CN114502572A - 展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 - Google Patents

展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 Download PDF

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CN114502572A
CN114502572A CN202080068157.1A CN202080068157A CN114502572A CN 114502572 A CN114502572 A CN 114502572A CN 202080068157 A CN202080068157 A CN 202080068157A CN 114502572 A CN114502572 A CN 114502572A
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N·P·金
B·菲亚拉
G·乌达
J·法拉斯
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University of Washington
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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CN202080068157.1A 2019-09-04 2020-09-03 展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 Pending CN114502572A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962895727P 2019-09-04 2019-09-04
US62/895,727 2019-09-04
PCT/US2020/049183 WO2021046207A1 (en) 2019-09-04 2020-09-03 Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use

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CN114502572A true CN114502572A (zh) 2022-05-13

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US (1) US20220306697A1 (https=)
EP (1) EP4025587A1 (https=)
JP (2) JP7818504B2 (https=)
CN (1) CN114502572A (https=)
WO (1) WO2021046207A1 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
WO2023133435A2 (en) * 2022-01-07 2023-07-13 University Of Washington Novel immunogens for influenza virus vaccines
AU2023273041A1 (en) * 2022-05-17 2024-12-05 Icosavax, Inc. Multivalent vaccine for paramyxoviruses and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180137234A1 (en) * 2016-11-16 2018-05-17 University Of Washington Computational Design of Self-Assembling Cyclic Protein Homo-oligomers
WO2018187325A1 (en) * 2017-04-04 2018-10-11 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2707385T3 (da) 2011-05-13 2017-11-20 Glaxosmithkline Biologicals Sa RSV-F-præfusionsantigener
EA201590683A1 (ru) 2012-11-20 2015-11-30 Глаксосмитклайн Байолоджикалс С.А. Тримеры rsv f, предшествующие слиянию
US20140141037A1 (en) 2012-11-20 2014-05-22 Novartis Ag Rsv f prefusion trimers
US9738689B2 (en) 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
FI2970398T3 (fi) 2013-03-13 2024-08-06 Us Health Rsv f -prefuusioproteiineja ja niiden käyttö
US9060975B2 (en) 2013-03-14 2015-06-23 Mucosis Bv Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions
JP6469081B2 (ja) 2013-04-25 2019-02-13 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 安定化された可溶性融合前ｒｓｖｆポリペプチド
MY171210A (en) 2013-06-17 2019-10-02 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f polypeptides
US20150166610A1 (en) 2013-10-14 2015-06-18 Glaxosmithkline Biologicals, S.A. Recombinant rsv antigens
CA2996762A1 (en) 2015-08-31 2017-03-09 Technovax, Inc. Human respiratory syncytial virus (hrsv) virus-like particles (vlps) based vaccine
EP3393512B1 (en) 2015-12-23 2025-11-19 Pfizer Inc. Rsv f protein mutants
US11174292B2 (en) 2016-03-29 2021-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Substitutions-modified prefusion RSV F proteins and their use
IL264119B2 (en) 2016-05-30 2023-04-01 Janssen Vaccines Prevention B V f proteins of rsv are stabilized before fusion
WO2017207477A1 (en) 2016-05-30 2017-12-07 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180137234A1 (en) * 2016-11-16 2018-05-17 University Of Washington Computational Design of Self-Assembling Cyclic Protein Homo-oligomers
WO2018187325A1 (en) * 2017-04-04 2018-10-11 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JESSICA MARCANDALLI ET AL.: "Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus", CELL, vol. 177, no. 6, pages 1420 - 1431 *

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EP4025587A1 (en) 2022-07-13
JP2022546813A (ja) 2022-11-09
US20220306697A1 (en) 2022-09-29
JP2025172875A (ja) 2025-11-26
JP7818504B2 (ja) 2026-02-20
WO2021046207A1 (en) 2021-03-11

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