CN114505108A - Liquid transfer device and adjusting method - Google Patents
Liquid transfer device and adjusting method Download PDFInfo
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- CN114505108A CN114505108A CN202210190292.4A CN202210190292A CN114505108A CN 114505108 A CN114505108 A CN 114505108A CN 202210190292 A CN202210190292 A CN 202210190292A CN 114505108 A CN114505108 A CN 114505108A
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 230000005540 biological transmission Effects 0.000 claims description 47
- 239000012530 fluid Substances 0.000 claims description 35
- 238000006073 displacement reaction Methods 0.000 claims description 13
- 239000004576 sand Substances 0.000 claims description 6
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 description 17
- 210000003811 finger Anatomy 0.000 description 12
- 230000002093 peripheral effect Effects 0.000 description 12
- 230000004323 axial length Effects 0.000 description 11
- 239000012224 working solution Substances 0.000 description 7
- 238000007789 sealing Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 239000010720 hydraulic oil Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/025—Displaying results or values with integrated means
- B01L2300/027—Digital display, e.g. LCD, LED
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- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model provides a liquid-transfering device, this liquid-transfering device includes casing, middle casing and casing down the inboard cover of going up the casing is equipped with liquid measure adjusting sleeve, and liquid measure adjusting sleeve can stretch out at liquid measure adjusting sleeve for last casing swivelling movement the one end body coupling of going up the casing has adjusting roller the other pot head of liquid measure adjusting sleeve is equipped with driven sleeve, and driven sleeve's bottom is provided with the screw thread, mechanical counter pass through the gear train with thread engagement, mechanical counter sets up in driven sleeve's below. According to the invention, through reasonable arrangement of the structure of the liquid transfer device, the diameter of the liquid transfer device is reduced, the liquid transfer device is convenient for operators to hold for a long time, and meanwhile, working liquid can be prevented from entering the liquid transfer gun, so that the influence on experimental result analysis caused by pollution in the process of extracting different working liquids is avoided.
Description
Technical Field
The invention relates to a liquid transfer device and a using method thereof, belonging to the field of analytical chemistry.
Background
Pipetting devices are used primarily in laboratories to meter liquids, which are aspirated and discharged at the tip of a pipette. In a gas cushion pipette, a gas plunger is integrated into the pipette and communicates with the pipette tip. The air cushion is moved back and forth by means of the plunger, so that the working fluid or reagent is sucked into the pipette tip and discharged through the pipette tip. The means for detachable attachment to the pipette tip is of conical type, facilitating the aspiration of working fluid or reagent.
The pipette tips are usually detachably connected to the pipetting device in order to replace a new pipette tip after use, thereby avoiding contamination of the reagent by pipetting different solutions or reagents with the pipette tip. Pipette tips are typically standard commercially available parts made of corrosion resistant plastic/polymer materials, and in some special applications, metal materials are also used.
Patent publication No. CN101912794A describes a pipette device that uses the principle of negative pressure to suck working fluid or reagent in the tip of a pipette; however, the device has the problem that the working solution or the reagent is sucked into the displacement device, usually the plunger moves upwards under the action of the return spring, if no action force is applied to the plunger, the plunger moves upwards too fast, so that a large amount of working solution or reagent is sucked into the tip of the pipette, and at the moment, the liquid has certain kinetic energy, and under the condition of small volume, the liquid can splash into the displacement device and be attached to the inner wall of the cavity of the displacement device; even if the adhesion of the inner wall of the cavity is found, the corresponding cleaning workload is brought, and the continuity of the extraction of the working solution or the reagent is not facilitated; meanwhile, in the next sucking process, the reagent attached to the inner wall of the cavity is conveyed into the tip of the pipette along with the downward movement of the plunger, so that the reagent or working liquid is polluted, and the analysis of an experimental result is influenced.
When an operator performs pipetting operation, the thumb is used for pressing the pressing cap, other fingers grasp the pipetting device, a mechanical counter and a transmission sleeve in the prior art are arranged in parallel at the same axial position, as described in the patent publication No. CN11701630, the parallel arrangement of the mechanical counter and the transmission sleeve causes the pipetting device to be thick, does not use the grasping of the operator, and is easy to generate fatigue during long-time pipetting operation; and meanwhile, the fingers are held around the shell on the periphery of the mechanical counter, so that the observation window of the mechanical counter is easily shielded, and the reading of the pipetting amount in the adjustment process or after the adjustment of the pipetting device by an operator is influenced.
Disclosure of Invention
The invention aims to solve the technical problem that working liquid or reagent splashes into a liquid transfer gun in the prior art, and provides a liquid transfer device, which reduces the diameter of the liquid transfer device through reasonable structural arrangement of the liquid transfer device and is convenient for an operator to hold for a long time; or the return speed of the plunger rod is controlled to prevent the working solution from entering the liquid-transferring gun, so that the pollution caused by the extraction of different working solutions is avoided, and the analysis of an experimental result is influenced.
The technical purpose of the invention is realized by the following technical scheme:
the invention provides a liquid transfer device, which comprises an upper shell, a middle shell and a lower shell, wherein a liquid amount adjusting sleeve is sleeved on the inner side of the upper shell and can rotate and move relative to the upper shell, the liquid amount adjusting sleeve can be axially limited and fixed in the upper shell in a bearing or limiting boss mode, one end of the liquid amount adjusting sleeve, which extends out of the upper shell, is integrally connected with an adjusting roller, the other end of the liquid amount adjusting sleeve is sleeved with a driven sleeve, the diameter of one end of the driven sleeve is smaller than the inner diameter of the liquid amount adjusting sleeve, so that the driven sleeve is inserted into the other end of the liquid amount adjusting sleeve, and the driven sleeve and the liquid amount adjusting sleeve rotate together to transmit torsion in an adjusting process; an adjusting nut is sleeved on the inner side of the driven sleeve and rotates along with the driven sleeve; the non-rotatable cover of screw nut sets up on the actuating lever, and the actuating lever can slide from top to bottom relative screw nut, set up a boss on the actuating lever with screw nut's lower terminal surface butt, driven telescopic bottom is provided with the screw thread, mechanical counter pass through the gear train with thread engagement, mechanical counter sets up in driven telescopic below the bottom of actuating lever is provided with at least one sand grip the bottom of going up the casing is provided with the board that restricts changeing, be provided with the confession on the board that restricts changeing the through-hole that the actuating lever passed, the through-hole be provided with in its radial direction with sand grip complex notch, through restrict changeing the board restriction the rotation of actuating lever. Through with mechanical counter setting in the below of driven sleeve to change the drive mode of the regulation of actuating lever, can make the diameter of pipetting device reduce, improve the circularity of pipetting device upper housing, reduce the space occupation of upper housing.
Furthermore, an observation window is arranged on the part of the upper shell close to the mechanical counter, the position of the observation window moves downwards along with the downward movement of the mechanical counter, and the observation window is positioned below a finger gripping area when the finger is gripped, so that the suction amount in the current suction process can be conveniently read, and the suction amount of the liquid transfer device can be conveniently adjusted and observed.
Furthermore, the middle shell and the upper shell are in sealed connection, preferably in a threaded connection mode, a clamping connection mode, a bonding mode and the like; the lower shell and the middle shell are in sealed connection, preferably in a threaded connection mode, a clamping connection mode, an adhesion mode and the like; the bottom of the lower shell is fixedly connected with a displacement device, a cavity matched with the plunger rod is formed in the displacement device, the bottom of the displacement device is connected with a pipette tip, and the pipette tip is preferably a KG series pipette tip produced by KIRGEN company.
In a preferred embodiment, the driven sleeve is provided with a limiting boss along the periphery so as to limit the driven sleeve to move axially in the upper shell, and the driven sleeve can be fixed at the other end of the liquid amount adjusting sleeve in a pin hole, a key groove, a threaded connection, a clamping connection and the like, so that the driven sleeve and the liquid amount adjusting sleeve rotate together to transfer torsion in the adjusting process.
In a preferred embodiment, the adjusting nut and the driven sleeve are fixed in a manner of interference fit, pin holes, key grooves, threaded connection or clamping connection and the like, at least one step is arranged on the inner periphery of the driven sleeve, and the adjusting nut is limited in at least one axial direction.
In a preferred embodiment, the adjusting roller may be provided with a groove penetrating from the upper surface to the lower surface thereof, so as to increase the friction force when an operator rotates the adjusting roller, and the adjusting roller may be made of metal, plastic or rubber, preferably rubber, so as to increase the friction force between fingers and the adjusting roller.
In a preferred embodiment, the thread is an external thread arranged at the bottom of the driven sleeve, the gear set comprises a first transmission gear, a second transmission gear and a third transmission gear, the first transmission gear and the second transmission gear are coaxially arranged on the outer shell, the first transmission gear is meshed with the external thread, the third transmission gear arranged at one end of the mechanical counter is meshed with the second transmission gear, the axis of the third transmission gear is arranged in a plane formed by the axis of the second transmission gear and the axis of the upper shell and is positioned at the inner side of the axis of the second transmission gear, so that the axis of the mechanical counter is moved inwards to reduce the diameter of the pipetting device, and the third transmission gear and the mechanical counter are coaxially arranged on the outer shell; when the liquid suction amount of the liquid-transferring device is adjusted, the driven sleeve rotates, the first transmission gear meshed with the external thread of the driven sleeve is driven to rotate, the third transmission gear rotates through the transmission of the second transmission gear, and therefore the number displayed by the mechanical counter corresponds to the volume of liquid sucked by the liquid-transferring device.
The concrete theory of operation of this application liquid-transfering device does: when an operator uses the liquid transfer device, the liquid amount adjusting sleeve is driven to rotate by manually rotating the adjusting roller, the liquid amount adjusting sleeve and the driven sleeve do not axially move under the action of a bearing or a limiting boss and the like in the rotating process, the liquid amount adjusting sleeve and the driven sleeve are rotated with an adjusting nut fixedly connected with the driven sleeve, the adjusting nut drives a lead screw nut to move up and down, the lead screw nut acts on the boss of the driving rod, the driving rod is enabled to move up and down, the driving rod drives a plunger rod to move, the volume of a cavity is changed until the mechanical counter displays the required volume, and the range of the liquid transfer device is adjusted.
In a preferred implementation, in order to control the return speed of the plunger rod and prevent the working fluid from entering the displacement device, a liquid transfer device is provided, which comprises an upper shell, a middle shell and a lower shell, wherein a liquid quantity adjusting sleeve is sleeved on the inner side of the upper shell and can rotate and move relative to the upper shell, the liquid quantity adjusting sleeve can be axially limited and fixed in the upper shell in a limiting way by a bearing or a limiting boss, an adjusting roller is integrally connected to one end of the liquid quantity adjusting sleeve, which extends out of the upper shell, a driven sleeve is sleeved on the other end of the liquid quantity adjusting sleeve, the diameter of one end of the driven sleeve is smaller than the inner diameter of the liquid quantity adjusting sleeve, so that the driven sleeve is inserted into the other end of the liquid quantity adjusting sleeve, and the driven sleeve and the liquid quantity adjusting sleeve rotate together to transmit the torsion force in the adjusting process; an adjusting nut is sleeved on the inner side of the driven sleeve and rotates along with the driven sleeve; the screw nut is arranged on the driving rod in a non-rotatable manner, the driving rod can slide up and down relative to the screw nut, a boss is arranged on the driving rod and is abutted against the lower end face of the screw nut, the bottom of the driven sleeve is provided with threads, and the mechanical counter is meshed with the threads through a gear set; the lower end face of the driving rod is abutted with a plunger rod, a speed adjusting unit is arranged in the middle shell, the piston is fixedly connected onto the plunger rod, the speed adjusting unit comprises an upper control cavity and a lower control cavity which are formed by separating the piston, fluid is filled in the upper control cavity and the lower control cavity, at least one first channel and at least one second channel which are communicated with the upper control cavity and the lower control cavity are arranged in the first channel, a throttling device is arranged in the first channel, and the flow of the piston moving upwards along with the plunger rod under the action of a plunger spring in the first channel is controlled, so that the return speed of the plunger rod is controlled, and working liquid is prevented from entering a liquid transfer gun to cause pollution when different working liquids are extracted, and the analysis of experimental results is influenced.
Furthermore, this move liquid device still including setting up upper cover plate and lower apron in the middle casing, the upper cover plate forms with mobilizable piston go up the control chamber, and lower apron forms with mobilizable piston control chamber down, and upper cover plate and lower apron are sealed to be set up in the middle casing, for the convenience of the installation of upper cover plate and lower apron, upper cover plate and lower apron can adopt mounting means such as threaded connection, joint, bonding, be suitable for among the prior art upper cover plate and lower apron with middle casing sealing connection's mode all can be suitable for.
Furthermore, the at least one second channel is arranged in the plunger rod, a one-way valve is arranged in the second channel and used for preventing the fluid in the upper control cavity from flowing into the lower control cavity through the second channel in the upward moving process of the plunger rod, the one-way valve can be designed by adopting a ball valve with a spring, and other valve forms for realizing one-way flow in the prior art can be applied to the second channel. The second channel is positioned in a second upper opening in the plunger rod and is positioned in the upper control cavity, and the second channel is positioned in a second lower opening in the plunger rod and is positioned in the lower control cavity; preferably, the second upper opening and the second lower opening are arranged adjacent to the piston, so that the upper control chamber and the lower control chamber have smaller axial lengths, and the axial lengths of the upper control chamber and the lower control chamber are arranged, so that when the pipetting device is at the maximum range or the maximum pipetting amount, the second upper opening of the second channel is positioned at the lower side of the upper cover plate, and the second lower opening of the second channel is positioned at the upper side of the lower cover plate, so that the second upper opening and the second lower opening are positioned in the corresponding upper control chamber or lower control chamber no matter how the pipetting amount is adjusted, and the second upper opening and the second lower opening are prevented from falling out of the control chamber during the movement of the plunger rod, and liquid leakage is caused.
Further, at least one second channel may be disposed in the peripheral wall of the upper housing, a second upper opening of the second channel in the peripheral wall of the upper housing is located in the upper control chamber, and a second lower opening of the second channel in the peripheral wall of the upper housing is located in the lower control chamber; the second upper opening is adjacent to the lower side of the upper cover plate, and the second lower opening is adjacent to the upper side of the lower cover plate, so that the volume of the upper control cavity and the volume of the lower control cavity can be utilized as much as possible, the axial length of the upper control cavity and the axial length of the lower control cavity are reduced, the second upper opening and the second lower opening are positioned in the corresponding upper control cavity or the corresponding lower control cavity no matter how the suction amount is adjusted, and the second upper opening and the second lower opening are prevented from being positioned in the same control cavity in the moving process of the plunger rod.
Furthermore, at least one first channel is arranged in the plunger rod, and the first channel is communicated with the second channel through a throttling device; one end of the first channel is positioned on the surface of the plunger rod and is provided with a first lower opening, and the first lower opening and the second lower opening are positioned in a flush position and are adjacent to the piston, so that the upper control cavity and the lower control cavity can be ensured to have smaller axial length, and the first lower opening is positioned in the lower control cavity no matter how the suction amount is adjusted. By communicating the first passage and the second passage by means of said throttling means such that the first passage and the second passage have a common upper opening, the amount of work of the opening in the plunger rod is reduced.
Further, at least one first channel may be disposed in the peripheral wall of the middle housing, the first channel is located in the upper control chamber at the first upper opening in the peripheral wall of the middle housing, the first channel is located in the lower control chamber at the first lower opening in the peripheral wall of the middle housing, and the first channel may be formed by 3D printing or by providing a sealing member after drilling in the middle housing; the first upper opening is adjacent to the lower side of the upper cover plate, the first lower opening is adjacent to the upper side of the lower cover plate, and the volume of the upper control cavity and the volume of the lower control cavity can be utilized as much as possible to reduce the axial length of the upper control cavity and the lower control cavity, so that the first upper opening and the first lower opening are positioned in the corresponding upper control cavity or lower control cavity no matter how the suction amount is adjusted, and the first upper opening and the first lower opening are prevented from being positioned in the same control cavity in the moving process of the plunger rod.
Further, the throttling device is in the form of a throttling orifice plate, or a reduced throat structure, or other devices capable of realizing fluid throttling; the fluid can be air, nitrogen with good stability, helium, hydraulic oil or other media; it can be understood that the throttling device such as a throttling orifice plate or a throat structure and the like is not required to be arranged, and the flow rate of the upper control cavity flowing into the lower control cavity when the plunger rod moves upwards is controlled by setting the diameter ratio of the first channel and the second channel or independently setting the first channel to have a smaller diameter so as to slow down the speed of the plunger rod when the plunger rod moves upwards; the ratio of the diameter of the first channel to the diameter of the second channel is preferably set to be in the range of 1:2 to 1:5, and multiple experiments show that the diameter of the first channel is set to be 0.5mm to 3mm, which has a good fluid control effect.
The working principle of the liquid-transfering device is as follows: when an operator presses a pressing cap connected with the driving rod, the driving rod drives a plunger rod to move downwards, meanwhile, a piston fixedly connected to the plunger rod moves downwards to pressurize fluid in the lower control cavity, so that the fluid flows into the upper control cavity through the second channel, a small amount of fluid flows into the upper control cavity through the throttling device through the first channel, and the plunger rod extends into the cavity to change the volume of the cavity; when the plunger rod moves upwards under the action of the plunger spring, the volume in the cavity is increased, the reagent is sucked into the tip of the pipette by utilizing the negative pressure principle, meanwhile, the piston moves upwards along with the plunger rod to compress the fluid in the upper control cavity, the fluid in the upper control cavity cannot return through the second channel due to the action of the one-way valve arranged in the second channel, the pressurized fluid only returns to the lower control cavity through the first channel, and the fluid returning speed is reduced under the action of the first channel and the throttle valve, so that the upwards moving speed of the plunger rod is reduced, the speed of the reagent flowing into the tip of the pipette is controlled, and the working fluid is prevented from entering the pipette gun to cause pollution during extraction of different working fluids and influence the subsequent experiment.
The invention has the following technical effects:
the diameter of the liquid transfer device is reduced by changing the position of the mechanical counter and changing the transmission mode of adjusting the liquid suction amount, so that the liquid transfer device is convenient to hold for a long time by an operator, the position of the observation window is also moved downwards along with the downward movement of the mechanical counter, and the observation window is positioned below a finger holding area when the operator holds the liquid transfer device by fingers, so that the suction amount in the current suction process is convenient to read, and the suction amount of the liquid transfer device is convenient to adjust and observe; when the suction amount is adjusted, the position of the liquid transfer device can be fixed by holding with fingers, the adjusting roller is screwed by the other hand, and the counting of the observation window is observed at the same time, so that the suction amount can be adjusted at one time; by controlling the return speed of the plunger rod, the working solution is prevented from entering the liquid-transferring gun, so that the pollution caused by extracting different working solutions is avoided, and the analysis of an experimental result is influenced.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is an enlarged partial schematic view at A of FIG. 1;
FIG. 3 is an enlarged partial schematic view at B of FIG. 1;
fig. 4 shows the position of the piston and the openings at the maximum suction amount.
Detailed Description
In order to more clearly explain the technical solution of the present application, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious to those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
Example 1
Fig. 1 to 4 show the overall structure of the pipetting device, which is used to show the technical features of the improvements related to the present application, and other technical features of the pipetting device, such as the driving rod, the stop device of the plunger rod, etc., are not related to the improvements related to the present application and are not shown. Referring to fig. 1 and 2, the invention provides a liquid transfer device, which comprises an upper shell 1, a middle shell 2 and a lower shell 3, wherein a liquid amount adjusting sleeve 11 is sleeved on the inner side of the upper shell 1, the liquid amount adjusting sleeve 11 can rotate and move relative to the upper shell 1, the liquid amount adjusting sleeve 11 can be axially limited and fixed in the upper shell 1 through a bearing or a limiting boss, an adjusting roller 12 is integrally connected to one end of the liquid amount adjusting sleeve 11, which extends out of the upper shell, a driven sleeve 13 is sleeved on the other end of the liquid amount adjusting sleeve 11, the diameter of one end of the driven sleeve 13 is smaller than the inner diameter of the liquid amount adjusting sleeve 11, so that the driven sleeve 13 is inserted into the other end of the liquid amount adjusting sleeve 11, the driven sleeve 13 and the liquid amount adjusting sleeve 11 rotate together to transmit torsion force in the adjusting process; an adjusting nut 14 is sleeved on the inner side of the driven sleeve 13, and the adjusting nut 14 rotates along with the driven sleeve 13; the nonrotatable cover of screw nut 15 sets up on actuating lever 4, and actuating lever 4 can slide from top to bottom relative screw nut 15, set up on actuating lever 4a boss 41 with screw nut 15's lower terminal surface butt, the bottom of driven sleeve 13 is provided with the screw thread, mechanical counter 5 pass through the gear train with thread engagement, mechanical counter 5 sets up in the below of driven sleeve 13 the bottom of actuating lever 4 is provided with at least one sand grip 42 the bottom of going up casing 1 is provided with limited rotating plate 43, be provided with the confession on the limited rotating plate 43 the through-hole that the actuating lever passed, the through-hole be provided with in its radial direction with sand grip 42 complex notch, through limited rotating plate 43 restricts the rotation of actuating lever 4. By arranging the mechanical counter 5 below the driven sleeve 13 and changing the transmission mode of the adjustment of the driving rod 4, the diameter of the pipetting device can be reduced, the roundness of the upper shell 1 of the pipetting device is improved, and the space occupation of the upper shell 1 is reduced.
In a preferred embodiment, a viewing window 6 is arranged at a part of the upper shell 1 close to the mechanical counter 5, the position of the viewing window 6 moves downwards along with the downward movement of the mechanical counter 5, and the viewing window is positioned below a finger gripping area when the finger gripping is carried out, so that the reading of the suction amount in the current suction process is facilitated, and the adjustment and the observation of the suction amount of the pipetting device are facilitated; when the suction amount is adjusted, the finger can be used for holding the pipetting device to fix the position of the pipetting device, the adjusting roller 12 is screwed by the other hand, and the counting of the observation window 6 is observed at the same time, so that the suction amount can be adjusted at one time. The middle shell 2 and the upper shell are in sealed connection, preferably in a threaded connection mode, a clamping connection mode, an adhesion mode and the like; the lower shell 4 and the middle shell 2 are in sealed connection, preferably in a threaded connection mode, a clamping connection mode, an adhesion mode and the like; a displacement device 31 is fixedly connected to the bottom of the lower housing 3, a cavity 8 which is matched with the plunger rod 7 is formed in the displacement device 31, a pipette tip 32 is connected to the bottom of the displacement device 31, and the pipette tip 32 is preferably a KG series pipette tip manufactured by KIRGEN company.
In a preferred embodiment, the driven sleeve 13 is provided with a limit boss 131 along the periphery to limit the axial movement of the driven sleeve 13 in the upper housing 1, and the driven sleeve 13 can be fixed at the other end of the liquid amount adjusting sleeve 11 by means of a pin hole, a key groove, a threaded connection, a snap connection, etc., so that the driven sleeve and the liquid amount adjusting sleeve 11 rotate together to transmit the torsion force during the adjustment process.
In a preferred embodiment, the adjusting nut 14 and the driven sleeve 13 may be fixed by interference fit, a pin hole, a key groove, a threaded connection, or a snap connection, and at least one step is provided on the inner circumference of the driven sleeve 13 to limit the adjusting nut 14 in at least one axial direction.
In a preferred embodiment, the adjusting roller 12 may be provided with a groove penetrating from the upper surface to the lower surface thereof to increase the friction force of the operator when rotating the adjusting roller 12, and the material of the adjusting roller 12 may be metal, plastic or rubber, preferably rubber, to increase the friction force of the fingers contacting the adjusting roller 12.
In a preferred embodiment, the thread is an external thread provided at the bottom of the driven sleeve 13, the gear set comprises a first transmission gear 51, a second transmission gear 52 and a third transmission gear 53, the first transmission gear 51 and the second transmission gear 52 are coaxially arranged on the outer shell 1, the first transmission gear 51 is meshed with the external thread, a third transmission gear 53 arranged at one end of the mechanical counter 5 is meshed with the second transmission gear 52, the axis of the third transmission gear 53 is arranged in the plane formed by the axis of the second transmission gear 52 and the axis of the upper shell 1 and is positioned on the inner side of the axis of the second transmission gear, thereby maximizing the axial line of the mechanical counter 5 and reducing the diameter of the pipetting device, and the third transmission gear 53 is arranged on the outer shell 1 coaxially with the mechanical counter 5; when the liquid suction amount of the pipetting device is adjusted, the driven sleeve 13 rotates to drive the first transmission gear 51 meshed with the external thread of the driven sleeve 13 to rotate, and the third transmission gear 53 is driven to rotate by the second transmission gear 51, so that the number displayed by the mechanical counter 5 corresponds to the volume of the pipetting device capable of sucking liquid, fig. 2 shows a transmission structure for driving the mechanical counter 5, the mechanical counter is driven to rotate and count by the third transmission gear 53, the mechanical counter 5 is a schematic structure in the figure, and the specific counting structure of the mechanical counter is not taken as the improvement of the application, and the conventional mechanical counter can be adopted.
The concrete theory of operation of this application liquid-transfering device does: when an operator uses the liquid transfer device, the liquid amount adjusting sleeve 11 drives the driven sleeve 13 to rotate by manually screwing the adjusting roller 12, in the rotating process, under the action of a bearing or a limiting boss and the like, the liquid amount adjusting sleeve 11 and the driven sleeve 13 do not axially move, the adjusting nut 14 fixedly connected with the driven sleeve 13 rotates, the adjusting nut 14 drives the lead screw nut 15 to move up and down, the lead screw nut 15 acts on the boss 41 of the driving rod 4 to enable the driving rod 4 to move up and down, the driving rod 4 drives the plunger rod 7 to move, the volume of the cavity 8 is changed until the mechanical counter 5 displays the required volume, and the range of the liquid transfer device is adjusted.
Example 2
Referring to fig. 3, a liquid transfer device comprises an upper casing 1, a middle casing 2 and a lower casing 3, wherein a liquid amount adjusting sleeve 11 is sleeved on the inner side of the upper casing 1, the liquid amount adjusting sleeve 11 can rotate and move relative to the upper casing 1, the liquid amount adjusting sleeve 11 can be axially fixed in the upper casing 1 in a limiting manner through a bearing or a limiting boss, an adjusting roller 12 is integrally connected to one end of the liquid amount adjusting sleeve 11 extending out of the upper casing, a driven sleeve 13 is sleeved on the other end of the liquid amount adjusting sleeve 11, the diameter of one end of the driven sleeve 13 is smaller than the inner diameter of the liquid amount adjusting sleeve 11, so that the driven sleeve 13 is inserted into the other end of the liquid amount adjusting sleeve 11, the driven sleeve 13 and the liquid amount adjusting sleeve 11 rotate together to transmit torsion force in the adjusting process; an adjusting nut 14 is sleeved on the inner side of the driven sleeve 13, and the adjusting nut 14 rotates along with the driven sleeve 13; the screw nut 15 is sleeved on the driving rod 4 in a non-rotatable manner, the driving rod 4 can slide up and down relative to the screw nut 15, a boss 41 is arranged on the driving rod 4 and is abutted against the lower end face of the screw nut 15, the bottom of the driven sleeve 13 is provided with threads, and the mechanical counter 5 is meshed with the threads through a gear set; the lower end surface of the driving rod 4 is connected with a plunger rod 7 in an abutting mode, a speed adjusting unit is arranged in the middle shell 2, a piston 23 is fixedly connected to the plunger rod 7, the speed regulation unit comprises an upper control chamber 22 and a lower control chamber 24, which are separated by a piston 23, the upper control chamber 22 and the lower control chamber 24 being filled with a fluid, at least one first passage 26, 28 and at least one second passage 29 communicating with the upper control chamber 22 and the lower control chamber 24, throttle means 27, 30 are arranged in the first passages 26, 28, said throttle means 27, 30 controlling the flow in said first passages 26, 28 as said piston 23 moves up with said plunger rod 7 under the action of the plunger spring, therefore, the return speed of the plunger rod 7 is controlled, and the working liquid is prevented from entering the liquid-transferring gun to cause pollution when different working liquids are extracted, so that the analysis of experimental results is influenced.
Further, the liquid-transfering device also comprises an upper cover plate 21 and a lower cover plate 25 which are arranged in the middle shell 2, the upper cover plate 21 and the movable piston 23 form the upper control cavity 22, the lower cover plate 25 and the movable piston 23 form the lower control cavity 24, the upper cover plate 21 and the lower cover plate 25 are arranged in the middle shell 2 in a sealing mode, in order to facilitate the installation of the upper cover plate 21 and the lower cover plate 25, the upper cover plate 21 and the lower cover plate 25 can adopt installation modes such as threaded connection, clamping connection and bonding, and the prior art can be suitable for the sealing connection of the upper cover plate 21 and the lower cover plate 25 and the middle shell 2.
Further, the at least one second channel 29 is arranged in the plunger rod 7, and a check valve is arranged in the second channel 29 to prevent the fluid in the upper control chamber 22 from flowing into the lower control chamber 24 through the second channel 29 during the upward movement of the plunger rod 7, and the check valve may be designed as a ball valve with a spring, and other valve forms for realizing the one-way flow in the prior art can be applied to the second channel 29. Said second channel 29 is located in said upper control chamber 22 at a second upper opening in said plunger rod 7 and said second channel 29 is located in said lower control chamber 24 at a second lower opening in said plunger rod 7; preferably, the second upper opening and the second lower opening are arranged adjacent to the piston 23, so that the upper control chamber 22 and the lower control chamber 24 have a smaller axial length, and the axial lengths of the upper control chamber 22 and the lower control chamber 24 are arranged, so that when the pipetting device is at the maximum range or the maximum pipetting amount, the second upper opening of the second channel is positioned at the lower side of the upper cover plate 21, and the second lower opening of the second channel is positioned at the upper side of the lower cover plate, so that the second upper opening and the second lower opening are positioned in the corresponding upper control chamber 22 or lower control chamber 24 no matter how the pipetting amount is adjusted, and the second upper opening and the second lower opening are prevented from falling out of the control chambers during the movement of the plunger rod 7, and causing liquid leakage.
Further, at least one second channel 29 may be provided in the peripheral wall of the intermediate housing, the second upper opening of said second channel 29 in the peripheral wall of said intermediate housing being located in the upper control chamber 22, the second lower opening of said second channel 29 in the peripheral wall 7 of said intermediate housing being located in the lower control chamber 24; the second upper opening is adjacent to the lower side of the upper cover plate 21, and the second lower opening is adjacent to the upper side of the lower cover plate 25, so that the volume of the upper control chamber 22 and the lower control chamber 24 can be utilized as much as possible, the axial length of the upper control chamber 22 and the lower control chamber 24 is reduced, the second upper opening and the second lower opening are located in the corresponding upper control chamber 22 or lower control chamber 24 no matter how the sucking amount is adjusted, the second upper opening and the second lower opening are prevented from being located in the same control chamber during the movement of the plunger rod 7, and if the second upper opening is located at a lower position when the plunger rod 7 moves upwards, the upper second upper opening is easily communicated with the lower control chamber 24, so that the fluid of the upper control chamber 22 is sealed, a rigid volume is formed, and the plunger rod 7 cannot move upwards to finish the preset reagent sucking.
Further, at least one first channel 28 is provided in said plunger rod 7, said first channel 28 communicating with said second channel 29 via throttling means 30; one end of said first channel 28 is located at the surface of said plunger rod 7 with a first lower opening which is located flush with a second lower opening, both adjacent to said piston 23, thus ensuring that the upper control chamber 22 and the lower control chamber 24 have a smaller axial length, so that the first lower opening is located in the lower control chamber 24 regardless of the amount of pipetting, as shown in fig. 4a, 4b, which shows that the second upper opening is still located adjacent to the lower side of the upper cover plate 21 when the pipetting means is adjusted to the maximum amount of pipetting, and that the first lower opening and the second lower opening are located adjacent to the upper side of the lower cover plate 25 when said plunger rod 7 is moved down to the maximum position. By communicating the first passage 28 and the second passage 29 by means of said throttling means 30, such that the first passage 28 and the second passage 29 have a common upper opening, the amount of work of the opening in the plunger rod is reduced.
Further, at least one first channel 26 may be provided in the peripheral wall of the middle housing 2, the first channel 26 is located in the upper control chamber 22 at the first upper opening in the peripheral wall of the middle housing 2, the first channel 26 is located in the lower control chamber 24 at the first lower opening in the peripheral wall of the middle housing, and the first channel 26 may be formed by 3D printing or by providing a sealing member after drilling in the middle housing; the first upper opening is adjacent to the lower side of the upper cover plate 21, and the first lower opening is adjacent to the upper side of the lower cover plate 25, so that the volume of the upper control chamber 22 and the lower control chamber 24 can be utilized as much as possible, the axial length of the upper control chamber 22 and the lower control chamber 24 can be reduced, the first upper opening and the first lower opening can be positioned in the corresponding upper control chamber 22 or lower control chamber 24 no matter how the sucking amount is adjusted, the first upper opening and the first lower opening are prevented from being positioned in the same control chamber during the movement of the plunger rod 7, and if the first upper opening is positioned downwards when the plunger rod 7 moves upwards, the upper first upper opening is easily communicated with the lower control chamber 24, so that the fluid of the upper control chamber 22 is sealed, a rigid volume is formed, and the plunger rod 7 cannot move upwards to complete the preset sucking of the reagent.
Further, the throttling devices 27, 30 are in the form of throttle orifice plates, or reduced throat structures, or other devices that can achieve fluid throttling; the fluid can be air, nitrogen with good stability, helium, hydraulic oil or other media. It can be understood that the throttling device such as a throttling orifice plate or a throat structure and the like is not required to be arranged, and the flow rate of the upper control cavity flowing into the lower control cavity when the plunger rod moves upwards is controlled by setting the diameter ratio of the first channel and the second channel or independently setting the first channel to have a smaller diameter so as to slow down the speed of the plunger rod when the plunger rod moves upwards; the diameter ratio of the first channel and the second channel is preferably set to be in the range of 1:2-1:5, and multiple experiments show that the setting of the diameter of the first channel to be 0.5mm-3mm has a good fluid throttling control effect.
According to the working principle of the liquid transfer device, when an operator presses a pressing cap connected with the driving rod 4, the driving rod 4 drives the plunger rod 7 to move downwards, meanwhile, the piston 23 fixedly connected to the plunger rod 7 moves downwards to pressurize fluid in the lower control cavity 24, so that the fluid flows into the upper control cavity 22 through the second channel 29, a small amount of fluid flows into the upper control cavity 22 through the throttling devices 27 and 30 through the first channel 28, and the plunger rod 7 extends into the cavity 8 to change the volume of the cavity 8; when the plunger rod 7 moves upwards under the action of the plunger spring, the volume in the cavity 8 is increased, the reagent is sucked into the pipette tip 32 by using the negative pressure principle, meanwhile, the piston 23 moves upwards along with the plunger rod 7 to compress the fluid in the upper control chamber 22, the fluid in the upper control chamber 22 cannot return through the second channel 29 due to the action of a one-way valve arranged in the second channel, the pressurized fluid only returns to the lower control chamber through the first channels 26 and 28, and the fluid return speed is reduced under the action of the throttle valves of the first channels 26 and 28, so that the upward movement speed of the plunger rod 7 is reduced, the speed of the reagent flowing into the pipette tip 32 is controlled, and working fluid is prevented from entering the pipette gun to cause pollution during extraction of different working fluids, and subsequent experiments are influenced.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. A liquid transfer device is characterized by comprising an upper shell, a middle shell and a lower shell, wherein a liquid quantity adjusting sleeve is sleeved on the inner side of the upper shell and can rotate and move relative to the upper shell; an adjusting nut is sleeved on the inner side of the driven sleeve; the non-rotatable cover of screw nut sets up on the actuating lever, and the actuating lever can slide from top to bottom relative screw nut, set up a boss on the actuating lever with screw nut's lower terminal surface butt, driven telescopic bottom is provided with the screw thread, mechanical counter pass through the gear train with thread engagement, mechanical counter sets up in driven telescopic below the bottom of actuating lever is provided with at least one sand grip the bottom of going up the casing is provided with the board that restricts changeing, be provided with the confession on the board that restricts changeing the through-hole that the actuating lever passed, the through-hole be provided with in its radial direction with sand grip complex notch, through restrict changeing the board restriction the rotation of actuating lever.
2. The pipetting device of claim 1, wherein the middle housing is sealingly connected to the upper housing and the lower housing is sealingly connected to the middle housing.
3. A pipetting device as recited in claim 2 wherein the lower housing has a displacement device fixedly attached to the bottom thereof, the displacement device having a cavity formed therein for engagement with the plunger rod, and a pipette tip attached to the bottom of the displacement device.
4. Pipetting device according to claim 3, characterized in that the pipette tips are preferably KG series pipette tips manufactured by KIRGEN.
5. Pipetting device according to claim 1, characterized in that the connection between the adjusting nut and the driven sleeve is a fixed connection.
6. The pipette device according to claim 1, wherein the thread is an external thread provided at the bottom of the driven sleeve, the gear train includes a first transmission gear, a second transmission gear, and a third transmission gear, the first transmission gear and the second transmission gear are coaxially provided on the outer casing, the first transmission gear is engaged with the external thread, the third transmission gear provided at one end of the mechanical counter is engaged with the second transmission gear, and an axis of the third transmission gear is provided inside an axis of the second transmission gear, which is formed in a plane with an axis of the upper casing.
7. A pipetting device as recited in claim 1 wherein the adjustment roller is provided with a groove extending therethrough from an upper surface to a lower surface thereof.
8. The pipette device according to claim 1, wherein a viewing window is provided in a portion of the upper housing that is close to the mechanical counter.
9. Pipetting device according to claim 1, characterized in that a speed adjusting unit is arranged in the intermediate housing, which speed adjusting unit comprises an upper control chamber and a lower control chamber by controlling the flow of fluid between the upper control chamber and the lower control chamber.
10. An adjusting method of a liquid-transfering device according to claim 1, characterized in that when an operator uses the liquid-transfering device, the liquid amount adjusting sleeve drives the driven sleeve to rotate by manually screwing the adjusting roller, in the rotating process, under the action of a bearing or a limit boss and the like, the liquid amount adjusting sleeve and the driven sleeve do not axially move, the adjusting nut fixedly connected with the driven sleeve rotates, the adjusting nut drives the screw nut to move up and down, the screw nut acts on the boss of the driving rod to enable the driving rod to move up and down, the driving rod drives the plunger rod to move, the volume of the cavity is changed until the mechanical counter displays the required volume, and the adjustment of the suction amount of the liquid-transfering device is realized.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210190292.4A CN114505108B (en) | 2022-03-01 | 2022-03-01 | Pipetting device and adjusting method |
| CN202310437828.2A CN116550403A (en) | 2022-03-01 | 2022-03-01 | Pipetting device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210190292.4A CN114505108B (en) | 2022-03-01 | 2022-03-01 | Pipetting device and adjusting method |
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| CN202310437828.2A Division CN116550403A (en) | 2022-03-01 | 2022-03-01 | Pipetting device |
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| CN114505108B CN114505108B (en) | 2023-05-12 |
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| CN202310437828.2A Pending CN116550403A (en) | 2022-03-01 | 2022-03-01 | Pipetting device |
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| CN112387321A (en) * | 2019-08-15 | 2021-02-23 | 埃佩多夫股份公司 | Pipette with adjustable metering volume |
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| EP0181957A1 (en) * | 1984-11-20 | 1986-05-28 | HTL High-Tech Lab Herstellung und Vertrieb medizinisch technischer Erzeugnisse GmbH | Adjustable-volume pipette |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN116550403A (en) | 2023-08-08 |
| CN114505108B (en) | 2023-05-12 |
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