CN114471761A - Can dismantle chip liquid drop and generate appearance - Google Patents
Can dismantle chip liquid drop and generate appearance Download PDFInfo
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- CN114471761A CN114471761A CN202210137130.4A CN202210137130A CN114471761A CN 114471761 A CN114471761 A CN 114471761A CN 202210137130 A CN202210137130 A CN 202210137130A CN 114471761 A CN114471761 A CN 114471761A
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- liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Abstract
The utility model provides a detachable chip liquid drop generator, which comprises a test tube, an instrument, a liquid output tube module and a gas output module, wherein the shell of the instrument is made of high-quality polystyrene material, and the gas output module is composed of an air compression pump, an air pressure controller and a control panel. The utility model utilizes the micro-channel chip technology to simulate the emulsification reaction, controls the liquid flow rate through the air pump, prepares the cell microcapsule bracket, the diameter, the degradation material and the additional factor of which are controllable, has uniform spheres, adopts the detachable module of the liquid output system, can carry out sterilization operation, can reduce the possible external pollution and cross contamination in the preparation of the microspheres to the utmost extent, and can better prepare the pollution-free cell microspheres.
Description
Technical Field
The utility model relates to the technical field of hydraulic microfluidic control, in particular to a detachable chip droplet generator.
Background
A microfluidic chip system comprises a chip and a split chip droplet generator, wherein the microfluidic chip technology (Microfluidics) integrates basic operation units of sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes on a micron-scale chip to automatically complete the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine and the like, the method has been developed into a new research field crossing the disciplines of biology, chemistry, medicine, fluid, electronics, materials, machinery and the like.
However, the existing chip droplet generation instruments are complex in structure and inconvenient to disassemble.
Disclosure of Invention
The object of the present invention is to solve at least one of the technical drawbacks mentioned.
Therefore, an object of the present invention is to provide a detachable chip droplet generator, which solves the above mentioned problems in the background art and overcomes the shortcomings of the prior art.
In order to achieve the above object, an embodiment of an aspect of the present invention provides a detachable chip droplet generator, which includes a test tube, an instrument, a liquid output tube module, and a gas output module, wherein a housing of the instrument is made of high-quality polystyrene material, and the gas output module is composed of an air compression pump, an air pressure controller, and a control panel.
Preferably, in any of the above embodiments, the apparatus is powered by 220 volts.
Preferably, according to any one of the above schemes, the test tube is cylindrical and is provided with a top cover, the top cover is provided with a sealing vent valve and a sealing liquid valve, wherein the inner part of the top cover of the sealing liquid valve is connected with a hose, the hose is in contact with the bottom of the test tube, and the outer part of the sealing liquid valve is connected with a thick hose for liquid output.
Preferably, in any of the above schemes, the gas output module is configured to prepare gas pressure by an air compression pump, adjust the gas pressure output by a gas pressure controller, output a certain positive pressure by the air compression pump, connect with a test tube sealing vent valve by a hose, press out and output the solvent in the test tube by the gas pressure, and adjust and control the gas pressure controller by using a control panel for output power.
Preferably, by any of the above schemes, the liquid output pipe module is of a detachable structure and comprises a thick hose and a thin hose which are connected with an adapter, the thick hose is connected with the liquid level valve of the test tube, the thick hose is connected with the thin hose through the adapter, liquid is transmitted into the thin hose from the thick hose, the thin hose is connected with the channel of the microfluidic chip, and the liquid output pipe module pipe can be subjected to aseptic treatment.
Preferably, in any of the above schemes, the gas output module instrument is a cuboid with an upper diameter of 65mm, a width of 36mm and a height of 25 mm; the chip card slot is 20mm long, 8mm wide and 10mm high, and the output system slot is 20mm long, 10mm wide and 10mm high; the test tube groove is 30mm long, 10mm wide and 23mm high.
Compared with the prior art, the utility model has the advantages and beneficial effects that:
the utility model utilizes the micro-channel chip technology to simulate the emulsification reaction, controls the liquid flow rate through the air pump, prepares the cell microcapsule bracket, the diameter, the degradation material and the additional factor of which are controllable, has uniform spheres, adopts the detachable module of the liquid output system, can carry out sterilization operation, can reduce the possible external pollution and cross contamination in the preparation of the microspheres to the utmost extent, and can better prepare the pollution-free cell microspheres.
Additional aspects and advantages of the utility model will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the utility model.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 and fig. 2 are schematic diagrams of a detachable chip droplet generator-liquid output tube module according to an embodiment of the present invention from different viewing angles;
FIGS. 3-5 are schematic diagrams of different viewing angles of a test tube of a detachable chip droplet generator-test tube in different states according to an embodiment of the present invention;
FIGS. 6-10 are schematic diagrams of a detachable chip droplet generator according to an embodiment of the present invention, showing different viewing angles of the front side;
FIGS. 11-13 are schematic diagrams of a detachable chip droplet generator according to an embodiment of the present invention, viewed from above in different states;
fig. 14 is a schematic perspective view of a detachable chip droplet generator according to an embodiment of the present invention.
Wherein: 1. a coarse hose liquid inlet valve; 2. a liquid outlet valve of the thin hose; 3. a converter; 4. a coarse hose; 5. a thin hose; 6. a liquid outlet pipe; 7. a test tube body; 8. a bottle mouth; 9. a liquid outlet hose; 10. a bottle cap; 11. an air inlet pipe; 12. a control panel; 13. a chip card slot; 14. an output system slot; 15. a test tube groove; 16. a test tube clamp; 17. an air outlet channel; 18. an air compression pump; 19. a gas pressure controller; 20. adjusting a valve; 21. an air hose.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the utility model and are not to be construed as limiting the utility model.
As shown in fig. 1 to 14, a liquid output module in the structure of the detachable chip droplet generator according to an embodiment of the present invention includes a thick-type hose liquid inlet valve 1, a converter 2, and a thin-type hose liquid outlet valve 3, where the thick-type hose liquid inlet valve 1 is connected to a thick-type hose 4, and the thin-type hose liquid outlet valve 3 is connected to a thin-type hose 5. The test tube comprises a test tube main body 7 and a bottle mouth 8 with a spiral groove, a bottle cap 10 with spiral lines comprises a liquid outlet tube 6, a liquid outlet hose 9 and an air inlet tube 11, the bottle cap 10 is aligned and screwed with the bottle mouth 8 to form a complete test tube, a control panel 12 is arranged at the front part outside the instrument, a chip clamping groove 13 is arranged at the rear part, the chip clamping groove 13 is connected with an output system groove 14, the output system groove 14 is connected with a test tube groove 15 in the middle part, the test tube groove 15 is provided with a test tube clamp 16 and an air outlet channel 17, the test tube clamp 16 can be used for loading a test tube, and the air outlet channel 17 is connected with the test tube air inlet tube 11 through an air outlet hose 21 and used for inputting air with air pressure into the test tube main body 7; the front part of the instrument is internally composed of an air outlet channel 17, an air compression pump 18, an air pressure controller 19 and a regulating valve 20, wherein the air compression pump 18 is connected with the regulating valve 20, the regulating valve 20 is controlled by the air pressure controller 19, the air pressure controller 19 is controlled and operated by an external control panel 12, and the air pressure controller 19 outputs air pressure generated by the air compression pump 18 to the outside through the air outlet channel 17.
The split chip liquid drop generator is connected with a power supply and can be normally used, and the control panel 12 is used for controlling gas output; the control panel 12 is connected to a gas pressure controller 19, and the gas pressure controller 19 adjusts and controls the regulating valve 20 to regulate the gas pressure output from the air compressor 18 and then output through the air outlet channel 17. Air outlet channel 17 passes through air hose 21 and links to each other with the test tube intake pipe 11 of test tube, with inside atmospheric pressure through test tube intake pipe 11 input test tube main part 7, press into out liquid hose 9 with the inside liquid of test tube main part 7, it links to each other with drain pipe 6 to go out liquid hose 9, drain pipe 6 links to each other with thick type hose feed liquor valve 1 that liquid output system can dismantle the module, the liquid that will extrude passes through thick type hose feed liquor valve 1 and inputs to liquid output system can dismantle the module in, and finally export on corresponding micro-fluidic chip by thin type hose drain valve 2.
The utility model adopts a split chip liquid drop generator, a chip liquid drop generator and test tubes, which comprises 3 air outlet channels 17, a control panel 12 and a test tube groove 15, wherein the test tube groove comprises 6 test tube clamps 16, an output system groove 14 and a chip clamping groove 13. The control panel 12 controls an internal gas pressure controller 19, the gas pressure controller 19 controls a regulating valve 20, the regulating valve 20 and the air compression pump 18, and the other end and the air outlet channel 17 for gas output. The device is connected with a test tube fixed in a test tube groove 13 and is connected with an air inlet pipe 11 of a test tube bottle cap 10, a liquid outlet pipe 6 of the bottle cap 10 is connected with a thick hose 4 in a detachable module of a liquid output system, the thick hose 4 is communicated with a thick hose liquid inlet valve 1 and a converter 2, and the converter 2 is connected with a thin hose 5 through a thin hose liquid outlet valve 3 on the surface.
The using method comprises the following steps:
the selected micro-fluidic chip is placed on the chip clamping groove, the sterilized test tube and the liquid output system are connected well, and meanwhile, liquid required to be injected into the chip is respectively placed into different test tubes. The power supply is turned on, the air pressure of the instrument is controlled through the display screen, so that the flow velocity of the liquid injected into the microfluidic chip reaches a certain stable value, and related experiments can be carried out.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
It will be understood by those skilled in the art that the present invention includes any combination of the summary and detailed description of the utility model described above and those illustrated in the accompanying drawings, which is not intended to be limited to the details and which, for the sake of brevity of this description, does not describe every aspect which may be formed by such combination. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made in the above embodiments by those of ordinary skill in the art without departing from the principle and spirit of the present invention. The scope of the utility model is defined by the appended claims and equivalents thereof.
Claims (6)
1. The utility model provides a can dismantle chip liquid drop and generate appearance, its characterized in that includes test tube, instrument, liquid output tube module and gaseous output module, and the instrument shell adopts high quality polyphenyl alkene material to make, and gaseous output module comprises air compression pump, air pressure controller and control panel.
2. The removable chip droplet generator of claim 1, wherein said generator is powered by 220 volts.
3. A detachable chip droplet generator according to claim 1, wherein the cuvette is cylindrical and has a top cover with a seal vent valve and a seal liquid valve, wherein the seal liquid valve is formed by partially linking a flexible tube to the top cover, the flexible tube is in contact with the bottom of the cuvette, and the seal liquid valve is externally connected to a wide flexible tube for liquid output.
4. The detachable chip droplet generator of claim 1, wherein the gas output module is configured to prepare a gas pressure by an air compression pump, adjust the gas pressure output by a gas pressure controller, output a positive pressure by the air compression pump, and connect with a test tube sealing vent valve through a hose, the gas pressure presses out the solvent in the test tube and outputs the solvent, and the output power of the gas output module can be adjusted and controlled by the gas pressure controller through a control panel.
5. The detachable chip droplet generator of claim 1, wherein the liquid outlet module is a detachable structure and comprises a thick hose and a thin hose, wherein the thick hose is connected to the liquid level valve of the test tube, the thick hose is connected to the thin hose through the adaptor, the liquid is introduced into the thin hose from the thick hose, the thin hose is connected to the channel of the microfluidic chip, and the liquid outlet module can be sterilized.
6. The detachable chip droplet generator according to claim 1, wherein the gas output module is a rectangular parallelepiped, 65mm in top, 36mm in width and 25mm in height; the chip card slot is 20mm long, 8mm wide and 10mm high, and the output system slot is 20mm long, 10mm wide and 10mm high; the test tube groove is 30mm long, 10mm wide and 23mm high.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210137130.4A CN114471761A (en) | 2022-02-15 | 2022-02-15 | Can dismantle chip liquid drop and generate appearance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210137130.4A CN114471761A (en) | 2022-02-15 | 2022-02-15 | Can dismantle chip liquid drop and generate appearance |
Publications (1)
| Publication Number | Publication Date |
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| CN114471761A true CN114471761A (en) | 2022-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210137130.4A Pending CN114471761A (en) | 2022-02-15 | 2022-02-15 | Can dismantle chip liquid drop and generate appearance |
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| JP2009136219A (en) * | 2007-12-06 | 2009-06-25 | Olympus Corp | Droplet-forming instrument, method for droplet formation, and method for nucleic acid amplification |
| WO2014201341A1 (en) * | 2013-06-14 | 2014-12-18 | Advanced Liquid Logic, Inc. | Droplet actuator and methods |
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Address after: 201, No. 33, Southeast Avenue, Changshu Hi tech Industrial Development Zone, Suzhou City, Jiangsu Province, 215500 Applicant after: Suzhou Century Coordinate Biotechnology Co.,Ltd. Address before: 300000 room 1-401-07, Dongli Lake Warner Jinghu Garden (Building 1, Jinghu science and Technology Park), Dongli District, Tianjin Applicant before: Tianjin Norway Baiao Technology Co.,Ltd. |