CN114514048A - 涡漩导管溶血栓系统及其溶血栓方法 - Google Patents

涡漩导管溶血栓系统及其溶血栓方法 Download PDF

Info

Publication number
CN114514048A
CN114514048A CN202080055408.2A CN202080055408A CN114514048A CN 114514048 A CN114514048 A CN 114514048A CN 202080055408 A CN202080055408 A CN 202080055408A CN 114514048 A CN114514048 A CN 114514048A
Authority
CN
China
Prior art keywords
vortex
conduit
thrombolytic
sound field
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080055408.2A
Other languages
English (en)
Inventor
叶秩光
罗尉辰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN114514048A publication Critical patent/CN114514048A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
    • A61B2017/00398—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like using powered actuators, e.g. stepper motors, solenoids
    • A61B2017/00402—Piezo electric actuators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22011—Combined types of vibration, e.g. ultrasonic and electrohydraulic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22014—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
    • A61B2017/22015—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire with details of the transmission member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22027—Features of transducers
    • A61B2017/22028—Features of transducers arrays, e.g. phased arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M2025/0073—Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/12—Flow characteristics the flow being spirally in a plane, e.g. against a plane side of a membrane filter element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

一种涡漩导管溶血栓系统（10,11），包括：一超音波换能器（105）：以及一发射漩涡声场的探头（100）与一导管（200），导管（200）设于发射漩涡声场的探头（100），导管（200）连接于超音波换能器（105），导管（200）具有一第一内通道（210）及一第二内通道（220），第一内通道（210）用以输送药物，第二内通道（220）则用以当作涡漩驱动：以及溶血栓（500）方法，包括：通过涡漩导管溶血栓系统（10,11,12），进行超声波执行步骤以产生声涡旋（S510）：执行聚焦步骤，将药物输送载体聚焦到声学涡旋的中心（S520）；以及执行操纵步骤以将药物递送载体操纵到病变区域（S530）。

Description

PCT国内申请，说明书已公开。

Claims (8)

  1. PCT国内申请，权利要求书已公开。
CN202080055408.2A 2019-07-30 2020-07-27 涡漩导管溶血栓系统及其溶血栓方法 Pending CN114514048A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/525,648 2019-07-30
US16/525,648 US20210030432A1 (en) 2019-07-30 2019-07-30 Vortex catheter thrombolytic system and thrombolytic method thereof
PCT/CN2020/104744 WO2021018074A1 (zh) 2019-07-30 2020-07-27 涡漩导管溶血栓系统及其溶血栓方法

Publications (1)

Publication Number Publication Date
CN114514048A true CN114514048A (zh) 2022-05-17

Family

ID=74230193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080055408.2A Pending CN114514048A (zh) 2019-07-30 2020-07-27 涡漩导管溶血栓系统及其溶血栓方法

Country Status (4)

Country Link
US (1) US20210030432A1 (zh)
EP (1) EP4005625A4 (zh)
CN (1) CN114514048A (zh)
WO (1) WO2021018074A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210138277A1 (en) * 2019-11-12 2021-05-13 National Tsing Hua University Vortexed-acoustic-field method for creating cell permeability and opening blood-brain barrier
CN113297789B (zh) * 2021-05-17 2024-03-19 南京大学 一种基于机器学习的声涡旋分束器设计方法
WO2023205437A1 (en) * 2022-04-22 2023-10-26 North Carolina State University Intravascular/endovascular ultrasound transducers capable of generating swirling acoustic field
CN117462209B (zh) * 2023-12-25 2024-03-19 北京小超科技有限公司 一种超声溶栓系统及其溶栓方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204670A1 (en) * 2003-04-08 2004-10-14 Flowcardia, Inc., A Delaware Corporation Ultrasound catheter devices and methods
CN102232856A (zh) * 2010-05-06 2011-11-09 高春平 双频超声多维聚焦脑血管溶栓系统
CN103706047A (zh) * 2013-12-17 2014-04-09 南京航空航天大学 一种基于超声处理溶栓药物的方法
CN105025977A (zh) * 2013-03-14 2015-11-04 Ekos公司 用于将药物递送至靶部位的方法和设备
US20180071505A1 (en) * 2016-09-13 2018-03-15 National Tsing Hua University Ultrasonic device for transversely manipulating drug delivery carriers and method using the same
CN109152583A (zh) * 2016-04-06 2019-01-04 沃克血管有限公司 用于溶解血栓和传送药剂的系统和方法
WO2019037783A1 (zh) * 2017-08-25 2019-02-28 蔡改贫 超声除栓系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846218A (en) * 1996-09-05 1998-12-08 Pharmasonics, Inc. Balloon catheters having ultrasonically driven interface surfaces and methods for their use
WO2004060448A2 (en) * 2003-01-03 2004-07-22 Ekos Corporation Ultrasonic catheter with axial energy field
EP2494932B1 (en) * 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
US9895158B2 (en) * 2007-10-26 2018-02-20 University Of Virginia Patent Foundation Method and apparatus for accelerated disintegration of blood clot
CN205548629U (zh) * 2016-03-24 2016-09-07 广州军区广州总医院 一种超声微泡空化溶栓系统
CN108187183B (zh) * 2017-12-22 2020-12-18 中国船舶重工集团公司第七一五研究所 一种内置式医用超声溶栓治疗仪
CN108888313B (zh) * 2018-06-29 2021-01-19 华中科技大学 一种操控磁性纳米材料提升静脉中溶栓效率的装置
CN109432586B (zh) * 2018-11-26 2021-02-19 南京航空航天大学 一种应用于浅表肿瘤的靶向治疗超声给药系统及工作方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204670A1 (en) * 2003-04-08 2004-10-14 Flowcardia, Inc., A Delaware Corporation Ultrasound catheter devices and methods
CN102232856A (zh) * 2010-05-06 2011-11-09 高春平 双频超声多维聚焦脑血管溶栓系统
CN105025977A (zh) * 2013-03-14 2015-11-04 Ekos公司 用于将药物递送至靶部位的方法和设备
CN103706047A (zh) * 2013-12-17 2014-04-09 南京航空航天大学 一种基于超声处理溶栓药物的方法
CN109152583A (zh) * 2016-04-06 2019-01-04 沃克血管有限公司 用于溶解血栓和传送药剂的系统和方法
US20180071505A1 (en) * 2016-09-13 2018-03-15 National Tsing Hua University Ultrasonic device for transversely manipulating drug delivery carriers and method using the same
WO2019037783A1 (zh) * 2017-08-25 2019-02-28 蔡改贫 超声除栓系统

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张蓉，吴军: "脑梗死溶栓与抗栓治疗进展" *

Also Published As

Publication number Publication date
US20210030432A1 (en) 2021-02-04
EP4005625A1 (en) 2022-06-01
WO2021018074A1 (zh) 2021-02-04
EP4005625A4 (en) 2023-08-16

Similar Documents

Publication Publication Date Title
CN114514048A (zh) 涡漩导管溶血栓系统及其溶血栓方法
Goertz An overview of the influence of therapeutic ultrasound exposures on the vasculature: high intensity ultrasound and microbubble-mediated bioeffects
Xie et al. Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles
Mannaris et al. Investigation of microbubble response to long pulses used in ultrasound-enhanced drug delivery
Wu et al. Improved sonothrombolysis from a modified diagnostic transducer delivering impulses containing a longer pulse duration
US12053194B2 (en) Systems and methods for treating vascular occlusions with catheter based ultrasound
CN108187183B (zh) 一种内置式医用超声溶栓治疗仪
Kim et al. Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis
Pfaffenberger et al. 2MHz ultrasound enhances t-PA-mediated thrombolysis: comparison of continuous versus pulsed ultrasound and standing versus travelling acoustic waves
US20180001114A1 (en) Automated ultrasound apparatus and method for noninvasive vessel recanalization treatment and monitoring
KR20140094956A (ko) 초음파 시스템 및 이의 제어 방법
Engelberger et al. Enhanced thrombolysis by ultrasound-assisted catheter-directed thrombolysis and microbubbles in an in vitro model of iliofemoral deep vein thrombosis
Zhang et al. A model of high-speed endovascular sonothrombolysis with vortex ultrasound-induced shear stress to treat cerebral venous sinus thrombosis
Hendley et al. Clot degradation under the action of histotripsy bubble activity and a lytic drug
Soltani et al. Potentiating intra-arterial sonothrombolysis for acute ischemic stroke by the addition of the ultrasound contrast agents (Optison™ & SonoVue®)
Li et al. Efficacy estimation of microbubble-assisted local sonothrombolysis using a catheter with a series of miniature transducers
Nahirnyak et al. Ultrasound-induced thermal elevation in clotted blood and cranial bone
Meunier et al. Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots
US20140107540A1 (en) Ultrasonic irradiation apparatus and method for irradiating ultrasonic wave
US20210138277A1 (en) Vortexed-acoustic-field method for creating cell permeability and opening blood-brain barrier
M Meunier et al. Combination treatment with rt-PA is more effective than rt-PA alone in an in vitro human clot model
Soltani et al. Sonothrombolysis: an emerging modality for the treatment of acute ischemic and hemorrhagic stroke
Zhang et al. Integration of Forward-viewing and Side-viewing Ultrasound Transducers in an Intravascular Sonothrombolysis Catheter
CN116058919B (zh) 血栓消散导管及具有该导管的球囊导管组件
Salman-Kesner et al. In-vitro assessment of the thrombolytic efficacy of therapeutic ultrasound

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20220517

RJ01 Rejection of invention patent application after publication