CN114558057A - Allicin related preparation for resisting infection, relieving fever and reducing fever and preparation method thereof - Google Patents
Allicin related preparation for resisting infection, relieving fever and reducing fever and preparation method thereof Download PDFInfo
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- CN114558057A CN114558057A CN202210024482.9A CN202210024482A CN114558057A CN 114558057 A CN114558057 A CN 114558057A CN 202210024482 A CN202210024482 A CN 202210024482A CN 114558057 A CN114558057 A CN 114558057A
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- allicin
- preparation
- antipyretic
- fever
- radix
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- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 title claims abstract description 55
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 title claims abstract description 55
- 235000010081 allicin Nutrition 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 206010037660 Pyrexia Diseases 0.000 title claims abstract description 25
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 13
- 230000001754 anti-pyretic effect Effects 0.000 claims abstract description 21
- 239000002221 antipyretic Substances 0.000 claims abstract description 18
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 15
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 15
- 230000002924 anti-infective effect Effects 0.000 claims abstract description 11
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 10
- 240000002234 Allium sativum Species 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 235000004611 garlic Nutrition 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 244000046146 Pueraria lobata Species 0.000 claims description 7
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 241000202726 Bupleurum Species 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 description 3
- 241001106477 Paeoniaceae Species 0.000 description 3
- 244000236658 Paeonia lactiflora Species 0.000 description 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Microbiology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
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Abstract
The invention discloses an anti-infection antipyretic fever-reducing allicin related preparation and a preparation method thereof, wherein the allicin related preparation comprises the following components in percentage by mass: allicin: 1-30%, radix bupleuri 1-30%, cassia twig 1-20%, radix puerariae 1-10%, radix scutellariae 1-15%, and radix paeoniae alba 1-20%, and the invention has the following beneficial effects: the compound preparation is prepared by the traditional formula and the garlicin, can resist infection when bringing down fever, improves the immunity of patients, has curative effect on both symptoms and root causes, and is safer when bringing down fever.
Description
Technical Field
The invention relates to the technical field of allicin related preparations, in particular to an allicin related preparation for resisting infection, relieving fever and reducing fever and a preparation method thereof.
Background
Although the existing clinical antipyretic medicines are various in types and good in effect, most western medicines are strong in antipyretic effect, easy to sweat after use, easy to cause electrolyte disorder due to short-time temperature reduction, and capable of increasing secondary infection risk to children or old patients and enabling the condition of an illness to be more complicated. The existing medicine can not realize anti-infection while bringing down fever, and can not improve the immunity of patients.
Disclosure of Invention
The invention aims to provide an allicin related preparation for resisting infection, relieving fever and reducing fever and a preparation method thereof, which aim to solve the problems in the background technology.
In order to achieve the purpose, the invention provides an anti-infection, antipyretic and antipyretic allicin related preparation according to the following technical scheme, which comprises the following components in percentage by mass: allicin: 1-30% of radix bupleuri, 1-30% of cassia twig, 1-20% of radix puerariae, 1-15% of radix scutellariae and 1-20% of radix paeoniae alba.
Preferably, the ratio of the bupleurum to the cassia twig to the kudzuvine root is 4: 3: 1.
Preferably, the preparation method of the allicin comprises the following steps:
s1, peeling and cleaning garlic, adding absolute ethyl alcohol to immerse the garlic, freezing, and cold-pressing to obtain a squeezed liquid;
s2, storing the squeezed liquid at constant temperature, filtering the squeezed liquid through a filter screen, adding absolute ethyl alcohol into the fermented garlic pulp, slowly adding the absolute ethyl alcohol while stirring, uniformly mixing, and filtering to obtain an aqueous solution containing allicin;
s3, sampling an aqueous solution containing allicin, and receiving an eluent;
s4, performing allicin purity identification and concentration detection;
s5, and freeze-drying the eluent to obtain the finished allicin product.
Preferably, the step S5 detects the prepared pure allicin product by HPLC.
Preferably, in step S2, the mixture is shaken and centrifuged, and the extract is concentrated to a volume that does not change with cold water to dissolve the allicin extract and centrifuged.
Preferably, the pressing liquid in the step S2 is stored at a constant temperature of 25-30 ℃.
Preferably, the ramulus cinnamomi is dried and then subjected to an ultrafine pulverization treatment before use.
A preparation method of allicin related preparation for resisting infection, relieving fever and reducing fever comprises the following steps:
s1, weighing allicin, radix bupleuri, cassia twig, radix puerariae, radix scutellariae and radix paeoniae alba according to the mass percentage;
s2, mixing and stirring the materials in the step S1, dissolving the mixed materials in distilled water, and mixing and homogenizing to prepare liquid medicine.
Compared with the prior art, the invention has the beneficial effects that: the compound preparation is prepared by the traditional formula and the garlicin, can resist infection when bringing down fever, improves the immunity of patients, has curative effect on both symptoms and root causes, and is safer when bringing down fever.
Detailed Description
The invention provides a technical scheme that: an anti-infection, antipyretic and antipyretic allicin related preparation comprises the following components in percentage by mass: allicin: 1-30% of radix bupleuri, 1-30% of cassia twig, 1-20% of radix puerariae, 1-15% of radix scutellariae and 1-20% of radix paeoniae alba.
Wherein the ratio of the bupleurum, the cassia twig and the kudzuvine root is 4: 3: 1.
The preparation method of the allicin comprises the following steps:
s1, peeling and cleaning garlic, adding absolute ethyl alcohol to immerse the garlic, freezing, and cold-pressing to obtain a squeezed liquid;
s2, storing the squeezed liquid at constant temperature, filtering the squeezed liquid through a filter screen, adding absolute ethyl alcohol into the fermented garlic pulp, slowly adding the absolute ethyl alcohol while stirring, uniformly mixing, and filtering to obtain an aqueous solution containing allicin;
s3, sampling an aqueous solution containing allicin, and receiving an eluent;
s4, performing allicin purity identification and concentration detection;
s5, and freeze-drying the eluent to obtain the finished allicin product.
Wherein, the step S5 is to detect the prepared pure allicin by HPLC method.
And S2, shaking after mixing, centrifuging, concentrating the extracting solution until the volume of the extracting solution is not changed, dissolving the allicin extract in cold water, and centrifuging.
Wherein the constant-temperature storage temperature of the squeezed liquid in the step S2 is 25-30 ℃.
Wherein, the cassia twig is dried and then subjected to superfine grinding treatment before use.
The method comprises the following steps:
s1, weighing allicin, radix bupleuri, cassia twig, kudzu root, radix scutellariae and white paeony root according to the mass percentage;
s2, mixing and stirring the materials in the step S1, dissolving the mixed materials in distilled water, and mixing and homogenizing to prepare the liquid medicine.
Example 1, an anti-infective, antipyretic and antipyretic allicin related preparation, comprising the following components in percentage by mass: allicin: 30 percent of radix bupleuri, 20 percent of cassia twig, 15 percent of kudzu root, 15 percent of radix scutellariae and 15 percent of white peony root.
A preparation method of allicin related preparation for resisting infection, relieving fever and reducing fever comprises the following steps:
s1, weighing the allicin according to the mass percentage: 30 percent of radix bupleuri, 20 percent of cassia twig, 150 percent of radix puerariae, 15 percent of radix scutellariae and 15 percent of white peony root;
s2, mixing and stirring the materials in the step S1, dissolving the mixed materials in distilled water, and mixing and homogenizing to prepare liquid medicine.
Example 2, an anti-infective, antipyretic and antipyretic allicin related preparation, comprising the following components in percentage by mass: allicin: 30 percent of radix bupleuri, 24 percent of cassia twig, 18 percent of kudzu root, 6 percent of radix scutellariae and 12 percent of white paeony root.
A preparation method of allicin related preparation for resisting infection, relieving fever and reducing fever comprises the following steps:
s1, weighing the allicin according to the mass percentage: allicin: 30 percent of radix bupleuri, 24 percent of cassia twig, 18 percent of kudzu root, 10 percent of radix scutellariae and 12 percent of white paeony root;
s2, mixing and stirring the materials in the step S1, dissolving the mixed materials in distilled water, and mixing and homogenizing to prepare the liquid medicine.
Furthermore, the terms "first", "second", "third", "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or as implying any number of indicated technical features, whereby the features defined as "first", "second", "third", "fourth" may explicitly or implicitly include at least one such feature.
In the present invention, unless otherwise explicitly stated or limited, the terms "mounted," "disposed," "connected," "fixed," "screwed" and the like are to be understood broadly, for example, as being fixedly connected, detachably connected, or integrated; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. An allicin related preparation for resisting infection, relieving fever and reducing fever is characterized by comprising the following components in percentage by mass: allicin: 1-30% of radix bupleuri, 1-30% of cassia twig, 1-20% of radix puerariae, 1-15% of radix scutellariae and 1-20% of radix paeoniae alba.
2. The allicin-related preparation for resisting infection and reducing fever according to claim 1, wherein: the ratio of the bupleurum, the cassia twig and the kudzuvine root is 4: 3: 1.
3. The allicin-related preparation for anti-infective, antipyretic and antipyretic effects as claimed in claim 1, wherein: the preparation method of the allicin comprises the following steps:
s1, peeling and cleaning garlic, adding absolute ethyl alcohol to immerse the garlic, freezing, and cold-pressing to obtain a pressed liquid;
s2, storing the squeezed liquid at constant temperature, filtering the squeezed liquid through a filter screen, adding absolute ethyl alcohol into the fermented garlic pulp, slowly adding the absolute ethyl alcohol while stirring, uniformly mixing, and filtering to obtain an aqueous solution containing allicin;
s3, sampling an aqueous solution containing allicin, and receiving an eluent;
s4, performing allicin purity identification and concentration detection;
s5, and freeze-drying the eluent to obtain the finished allicin product.
4. An anti-infective, antipyretic and antipyretic allicin-related preparation as claimed in claim 3 which is characterized by: and S5, detecting the prepared pure allicin by using an HPLC method.
5. An anti-infective, antipyretic and antipyretic allicin-related preparation as claimed in claim 3 which is characterized by: and step S2, shaking after mixing, centrifuging, concentrating the extracting solution until the volume of the extracting solution is not changed, dissolving the allicin extract in cold water, and centrifuging.
6. An anti-infective, antipyretic and antipyretic allicin-related preparation as claimed in claim 3 which is characterized by: in the step S2, the constant-temperature storage temperature of the squeezed liquid is 25-30 ℃.
7. The allicin-related preparation for anti-infective, antipyretic and antipyretic effects as claimed in claim 1, wherein: the ramulus Cinnamomi is dried and then subjected to superfine grinding before use.
8. A preparation method of an allicin related preparation for resisting infection, relieving fever and reducing fever is characterized in that: the method comprises the following steps:
s1, weighing allicin, radix bupleuri, cassia twig, radix puerariae, radix scutellariae and radix paeoniae alba according to the mass percentage;
s2, mixing and stirring the materials in the step S1, dissolving the mixed materials in distilled water, and mixing and homogenizing to prepare liquid medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210024482.9A CN114558057A (en) | 2022-01-11 | 2022-01-11 | Allicin related preparation for resisting infection, relieving fever and reducing fever and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210024482.9A CN114558057A (en) | 2022-01-11 | 2022-01-11 | Allicin related preparation for resisting infection, relieving fever and reducing fever and preparation method thereof |
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| CN114558057A true CN114558057A (en) | 2022-05-31 |
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|---|---|---|---|
| CN202210024482.9A Pending CN114558057A (en) | 2022-01-11 | 2022-01-11 | Allicin related preparation for resisting infection, relieving fever and reducing fever and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107619A (en) * | 2020-04-23 | 2020-12-22 | 广州宏康医药科技有限公司 | Allicin Chaiqin soft capsule and preparation and storage method thereof |
| CN113616635A (en) * | 2020-05-09 | 2021-11-09 | 广州宏康医药科技有限公司 | Compound allicin mixture and preparation method thereof |
| CN113797289A (en) * | 2020-06-11 | 2021-12-17 | 广州宏康医药科技有限公司 | Coronaviral-resistant allicin related preparation and preparation method thereof |
-
2022
- 2022-01-11 CN CN202210024482.9A patent/CN114558057A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107619A (en) * | 2020-04-23 | 2020-12-22 | 广州宏康医药科技有限公司 | Allicin Chaiqin soft capsule and preparation and storage method thereof |
| CN113616635A (en) * | 2020-05-09 | 2021-11-09 | 广州宏康医药科技有限公司 | Compound allicin mixture and preparation method thereof |
| CN113797289A (en) * | 2020-06-11 | 2021-12-17 | 广州宏康医药科技有限公司 | Coronaviral-resistant allicin related preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘德胜,金顺善,刘善慧,陈健: "小儿柴桂退热口服液的药理作用" * |
| 王勇;刘晓锋;: "小儿柴桂退热糖浆药效学研究" * |
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Application publication date: 20220531 |