The invention relates to the technical field of medical equipment and discloses an ultrasonic colpitis noninvasive treatment and vaginal flora regulation and control device which comprises an ultrasonic generation unit, wherein the ultrasonic generation unit comprises a treatment rod and a treatment sleeve sleeved on the outer peripheral wall of the treatment rod, an ultrasonic transducer used for emitting annular ultrasonic waves is arranged in the treatment rod, a groove used for storing medicines is formed in the outer peripheral wall of the treatment rod, and the treatment sleeve is made of porous membrane materials. In the invention, the medicine is stored in the groove and distributed between the treatment sleeve and the treatment rod, when in use, the medicine penetrates through the treatment sleeve, and the annular ultrasonic wave can promote the medicine to penetrate under the vaginal mucosa to reach the deep part of an infected area, thereby improving the curative effect of the medicine; meanwhile, the treatment effect is further improved through the synergistic effect of the medicines and the ultrasonic waves. Moreover, the invention can realize quantitative and accurate medication. In addition, the invention also has the functions of repairing the vaginal tissue structure, promoting the ecological balance of flora in the vagina and improving the inflammation and the immune function of female organisms.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an ultrasonic colpitis noninvasive treatment and vaginal flora regulating and controlling device.
Background
More than 80% of women all over the world experience some forms of vaginal infection in a lifetime, common bacterial, mycotic and trichomonas vaginitis, more than half of which are difficult to cure radically at one time, and the vaginal inflammation attacks repeatedly and even develops into biofilm refractory vaginitis. The main reasons for the difficulty in radical treatment of vaginitis include that pathogenic bacteria causing vaginitis often generate biomembrane substances to cover the surface of vagina, conventional medicines cannot permeate the biomembrane easily, so that clinical medicine treatment is not thorough, pathogenic bacteria have poor sensitivity and strong drug resistance to the conventional medicines, and the imbalance of environmental flora in the vagina stimulates repeated attack of vaginitis, so that the medicines cannot kill the pathogenic bacteria efficiently at one time and can be radical-cured thoroughly.
The traditional treatment of vaginitis mostly adopts oral antibiotics or external alkaline lotion to diminish inflammation and kill germs. However, abuse of antibiotics while diminishing inflammation will kill a large number of beneficial bacterial flora, resulting in imbalance of bacterial flora in the vagina, disturbance of the mutual restriction relationship between microorganisms in the vagina, and aggravation of candida infection. Moreover, the whole body has large toxic and side effects, and can cause damage to the body of a patient. When a patient uses alkaline washing liquor to wash the vagina, the vaginal douche is difficult to hold well, and over-washing can inhibit lactic acid bacteria in the vagina instead, so that flora imbalance is caused, and further inflammation relapse is caused. The single vaginal local medicine is difficult to eliminate pathogenic bacteria hidden in folds of the inner wall of the vagina. Moreover, if a large amount of antibiotic drugs are used by pregnant women, serious consequences such as fetal deformity, asthma, eczema and the like can be caused. Thus, conventional vaginal administration is limited in several ways: the diffusion of the medicine on the surface of the vagina is insufficient, the contact between the medicine and the lesion part of the plica is limited, the vaginal dosage form is poor in retention, the dosage of a patient is poor in control and the like, so that the existing clinical medicine for treating vaginitis has poor curative effect and incomplete treatment, long-term repeated medication is needed, and huge psychological pressure and economic pressure are brought to the patient.
In recent years, researches show that cavitation effect and mechanical effect of ultrasound can transiently open various drug delivery barriers in a human body, such as blood brain barrier, skin stratum corneum barrier and in-vivo mucosal barriers, so that the curative effect of the drug is obviously improved, the dosage of the drug is reduced, and the synergistic effect is obvious. In view of the limitations and poor curative effects of traditional vaginal medicines, ultrasound and vaginitis medicines can be combined to break through the limitations of traditional vaginal medicines and improve the curative effects of vaginitis medicines, but how to combine ultrasound and vaginitis medicines is to be further developed.
Disclosure of Invention
In view of the above disadvantages of the prior art, the present invention provides an apparatus for noninvasive treatment of ultrasonic vaginitis and regulation of vaginal flora, which is used to solve the clinical problems of poor therapeutic effect of the conventional vaginal drugs in the prior art.
In order to achieve the above and other related objects, the present invention provides an ultrasonic colpitis noninvasive treatment and vaginal flora regulation and control device, which comprises an ultrasonic generation unit, wherein the ultrasonic generation unit comprises a treatment rod and a treatment sleeve sleeved on the outer peripheral wall of the treatment rod, an ultrasonic transducer for emitting annular ultrasonic waves is arranged in the treatment rod, a groove for storing medicine is arranged on the outer peripheral wall of the treatment rod, and the treatment sleeve is made of a porous membrane material.
Optionally, a cavity capable of being communicated with the outside is formed inside the treatment rod, the ultrasonic transducer is located in the cavity, and the ultrasonic transducer comprises a plurality of piezoelectric material blocks which are linearly arranged; the ultrasonic generating unit also comprises a host, wherein an ultrasonic generator and a control processor are arranged in the host, and the control processor is used for controlling the ultrasonic generator to work and transmitting the excitation current generated by the ultrasonic generator to the ultrasonic transducer.
Optionally, a cavity which can be communicated with the outside is formed in the treatment rod, the ultrasonic transducer is located in the cavity, the ultrasonic transducer comprises a plurality of ultrasonic generation heads which are linearly arranged, each ultrasonic generation head comprises a metal cylinder, a plurality of piezoelectric array elements which are annularly arranged around the metal cylinder and cables which are respectively connected with the corresponding piezoelectric array elements, a backing material layer for absorbing sound is arranged between each piezoelectric array element and the metal cylinder, a matching material layer covers the outer sides of the piezoelectric array elements, and a decoupling material layer is filled between the piezoelectric array elements; the ultrasonic generating unit also comprises a host, wherein an ultrasonic generator and a control processor are arranged in the host, and the control processor is used for controlling the ultrasonic generator to work and transmitting the excitation current generated by the ultrasonic generator to the ultrasonic transducer.
Optionally, a display screen connected to the control processor is provided on the host, and the display screen is configured to display ultrasonic data, where the ultrasonic data includes ultrasonic power, ultrasonic frequency, ultrasonic sound intensity, duty ratio, and ultrasonic irradiation duration.
Optionally, the sound intensity of the ultrasonic waves emitted by the treatment rod is 0.15-1W/cm2。
Optionally, the frequency of the ultrasonic waves emitted by the treatment rod is 20kHz to 1 MHz.
Optionally, a cooling duct is provided in the cavity.
Optionally, the ultrasonic generating unit further comprises a movable carrying vehicle, the host is mounted on the movable carrying vehicle, and a cooling water tank for supplying water to the cooling pipeline is arranged on the side wall of the movable carrying vehicle.
Optionally, the treatment sleeve has an open end and a closed end, the open end being provided with an elastic rubber ring for securing the treatment sleeve to the treatment rod.
Optionally, the grooves are spirally distributed on the outer peripheral wall of the treatment rod;
or, the quantity of recess is a plurality of, and the recess sets up along the axial of treatment stick, and a plurality of recesses distribute on the periphery wall of treatment stick.
Optionally, the device further comprises a drug monitoring unit, the drug monitoring unit comprises a laser generator and a fluorescence sensor, the laser generator and the fluorescence sensor are arranged on the treatment rod, the laser generator is used for emitting laser, the laser excites the drug marked by the fluorescent substance to emit a fluorescence signal, the fluorescence sensor is used for collecting the fluorescence signal and transmitting the fluorescence signal to the control processor, the control processor generates a fluorescence image according to the fluorescence signal transmitted by the fluorescence sensor, and the fluorescence image is displayed through the display screen.
As described above, the device for noninvasive treatment of ultrasonic vaginitis and vaginal flora regulation and control of the present invention has the following beneficial effects:
1. according to the ultrasonic generating unit, the control processor controls the ultrasonic generator to generate the excitation current with specific frequency and intensity, the control processor selects a specific cable according to the frequency of the excitation current to transmit the excitation current to the ultrasonic transducer in the treatment rod corresponding to the working frequency and drives the ultrasonic transducer to work to generate the annular ultrasonic wave, so that the medicine permeated from the treatment sleeve can permeate under vaginal mucosa to reach the deep part of an infected area, the permeability of a cell wall can be increased, the compact structure of an extracellular matrix of a fungal biomembrane can be loosened, the permeability of the medicine is enhanced, the curative effect of the medicine is improved, the using amount of the medicine is reduced, and the treatment duration is shortened.
2. The release amount of the medicament in the treatment sleeve can be controlled by controlling the action duration of the treatment rod in the vagina, so that the use amount of the medicament is controlled, and the problems of poor treatment effect caused by insufficient medicament and side effect caused by excessive medicament are avoided.
3. In the invention, the ultrasonic transducer in the treatment rod can emit ultrasonic waves with the frequency of 20 kHz-1 MHz and the sound intensity of 0.15-1W/cm2The annular ultrasonic wave, therefore, the invention can realize the synergistic Candida albicans resisting effect of the low-frequency low-intensity annular ultrasonic wave combined with the AMB loaded PLGA nano particles on the Candida albicans biomembrane, and the low-frequency low-intensity annular ultrasonic wave combined with the AMB loaded PLGA nano particles can obviously enhance the in vitro cell death of the Candida albicans and improve the curative effect. In addition, if the medicament carried in the treatment sleeve is the AmB-carried PLGA nano-particles decorated with AD1, and the medicament-carried nano-particles are used as microbubbles for exogenous system administration, the cavitation nucleus number can be greatly increased, the local cavitation threshold value is reduced, and the cavitation effect is enhanced. Ultrasound in conjunction with AD1The decorated AmB carries the PLGA nano-particles, the drug can be controllably released at a target point, a large amount of drug can rapidly enter the cells of the candida to play a role, the candida is killed, the targeted therapy is realized, and a good synergistic sterilization effect can be obtained aiming at the lesion part of the plica and the candida in the formed biomembrane.
4. The invention realizes the high-efficiency delivery of the ultrasonic intravaginal drug, and has the functions of repairing the vaginal tissue structure, promoting the ecological balance of the vaginal flora and improving the immunologic function of the female organism.
5. According to the invention, the treatment sleeve can carry a plurality of different medicines according to different diseased conditions, and the treatment range is wide. Compared with systemic administration, the invention reduces the dosage of the medicine, prevents the generation of drug-resistant bacteria, and greatly reduces the side effect of the medicine on human body; compared with the local application which only acts on the superficial lesion part, the invention can ensure that the action range of the medicine covers all lesion parts in the vagina, including lesion parts in plica, lesion parts in biomembranes, lesion parts under mucosa and other parts which are difficult to be deeply penetrated by the traditional vaginitis treating medicine.
6. The medicine monitoring unit can detect the distribution condition of the medicine in real time according to the fluorescent image on the display screen, so that an operator can adjust a treatment scheme according to the distribution condition of the medicine, the medicine can be used more accurately, and the side effect of the medicine on a human body is reduced to the minimum under the condition of ensuring the treatment effect of the medicine.
7. The annular ultrasonic wave emitted by the treatment rod is low-frequency low-intensity ultrasonic wave, the synergistic effect of the medicament and the low-frequency low-intensity ultrasonic wave has a synergistic effect, pathogenic bacteria are gradually disintegrated from the outside of the cell wall to the internal structure through the ultrasonic cavitation effect, the chemical activity of ROS and other ways, the synergistic effect of the medicament and the ultrasonic wave is realized, and the pathogenic bacteria are killed efficiently.
Drawings
Fig. 1 is a schematic structural view of an apparatus for noninvasive treatment of ultrasonic vaginitis and vaginal flora control in embodiment 1 of the present invention;
FIG. 2 is an axial sectional view of a treatment rod and a schematic structural view of a treatment sleeve in example 1 of the present invention (when the treatment sleeve is not sleeved on the treatment rod);
FIG. 3 is an enlarged view of A in FIG. 2;
FIG. 4 is an axial sectional view of a treatment rod and a schematic structural view of a treatment sleeve in example 2 of the present invention (when the treatment sleeve is not sleeved on the treatment rod);
FIG. 5 is an axial cross-sectional view of a treatment rod in example 3 of the present invention;
fig. 6 is a schematic structural view of an ultrasonic wave generating head in embodiment 3 of the present invention.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Please refer to fig. 1 to 6. It should be noted that the drawings provided in the present embodiment are only for illustrating the basic idea of the present invention, and the components related to the present invention are only shown in the drawings rather than drawn according to the number, shape and size of the components in actual implementation, and the type, quantity and proportion of the components in actual implementation may be changed freely, and the layout of the components may be more complicated. The structures, the proportions, the sizes, and the like shown in the drawings attached to the present specification are only used for matching with the disclosure of the present specification, so as to be understood and read by those skilled in the art, and are not used for limiting the conditions under which the present invention can be implemented, so that the present invention has no technical essence, and any structural modification, changes of the proportion relation, or adjustment of the size, should fall within the scope of the technical disclosure of the present invention without affecting the efficacy and the achievable purpose of the present invention. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.
Reference numerals in the drawings of the specification include: the device comprises a movable carrying vehicle 1, a main machine 2, a treatment rod 3, a handheld part 310, a working part 320, a groove 321, a cavity 330, a treatment sleeve 4, a wheel 5, a fixing part 6, an ultrasonic transducer 7, a piezoelectric material block 710, an ultrasonic wave generating head 720, a metal cylinder 721, a piezoelectric array element 722, a cable 723, a backing material layer 724, a matching material layer 725, a decoupling material layer 726, a cooling pipeline 8, a cooling water tank 9, a display screen 10, a cable 11, an elastic rubber ring 12, a laser generator 13 and a fluorescence sensor 14.
Example 1
This embodiment is substantially as shown in fig. 1 to 3: the utility model provides an ultrasonic wave vaginitis does not have treatment of wound and vagina fungus crowd regulation and control device, includes supersound generating element and medicine monitoring unit, and supersound generating element includes that portable carrier vehicle 1, host computer 2, treatment stick 3 and cover locate treatment cover 4 on the excellent 3 periphery walls of treatment, and host computer 2 fixed mounting bears on portable carrier vehicle 1, and portable carrier vehicle 1's bottom fixed mounting has wheel 5, makes things convenient for operating personnel to promote portable carrier vehicle 1 and removes. In this embodiment, the main machine 2 is fixedly mounted on the top end of the movable carrier 1 through bolts or screws, and the wheels 5 are fixedly mounted on the bottom end of the movable carrier 1 through screws. The welding has the mounting 6 that is used for fixed treatment stick 3 on the lateral wall of portable carrier 1, specifically, mounting 6 includes curb plate and two splint, and two splint integrated into one piece respectively in the left end and the right-hand member of curb plate (splint atress can outwards deflect, and splint rely on self elasticity automatic re-setting after external force disappears), and curb plate and two splint form the centre gripping chamber, and the fixed treatment stick 3 in centre gripping chamber. When the treatment rod 3 is not used, the treatment rod 3 is clamped and fixed by the clamping cavity of the fixing piece 6; when the treatment rod 3 needs to be used, the operator applies force to take the treatment rod 3 out of the clamping cavity of the fixing piece 6.
The peripheral wall of treatment stick 3 is equipped with the recess 321 that is used for storing the medicine, and in this embodiment, recess 321 is the heliciform, and the heliciform recess 321 distributes on the peripheral wall of treatment stick 3. The inside of the treatment rod 3 is provided with a cavity 330 capable of communicating with the outside, the cavity 330 is provided with an ultrasonic transducer 7 for emitting ring-shaped ultrasonic waves, the ultrasonic transducer 7 comprises a plurality of piezoelectric material blocks 710 which are arranged linearly, in the present embodiment, the number of the piezoelectric material blocks 710 is 15, the piezoelectric material blocks 710 are piezoelectric ceramics (in the present embodiment, the operating frequencies of the 15 piezoelectric material blocks 710 are not completely the same, for example, the 15 piezoelectric material blocks 710 are divided into 5 groups, each group comprises 3 piezoelectric material blocks, the operating frequencies between the groups are different, the operating frequencies of the piezoelectric material blocks 710 in each group are the same, and the piezoelectric material blocks 710 with different operating frequencies are arranged in a staggered manner, a person skilled in the art can select the piezoelectric material blocks 710 with different operating frequencies according to actual needs, in addition, the piezoelectric material blocks 710 are ring-shaped, and electrode layers are coated on the inner peripheral wall and the outer peripheral wall of the piezoelectric material blocks 710, for emitting a ring-shaped ultrasonic wave). In addition, the block 710 of piezoelectric material at the rightmost end of the cavity 330 can be made of hemispherical piezoelectric ceramics, so that the right end of the therapeutic rod 3 can emit right-handed ultrasonic waves, and the area of ultrasonic wave radiation is larger. A cooling pipeline 8 is further arranged in the cavity 330, the cooling pipeline 8 is a hose, and a cooling water tank 9 for supplying water to the cooling pipeline 8 and a water pump (not shown) for pumping cooling water in the cooling water tank 9 into the cooling pipeline 8 are fixedly mounted on the side wall of the movable carrier vehicle 1.
The main machine 2 is internally provided with an ultrasonic generator and a control processor, the control processor is used for controlling the ultrasonic generator to work and transmitting the excitation current generated by the ultrasonic generator to the ultrasonic transducer 7, and in the embodiment, the control processor transmits the excitation current generated by the ultrasonic generator to the ultrasonic transducer 7 through a cable 11. The host machine 2 is provided with a display screen 10 connected with the control processor, and the display screen 10 is used for displaying ultrasonic data, wherein the ultrasonic data comprises ultrasonic power, ultrasonic frequency, ultrasonic sound intensity, duty ratio and ultrasonic irradiation duration.
The treatment rod 3 comprises a working part 320 and a handheld part 310, a groove 321 is arranged on the peripheral wall of the working part 320, the treatment sleeve 4 is sleeved on the peripheral wall of the working part 320, the inner diameter of the treatment sleeve 4 is equal to or slightly larger than the outer diameter of the working part 320 of the treatment rod 3, and in the embodiment, the inner diameter of the treatment sleeve 4 is equal to the outer diameter of the working part 320 of the treatment rod 3. The working part 320 of the treatment rod 3 is cylindrical, the diameter of the working part 320 is 0.5cm, and the length of the treatment rod 3 is 10 cm. The treatment cover 4 is made of a porous membrane material, for example, the treatment cover 4 is made of a medical porous fiber membrane (disclosed in patent document cn20191153991. x) or a porous chitosan membrane (madali, yaoshaohua, xuwei, smithga, liuyueyingling, preparation and performance research of the medical porous chitosan membrane [ J ] functional polymer science, 2005, 18(3):434 + 440), and for example, the treatment cover 4 is made of facial mask paper, so that when the treatment cover 4 is used, a drug loaded or loaded in the treatment cover 4 can penetrate through the treatment cover 4 into the vagina, and the temporary storage of the drug is realized. Therefore, as long as the porous film material through which the drug can penetrate can be used as a material for producing the treatment cover 4 in the present embodiment. The treatment sleeve 4 is provided with an open end and a closed end, the open end is provided with an elastic rubber ring 12 used for fixing the treatment sleeve 4 on the treatment rod 3, in the embodiment, the elastic rubber ring 12 is adhered to the open end of the treatment sleeve 4, and the circumferential direction of the elastic rubber ring 12 is coincided with the circumferential direction of the open end of the treatment sleeve 4.
The medicine monitoring unit is including locating laser generator 13 and the fluorescence sensor 14 on the treatment stick 3, and in this embodiment, the quantity of laser generator 13 is two, and fluorescence sensor 14 and two laser generator 13 all bond in the right-hand member of treatment stick 3, and fluorescence sensor 14 is located the centre of two laser generator 13. The laser generator 13 is used for emitting laser, the laser excites the medicine marked by the fluorescent substance to emit a fluorescent signal, the fluorescent sensor 14 is used for collecting the fluorescent signal and transmitting the fluorescent signal to the control processor, the control processor generates a fluorescent image according to the fluorescent signal transmitted by the fluorescent sensor 14, and the fluorescent image is displayed through the display screen 10. In this embodiment, the display screen 10 is a touch display screen 10 capable of human-computer interaction. In addition, if the porous membrane material adopted by the treatment sleeve 4 has no light transmittance, a hole for leaking the laser generator 13 and the fluorescence sensor 14 is formed in the closed end of the treatment sleeve 4, so that the laser generator 13 and the fluorescence sensor 14 can work normally.
The specific implementation process is as follows: the vaginitis medicament is loaded in the treatment sleeve 4 (the vaginitis medicament is a liquid medicament, if the vaginitis medicament is a solid medicament, the solid medicament is dissolved in physiological saline to form the liquid medicament), then the working part 320 of the treatment rod 3 is inserted into the treatment sleeve 4, namely, the treatment sleeve 4 is sleeved on the peripheral wall of the working part 320 of the treatment rod 3, the treatment sleeve 4 is fixed on the working part 320 of the treatment rod 3 by utilizing the elastic rubber ring 12 on the treatment sleeve 4, and the open end of the treatment sleeve 4 is sealed (the open end of the treatment sleeve 4 is tightly attached to the peripheral wall of the working part 320 of the treatment rod 3, so that the open end is sealed), and the medicament is prevented from flowing out. In this process, a part of the medicine is stored in the groove 321, and a part of the medicine is distributed in the gap between the inner wall of the treatment sleeve 4 and the outer peripheral wall of the working part 320 of the treatment rod 3. Alternatively, after the treatment sleeve 4 is fixed to the treatment rod 3, a liquid vaginitis medicament is injected into the gap between the treatment sleeve 4 and the working portion 320 of the treatment rod 3 by using a syringe.
Then, the working part 320 of the treatment rod 3 is placed in the vagina of the patient, the operator clicks the display screen 10 to select proper ultrasonic frequency and ultrasonic sound intensity, the selection range of the ultrasonic frequency is 20 kHz-1 MHz, and the selection range of the ultrasonic sound intensity is 0.15W/cm-1W/cm2. Then, the control processor controls the ultrasonic generator to generate an excitation current with a specific frequency and intensity, selects a specific cable 11 according to the excitation current generated by the ultrasonic generator, and transmits the excitation current to the ultrasonic transducer 7 with the corresponding working frequency in the cavity 330, the ultrasonic transducer 7 with the corresponding working frequency starts and emits an annular ultrasonic wave, that is, the piezoelectric material block 710 with the corresponding working frequency in the cavity 330 works to emit the annular ultrasonic wave, and the ultrasonic frequency and the ultrasonic sound intensity of the annular ultrasonic wave are displayed on the display screen 10.
The medicine in the treatment sleeve 4 penetrates through the treatment sleeve 4 to reach the vagina of a patient, and quickly permeates to the lower part of the mucosa of the vagina to reach the deep part of an infected area through annular ultrasonic waves, and the medicine and the annular ultrasonic waves have synergistic effect to efficiently sterilize. In this process, the fluidity of the drug is improved by the action of the ring-shaped ultrasonic waves, and therefore, the drug can penetrate through the treatment sheath 4 more quickly and diffuse into the vagina. And the annular ultrasonic waves can enhance the permeability of cell walls and cell membranes through cavitation effect so that the medicine can easily enter the pathogenic bacteria, and the ultrasonic irradiation plays a role in synergy through the mechanisms of chemical activity of ROS and the like. The ultrasonic wave and the medicine have synergistic effect to realize high-efficiency sterilization, thereby reducing the dosage and improving the treatment effect of the medicine.
In the process, the cooling water in the cooling water tank 9 enters the cooling pipeline 8, so that the heat generated by the piezoelectric material block 710 in the cavity 330 is absorbed, and the vaginal discomfort or injury of the patient caused by the overhigh temperature of the working part 320 of the treatment rod 3 is avoided.
In the using process, the medicine monitoring unit also starts to work synchronously, specifically, the laser generator 13 on the right end of the treatment rod 3 emits laser, the laser excites the medicine marked by fluorescent substance (in the embodiment, the fluorescent substance selects fluorescent protein) to emit fluorescent signal, the fluorescent signal is collected by the fluorescent sensor 14, the fluorescent sensor 14 transmits the collected fluorescent signal to the control processor, the control processor generates a fluorescent image according to the fluorescent signal transmitted by the fluorescent sensor 14, the fluorescent image is displayed by the display screen 10, the operator estimates the enrichment degree of the medicine in the lesion part according to the fluorescent image displayed on the display screen 10, namely, the medicine monitoring unit can detect the distribution condition of the medicine in real time, so that an operator can adjust the treatment scheme in time, and the side effect of the medicine on the human body is reduced to the minimum under the condition of ensuring the curative effect of the medicine. In addition, an operator can adjust the ultrasonic treatment dosage in time according to the enrichment degree of the medicine at the pathological change part, so that the dosage can be accurately controlled, and the problems of poor treatment effect caused by insufficient medicine and side effect caused by excessive medicine are solved.
In summary, in this embodiment, the ultrasound generating unit can emit ring-shaped ultrasound with a frequency of 20kHz to 1MHz and a sound intensity of 0.15 to 1W/cm2, so that the permeability of the cell membrane is increased, thereby enhancing the permeability of the drug, improving the therapeutic effect of the drug, reducing the dosage of the drug, and shortening the treatment duration. Moreover, in this embodiment, the operator can master the distribution of the drugs through the drug monitoring unit, so as to control the duration of the treatment of the working part 320 of the treatment rod 3 in the vagina of the patient, further control the usage amount of the drugs, and avoid the problems of insufficient drugs and excessive drugs, i.e., this embodiment can realize accurate drug control. Moreover, the treatment sleeve 4 in the embodiment can be loaded with various different medicines, has a wide treatment range, and adopts an ultrasonic intravaginal medicine delivery system, so that the vagina treatment sleeve has the effects of repairing the vaginal tissue structure, promoting the ecological balance of flora in the vagina and improving the inflammatory and immune functions of organisms. In addition, compared with systemic administration, the embodiment greatly reduces the dosage of the medicament, prevents the generation of drug-resistant bacteria, and reduces the side effect of the medicament on human bodies; compared with the local application which only acts on a few pathological changes, the medicine action range in the embodiment almost covers all the pathological changes in the vagina, and the treatment effect is better.
Example 2
This embodiment differs from embodiment 1 only in that: as shown in fig. 4, the number of the grooves 321 on the peripheral wall of the working portion 320 of the treatment rod 3 is multiple, the grooves 321 are arranged along the axial direction of the working portion 320, and the multiple grooves 321 are uniformly distributed on the peripheral wall of the working portion 320. In the present embodiment, the number of the grooves 321 is six.
In this embodiment, the six grooves 321 can store a larger amount of medicine, so that the operator can load a larger amount of medicine into the treatment sleeve 4 at one time, thereby satisfying the dosage requirement and avoiding loading medicine for multiple times.
Example 3
This embodiment differs from embodiment 1 only in that: the ultrasonic transducer 7 in this embodiment is different from the ultrasonic transducer 7 in embodiment 1 in composition, and as shown in fig. 1, fig. 5 and fig. 6 in this embodiment, the ultrasonic transducer 7 includes a plurality of linearly arranged ultrasonic generation heads 720, each ultrasonic generation head 720 includes a metal cylinder 721, a plurality of piezoelectric array elements 722 annularly arranged around the outer circumference of the metal cylinder 721, and cables 723 connected to the corresponding piezoelectric array elements 722 respectively, a backing material layer 724 for absorbing sound is provided between the piezoelectric array elements 722 and the metal cylinder 721, the outside of the piezoelectric array elements 722 is covered with a matching material layer 725, and a decoupling material layer 726 is filled between the piezoelectric array elements 722. The number of the piezoelectric array elements 722 in each of the ultrasonic wave generating heads 720 can be 30, 60, 120, the invention is not limited, the working frequency of the piezoelectric array elements 722 in each of the ultrasonic wave generating heads 720 is not completely the same, and the piezoelectric array elements 722 can be made of various piezoelectric ceramics and piezoelectric single crystal materials. In this embodiment, the number of the ultrasound generating heads 720 is 7, and the number of the piezoelectric array elements 722 in each ultrasound generating head 720 is 30 (30 piezoelectric array elements 722 can be divided into 10 groups, each group has 3 piezoelectric array elements, the operating frequencies of the groups are different, the operating frequencies of the piezoelectric array elements 722 in each group are the same, and the piezoelectric array elements 722 with different operating frequencies are arranged in a staggered manner).
The metal cylinder 721 is positioned in the center to play a supporting role and also play a role of connecting the motor at the bottom of the piezoelectric array element 722 with the ground wires of all cables 723; a backing material layer 724 is disposed between the piezoelectric array element 722 and the metal cylinder 721 for absorbing the ultrasonic waves emitted from the piezoelectric array element 722; the matching material layer 725 covers the periphery of the piezoelectric array element 722, and may be a single layer, a double layer or even a multilayer, and the thickness and acoustic parameters of the matching material layer 725 are designed according to the operating frequency and the electrical and acoustic parameters of the piezoelectric array element 722; each piezoelectric array element 722 is connected with a cable 723 for transmitting an excitation current signal; a layer 726 of decoupling material between each piezoelectric array element 722 to reduce the effects of cross waves between piezoelectric array elements 722.
In embodiment 1, the blocks 710 of piezoelectric material in the cavity 330 cannot all work simultaneously, that is, only the block 710 of piezoelectric material at the corresponding working frequency works and emits the ring-shaped ultrasonic wave during the treatment process, and the points of the ring-shaped ultrasonic wave emitted in the axial direction of the working part 320 of the treatment rod 3 are not continuous. In this embodiment, each ultrasound generating head 720 includes a plurality of piezoelectric array elements 722, the working frequencies of the plurality of piezoelectric array elements 722 are not completely the same, so that, in the treatment process, when an operator clicks the display screen 10 to select a proper ultrasound frequency and ultrasound intensity, the control processor controls the ultrasound generator to generate an excitation current with a specific frequency and intensity, and selects a specific cable 11 according to the excitation current generated by the ultrasound generator to transmit the excitation current to the cable 723 of the piezoelectric array element 722 with the corresponding working frequency in the cavity 330, thereby the piezoelectric array element 722 with the corresponding working frequency is activated and emits an ultrasound wave, so that all the ultrasound generating heads 720 in the cavity 330 can activate and emit an ultrasound wave, the working part 320 of the treatment rod 3 emits a ring-shaped ultrasound wave, that is, the positions of the working part 320 of the treatment rod 3 emitting ultrasound waves in the axial direction are more continuous, the ultrasonic wave is cooperated with the medicine to achieve better treatment effect, thereby further improving the treatment effect.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The utility model provides an ultrasonic wave vaginitis does not have wound treatment and vagina fungus crowd regulation and control device which characterized in that: including the supersound generating unit, the treatment cover on the excellent periphery wall of treatment is located including treatment stick and cover to the supersound generating unit, be equipped with the ultrasonic transducer who is used for sending annular ultrasonic wave in the treatment stick, offer the recess that is used for storing the medicine on the periphery wall of treatment stick, the treatment cover adopts porous membrane material to make.
2. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 1, wherein said device comprises: the inside of the treatment rod is provided with a cavity which can be communicated with the outside, the ultrasonic transducer is positioned in the cavity, and the ultrasonic transducer comprises a plurality of piezoelectric material blocks which are linearly arranged; the ultrasonic generating unit also comprises a host, wherein an ultrasonic generator and a control processor are arranged in the host, and the control processor is used for controlling the ultrasonic generator to work and transmitting the excitation current generated by the ultrasonic generator to the ultrasonic transducer.
3. The ultrasonic vaginitis noninvasive treatment and vaginal flora regulating device as claimed in claim 1, wherein: the ultrasonic transducer is positioned in the cavity and comprises a plurality of ultrasonic generating heads which are linearly arranged, each ultrasonic generating head comprises a metal cylinder, a plurality of piezoelectric array elements which are annularly arranged around the metal cylinder and cables which are respectively connected with the corresponding piezoelectric array elements, a backing material layer for absorbing sound is arranged between the piezoelectric array elements and the metal cylinder, a matching material layer covers the outer sides of the piezoelectric array elements, and a decoupling material layer is filled between the piezoelectric array elements; the ultrasonic generating unit also comprises a host, wherein an ultrasonic generator and a control processor are arranged in the host, and the control processor is used for controlling the ultrasonic generator to work and transmitting the excitation current generated by the ultrasonic generator to the ultrasonic transducer.
4. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 2 or 3, wherein: the host is provided with a display screen connected with the control processor, the display screen is used for displaying ultrasonic data, and the ultrasonic data comprises ultrasonic power, ultrasonic frequency, ultrasonic sound intensity, duty ratio and ultrasonic irradiation duration.
5. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 1, wherein said device comprises: the sound intensity of the ultrasonic wave emitted by the treatment rod is 0.15-1W/cm2；
And/or the frequency of the ultrasonic wave emitted by the treatment rod is 20 kHz-1 MHz.
6. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 2, wherein: and a cooling pipeline is arranged in the cavity.
7. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 6, wherein said device comprises: the ultrasonic generation unit further comprises a movable bearing vehicle, the host is installed on the movable bearing vehicle, and a cooling water tank used for supplying water for a cooling pipeline is arranged on the side wall of the movable bearing vehicle.
8. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 1, wherein said device comprises: the treatment sleeve is provided with an opening end and a closed end, and the opening end is provided with an elastic rubber ring used for fixing the treatment sleeve on the treatment rod.
9. The device for noninvasive treatment of ultrasonic vaginitis and vaginal flora control according to claim 1, wherein said device comprises: the grooves are spirally distributed on the outer peripheral wall of the treatment rod;
or, the quantity of recess is a plurality of, and the recess sets up along the axial of treatment stick, and a plurality of recesses distribute on the periphery wall of treatment stick.
10. The device for noninvasive treatment of ultrasonic vaginitis and regulation of vaginal flora according to claim 3, wherein: the device still includes medicine monitoring unit, medicine monitoring unit is including locating laser generator and the fluorescence sensor on the treatment stick, laser generator is used for launching laser, and laser excitation is launched fluorescence signal by the medicine of fluorescent substance mark, fluorescence sensor is used for gathering fluorescence signal and with fluorescence signal transmission extremely control processor, control processor generates fluorescence image according to the fluorescence signal of fluorescence sensor transmission, and fluorescence image shows through the display screen.
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| CN202210109028.3A CN114569904A (en) | 2022-01-28 | 2022-01-28 | Ultrasonic colpitis noninvasive treatment and vaginal flora regulation and control device |
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