CN114532241A

CN114532241A - Animal feeding cage with full-telemetry physiological monitoring function

Info

Publication number: CN114532241A
Application number: CN202210133062.4A
Authority: CN
Inventors: 徐子涵
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-02-14
Filing date: 2022-02-14
Publication date: 2022-05-27
Anticipated expiration: 2042-02-14
Also published as: CN114532241B

Abstract

The invention relates to an animal feeding cage with a full telemetering physiological monitoring function, which comprises a first cage body and a second cage body; the first cage body comprises a first cage bottom and a first cage cover, the second cage body comprises an inner cage body and an outer cage body, the inner cage body comprises a second cage bottom and a second cage cover, and the outer cage body comprises a third cage bottom and a third cage cover; the first cage cover and the second cage cover are both in a grid shape, and the second cage bottom, the third cage bottom and the third cage cover are all solid bodies; the first cage bottom is hollow, an accommodating cavity is arranged below the first cage bottom, and a collecting box is arranged in the accommodating cavity; according to the invention, the sleeping area, the excretion area and the diet area in the rearing cage are respectively arranged, so that the living environment of the mouse can be obviously improved, and the sleeping area and the excretion area are set to have larger temperature difference through the arrangement of different area structures and temperatures, so that the mouse can approach to a warm area, and the sleeping area and the excretion area can be distinguished. In addition, the mouse is monitored by adopting a non-contact full-remote-measurement mode of body temperature, activity and respiratory metabolism.

Description

Animal feeding cage with full remote measurement physiological monitoring function

Technical Field

The invention belongs to the technical field of feeding equipment, and particularly relates to an animal feeding cage with a full telemetering physiological monitoring function.

Background

In the medical or biological field, biotechnology development is often applied, and mice are generally used as experimental subjects in the development process. The reason why the experiment is performed using a mouse is that since the gene sequence of a mouse is similar to that of a human being, some medical research and clinical experiments are performed using a mouse, and a genetic experiment using a mouse is good. Because the similarity between the whole genome and the human is extremely high, many diseases which are difficult to cure by the human can find similar characters on mice, so that the disease curing genes can be found by experiments. Many experiments require statistical analysis, which requires a certain number of rats and mice, especially mice, to meet this requirement under artificial breeding conditions. The experiment with good germ line purity needs to strictly control the variety of experimental animals, which is easy to solve by using mice. Also on an animal scale, mice belong to mammals and, except for small size, are not as poor as the evolutionary levels of other mammals. The small size of the body becomes the favorable condition for artificial breeding and feeding.

In the correlation technique, because the mouse will be used for the experiment, consequently the mouse will have clean environment of raising, and mouse cage among the prior art exists and distinguishes the living area and the drainage area of mouse, and it is external only simply to excrete the drainage area through the mode of fretwork outside the cage, and the cage body that has hollow out construction is to carrying out the fretwork to whole bottom, though be favorable to excrement filtering like this, but also because hollow out construction can't place the bedding and padding, has influenced the life comfort level of mouse. Or the mice select the angle to excrete by themselves, and the padding needs to be replaced periodically to clean the excrement so as to keep the interior of the cage clean. In addition, the existing mouse rearing cage has a large space, so that the mouse has more selectable sleeping areas, the fixed equipment has different angles and distances for different monitoring areas, certain errors can be caused to monitoring data, and the mouse rearing cage does not have the mouse respiratory metabolism monitoring capability. At present, a detection method of respiratory metabolism is invasive implant measurement, which can measure the body temperature, the activity, the respiratory metabolism and the heart rate of a mouse, but because of high invasiveness, the mouse generally can survive for only two weeks, if postoperative infection occurs, other influences on the experiment can be caused, the life cycle of the mouse is shorter (only two or three days), and the implant is expensive. Or a metabolism cage which integrates a plurality of sensors and specially monitors the metabolism of the mouse or the rat, has an ultra-perfect monitoring system, but has a complex structure and needs a plurality of external devices (such as a ventilation system) for assisting completion. The physiological detection system integrating multiple sensors is expensive in manufacturing cost, at least 8 cages are needed in one test, and the common laboratory is difficult to bear.

Disclosure of Invention

In view of the above, the present invention aims to overcome the defects of the prior art, and provides an animal feeding cage with a full telemetering physiological monitoring function, so as to solve the problem of inaccurate monitoring data caused by the fact that a sleep area and a excretion area cannot be distinguished in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme: an animal feeding cage with full telemetry physiological monitoring, comprising: the first cage body and the second cage body are arranged in parallel;

the first cage body comprises a first cage bottom and a first cage cover, the second cage body comprises an inner cage body and an outer cage body, the inner cage body comprises a second cage bottom and a second cage cover, and the outer cage body comprises a third cage bottom and a third cage cover; the first cage cover and the second cage cover are both in a grid shape; the first cage bottom is hollow, an accommodating cavity is arranged below the first cage bottom, and a collecting box is arranged in the accommodating cavity; the collecting box can extend into and withdraw out of the accommodating cavity and is used for collecting and taking out excrement; wherein the inner space of the first cage is larger than the inner space of the inner cage;

an electric door is arranged between the first cage body and the second cage body, a control device is arranged above the second cage cover, and the control device comprises a motor, a microcontroller and a wireless communication module; the motor is used for driving the electric door;

a first pressure sensor is arranged on the outer side of the first cage bottom, a second pressure sensor is arranged on the outer side of the second cage bottom, a first infrared thermal imaging sensor is arranged above the first cage cover, and a second infrared thermal imaging sensor is arranged above the second cage cover; the motor, the wireless communication module, the first pressure sensor, the second pressure sensor, the first infrared thermal imaging sensor and the second infrared thermal imaging sensor are respectively connected with the microcontroller.

Furthermore, a feeding port and a drinking port are further formed in the first cage body.

Furthermore, a carbon dioxide sensor is further arranged on the inner side of the second cage cover and connected with the microcontroller.

Furthermore, a temperature and humidity sensor is arranged in the inner cage body and connected with the microcontroller.

Furthermore, the side wall of the first cage body, the side wall of the second cage body, the bottom of the second cage, the bottom of the third cage and the third cage cover are all made of acrylic materials.

Further, the power door includes:

the sliding door is installed on the guide rail and matched with the sliding groove, the sliding door slides on the sliding groove based on the guide rail, and the guide rail is connected with the motor.

Further, the control device further includes:

the touch switch is used for opening and closing the electric door;

the touch switch is connected with the microcontroller.

Further, the method also comprises the following steps:

and the power supply device is used for providing electric energy for the motor, the microcontroller, the wireless communication module, the first pressure sensor, the second pressure sensor, the first infrared thermal imaging sensor, the second infrared thermal imaging sensor, the carbon dioxide sensor and the temperature and humidity sensor.

Furthermore, first infrared thermal imaging sensor is located the positive intermediate position of first cage lid top, the positive intermediate position of second infrared thermal imaging sensor is located second cage lid top.

By adopting the technical scheme, the invention can achieve the following beneficial effects:

this application can obviously improve the living environment of mouse through setting up respectively of sleep region, excretion area and diet region in the rearging cage, in addition, through the setting of different regional structures and temperature, this application sets up to great temperature difference to sleep region, excretion area to make the mouse can draw close to warm region, and then can oneself distinguish sleep region and excretion area. This application can make the vital sign data acquisition to the mouse in the sleep region more accurate through the setting to the differentiation in region and electrically operated gate, in addition, the structure that this application adopted still has simply, convenient operation, low cost's beneficial effect. First infrared thermal imaging sensor, the infrared thermal imaging sensor of second, carbon dioxide sensor and temperature and humidity sensor in this application constitute the full remote sensing system of non-contact, through the full remote sensing system of non-contact that this application set up, can realize body temperature, activity degree and the respiratory metabolism of contactless monitoring mouse, avoid causing the injury to the mouse.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural view of an animal feeding cage with full telemetry physiological monitoring function according to the present invention;

fig. 2 is a schematic structural diagram of a control device provided in the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

A specific animal rearing cage with full telemetering physiological monitoring function provided in the embodiment of the application is described below with reference to the accompanying drawings.

As shown in fig. 1, the animal feeding cage with full telemetry physiological monitoring function provided in the embodiment of the application comprises a first cage body 1 and a second cage body 2 which are arranged side by side;

the first cage body 1 comprises a first cage bottom 11 and a first cage cover 12, the second cage body 2 comprises an inner cage body 201 and an outer cage body 202, the inner cage body 201 comprises a second cage bottom 21 and a second cage cover 22, and the outer cage body 202 comprises a third cage bottom 23 and a third cage cover 24; the first cage cover 12 and the second cage cover 22 are both in a grid shape; the first cage bottom 11 is hollow, an accommodating cavity 13 is arranged below the first cage bottom 11, and a collecting box is arranged in the accommodating cavity 13; the collecting box can extend into and withdraw out of the containing cavity 13 for collecting and taking out excrement; wherein the inner space of the first cage 1 is larger than the inner space of the inner cage 201;

an electric door 3 is arranged between the first cage body 1 and the second cage body 2, a control device 221 is arranged above the second cage cover 22, and as shown in fig. 2, the control device 221 comprises a motor 2211, a microcontroller 2212 and a wireless communication module 2213; the motor 2211 is used for driving the electric door 3;

a first pressure sensor 2214 is arranged on the outer side of the first cage bottom 11, a second pressure sensor 2215 is arranged on the outer side of the second cage bottom 21, a first infrared thermal imaging sensor 2216 is arranged above the first cage cover 12, and a second infrared thermal imaging sensor 2217 is arranged above the second cage cover 22; the motor 2211, the wireless communication module 2213, the first pressure sensor 2214, the second pressure sensor 2215, the first infrared thermal imaging sensor 2216 and the second infrared thermal imaging sensor 2217 are respectively connected with the microcontroller 2212.

Preferably, a feeding port (not shown) and a drinking port (not shown) are also arranged in the first cage body 1.

Preferably, heat insulation cotton is filled between the inner cage 201 and the outer cage 202. Specifically, heat insulation cotton is filled between the bottom of the inner cage body 201 and the outer cage body 202, the inner cage body 201 is removed from the side wall adjacent to the electric door, and heat insulation cotton is filled between other side walls and the outer cage body 202.

The working principle of the animal rearing cage with the full remote physiological monitoring function is as follows: in this application, 11 are the structure of ventilation at the bottom of 12 and the first cage of first cage body 1's first cage lid, and interior cage body 201 outside still is equipped with

outer cage body

202, and 23 and the third cage lid 24 of the third cage of outer cage body 202 are solid structure, 21 also are solid structure at the bottom of the second cage of interior cage body 201, consequently, the temperature of interior cage body 201 will be higher than the temperature of

first cage body

1, and 11 are hollow out construction at the bottom of the first cage, the mouse can not sleep in the place of bottom broad fretwork, and can the preferred selection comparatively warm position. And the design of this application is similar to the overall arrangement in a room, and interior cage body 201 is equivalent to the bedroom, and first cage body 1 is equivalent to the sitting room, and wherein the bedroom bottom is sealed, and for keeping warm, has set up the heat preservation cotton between the interior cage body 201 of this application and outer cage body 202, can keep the whole temperature in bedroom warm, but the space is less, and the sitting room bottom adopts the stainless steel silk net fretwork, and the temperature is lower relatively, and the space is great. Thus, the present application may be directed by structure and temperature such that the mice will choose a bedroom for rest, and because the bedroom space is limited, they will not be excreting stool in the sleeping position and thus will tend to go to the living room for defecation. In addition, the eating and drinking ports (eating area) are also designed at the other corner of the living room. Thereby achieving the purpose of partitioning the sleeping area, the excretion area and the diet area.

The collecting box provided in the present application can be extended into and extracted from the accommodating chamber 13 for collecting and taking out excrement; so that the mouse can be moved out without opening the cage body when the excrement is cleared, and only the collecting box at the bottom needs to be taken out for washing. The electrically operated gate 3 that this application set up conveniently concentrates on carrying out sleep monitoring to the sleep district, and the controllable switch door of sleep district design can convert the bedroom environment into airtight and scientific detection mouse's vital sign data.

The vital sign data of the mouse comprises mouse movement and body temperature data, the first pressure sensor 2214 and the second pressure sensor 2215 in the application can detect the movement of the mouse, for example, when the mouse moves into the first cage body 1, the first pressure sensor 2214 can show a number, when the mouse moves into the inner cage body 201, the second pressure sensor 2215 can show a number, the first infrared thermal imaging sensor 2216 can detect the body temperature of the mouse in the first cage body 1, and the second infrared thermal imaging sensor 2217 can detect the body temperature of the mouse in the inner cage body 201.

It can be understood that, when the experimenter wants to detect the vital sign data of the mouse, the electric door 3 can be closed first and then the detection is performed, the experimenter can set the opening and closing of the electric door 3 through a remote switch, after the experimenter presses the remote control, the wireless communication module 2213 receives the control signal and sends the control signal to the microcontroller 2212, and the microcontroller 2212 controls the motor 2211 to drive the electric door 3 according to the control signal. The electric door 3 may be a rotary electric door 3 or a sliding electric door 3.

In some embodiments, a carbon dioxide sensor 2218 is further disposed inside the second cage cover 22, and the carbon dioxide sensor 2218 is connected to the microcontroller 2212.

Specifically, the vital sign data of the mouse further includes respiratory metabolism speed, specifically, by detecting the change rate of the volume concentration (ppm) of carbon dioxide in the present application, specifically, by cumulatively increasing the time required for 2000ppm of the volume concentration of carbon dioxide, the shorter the time, the higher the respiratory metabolism rate, and vice versa. Carbon dioxide sensor 2218 is located mouse cage bedroom top stainless wire net inboard, passes through stainless wire net with the mouse and separates, and is safe convenient. And reading indoor carbon dioxide once every ten seconds, and outputting a stable and continuous indoor carbon dioxide concentration value. Meanwhile, the bedroom door was closed once an hour while the mouse was in the bedroom, the time for accumulating 2000ppm of the mouse in the bedroom was measured, and the respiratory metabolic rate of the mouse per hour was output. After the detection is finished, the bedroom door is opened, and through the test, the detection time (namely the door closing time) is averagely 5 minutes every time, so that the influence on the normal life of the mouse is small.

Preferably, a temperature and humidity sensor 2219 is arranged in the inner cage body, and the temperature and humidity sensor 2219 is respectively connected with the microcontroller.

Specifically, the temperature and humidity sensor 2219 is used for detecting the temperature and humidity of the inner cage body, wherein the temperature and humidity sensor reads the temperature and humidity once every 10 seconds. The laboratory technician can receive humiture data once in certain time interval, can adjust the humiture of bedroom according to humiture data, guarantees that the mouse is in comfortable environment.

Preferably, the side wall of the first cage body 1, the side wall of the second cage body 2, the second cage bottom 21, the third cage bottom 23 and the third cage cover 24 are all made of acrylic materials.

Preferably, the power door 3 comprises:

sliding door, spout and guide rail, the sliding door install on the guide rail and with spout looks adaptation, the sliding door is based on the guide rail is in slide on the spout, the guide rail with motor 2211 is connected.

In some embodiments, the control device 221 further comprises:

a touch switch for opening and closing the power door 3;

the touch switch is connected to the microcontroller 2212.

It can be understood that the electric door 3 adopted in the present application may be a rotary electric door 3 or a sliding electric door 3, and the specific control mode may be a mode of using a remote control button by an experimenter or a mode of clicking a touch switch.

In some embodiments, the animal feeding cage with full telemetry physiological monitoring provided herein further comprises:

and a power supply device for supplying power to the motor 2211, the microcontroller 2212, the wireless communication module 2213, the first pressure sensor 2214, the second pressure sensor 2215, the first infrared thermal imaging sensor 2216, the second infrared thermal imaging sensor 2217, the carbon dioxide sensor 2218 and the temperature and humidity sensor 2219.

In some embodiments, the first infrared thermal imaging sensor 2216 is positioned at a midpoint above the first cage 12 and the second infrared thermal imaging sensor 2217 is positioned at a midpoint above the second cage 22.

Specifically, the infrared thermal imaging probe is arranged in the middle of two positions at the top of a small mouse cage living room and a bedroom. The position and angle of the thermographic sensor was tested to cover all floor areas, with a maximum of the real-time body temperature of the mouse being read every second. Place infrared thermal imaging sensor in positive middle position, and the interior cage 201 that sets up in this application is less, can make no matter what angle or position the mouse is in, and the data that infrared thermal imaging sensor gathered are all more accurate.

It can be understood that, first infrared thermal imaging sensor 2216, second infrared thermal imaging sensor 2217, carbon dioxide sensor 2218 and humiture sensor 2219 in this application constitute the full remote sensing system of non-contact, and through the full remote sensing system of non-contact that this application set up, can realize the body temperature, activity and the respiratory metabolism of contactless monitoring mouse, avoid causing the injury to the mouse.

In summary, the present invention provides an animal feeding cage with full telemetry physiological monitoring function, which comprises a first cage body and a second cage body; the first cage body comprises a first cage bottom and a first cage cover, the second cage body comprises an inner cage body and an outer cage body, the inner cage body comprises a second cage bottom and a second cage cover, and the outer cage body comprises a third cage bottom and a third cage cover; the first cage cover and the second cage cover are both in a grid shape, and the second cage bottom, the third cage bottom and the third cage cover are all solid bodies; the first cage bottom is hollow, an accommodating cavity is arranged below the first cage bottom, and a collecting box is arranged in the accommodating cavity; the collecting box can extend into and draw out of the accommodating cavity and is used for collecting and taking out excrement; in addition, by setting different area structures and temperatures, the sleep area and the excretion area are set to have larger temperature difference, so that the mouse can approach to the warm area, and further can distinguish the sleep area and the excretion area by self. This application can make the vital sign data acquisition to the mouse in the sleep region more accurate through the setting to the differentiation in region and electrically operated gate, in addition, the structure that this application adopted still has simply, convenient operation, low cost's beneficial effect.

It is to be understood that the system embodiments provided above correspond to the method embodiments described above, and corresponding specific contents may be referred to each other, which are not described herein again.

As will be appreciated by one skilled in the art, embodiments of the present application may be provided as a method, system, or computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, optical storage, and the like) having computer-usable program code embodied therein.

The present application is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the application. It will be understood that each flow and/or block of the flow diagrams and/or block diagrams, and combinations of flows and/or blocks in the flow diagrams and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. An animal feeding cage with full telemetry physiological monitoring, comprising: the first cage body and the second cage body are arranged in parallel;

2. The animal feeding cage with full telemetry physiological monitoring function of claim 1,

and a feeding port and a drinking port are also arranged in the first cage body.

3. The animal feeding cage with the function of fully telemetric physiological monitoring of claim 1, wherein a carbon dioxide sensor is further provided inside the second cage cover, and the carbon dioxide sensor is connected with the microcontroller.

4. The animal feeding cage with the function of fully telemetering physiological monitoring according to claim 1, wherein a temperature and humidity sensor is arranged in the inner cage body, and the temperature and humidity sensor is connected with the microcontroller.

5. The animal feeding cage with full telemetry physiological monitoring function of claim 1,

the side wall of the first cage body, the side wall of the second cage body, the bottom of the second cage, the bottom of the third cage and the third cage cover are all made of acrylic materials.

6. The animal feeding cage with full telemetry physiological monitoring function of claim 1, wherein the powered door comprises:

7. An animal feeding cage with full telemetry physiological monitoring capability as claimed in claim 6, wherein the control means further comprises:

the touch switch is used for opening and closing the electric door;

the touch switch is connected with the microcontroller.

8. An animal feeding cage with full telemetry physiological monitoring as claimed in claim 1, further comprising:

9. The animal feeding cage with full telemetry physiological monitoring function of claim 1, wherein the cage is characterized in that

First infrared thermal imaging sensor is located the positive intermediate position of first cage lid top, the infrared thermal imaging sensor of second is located the positive intermediate position of second cage lid top.