CN114503996A - Bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof - Google Patents
Bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof Download PDFInfo
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- CN114503996A CN114503996A CN202111676716.XA CN202111676716A CN114503996A CN 114503996 A CN114503996 A CN 114503996A CN 202111676716 A CN202111676716 A CN 202111676716A CN 114503996 A CN114503996 A CN 114503996A
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- Prior art keywords
- methyl
- sodium pyrithione
- benzisothiazole
- ketone
- benzisothiazol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilization preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione, belonging to the technical field of preservatives. The mass ratio of the 2-methyl-1, 2-benzisothiazole-3-ketone to the sodium pyrithione is 1: 0.01-1: 100, and the total amount of the preservative added after the 2-methyl-1, 2-benzisothiazole-3-ketone and the sodium pyrithione are used in combination is reduced, so that the production cost is saved, and the environment protection is facilitated.
Description
Technical Field
The invention belongs to the technical field of sterilization preservatives, and particularly relates to a sterilization preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof.
Background
Methyl-1, 2-benzisothiazol-3-one (MBIT) is commonly used in antimicrobial formulations, primarily as a preservative for products during in-can storage or storage, such as mud ash, adhesives, latex emulsions, tackifiers, mineral slurries, pigment dispersions, household products, and other aqueous products. And can also be used as a metal cutting fluid preservative for preventing the growth of microorganisms (bacteria and fungi).
The Sodium Pyrithione (SPT) belongs to a water-soluble industrial antiseptic and mildew preventive, is mainly used for daily chemical industry (shampoo and hair care products), can also be used for antibiosis and mildew prevention of products in the fields of building coatings, adhesives, sealants, pesticides, textiles, leather products, paper pulp, printing ink, metal processing liquid, water treatment, oilfield water injection systems and the like, and can also be prepared into products such as disinfectants, medical broad-spectrum antifungal dermatology medicines and the like.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to provide a sterilizing preservative containing 2-methyl-1, 2-benzisothiazol-3-one (MBIT) and Sodium Pyrithione (SPT) so as to provide a preservative with good sterilizing effect and low dosage.
The invention also aims to provide the application of the bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and Sodium Pyrithione (SPT) in the field of sterilization and mildew prevention.
The technical scheme is as follows: in order to solve the technical problems, the invention provides the following technical scheme:
the bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione comprises 2-methyl-1, 2-benzisothiazole-3-ketone and zinc pyrithione.
Preferably, the mass ratio of the 2-methyl-1, 2-benzisothiazol-3-one to the sodium pyrithione is 1:0.01 to 1: 100; further, the mass ratio of the 2-methyl-1, 2-benzisothiazole-3-ketone to the sodium pyrithione is 1: (0.5-2).
The application of the bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione is in the protection scope of the invention.
The bactericidal preservative can be directly added as a raw drug when being added, or can be added after being mixed by a solvent or a solid carrier, such as water, an organic solvent, a surfactant, paraffin, fiber, a metal carrier and the like.
The bactericidal preservative containing 2-methyl-1, 2-benzisothiazol-3-one and sodium pyrithione can be used in the following industries: industrial water (process water, cleaning water); gas purification (filter element, gas scrubber); water treatment (sewage treatment, seawater treatment, reverse osmosis filtration, RO membrane); a heat exchange device; the paper industry; industrial raw materials (starch, emulsion, dispersion, surfactant, auxiliaries); materials (plastics, special materials); the construction and coating industry (paints, emulsion paints, diatom oozes); adhesives (latex, silicone adhesive, industrial adhesives); the printing industry (printing liquids, inks, printing aids); the daily cosmetics industry (shampoos, body washes, detergents, soaps, laundry detergents, skin care products, cosmetics); an industrial cleaning agent; maintaining the product on the floor; metal working industries (metal working fluids, metal cutting fluids); industrial or mechanical oil (lubricating oil, hydraulic oil); leather treatment and leather product protection; the textile industry; wood and wood processing industries.
When the sterilization preservative is applied to preservation, a product can be directly added at any site in the production process, and the addition mode can be that two components are combined and then added according to a proportion, or the two components are separated at different sites and are separately added according to a proportion, so that the specified proportion and concentration in the product are finally achieved.
Has the advantages that: the invention discloses a composition containing 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and Sodium Pyrithione (SPT), wherein when in use, the mass ratio of the 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) to the Sodium Pyrithione (SPT) is 1:0.01 to 1:100, the antibacterial effect is better than that of any one of the components used alone under the same concentration. The combination mode of the invention needs lower adding amount than that of singly using one component, which is more beneficial to controlling the cost of the sterilizing preservative in the product and simultaneously ensures that the product is more environment-friendly.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the synergy index in the present invention is defined as follows:
synergy index
Synergy index (Si) ═ Ca/CA + Cb/CB
CA: the component A is used alone in a concentration required to achieve a certain antibacterial efficiency.
Ca: the component A and the component B are used cooperatively to reach the concentration of the component A when the same antibacterial efficiency is achieved.
CB: the B component used alone is the concentration required to achieve the same antimicrobial efficiency.
Cb: the component A and the component B are used cooperatively to reach the concentration of the component B when the same antibacterial efficiency is achieved.
Three bacterial suspensions, namely Escherichia coli (ATCC-8739), staphylococcus aureus (ATCC-6538) and pseudomonas aeruginosa (ATCC-9027), are mixed in equal amount to form a bacterial test group, and Aspergillus niger (ATCC-16404) spore suspension and Candida albicans (ATCC-10231) bacterial suspension are mixed in equal amount to form a fungal test group. The bacterial concentration is about 108cfu/ml, and the fungal concentration is about 107 cfu/ml. We record the concentrations (ppm) of two components when bacteria and fungi are reduced by more than or equal to 4log values in 24 hours according to different proportions of the two components of 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and Sodium Pyrithione (SPT), calculate a synergy index, and verify the synergy of the two components. The specific results are as follows:
TABLE 1 synergistic Effect of MBIT and SPT on bacteria
TABLE 1 synergistic Effect of MBIT and SPT on fungi
Claims (6)
1. The bactericidal preservative containing 2-methyl-1, 2-benzisothiazol-3-one and sodium pyrithione is characterized by comprising 2-methyl-1, 2-benzisothiazol-3-one and sodium pyrithione.
2. The bactericidal preservative containing 2-methyl-1, 2-benzisothiazol-3-one and sodium pyrithione according to claim 1, characterized in that the mass ratio of the 2-methyl-1, 2-benzisothiazol-3-one and the sodium pyrithione is 1:0.01 to 1: 100.
3. The bactericidal preservative containing 2-methyl-1, 2-benzisothiazol-3-one and sodium pyrithione according to claim 2, wherein the mass ratio of the 2-methyl-1, 2-benzisothiazol-3-one and the sodium pyrithione is 1: (1-2).
4. The application of the bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione.
5. The use according to claim 4, wherein the antimicrobial preservative comprising 2-methyl-1, 2-benzisothiazol-3-one and zinc pyrithione is added directly or after formulating with a solvent, a solid carrier.
6. The use according to claim 4, wherein the solvent is one or more of water, organic solvent, surfactant, and paraffin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111676716.XA CN114503996A (en) | 2021-12-31 | 2021-12-31 | Bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111676716.XA CN114503996A (en) | 2021-12-31 | 2021-12-31 | Bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114503996A true CN114503996A (en) | 2022-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111676716.XA Pending CN114503996A (en) | 2021-12-31 | 2021-12-31 | Bactericidal preservative containing 2-methyl-1, 2-benzisothiazole-3-ketone and sodium pyrithione and application thereof |
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| CN (1) | CN114503996A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283207A (en) * | 2005-10-04 | 2011-12-21 | 罗门哈斯公司 | Microbicidal composition |
| CN104270947A (en) * | 2012-05-24 | 2015-01-07 | 陶氏环球技术有限公司 | Microbicidal composition |
-
2021
- 2021-12-31 CN CN202111676716.XA patent/CN114503996A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283207A (en) * | 2005-10-04 | 2011-12-21 | 罗门哈斯公司 | Microbicidal composition |
| CN104270947A (en) * | 2012-05-24 | 2015-01-07 | 陶氏环球技术有限公司 | Microbicidal composition |
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