CN114569632A - External sterilizing ointment of silver metal nano micelle complexing agent - Google Patents
External sterilizing ointment of silver metal nano micelle complexing agent Download PDFInfo
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- CN114569632A CN114569632A CN202210297329.3A CN202210297329A CN114569632A CN 114569632 A CN114569632 A CN 114569632A CN 202210297329 A CN202210297329 A CN 202210297329A CN 114569632 A CN114569632 A CN 114569632A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a silver metal nano micelle complexing agent external sterilization ointment which is prepared from the following components in parts by weight: 60-80 parts of silver powder and nano Cu3B2O670-110 parts of fluorocarbon resin, 10-20 parts of fluorocarbon resin, 15-20 parts of biomass elastic fiber, 0.5-1.5 parts of rare earth tricolor fluorescent powder, 10-20 parts of photosensitive resin and 10-20 parts of flatting agent; what is needed isThe fluorocarbon resin is selected from one or a mixture of two of FEVE resin and chlorotrifluoroethylene-alkyl vinyl ether copolymerized fluorocarbon resin; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and urethane acrylate; the silver powder is prepared by preparing microemulsion from silver nitrate solution and sodium halide, mixing the microemulsion at room temperature in a dark place to prepare silver halide nanoparticles, and cleaning and drying the silver halide nanoparticles.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a silver metal nano micelle complexing agent external sterilization ointment.
Background
The medical antibacterial external ointment products which are already sold in the market at present mainly comprise antibiotics and sulfonamides. The antibiotic antibacterial drugs are used in a large area for a long time, and systemic toxic and side effects can be generated; on the other hand, the emergence of drug-resistant strains is also induced, so that the use of antibacterial agents in the future is ineffective. Sulfonamides belong to broad-spectrum antibacterial drugs, but because many common clinical pathogenic bacteria have drug resistance to the drugs at present, the sulfonamides are only used for infection caused by sensitive bacteria and other sensitive pathogenic microorganisms.
Antibacterial disinfectants containing silver ions have been used for sterilization for a long time, and in particular, have been widely used as ionized water disinfectants for water treatment at home and abroad. At present, the silver ion technology becomes an effective method for resisting viruses and germs for human beings. Silver ion antibacterial disinfectants have become one of the new points of research in the biotechnology industry at present.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides the external bactericidal ointment of the silver metal nano micelle complexing agent.
In order to achieve the purpose, the invention adopts the technical scheme that: an external sterilizing ointment of silver metal nano micelle complexing agent is characterized in that: the composition comprises the following components in parts by weight: 60-80 parts of silver powder and nano Cu3B2O670-110 parts of fluorocarbon resin, 10-20 parts of fluorocarbon resin, 15-20 parts of biomass elastic fiber, 0.5-1.5 parts of rare earth tricolor fluorescent powder, 10-20 parts of photosensitive resin and 10-20 parts of flatting agent; the fluorocarbon resin is selected from one or a mixture of two of FEVE resin and chlorotrifluoroethylene-alkyl vinyl ether copolymerized fluorocarbon resin; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and urethane acrylate; the silver powder is prepared by preparing microemulsion from silver nitrate solution and sodium halide, mixing the microemulsion at room temperature in a dark place to prepare silver halide nanoparticles, and cleaning and drying the silver halide nanoparticles to obtain the silver powder.
In a preferred embodiment of the present invention, the silver halide nanoparticles comprise silver chloride, silver bromide or silver iodide.
In a preferred embodiment of the invention, the ratio of the concentration of the silver nitrate solution to the concentration of the sodium halide is 1: 1.
In a preferred embodiment of the present invention, a surfactant is further added in the silver powder preparation process.
In a preferred embodiment of the invention, the biomass elastic fiber is selected from one or a mixture of two of spider silk and silk.
In a preferred embodiment of the invention, the concentration of the silver nitrate solution is 0.01-2 mol/L.
The invention solves the defects in the background technology, and has the following beneficial effects:
(1) the silver component is added into the antibacterial external ointment, the silver-containing preparation is used as a disinfectant, an antibacterial agent and an antibacterial material, and has the advantages of antivirus and sterilization, no toxic or side effect on a human body because silver ions do not need to pass through the in-vivo cell metabolism process, no reduction of the metabolism of the human body, and no generation of variant varieties.
(2) The method only generates sodium halide which is a byproduct, is beneficial to environmental protection, and has the advantages of quick and efficient reaction, thorough separation, low preparation cost and safety.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and all other embodiments obtained by a person skilled in the art without making creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
Silver halide nanoparticles are very important in photographic emulsions. However, it is difficult to obtain monodisperse nano-sized silver halide particles by the conventional method. The micro-emulsion method is a novel method for preparing nano materials, which is simple and easy to implement and has the intelligent characteristic, the surface of the prepared particles is coated with a layer of surfactant molecules, so that the particles are not easy to coalesce, and the size of the water core in the micro-reactor can be controlled by selecting different molar ratios of the surfactant molecules to the water phase so as to control the size of the prepared nano particles, thereby obtaining the monodisperse nano silver halide particles.
Example one
A silver metal nano micelle complexing agent external sterilization ointment is composed of the following components in parts by weight: 60 parts of silver powder and nano Cu3B2O670 parts of fluorocarbon resin, 10 parts of silk, 0.5 part of rare earth tricolor fluorescent powder, 10 parts of photosensitive resin and 10 parts of flatting agent; the fluorocarbon resin is selected from one or a mixture of two of FEVE resin and chlorotrifluoroethylene-alkyl vinyl ether copolymerized fluorocarbon resin; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and polyurethane acrylate; the silver powder adopts silver nitrate solution and sodium halide to prepare microemulsion, the concentration ratio of the silver nitrate solution and the sodium halide is 1:1, the concentration of the silver nitrate solution is 0.01mol/L, and the added surfactant is AOT [ (2-ethylhexyl) sulfenyl sodium succinate]And the alkane is isooctane, silver iodide nanoparticles are prepared by mixing at room temperature in a dark place, and the silver iodide nanoparticles are obtained after cleaning and drying.
Example two
A silver metal nano micelle complexing agent external sterilization ointment is composed of the following components in parts by weight: 80 parts of silver powder and nano Cu3B2O6110 parts of fluorocarbon resin, 20 parts of silk, 1.5 parts of rare earth tricolor fluorescent powder, 20 parts of photosensitive resin and 20 parts of flatting agent; the fluorocarbon resin is selected from one or a mixture of two of FEVE resin and chlorotrifluoroethylene-alkyl vinyl ether copolymerized fluorocarbon resin; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and urethane acrylate; the silver powder is prepared into microemulsion by adopting silver nitrate solution and sodium halide, the concentration ratio of the silver nitrate solution to the sodium halide is 1:1, the concentration of the silver nitrate solution is 2mol/L, and the added surfactant is AOT [ (2-ethylhexyl) sodium sulfosuccinate]And the alkane is isooctane, silver iodide nanoparticles are prepared by mixing at room temperature in a dark place, and the silver iodide nanoparticles are obtained after cleaning and drying.
EXAMPLE III
A silver metal nano micelle complexing agent external sterilization ointment is composed of the following components in parts by weight: silver powder 70 parts, nano Cu3B2O690 parts of fluorocarbon resin, 15 parts of silk, 1 part of rare earth tricolor fluorescent powder, 15 parts of photosensitive resin and 15 parts of flatting agent; the fluorocarbon resin is selected from FEVE resin and chlorotrifluoroethylene-one or a mixture of two of alkyl vinyl ether co-fluorocarbon resins; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and polyurethane acrylate; the silver powder is prepared into microemulsion by adopting silver nitrate solution and sodium halide, the concentration ratio of the silver nitrate solution to the sodium halide is 1:1, the concentration of the silver nitrate solution is 1.5mol/L, and the added surfactant is AOT [ (2-ethylhexyl) sodium thiosuccinate]And the alkane is isooctane, silver iodide nanoparticles are prepared by mixing at room temperature in a dark place, and the silver iodide nanoparticles are obtained after cleaning and drying.
The silver component is added into the antibacterial external ointment, the silver-containing preparation is used as a disinfectant, an antibacterial agent and an antibacterial material, and has the advantages of antivirus and sterilization, no toxic or side effect on a human body because silver ions do not need to pass through the in-vivo cell metabolism process, no reduction of the metabolism of the human body, and no generation of variant varieties.
The method only generates sodium halide which is a byproduct, is beneficial to environmental protection, and has the advantages of quick and efficient reaction, thorough separation, low preparation cost and safety.
In light of the foregoing description of the preferred embodiment of the present invention, it is to be understood that various changes and modifications may be made by one skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (6)
1. An external sterilizing ointment of silver metal nano micelle complexing agent is characterized in that:
the composition comprises the following components in parts by weight: 60-80 parts of silver powder and nano Cu3B2O670-110 parts of fluorocarbon resin, 10-20 parts of fluorocarbon resin, 15-20 parts of biomass elastic fiber, 0.5-1.5 parts of rare earth tricolor fluorescent powder, 10-20 parts of photosensitive resin and 10-20 parts of flatting agent;
the fluorocarbon resin is selected from one or a mixture of two of FEVE resin and chlorotrifluoroethylene-alkyl vinyl ether copolymerized fluorocarbon resin; the photosensitive resin is selected from one of epoxy acrylic resin, unsaturated polyester resin and urethane acrylate; the silver powder is prepared by preparing microemulsion from silver nitrate solution and sodium halide, mixing the microemulsion at room temperature in a dark place to prepare silver halide nano particles, and cleaning and drying the silver halide nano particles to obtain the silver powder.
2. The external bactericidal ointment of claim 1, wherein the external bactericidal ointment comprises the following components: the silver halide nanoparticles include silver chloride, silver bromide, or silver iodide.
3. The external bactericidal ointment of claim 1, which is prepared from the silver metal nano micelle complexing agent, and is characterized in that: the concentration ratio of the silver nitrate solution to the sodium halide is 1: 1.
4. The external bactericidal ointment of claim 1, wherein the external bactericidal ointment comprises the following components: and a surfactant is also added in the silver powder preparation process.
5. The external bactericidal ointment of claim 1, wherein the external bactericidal ointment comprises the following components: the biomass elastic fiber is selected from one or a mixture of two of spider silk and silk.
6. The external bactericidal ointment of claim 1, wherein the external bactericidal ointment comprises the following components: the concentration of the silver nitrate solution is 0.01-2 mol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210297329.3A CN114569632A (en) | 2022-03-24 | 2022-03-24 | External sterilizing ointment of silver metal nano micelle complexing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210297329.3A CN114569632A (en) | 2022-03-24 | 2022-03-24 | External sterilizing ointment of silver metal nano micelle complexing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114569632A true CN114569632A (en) | 2022-06-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210297329.3A Withdrawn CN114569632A (en) | 2022-03-24 | 2022-03-24 | External sterilizing ointment of silver metal nano micelle complexing agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114569632A (en) |
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2022
- 2022-03-24 CN CN202210297329.3A patent/CN114569632A/en not_active Withdrawn
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20220603 |
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| WW01 | Invention patent application withdrawn after publication |