CN114365745A

CN114365745A - Preservative composition containing MBIT and OPP and application thereof

Info

Publication number: CN114365745A
Application number: CN202111676717.4A
Authority: CN
Inventors: 孔维峰; 郑晓平
Original assignee: Nanjing Tiansland Biotechnology Co ltd
Current assignee: Nanjing Tiansland Biotechnology Co ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2022-04-19

Abstract

The present invention discloses a preservative composition comprising MBIT and OPP, comprising: 2-methyl-1, 2-benzisothiazol-3-one, o-phenylphenol and/or a sodium salt thereof, and a weight ratio of the 2-methyl-1, 2-benzisothiazol-3-one to p-o-phenylphenol and/or a sodium salt thereof is 1:0.01 to 1: 100. The invention also discloses application of the preservative composition containing MBIT and OPP. The two preservative compositions of the invention require lower addition than one of the components used alone, which is more beneficial to controlling the cost of the sterilizing preservative in the product, and simultaneously, the product is more environment-friendly and has better market application prospect.

Description

Preservative composition containing MBIT and OPP and application thereof

Technical Field

The invention belongs to the technical field of sterilization preservatives, and particularly relates to a composition containing 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and o-phenylphenol (OPP) and application thereof.

Background

Methyl-1, 2-benzisothiazol-3-one (MBIT) is commonly used in antimicrobial formulations, primarily as an in-can storage preservative for products such as mud ash, adhesives, latex emulsions, tackifiers, mineral slurries, pigment dispersions, household products, and other aqueous products. And can also be used as a metal cutting fluid preservative for preventing the growth of microorganisms (bacteria and fungi).

The o-phenylphenol belongs to a deoxyribonuclease inhibitor and has broad-spectrum bactericidal and mildew-proof capabilities. The o-phenylphenol and its sodium salt are high-activity bactericide and disinfectant, are commonly used for fresh-keeping of fruits and vegetables and antiseptic sterilization in industrial production, and can also be used for preparation of plastic products and varnish.

Disclosure of Invention

The purpose of the invention is as follows: the invention aims to provide a preservative composition containing MBIT and OPP, and aims to solve the problems of large addition amount of a preservative and narrow bactericidal spectrum in the prior art.

The invention also aims to provide the application of the preservative composition containing MBIT and OPP in the field of sterilization and mildew prevention.

The technical scheme is as follows: in order to solve the technical problems, the invention provides the following technical scheme:

a preservative composition comprising MBIT and OPP comprising: 2-methyl-1, 2-benzisothiazol-3-one, o-phenylphenol and/or a sodium salt thereof.

The bacteria inhibited by the preservative composition include: escherichia coli (ATCC-8739), Staphylococcus aureus (ATCC-6538), Pseudomonas aeruginosa (ATCC-9027);

the fungi inhibited by the preservative composition comprise: aspergillus niger (ATCC-16404), Candida albicans (ATCC-10231).

Preferably, the weight ratio of the 2-methyl-1, 2-benzisothiazol-3-one to the p-phenylphenol and/or the sodium salt thereof is 1:0.01 to 1: 100; most preferably 2-methyl-1, 2-benzisothiazol-3-one (MBIT): the ratio of o-phenylphenol and/or its sodium salt (OPP) is 1 (10-20).

The bactericidal preservative of the invention can be added directly or after being mixed with a solvent or a solid carrier during the addition, wherein the solvent comprises: water, organic solvent, surfactant and paraffin, wherein the solid carrier comprises: fibers, metal supports.

Use of the preservative composition comprising MBIT and OPP as described above. The preservative compositions of MBIT and OPP of the present invention can be used in the following industries: industrial water (process water, cleaning water); gas purification (filter element, gas scrubber); water treatment (sewage treatment, seawater treatment, reverse osmosis filtration, RO membrane); a heat exchange device; the paper industry; industrial raw materials (starch, emulsion, dispersion, surfactant, auxiliaries); materials (plastics, special materials); the construction and coating industry (paints, emulsion paints, diatom oozes); adhesives (latex, silicone adhesive, industrial adhesives); the printing industry (printing liquids, inks, printing aids); the daily cosmetics industry (shampoos, body washes, detergents, soaps, laundry detergents, skin care products, cosmetics); an industrial cleaning agent; maintaining the product on the floor; metal working industries (metal working fluids, metal cutting fluids); industrial or mechanical oil (lubricating oil, hydraulic oil); leather treatment and leather product protection; the textile industry; wood and wood processing industries;

when the sterilization preservative is applied to preservation, a product can be directly added at any site in the production process, and the addition mode can be that two components are combined and then added according to a proportion, or the two components are separated at different sites and are separately added according to a proportion, so that the specified proportion and concentration in the product are finally achieved.

Has the advantages that: the invention discloses a composition containing 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and o-phenylphenol (OPP), and the invention comprises two active ingredients, namely 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and o-phenylphenol and/or sodium salt thereof (OPP)1:0.01 to 1: the combination of any proportion within 100 is better than the antibacterial effect of any component used alone under the same concentration, that is, the combination mode of the invention is used with lower addition amount than the addition amount required by using one component alone to achieve the same antibacterial effect, which is more beneficial to the cost control of the sterilizing preservative in the product and simultaneously leads the product to be more environment-friendly.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

the synergy index in the present invention is defined as follows:

synergy index (Si) ═ Ca/CA + Cb/CB

CA: when the component A is used independently, the concentration required by certain antibacterial efficiency is achieved.

Ca: the component A and the component B are used cooperatively to reach the concentration of the component A when the same antibacterial efficiency is achieved.

CB: the B component used alone is the concentration required to achieve the same antimicrobial efficiency.

Cb: the component A and the component B are used cooperatively to reach the concentration of the component B when the same antibacterial efficiency is achieved.

Three bacterial suspensions, namely Escherichia coli (ATCC-8739), staphylococcus aureus (ATCC-6538) and pseudomonas aeruginosa (ATCC-9027), are mixed in equal amount to form a bacterial test group, and Aspergillus niger (ATCC-16404) spore suspension and Candida albicans (ATCC-10231) bacterial suspension are mixed in equal amount to form a fungal test group. Bacteria concentration of about 10⁸cfu/ml, fungal concentration about 10⁷cfu/ml. We record the concentrations (ppm) of two components when bacteria and fungi are reduced by more than or equal to 4log values in 24 hours according to different proportions of the two components of 2-methyl-1, 2-benzisothiazole-3-ketone (MBIT) and o-phenylphenol (OPP), calculate a synergy index and verify the synergy of the two components. Specific results are shown in table 1. As can be seen from Table 1, when the mass ratio of 2-methyl-1, 2-benzisothiazol-3-one (MBIT) to o-phenylphenol (OPP) is 1: 10-20, the two bactericides have the best synergistic inhibition effect on bacteria and fungi.

TABLE 1 Effect of MBIT and OPP on bacteria

TABLE 2 Effect of MBIT and OPP on fungi

Claims

1. A preservative composition comprising MBIT and OPP comprising: 2-methyl-1, 2-benzisothiazol-3-one, o-phenylphenol and/or a sodium salt thereof.

2. Preservative composition according to claim 1, comprising MBIT and OPP, characterized in that the weight ratio of 2-methyl-1, 2-benzisothiazol-3-one to p-phenylphenol and/or the sodium salt thereof is 1:0.01 to 1: 100.

3. The preservative composition comprising MBIT and OPP according to claim 2, wherein the weight ratio of 2-methyl-1, 2-benzisothiazol-3-one to p-phenylphenol and/or a sodium salt thereof is 1 (10 to 20).

4. Use of the preservative composition comprising MBIT and OPP according to claim 1.

5. The use according to claim 4, wherein the preservative composition comprising MBIT and OPP is added after formulation with a solvent or a solid carrier.

6. Use according to claim 5, wherein the solvent comprises: water, organic solvent, surfactant and paraffin.

7. Use according to claim 4, wherein the preservative composition comprising MBIT and OPP is added during any process of product preparation.