CN114544922A

CN114544922A - Thrombus elastogram detection device and thromboelastogram instrument

Info

Publication number: CN114544922A
Application number: CN202011329751.XA
Authority: CN
Inventors: 艾峰; 王石磊; 黄阁锋
Original assignee: Shenzhen Youdi Biotechnology Co ltd
Current assignee: Shenzhen Youdi Biotechnology Co ltd
Priority date: 2020-11-24
Filing date: 2020-11-24
Publication date: 2022-05-27

Abstract

The thrombelastogram detection device of the embodiment of the application comprises a fixed seat, a driving part and a magnetic assembly. The fixing base is used for installing the test cup. The driving part is connected with the fixed seat through the torsion wire and is used for driving the fixed seat to rotate. The magnetic assembly comprises a first magnetic part and a second magnetic part which are oppositely arranged, the first magnetic part is fixedly connected with the fixed seat, and the second magnetic part and the first magnetic part repel each other to enable the fixed seat to keep suspended above the driving part. Through setting up first magnetism spare and second magnetism spare into the state of repelling for the fixing base is in stable suspended state for driver part, has avoided the direct contact of fixing base with other subassemblies, and then makes the test cup avoid the interference of other external forces such as gravity. In this way, the level of the layout of the thrombelastogram detection apparatus is reduced. The performance of the thrombelastogram detection device can be fully exerted, and the test cup can obtain an accurate detection result.

Description

Thrombus elastogram detection device and thromboelastogram instrument

Technical Field

The application relates to the field of medical instruments, in particular to a thromboelastogram detection device and a thromboelastogram instrument.

Background

The conventional thromboelastography instrument uses a torsion wire to hang the rotation angle detection assembly from contact with other components, thereby removing interference from external force. During testing, a sample to be measured (such as blood dissolved in a reagent) is placed on the rotating assembly, the suspension wire rotating shaft extends into the sample to be measured, and the rotating assembly rotates to drive the sample to be measured to rotate so as to drive the suspension wire rotating shaft to rotate. Therefore, the torque force applied to the suspension wire rotating shaft by the solution to be detected can be obtained by analyzing the torsion variation of the suspension wire rotating shaft. And analyzing the data of the torque force obtained by the test to further obtain the thrombelastogram of the blood in the sample to be tested. However, the requirement on the levelness of the placement of the thrombelastogram instrument in the testing process is high, and the detection efficiency and the accuracy are low in the environment which cannot meet the levelness.

Disclosure of Invention

The embodiment of the application provides a thrombelastogram detection device and a thrombelastogram instrument.

The thrombelastogram detection device of the embodiment of the application comprises a fixed seat, a driving part and a magnetic assembly. The fixing seat is used for installing the test cup. The driving part is connected with the fixed seat through a torsion wire and is used for driving the fixed seat to rotate. The magnetic assembly comprises a first magnetic part and a second magnetic part which are oppositely arranged, the first magnetic part is fixedly connected with the fixed seat, and the second magnetic part and the first magnetic part repel each other to enable the fixed seat to keep suspended above the driving part.

In the thrombelastogram detection device of this application embodiment, through setting up first magnetic part and second magnetic part into the state of repelling mutually for the fixing base is in stable suspended state for driver part, has avoided the direct contact of fixing base with other subassemblies, and then makes the test cup avoid the interference of other external forces such as gravity. In this way, the level of the layout of the thrombelastogram detection apparatus is reduced. The performance of the thrombelastogram detection device can be fully exerted, and the test cup can obtain an accurate detection result.

In some embodiments, the fixing seat comprises a mounting part and a connecting rod, and the mounting part is used for mounting the test cup. The installation department is connected the connecting rod, the connecting rod with the torsion silk is connected.

In some embodiments, the torsion wire is disposed concentrically with the linkage rod.

In some embodiments, the first magnetic member and the second magnetic member are both annular, and the second magnetic member inner diameter is greater than the first annular magnetic member outer diameter.

In some embodiments, the test cup includes a cup body, a cup lid, and a projecting rod. The protruding rod is fixed on the cup cover. The cup body is arranged on the fixed seat. The cup covers are fixed relative to the cup body and are arranged at intervals to contain samples to be tested. The protruding rod extends into the cup body and is arranged at an interval with the cup body.

In certain embodiments, the thromboelastogram detection device comprises a rotation angle detection assembly. The corner detection assembly and the connecting rod are arranged concentrically, and the corner detection assembly is used for detecting the rotation angle of the connecting rod.

In certain embodiments, the thromboelastography detection device comprises a heating assembly. The heating assembly is arranged around the fixed seat and is separated from the fixed seat, and the heating assembly is used for keeping the fixed seat at a constant temperature.

In certain embodiments, the thromboelastography detection device comprises a temperature sensor. The temperature sensor is placed on one side of the fixed seat and used for detecting the temperature of the fixed seat.

In some embodiments, the thromboelastogram detecting device comprises a support seat, the driving part is accommodated in the support seat, and the second magnetic part is fixed on the support seat.

The thrombelastogram instrument according to an embodiment of the present invention includes the thrombelastogram detection apparatus according to any one of the above embodiments.

Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.

Drawings

The above and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

fig. 1 is a schematic cross-sectional view of a thromboelastogram detection apparatus according to an embodiment of the present application.

Description of the main element symbols:

a thromboelastogram detecting apparatus 100;

the testing device comprises a fixed seat 200, a mounting part 210, a connecting rod 220, a driving part 300, a torsion wire 310, a rotating shaft 320, a magnetic assembly 400, a first magnetic piece 410, a second magnetic piece 420, a testing cup 500, a cup body 510, a cup cover 520, a protruding rod 530, a corner detecting assembly 600, a heating assembly 700, a temperature sensor 800 and a supporting seat 900.

Detailed Description

Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative and are only for the purpose of explaining the present application and are not to be construed as limiting the present application.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

The following disclosure provides many different embodiments or examples for implementing different features of the application. To simplify the disclosure of the present application, the components and settings of a specific example are described below. Of course, they are merely examples and are not intended to limit the present application. Moreover, the present application may repeat reference numerals and/or reference letters in the various examples, which have been repeated for purposes of brevity and clarity and do not in themselves dictate a relationship between the various embodiments and/or configurations discussed. In addition, examples of various specific processes and materials are provided herein, but one of ordinary skill in the art may recognize applications of other processes and/or use of other materials.

Referring to fig. 1, the present application provides a thromboelastography detection device 100, which includes a holder 200, a driving component 300 and a magnetic assembly 400. The holder 200 is used for mounting the test cup 500. The driving member 300 is connected to the fixing base 200 through a torsion wire 310, and is used for driving the fixing base 200 to rotate. The magnetic assembly 400 includes a first magnetic member 410 and a second magnetic member 420 disposed opposite to each other, the first magnetic member 410 is fixedly connected to the fixing base 200, and the second magnetic member 420 and the first magnetic member 410 repel each other to keep the fixing base 200 suspended above the driving member 300.

In the thrombelastogram detection device 100 according to the embodiment of the present application, the first magnetic member 410 and the second magnetic member 420 are set in the repulsive state, so that the fixing base 200 is in a stable floating state with respect to the driving component 300, thereby preventing the fixing base 200 from directly contacting other components, and further preventing the test cup 500 from being interfered by other external forces such as gravity. In this way, the levelness of the layout of the thrombelastogram detection apparatus 100 is reduced. The performance of the thromboelastogram detection device 100 can be fully exerted, and the test cup 500 can obtain an accurate detection result.

In the present embodiment, the thromboelastogram detecting apparatus 100 can be applied to various suitable applications. Specifically, the thromboelastogram detection device 100 may be used to test thromboelastogram, for example, the solution sample to be tested may be blood to which reagents are added.

In the embodiment of the present application, the first magnetic member 410 is fixedly connected to the fixing base 200, and the second magnetic member 420 and the first magnetic member 410 generate an upward repulsive force to the first magnetic member 410 through a magnetic force, so that the fixing base 200 is kept suspended above the driving component 300. The magnetic member 400 may be a magnet made of a metal material such as a ferrite magnet, an alnico magnet, or a ferrochrome magnet, or may be an electromagnet formed of an electrically conductive wire.

Specifically, the driving part 300 is used to generate a rotational torque, and the driving part 300 may be a motor driven using electricity. The driving member 300 includes a rotating shaft 320, the rotating shaft 320 is connected to the torsion wire 310, and the torsion wire 310 is connected to the fixing base 200. The rotation shaft 320 of the driving part 300 rotates to drive the fixing base 200 to rotate, the testing cup 500 in the fixing base 200 rotates accordingly, and the testing cup 500 is used for containing a sample to be tested. Rotation of the test cup 500 causes the sample to be tested in the test cup 500 to rotate along with the test cup 500. Thus, the sample to be tested can show its elasticity characteristics. In one example, the sample to be tested is a human blood sample, and the thromboelastogram test device 100 performs dynamic analysis of processes such as blood coagulation factor activation, platelet aggregation, and fibrinolysis.

The torsion wire 310 is connected to the fixing base 200, and generates a downward pulling force on the fixing base 200. The second magnetic member 420 generates an upward repulsive force to the first magnetic member 410, the first magnetic member 410 is fixedly connected to the fixing base 200, and the upward repulsive force is transmitted to the fixing base 200 to form a two-force balance with a downward pulling force of the torsion wire 310 on the fixing base 200, so that the fixing base 200 is in a suspended state. Compared with the traditional thrombus elastogram detection device 100 adopting a gravity suspension mode, the device has low requirement on levelness and wider application conditions.

Additionally, torsion wire 310 provides a gradual torsional resistance of a suitable magnitude to resist torque from shaft 320 of drive member 300. The use of the torsion wire 310 in transmitting torque avoids problems of uneven torque, abrupt changes in torque, too large or too small torque constants, etc. The rotation speed of the sample to be detected driven by the test cup 500 is gradually increased, and a stable detection result is finally obtained.

Referring to fig. 1, in some embodiments, the fixing base 200 includes a mounting portion 210 and a connecting rod 220, and the mounting portion 210 is used for mounting the test cup 500. The mounting portion 210 is connected to the link 220, and the link 220 is connected to the torsion wire 310.

Therefore, the driving part 300 can drive the testing cup 500 to rotate, so as to drive the sample to be tested to rotate, and an accurate testing result is obtained.

Specifically, the mounting part 210 includes a placing space, which may be a cylinder having the same shape as the test cup 500, and the inner diameter of the placing space may be slightly smaller than the outer diameter of the test cup 500, so that the test cup 500 may be placed in the placing space and clamped. The connecting rod 220 is securely connected to the mounting portion 210 and may be considered as an integral device. Therefore, the fixing base 200 and the driving part 300 can be regarded as rigid pieces, so that the test cup 500 and the fixing base 200 cannot slide relatively, and errors of the test result are avoided. The torsion wire 310 can be regarded as a flexible member for providing a uniform and gradual torsion resistance, which facilitates obtaining a stable detection curve.

Referring to fig. 1, in some embodiments, the torsion wire 310 is disposed concentrically with the connecting rod 220.

Therefore, the rotating concentricity is ensured, and the low measurement precision caused by too large circle center offset is avoided.

Specifically, the shaft 320, the torsion wire 310 and the fixing base 200 are concentrically arranged, and the center of the testing cup 500 is also kept on the same straight line with the torsion wire 310. For example, the driving part 300, the rotation shaft 320, the torsion wire 310, the connecting rod 220, the mounting part 210 and the test cup 500 are arranged in sequence from bottom to top, and the test cup 500 may be cylindrical. At this time, the rotation shaft 320, the torsion wire 310, the connecting rod 220, the mounting portion 210 and the test cup 500 are kept on a uniform center line. Therefore, the torsion moment generated by the driving part 300 can be along the straight line of the center of the circle where the torsion wire 310 is located, and the detection precision is ensured.

Referring to fig. 1, in some embodiments, the first magnetic member 410 and the second magnetic member 420 are annular, and the inner diameter of the second magnetic member 420 is larger than the outer diameter of the first annular magnetic member.

Thus, it is ensured that the repulsive force directions of the second magnetic member 420 and the first magnetic member 410 are concentrated, and are opposite to the pulling force direction of the torsion wire 310, and the acting points are on the same straight line.

Specifically, the first magnetic member 410 and the second magnetic member 420 are both of an annular structure, and the annular structure may allow the connecting rod 220 to pass through the center of the magnetic assembly 400, and further allow the first magnetic member 410 and the second magnetic member 420 to be concentrically disposed with the torsion wire 310 and the connecting rod 220. Thus, the repulsive force generated by the second magnetic member 420 to the first magnetic member 410 is upward along the torsion wire 310 and the connecting rod 220, and is equal to and opposite to the downward pulling force of the torsion wire 310 to the connecting rod 220, and the acting points are on the same straight line, i.e. the straight line where the torsion wire 310 is located. Thus, the fixing base 200 is in a floating state under the combined action of the magnetic assembly 400, the torsion wire 310 and the connecting rod 220. And then make test cup 500 be in good experimental environment, the testing result is more accurate.

In some embodiments, the first magnetic member 410 and the second magnetic member 420 may be discontinuous tile-shaped sintered magnets, and a plurality of tile-shaped sintered magnets are uniformly arranged on a circumference with a center in the direction along the torsion wire 310, so as to ensure that the arrangement intervals are equal. On the premise of ensuring that the torsion wire 310 is not loosened, the tile-shaped sintered magnet has stronger output capacity than a square sintered magnet or an annular bonded magnet, and meanwhile, the weight of the tile-shaped magnet is smaller than that of the annular magnet, so that the quality of the thrombelastogram detection device 100 can be effectively reduced.

In some embodiments, one of the first magnetic member 410 and the second magnetic member 420 has a ring shape, and the other one is a block-shaped magnetic member disposed in a straight line symmetrical manner with respect to the torsion wire 310. For example, the first magnetic member 410 has a ring shape, and the second magnetic member 420 has four symmetrically arranged rectangular magnetic members. The first magnetic member 410 and the second magnetic member 420 ensure that the repulsive force is along the direction of the torsion wire 310 by magnetic force.

Referring to fig. 1, in some embodiments, a test cup 500 includes a cup body 510, a cup lid 520, and a projecting rod 530. Projecting rod 530 is fixed to cap 520. Cup 510 is mounted on mount 200. The lid 520 is fixed relative to the cup 510 and is spaced apart to contain a sample to be tested. A projecting rod 530 extends into the bowl 510 and is spaced apart from the bowl 510.

Thus, the protrusion rod 530 extends into the cup 510 to increase the contact area between the lid 520 and the sample to be tested, thereby speeding up the testing process.

For example, the sample to be tested in the cup 510 is a human blood sample, and when the holder 200 drives the cup 510 to rotate, the cap 520 and the protrusion rod 530 are fixed, and the protrusion rod 530 extends into the cup 510. When blood begins to coagulate, resistance is generated between the blood in the cup body 510 and the protruding rod 530 due to fibrin adhesion, the resistance is continuously increased along with the increase of fibrin, the movement of the fixing seat 200 and the connecting rod 220 driven by the cup body 510 is changed, a signal is drawn on a tracing paper to form a special thrombus elastogram, and the thrombus elasticity is calculated by measuring an angle through the rotation angle detecting component 600. During this process, cap 520 and protruding rod 530 are suspended vertically in cup 510 and cannot be separated from the blood in cup 510 during the entire reaction process.

Referring to fig. 1, in some embodiments, the thromboelastogram detection device 100 includes a rotation angle detection assembly 600. The rotation angle detecting assembly 600 is concentrically disposed with the connecting rod 220, and the rotation angle detecting assembly 600 is used to detect the rotation angle of the connecting rod 220.

Therefore, the angle can be measured through the corner detection assembly 600, the thrombus elastic force is calculated, and the thrombus elastogram is drawn.

Specifically, cup 510 is tightly connected to mount 200 such that cup 510 does not slide relative to mount 200, i.e., cup 510 does not slide relative to link 220. The rotation angle detecting assembly 600 is concentrically disposed with the connecting rod 220, and the rotation angle of the cup 510 is obtained by detecting the rotation angle of the connecting rod 220. In this process, the rotation angle detecting assembly 600 does not significantly affect the rotation of the cup 510 and the holder 200. The corner detection assembly 600 includes two electrode plates and a sensing circuit, which are used to convert the angle signal into an electrical signal, so as to draw a thromboelastogram.

Referring to fig. 1, in some embodiments, the thromboelastogram detection device 100 includes a heating element 700. The heating assembly 700 is disposed around the holder 200 and spaced apart from the holder 200, and the heating assembly 700 serves to maintain the holder 200 at a constant temperature.

Thus, the fixing base 200 is heated by the heating assembly 700, so that the fixing base 200 keeps a constant temperature, and the sample to be measured in the cup 510 is constant.

Specifically, the heating assembly 700 may be a resistance wire heater, and the fixing base 200 has a sufficient space in the side direction of the mounting portion 210, and a resistance wire coil may be wound around the heating assembly, or the resistance wire coil may be wound around the periphery of the placing space. The resistance wire coil can be suspended above the fixing base 200 without contacting the fixing base 200. The fixing base 200 can conduct heat, and the resistance wire coil can heat the cup 510 placed in the placing space, so as to heat a sample to be measured in the cup 510. In practical use, because the sample to be measured can dissipate heat, the temperature is reduced, and the heating component 700 heats the sample to be measured, so that the heat dissipation capacity and the heating capacity of the sample to be measured are at balance points, namely, the temperature of the sample to be measured is kept unchanged. For example, the sample to be tested can be kept at about 37 ℃ (normal body temperature). In the embodiment of the present application, the type of the heating assembly 700 is not limited to meet various requirements.

Referring to fig. 1, in some embodiments, the thromboelastogram detection device 100 includes a temperature sensor 800. The temperature sensor 800 is disposed at one side of the fixing base 200, and the temperature sensor 800 is used for detecting the temperature of the fixing base 200.

Thus, the temperature sensor 800 can detect the temperature of the fixing base 200 at any time to detect the temperature of the sample to be detected in the cup 510.

Specifically, the temperature sensor 800 is used for detecting the temperature of the fixing base 200, and further detecting the temperature of the sample to be detected. The temperature sensor 800 can use a non-contact temperature sensor 800, so that the temperature sensor 800 is prevented from influencing the rotation process of the fixing base 200, for example, the infrared temperature sensor 800. In the actual use process, the temperature of the fixing base 200 is close to the temperature of the sample to be measured, so the set temperature of the temperature sensor 800 is about 37 ℃. When the temperature sensor 800 detects that the temperature of the fixing base 200 is lower than the set temperature, the temperature sensor 800 generates a signal to be transmitted back to the system, and the system controls the heating assembly 700 to heat the fixing base 200, so that the temperature of the sample to be measured is constant. In the embodiment of the present application, the type of the temperature sensor 800 is not limited, and the requirement may be satisfied.

Referring to fig. 1, in some embodiments, the thromboelastogram detecting device 100 includes a supporting base 900, the driving component 300 is accommodated in the supporting base 900, and the second magnetic member 420 is fixed on the supporting base 900.

Thus, the support base 900 ensures the determination of the relative positions of various components and has the effect of protecting the driving part 300.

Specifically, the supporting base 900 is a box structure, the driving part 300 is accommodated in the supporting base 900, and the top of the supporting base 900 includes a through hole for the connection rod 220 to pass through. The aperture of the through hole is equal to the inner diameter of the second magnetic member 420, and the second magnetic member 420 is fixed on the supporting base 900 to support the second magnetic member 420. The supporting base 900 supports the force of the first magnetic element 410 on the second magnetic element 420 and the gravity of the second magnetic element 420 itself. In addition, the temperature sensor 800 may also be disposed on the top of the support base 900.

A thromboelastogram apparatus according to an embodiment of the present invention includes the thromboelastogram detection apparatus 100 according to any one of the embodiments described above.

In the thrombelastogram apparatus according to the embodiment of the present application, the first magnetic member 410 and the second magnetic member 420 are set to be in a repulsive state, so that the fixing base 200 is in a stable suspension state relative to the driving component 300, thereby preventing the fixing base 200 from directly contacting other components, and further preventing the test cup 500 from being interfered by other external forces such as gravity. In this way, the levelness of the layout of the thrombelastogram detection apparatus 100 is reduced. The performance of the thromboelastogram detection device 100 can be fully exerted, and the test cup 500 can obtain an accurate detection result.

In the description of the embodiments of the present invention, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the embodiments of the present invention, "a plurality" means two or more unless specifically limited otherwise.

In the description herein, references to the description of the terms "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although embodiments of the present application have been shown and described above, it is to be understood that the above embodiments are exemplary and not to be construed as limiting the present application, and that changes, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present application.

Claims

1. A thromboelastogram detecting device, comprising:

the fixing seat is used for mounting the test cup;

the driving part is connected with the fixed seat through a torsion wire and is used for driving the fixed seat to rotate;

the magnetic assembly comprises a first magnetic part and a second magnetic part which are oppositely arranged, the first magnetic part is fixedly connected with the fixed seat, and the second magnetic part and the first magnetic part repel each other to enable the fixed seat to keep suspended above the driving part.

2. The thromboelastogram detection device of claim 1, wherein the holder comprises:

the mounting part is used for mounting the test cup; and

and the connecting rod is connected with the torsion wire.

3. The thromboelastogram testing device of claim 2, wherein the torsion wire is disposed concentrically with the linkage rod.

4. The thromboelastogram testing device of claim 1, wherein the first and second magnetic members are annular, the second magnetic member inner diameter being larger than the first annular magnetic member outer diameter.

5. The thromboelastogram test device of claim 1,

the test cup comprises a cup body, a cup cover and a protruding rod fixed on the cup cover, the cup body is installed on the fixing seat, the cup cover is fixed relative to the cup body and arranged at intervals to be filled with samples to be tested, and the protruding rod extends into the cup body and is arranged at intervals with the cup body.

6. The thromboelastogram detection device of claim 1, comprising a rotation angle detection component arranged concentrically with the connecting rod, the rotation angle detection component being configured to detect a rotation angle of the connecting rod.

7. The thromboelastogram test device of claim 1, comprising a heating assembly disposed around and spaced apart from the holder, the heating assembly being configured to maintain the holder at a constant temperature.

8. The thromboelastogram detection device of claim 1, wherein the thromboelastogram detection device comprises a temperature sensor, the temperature sensor is placed on one side of the fixing seat, and the temperature sensor is used for detecting the temperature of the fixing seat.

9. The thromboelastogram test device of claim 1, wherein the thromboelastogram test device comprises a support seat, the driving member is accommodated in the support seat, and the second magnetic member is fixed on the support seat.

10. A thromboelastography device, comprising:

a thromboelastogram test device as claimed in any one of claims 1 to 9.