CN114471165A

CN114471165A - Cephalosporin fermentation liquor purification device and use method

Info

Publication number: CN114471165A
Application number: CN202210150907.0A
Authority: CN
Inventors: 王福清; 王福华; 许荔新
Original assignee: Zhongke Medical Industry Productivity And Promotion Center Co ltd
Current assignee: Zhongke Medical Industry Productivity And Promotion Center Co ltd
Priority date: 2022-02-18
Filing date: 2022-02-18
Publication date: 2022-05-13
Anticipated expiration: 2042-02-18
Also published as: CN114471165B

Abstract

The invention discloses a cephalosporin fermentation liquor purification device and a use method thereof, wherein the cephalosporin fermentation liquor purification device comprises: a support frame; the driving wheel is vertically arranged in a cylindrical shape, the driving wheel is driven to rotate by the driving device, the driving device is fixedly connected with the supporting frame, and a feeding hole penetrates through the middle part of the driving wheel; the cylinder is vertically arranged, the outer side of the cylinder is vertically and slidably connected with the support frame, the top and the bottom of the cylinder are both open, a first internal thread is arranged in the cylinder along the height direction of the cylinder, and the cylinder is screwed with the driving wheel through the first internal thread so as to drive the cylinder to move up and down; the horizontal plate is arranged below the cylinder body, a through hole is formed in the horizontal plate in a penetrating mode, and an ultrafiltration membrane is laid in the through hole; the water spraying pipe is positioned above the horizontal plate and sprays water towards the ultrafiltration membrane.

Description

Cephalosporin fermentation liquor purification device and use method

Technical Field

The invention relates to the technical field of separation and purification. More specifically, the invention relates to a cephalosporin fermentation liquid purification device and a use method thereof.

Background

The cephalosporin is called cephalosporin, and penicillin belongs to beta-lactam antibiotics, so that the cephalosporin is widely applied to semi-synthetic cephalosporin antibiotics containing cephem in molecules. Cephalosporin is industrially produced by a fermentation method, and is separated and purified by a solvent extraction method, wherein the solvent extraction method is provided according to the principle that a solute is transferred from one solvent to another solvent, so that the purposes of concentration, separation and purification are achieved, and when the antibiotic is separated, the selected solvent needs to be insoluble in water and has high solubility and selectivity for the antibiotic to be separated. Because the cephalosporin fermentation liquor contains a large amount of soluble biosurfactant impurities, the surfactants are dispersed in the filtrate and are in a colloidal state, so that when the cephalosporin fermentation liquor is separated and purified by using a solvent extraction method, an aqueous phase and an organic solvent phase are difficult to separate, the separation speed is reduced, and the separation is difficult.

In order to solve the problem, in the prior art, when a cephalosporin fermentation broth is purified, the fermentation broth is filtered by medium-speed filter paper to remove solid particulate impurities in the fermentation broth, then the fermentation broth is filtered by a microfiltration membrane to obtain a relatively clear solution, and the relatively clear solution is subjected to ultrafiltration by an ultrafiltration membrane to remove surfactant impurities in the fermentation broth.

After the ultrafiltration membrane is used for filtering for a long time, colloidal particles, microparticles, biological macromolecules and the like in the surfactant can block the ultrafiltration membrane, so that the filtering efficiency of the ultrafiltration membrane is reduced.

Disclosure of Invention

An object of the present invention is to solve at least the above problems and to provide at least the advantages described later.

The invention also aims to provide a cephalosporin fermentation liquor purification device and a use method thereof, and the ultrafiltration membrane is cleaned in a mechanical manner, so that the device is simple, convenient and quick.

To achieve these objects and other advantages in accordance with the present invention, there is provided an apparatus for purifying a cephalosporin fermentation broth, comprising:

the support frame is fixedly connected with the ground;

the driving wheel is vertically arranged in a cylindrical shape, the driving wheel is driven to rotate by a driving device, the driving device is fixedly connected with the supporting frame, and a feeding hole penetrates through the middle of the driving wheel;

the cylinder body is vertically arranged, the outer side of the cylinder body is vertically and slidably connected with the support frame, the top and the bottom of the cylinder body are both open, first internal threads are arranged in the cylinder body along the height direction of the cylinder body, and the cylinder body is screwed with the driving wheel through the first internal threads so as to drive the cylinder body to move up and down;

the horizontal plate is arranged below the cylinder body, a through hole is formed in the horizontal plate in a penetrating mode, and an ultrafiltration membrane is laid in the through hole;

a water spray pipe located above the horizontal plate, the water spray pipe spraying water towards the ultrafiltration membrane;

the containing box is arranged below the ultrafiltration membrane and is used for containing sewage;

the barrel is arranged in such a way that when the barrel moves to the lowest position, the bottom of the barrel is abutted to the horizontal plate, the ultrafiltration membrane is positioned in the barrel, and the water spray pipe is positioned outside the barrel.

Preferably, a plurality of drainage holes are formed in the horizontal plate in a penetrating manner, and when the cylinder abuts against the horizontal plate, the drainage holes are located on the outer side of the cylinder.

Preferably, the method further comprises the following steps:

the sleeve is coaxially sleeved on the outer side of the barrel and fixedly connected with the support frame, an annular water inlet pipe is fixedly arranged on the inner wall of the lower part of the sleeve along the circumferential direction of the sleeve, the water inlet pipe comprises a C-shaped pipe with a C-shaped longitudinal section and an annular plate which is arranged at the opening of the C-shaped pipe and is rotatably connected with the C-shaped pipe, a water inlet port communicated with the outside is arranged on one side of the C-shaped pipe, which is far away from the annular plate, a water outlet port is arranged on the annular plate, and the water outlet port is communicated with the water spray pipe through a pipeline;

rotatory ring, its level is located telescopic inside, and the cover is established the outside of barrel, rotatory ring is located the top of horizontal plate, rotatory ring with the sleeve rotates the joint, rotatory ring's top is equipped with the spout along circumference, the action wheel pass through the slide bar with spout slip joint, lay in the spout and inhale the material, the slide bar with the tip of spout slip joint is equipped with the electro-magnet that corresponds with magnetism and inhale the material, the spray pipe with rotatory jogged joint.

Preferably, the first internal thread of the cylinder is positioned at the middle upper part, and the distance between the bottom of the first internal thread of the cylinder and the bottom of the cylinder is equal to the height of the driving wheel;

the top of barrel is equipped with stop device, stop device includes the first board that the level was placed, and the level is located the second board of first board top, the first board with through first spring coupling between the second board, the second board with the support frame rigid coupling works as the barrel removes to highest position, and just with when the action wheel is unscrewed soon, the barrel with first board butt, first spring is in compression state.

Preferably, the water spraying device further comprises an annular pipe which is coaxially arranged below the driving wheel, the top of the annular pipe is fixedly connected with the driving wheel, the annular pipe is communicated with a water pipe, the water pipe is used for conveying water into the annular pipe, a water spraying head matched with the first internal thread of the barrel, a brush with bristles and a scraping plate are sequentially arranged below the annular pipe from bottom to top, the water spraying head, the brush and the scraping plate are connected with the annular pipe and attached to the first internal thread of the barrel, and the water spraying head is communicated with the annular pipe.

Preferably, an inner tube is coaxially sleeved on the inner side of the annular tube and fixedly connected with the annular tube, a second internal thread is arranged in the inner tube, a moving tube is coaxially sleeved in the inner tube and coaxially sleeved with an external thread, the outer side of the moving tube is provided with an external thread, the moving tube is screwed with the inner tube, a fixed rod is coaxially sleeved in the moving tube and vertically slidably clamped with the fixed rod, an elastic rope is connected between the top of the moving tube and the fixed rod, the top of the fixed rod penetrates through the driving wheel and is fixedly connected with the support frame, and an elastic limiting part is arranged on the fixed rod;

the sprinkler head is plate-shaped, one end of the sprinkler head is communicated with the annular pipe through a connecting pipe, the sprinkler head is hinged with the connecting pipe, one side of the sprinkler head, which is far away from the horizontal plate, is connected with the connecting pipe through an elastic piece, when the sprinkler head is attached to the internal thread of the cylinder body, the elastic piece is in a natural extension state, and a rope is connected between one side of the sprinkler head, which is close to the horizontal plate, and the bottom of the moving pipe;

the moving pipe is arranged in a manner that the moving direction of the moving pipe is opposite to the moving direction of the cylinder, when the sprinkler head leaves the first internal thread of the cylinder, the moving pipe moves to the lowest position, the moving pipe is unscrewed from the inner pipe, the elastic rope is in a stretching state, and the rope is in a tensioning state, so that the other end of the sprinkler head is abutted against the inner side wall of the cylinder; when the barrel moves to the lowest position, the moving pipe moves to the highest position, the moving pipe is screwed with the inner pipe in a loosening mode, the top of the moving pipe is abutted to the elastic limiting part, the elastic limiting part is in a compression state, and the rope is in a tensioning state.

Preferably, the elastic limiting member includes a third plate sleeved outside the fixing rod, the third plate is fixed to the fixing rod, a fourth plate is located below the third plate, the fourth plate is sleeved outside the fixing rod, a second spring is connected between the fourth plate and the third plate, when the movable pipe moves to the highest position, the top of the movable pipe abuts against the fourth plate, and the second spring is in a compressed state.

Preferably, a water spraying pipeline is arranged below the water spraying head, is communicated with the annular pipe and sprays water towards the inner side wall of the barrel.

The use method of the cephalosporin fermentation liquor purification device comprises the following steps:

s1, driving a driving wheel to move the cylinder body, and enabling the bottom of the cylinder body to be abutted against the horizontal plate so as to seal the bottom of the cylinder body;

s2, feeding materials into the barrel through the feed inlet, and filtering the fed materials through the ultrafiltration membrane;

s3, after filtration is finished, when the ultrafiltration membrane needs to be cleaned, firstly, the cylinder is moved upwards to the position where the cylinder is far away from the horizontal plate by rotating a driving wheel;

s4, placing the containing box below the horizontal plate, opening the water spray pipe to spray pure water to clean the ultrafiltration membrane, spraying 0.4% (wt) NaOH solution to the ultrafiltration membrane after cleaning the surface of the ultrafiltration membrane, and finally spraying pure water to the ultrafiltration membrane until the ultrafiltration membrane is cleaned to be neutral;

s5, after the washing in step S4, the cylinder is moved downward to abut against the horizontal plate by driving a driving wheel.

The invention at least comprises the following beneficial effects:

firstly, when the ultrafiltration membrane needs to be cleaned, the rotary driving wheel drives the cylinder to move upwards to enable the cylinder to be away from the water flat plate, and after the cylinder leaves the horizontal plate, the water spraying pipe is opened to spray water towards the ultrafiltration membrane to clean the ultrafiltration membrane.

Secondly, when the barrel moves to a certain height, the barrel is unscrewed from the driving ring, the barrel is not driven to move by the rotation of the driving ring at the moment, the electromagnet on the sliding rod is electrified and is attracted with the chute in the rotating ring, the driving ring drives the sliding rod, the sliding rod drives the rotating ring to rotate, the rotating ring drives the spray pipe to rotate, the spray pipe can spray water relative to the ultrafiltration membrane in a rotating mode instead of spraying water at a fixed position, the cleaning is more thorough, after the cleaning is finished, the electromagnet is powered off and is not attracted with the rotating ring, meanwhile, the driving ring rotates reversely, the driving ring is screwed with the barrel again at the moment, the driving ring drives the barrel to move downwards to abut against the horizontal plate, the bottom of the barrel is sealed by the horizontal plate, the filtering operation can be started again, and the whole process is rapid and convenient.

And thirdly, the water spraying head, the brush and the scraper are arranged in the barrel from bottom to top, the water spraying head, the brush and the scraper are attached to the first internal thread of the barrel, and when the barrel rotates, the water spraying head, the brush and the scraper can rotate along the first internal thread to clean the first internal thread, so that the cleaning mode is thorough and clean.

Fourthly, an inner pipe is arranged in the annular pipe, a moving pipe is screwed in the inner pipe, a fixed rod is vertically clamped in the moving pipe in a sliding manner, the moving direction of the moving pipe is opposite to that of the barrel, when the barrel moves upwards, the driving wheel drives the annular pipe to rotate, the annular pipe drives the inner pipe to rotate, the inner pipe rotates to enable the moving pipe to move downwards, when the sprinkler head leaves the first internal thread, the moving pipe moves to the lowest position, the sprinkler head is pulled by the moving pipe through a rope at the moment, the sprinkler head is abutted against the inner side wall of the barrel to play a role of scraping the inner side wall of the barrel, the inner side wall of the barrel can be cleaned more strongly, the elastic rope between the moving pipe and the fixed rod is in a tensioning state, the moving pipe and the inner pipe are in an unscrewing state, namely, the moving pipe cannot be driven to move by the rotation of the driving wheel, when the cleaning of the ultrafiltration membrane is completed, the driving wheel rotates reversely, and the barrel moves downwards, at the moment, the movable pipe is screwed with the inner pipe again to enable the movable pipe to move upwards, at the moment, the rope between the movable pipe and the sprinkler head is loosened, the sprinkler head is restored to the original state under the action of the elastic piece, the sprinkler head can be attached to the first inner thread of the cylinder again in the downward rotating process of the cylinder, when the cylinder rotates to the lowest position, the movable pipe moves to the highest position, at the moment, the movable pipe is screwed with the inner pipe in an unscrewing mode, meanwhile, the top of the movable pipe is abutted to the elastic limiting piece to enable the movable pipe to be screwed with the inner pipe again at any time, and through the structure, the side wall of the cylinder without the first inner thread can be thoroughly cleaned.

Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.

Drawings

FIG. 1 is a cross-sectional view of a cephalosporin fermentation broth purification device in filtration according to one embodiment of the present invention;

FIG. 2 is an enlarged view of a portion A of FIG. 1;

FIG. 3 is a sectional view of a device for purifying cephalosporin fermentation broth in an upward movement process of a cylinder of the device according to one embodiment of the present invention;

FIG. 4 is a cross-sectional view of the device for purifying cephalosporin fermentation broth in accordance with one embodiment of the present invention when the barrel is moved to the uppermost position.

Reference numerals: the device comprises a driving wheel 1, a cylinder 2, a horizontal plate 3, an ultrafiltration membrane 4, a water spray pipe 5, a containing box 6, a sleeve 7, a C-shaped pipe 8, an annular plate 9, a rotating ring 10, a first plate 11, a second plate 12, a first spring 13, an annular pipe 14, a water spray head 15, a brush 16, a scraper 17, an inner pipe 18, a moving pipe 19, a fixing rod 20, an elastic rope 21, an elastic limiting piece 22, a connecting pipe 23, an elastic piece 24, a third plate 25, a fourth plate 26, a second spring 27, a water spray pipeline 28 and a rope 29.

Detailed Description

The present invention is further described in detail below with reference to the attached drawings so that those skilled in the art can implement the invention by referring to the description text.

It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or combinations thereof.

As shown in fig. 1-4, the present invention provides a cephalosporin fermentation broth purification device, which comprises:

the support frame is fixedly connected with the ground;

the driving wheel 1 is vertically arranged and cylindrical, the driving wheel 1 is driven to rotate through a driving device, the driving device is fixedly connected with the supporting frame, and a feeding hole penetrates through the middle part of the driving wheel 1;

the barrel body 2 is vertically arranged, the outer side of the barrel body 2 is vertically and slidably connected with the support frame, the top and the bottom of the barrel body 2 are both open, first internal threads are arranged in the barrel body 2 along the height direction of the barrel body, and the barrel body 2 is screwed with the driving wheel 1 through the first internal threads so as to drive the barrel body 2 to move up and down;

the horizontal plate 3 is arranged below the cylinder 2, a through hole is formed in the horizontal plate 3 in a penetrating mode, and an ultrafiltration membrane 4 is laid in the through hole;

a water spray pipe 5 located above the horizontal plate 3, the water spray pipe 5 spraying water toward the ultrafiltration membrane 4;

the containing box 6 is arranged below the ultrafiltration membrane 4 and is used for containing sewage;

when the cylinder 2 moves to the lowest position, the bottom of the cylinder 2 abuts against the horizontal plate 3, the ultrafiltration membrane 4 is located inside the cylinder 2, and the water spray pipe 5 is located outside the cylinder 2.

In the technical scheme, the cephalosporin fermentation liquor purification device comprises a support frame, a driving wheel 1, a cylinder 2, a horizontal plate 3, a water spray pipe 5 and a containing box 6, the invention does not limit the specific shape of the support frame, and the cephalosporin fermentation liquor purification device plays a role of fixing and supporting other structures, the driving wheel 1 is driven by a driving device such as a motor, the cylinder 2 is a hollow columnar body which is screwed with the driving wheel 1 in a mode of figure 1, and the outer side of the cylinder 2 is vertically clamped with the support frame in a sliding way, so that the cylinder 2 can be driven to move up and down when the driving wheel 1 rotates, when the cylinder 2 moves to the lowest position, the bottom of the cylinder 2 is abutted against the horizontal plate 3, so that objects to be filtered can be filtered, when the ultrafiltration membrane 4 needs to be cleaned, the driving wheel 1 is rotated to enable the cylinder 2 to move up, then the water spray pipe 5 is opened, water is sprayed to the ultrafiltration membrane 4 through the water spray pipe 5, the ultrafiltration membrane cleaning device is used for cleaning the ultrafiltration membrane 4, and after cleaning is completed, the barrel body 2 is moved to abut against the horizontal plate 3.

In another technical scheme, a plurality of drainage holes penetrate through the horizontal plate 3, and when the cylinder 2 abuts against the horizontal plate 3, the drainage holes are located on the outer side of the cylinder 2, so that water for washing the ultrafiltration membrane 4 is drained from the drainage holes.

In another technical solution, the method further comprises:

the sleeve 7 is coaxially sleeved on the outer side of the barrel 2 and fixedly connected with the support frame, an annular water inlet pipe is fixedly arranged on the inner wall of the lower portion of the sleeve 7 along the circumferential direction of the sleeve, the water inlet pipe comprises a C-shaped pipe 8 with a C-shaped longitudinal section and an annular plate 9 which is arranged at the opening of the C-shaped pipe 8 and is rotatably connected with the C-shaped pipe, a water inlet port communicated with the outside is arranged on one side, away from the annular plate 9, of the C-shaped pipe 8, a water outlet port is arranged on the annular plate 9, and the water outlet port is communicated with the water spray pipe 5 through a pipeline;

rotatory ring 10, its level is located the inside of sleeve 7, and the cover is established the outside of barrel 2, rotatory ring 10 is located the top of horizontal plate 3, rotatory ring 10 with sleeve 7 rotates the joint, the top of rotatory ring 10 is equipped with the spout along circumference, action wheel 1 pass through the slide bar with spout slip joint, laid the material of inhaling in the spout, the slide bar with the tip of spout slip joint is equipped with the electro-magnet that corresponds with the material of inhaling, spray pipe 5 with rotatory ring 10 is connected.

Adopt this kind of mode, leave behind horizontal plate 3 when barrel 2, the slide bar can drive rotatory ring 10 rotation with rotatory ring 10 actuation, and rotatory ring 10 rotation drives spray pipe 5 rotation, and spray pipe 5 rotation drives annular plate 9 rotation to make spray pipe 5 rotate along the periphery of milipore filter 4, spray water washing milipore filter 4 in the rotation, the abluent cleaner, quick of this kind of mode. Wherein, the attraction force of the electromagnet on the sliding rod after being electrified is large enough to enable the rotating ring 10 to rotate in the horizontal direction, as shown in figure 1, the annular plate 9 is hollow and communicated with the water spraying pipe 5, and the water passing through the C-shaped pipe 8 can enter the annular plate 9 and then enter the water spraying pipe 5.

In another technical scheme, the first internal thread of the cylinder 2 is positioned at the middle upper part, and the distance between the bottom of the first internal thread of the cylinder 2 and the bottom of the cylinder 2 is equal to the height of the driving wheel 1;

the top of barrel 2 is equipped with stop device, stop device includes the first board 11 that the level was placed, and the level is located the second board 12 of first board 11 top, first board 11 with connect through first spring 13 between the second board 12, second board 12 with the support frame rigid coupling works as barrel 2 removes to the highest position, and just with during the unwrapping spiral shell of action wheel 1 closes, barrel 2 with first board 11 butt, first spring 13 is in compression state.

By adopting the scheme, after the barrel body 2 moves to a certain height, the barrel body 2 is unscrewed from the driving wheel 1, at the moment, the driving wheel 1 rotates and does not drive the barrel body 2 to move, the electromagnet on the sliding rod is electrified and is attracted with the sliding groove in the rotating ring 10, the driving wheel 1 drives the sliding rod, the sliding rod drives the rotating ring 10 to rotate, the rotating ring 10 drives the spray pipe 5 to rotate, the spray pipe 5 can spray water relative to the ultrafiltration membrane 4 in a rotating mode instead of spraying water at a fixed position, so that the cleaning is more thorough, after the cleaning is finished, the electromagnet is powered off and is not attracted with the rotating ring 10, meanwhile, the driving wheel 1 rotates reversely, at the moment, the driving wheel 1 is screwed with the barrel body 2 again, the driving wheel 1 drives the barrel body 2 to move downwards to abut against the horizontal plate 3, so that the horizontal plate 3 seals the bottom of the barrel body 2, the filtering operation can be started again, and the whole process is rapid and convenient.

The limiting device is used for abutting the barrel 2 through the limiting device when the barrel 2 rotates to the highest height, a downward force is given to the barrel 2, the bottom of a first internal thread in the barrel 2 is in contact with the top of a thread of the driving wheel 1, and when the driving wheel 1 rotates reversely, the barrel 2 can be easily screwed with the driving wheel 1.

The purpose that the height of the first internal thread is smaller than that of the cylinder 2 is that when the cylinder 2 is unscrewed with the driving wheel 1, the cylinder 2 can still be sleeved on the outer side of the driving wheel 1, so that the cylinder 2 cannot shake randomly.

In another technical scheme, the water spraying device further comprises an annular pipe 14 which is coaxially arranged below the driving wheel 1, the top of the annular pipe is fixedly connected with the driving wheel 1, the annular pipe 14 is communicated with a water conveying pipe, the water conveying pipe is used for conveying water into the annular pipe 14, a water spraying head 15, a brush 16 with bristles and a scraping plate 17 which are matched with the first internal thread of the cylinder 2 are sequentially arranged below the annular pipe 14 from bottom to top, the water spraying head 15, the brush 16 and the scraping plate 17 are all connected with the annular pipe 14 and attached to the first internal thread of the cylinder 2, the water spraying head 15 is communicated with the annular pipe 14, the specific structure is shown in fig. 2, the water spraying head 15 is used for spraying water to the first internal thread, the brush 16 is used for cleaning the first internal thread, the scraping plate 17 is used for scraping water stains on the first internal thread, when the cylinder 2 rotates, the sprinkler head 15, the brush 16 and the scraper 17 can rotate along the first internal thread to clean the first internal thread, and the cleaning mode can clean the first internal thread thoroughly.

In another technical scheme, an inner tube 18 is coaxially sleeved on the inner side of the annular tube 14, the inner tube 18 is fixedly connected with the annular tube 14, a second internal thread is arranged in the inner tube 18, a moving tube 19 is coaxially sleeved in the inner tube 18, an external thread is arranged on the outer side of the moving tube 19, the moving tube 19 is screwed with the inner tube 18, a fixing rod 20 is coaxially sleeved in the moving tube 19, the moving tube 19 is vertically and slidably clamped with the fixing rod 20, an elastic rope 21 is connected between the top of the moving tube 19 and the fixing rod 20, the top of the fixing rod 20 penetrates through the driving wheel 1 and is fixedly connected with the support frame, and an elastic limiting piece 22 is arranged on the fixing rod 20;

the sprinkler head 15 is plate-shaped, one end of the sprinkler head 15 is communicated with the annular pipe 14 through a connecting pipe 23, the sprinkler head 15 is hinged with the connecting pipe 23, one side of the sprinkler head 15 far away from the horizontal plate 3 is connected with the connecting pipe 23 through an elastic piece 24, when the sprinkler head 15 is attached to the internal thread of the cylinder 2, the elastic piece 24 is in a natural extension state, and a rope 29 is connected between one side of the sprinkler head 15 close to the horizontal plate 3 and the bottom of the moving pipe 19;

the moving pipe 19 is disposed such that the moving direction of the moving pipe 19 is opposite to the moving direction of the cylinder 2, and when the sprinkler head 15 is separated from the first internal thread of the cylinder 2, the moving pipe 19 moves to the lowest position, the moving pipe 19 is unscrewed from the inner pipe 18, the elastic cord 21 is in a stretched state, and the cord 29 is in a tensioned state such that the other end of the sprinkler head 15 abuts against the inner wall of the cylinder 2; when the barrel 2 moves to the lowest position, the moving tube 19 moves to the highest position, the moving tube 19 is unscrewed from the inner tube 18, the top of the moving tube 19 is abutted against the elastic limiting part 22, the elastic limiting part 22 is in a compressed state, and the rope 29 is in a tensioned state.

In the above technical solution, an inner tube 18 is arranged in an annular tube 14, a moving tube 19 is screwed in the inner tube 18, a fixed rod 20 is vertically slidably clamped in the moving tube 19, the moving direction of the moving tube 19 is opposite to that of the barrel 2, when the barrel 2 moves upwards, the driving wheel 1 drives the annular tube 14 to rotate, the annular tube 14 drives the inner tube 18 to rotate, the inner tube 18 rotates to make the moving tube 19 move downwards, when the sprinkler head 15 leaves a first internal thread, the moving tube 19 moves to the lowest position, at this time, the moving tube 19 pulls the sprinkler head 15 through a rope 29 to make the sprinkler head 15 abut against the inner side wall of the barrel 2, so as to play a role of scraping the inner side wall of the barrel 2, and wash the inner side wall of the barrel 2 with more strength, at this time, an elastic rope 21 between the moving tube 19 and the fixed rod 20 is in a tensioned state, and the moving tube 19 and the inner tube 18 are in an unthreaded state, that the moving tube 19 is not driven by the rotation of the driving wheel 1 to move, after the ultrafiltration membrane 4 is cleaned, the driving wheel 1 rotates reversely, the cylinder body 2 moves downwards, the moving pipe 19 is screwed with the inner pipe 18 again at the moment, the moving pipe 19 moves upwards, the rope 29 between the moving pipe 19 and the sprinkler head 15 is loosened at the moment, the sprinkler head 15 returns to the original state under the action of the elastic piece 24, the sprinkler head 15 can be attached to the first inner thread of the cylinder body 2 again in the downward rotation process of the cylinder body 2, when the cylinder body 2 rotates to the lowest position, the moving pipe 19 moves to the highest position, the moving pipe 19 is unscrewed from the inner pipe 18 at the moment, the top of the moving pipe 19 is abutted to the elastic limiting piece 22, and the elastic limiting piece 22 can be screwed with the inner pipe 18 again at any time.

The elastic rope 21 is used for limiting the position of the moving tube 19 by the elastic piece 24 when the moving tube 19 moves to the lowest position, so that the thread at the top of the moving tube 19 can be contacted with the thread at the bottom of the inner tube 18, and the inner tube 18 and the moving tube 19 can be screwed together again when the inner tube 18 rotates reversely;

the function of the elastic limiting piece 22 is basically consistent with that of the elastic rope 21, when the moving pipe 19 moves to the highest position, the elastic limiting piece 22 plays a limiting role on the moving pipe 19, so that the thread at the bottom of the moving pipe 19 is contacted with the thread at the top of the inner pipe 18, and the inner pipe 18 is screwed with the moving pipe 19 again when the inner pipe 18 rotates reversely;

the connecting pipe 23 is articulated with the one end of sprinkler bead 15, be connected through elastic component 24 between sprinkler bead 15 and the connecting pipe 23 simultaneously, elastic component 24 can be other components such as spring, when rope 29 is in the state of relaxing, under elastic component 24's effect, sprinkler bead 15 can laminate with first internal thread, when rope 29 gives sprinkler bead 15 a pulling force, sprinkler bead 15 can carry out the butt with the inside wall of barrel 2, play a clear effect to the inside wall of barrel 2.

In another technical solution, the elastic limiting member 22 includes a third plate 25 sleeved on the outside of the fixing rod 20, the third plate 25 is fixed to the fixing rod 20, a fourth plate 26 located below the third plate 25, the fourth plate 26 is sleeved on the outside of the fixing rod 20, a second spring 27 is connected between the fourth plate 26 and the third plate 25, when the moving tube 19 moves to the highest position, the top of the moving tube 19 abuts against the fourth plate 26, the second spring 27 is in a compressed state, and the specific structure of the elastic limiting member 22 is as shown in fig. 3, and is composed of the third plate 25, the fourth plate 26 and the second spring 27, and is used for limiting the moving tube 19.

In another technical solution, a water spraying pipe 28 is arranged below the water spraying head 15, the water spraying pipe 28 is communicated with the annular pipe 14 and sprays water towards the inner side wall of the cylinder 2, when the water spraying head 15 abuts against the inner side wall of the cylinder 2, the water spraying pipe 28 firstly sprays water to the inner side wall of the cylinder 2, and then the water spraying head 15 scrapes off stains on the inner side wall of the cylinder 2, so as to clean the cylinder.

s1, driving the driving wheel 1 to move the cylinder 2, and making the bottom of the cylinder 2 abut against the horizontal plate 3 to seal the bottom of the cylinder 2;

s2, feeding materials into the cylinder body 2 through the feed inlet, and filtering the fed materials through the ultrafiltration membrane 4;

s3, after filtration is finished, when the ultrafiltration membrane 4 needs to be cleaned, firstly, the barrel 2 is moved upwards to the position where the barrel 2 is far away from the horizontal plate 3 by rotating the driving wheel 1;

s4, placing the containing box 6 below the horizontal plate 3, opening the water spray pipe 5 to spray pure water to the ultrafiltration membrane 4 for cleaning, spraying 0.4% (wt) NaOH solution to the ultrafiltration membrane 4 after cleaning the surface of the ultrafiltration membrane 4, and finally spraying pure water to the ultrafiltration membrane 4 until the ultrafiltration membrane 4 is cleaned to be neutral;

s5, after the washing in step S4, the drum 2 is moved downward by driving the driver 1 to abut against the horizontal plate 3.

The ultrafiltration membrane 4 is washed by pure water, then the ultrafiltration membrane 4 is washed by NaOH solution, which helps to open the clogged pores of the ultrafiltration membrane 4, and finally the ultrafiltration membrane 4 is washed to be neutral by pure water, thereby completing the washing of the ultrafiltration membrane 4.

The number of apparatuses and the scale of the process described herein are intended to simplify the description of the present invention. Applications, modifications and variations of the apparatus for purifying a cephalosporin fermentation broth and the method of use of the present invention will be apparent to those skilled in the art.

While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.

Claims

1. Cephalosporin fermentation liquor purification device, which is characterized by comprising:

the support frame is fixedly connected with the ground;

2. The apparatus for purifying cephalosporin fermentation solution according to claim 1, characterized in that a plurality of drainage holes are provided through the horizontal plate, and when the cylinder body abuts against the horizontal plate, the plurality of drainage holes are located outside the cylinder body.

3. The apparatus for purifying cephalosporin fermentation broth according to claim 2, further comprising:

rotatory ring, its level is located telescopic inside, and the cover is established the outside of barrel, rotatory ring is located the top of horizontal plate, rotatory ring with the sleeve rotates the joint, rotatory ring's top is equipped with the spout along circumference, the action wheel pass through the slide bar with spout slip joint, laid the magnetism in the spout and inhaled the material, the slide bar with the tip of spout slip joint is equipped with the electro-magnet that corresponds with magnetism and inhales the material, the spray pipe with rotatory ring connection.

4. The apparatus for purifying cephalosporin fermentation solution in claim 3, characterized in that the first internal thread of the cylinder is located at the upper part of the cylinder, and the distance between the bottom of the first internal thread of the cylinder and the bottom of the cylinder is equal to the height of the driving wheel;

5. The cephalosporin fermentation liquid purification device according to claim 4, further comprising an annular tube coaxially disposed below the driving wheel, wherein the top of the annular tube is fixedly connected with the driving wheel, the annular tube is communicated with a water pipe, the water pipe is used for conveying water into the annular tube, a water spray head, a brush with bristles and a scraper are sequentially disposed below the annular tube from bottom to top, the water spray head, the brush and the scraper are adapted to the first internal thread of the cylinder, the water spray head, the brush and the scraper are all connected with the annular tube and attached to the first internal thread of the cylinder, and the water spray head is communicated with the annular tube.

6. The apparatus for purifying cephalosporin fermentation broth according to claim 5, characterized in that an inner tube is coaxially sleeved on the inner side of the annular tube, the inner tube is fixedly connected with the annular tube, a second internal thread is arranged in the inner tube, a moving tube is coaxially sleeved in the inner tube, an external thread is arranged on the outer side of the moving tube, the moving tube is screwed with the inner tube, a fixed rod is coaxially sleeved in the moving tube, the moving tube is vertically slidably clamped with the fixed rod, an elastic rope is connected between the top of the moving tube and the fixed rod, the top of the fixed rod penetrates through the driving wheel and is fixedly connected with the support frame, and an elastic limit piece is arranged on the fixed rod;

the moving pipe is arranged in a way that the moving direction of the moving pipe is opposite to the moving direction of the cylinder, when the sprinkler head leaves the first internal thread of the cylinder, the moving pipe moves to the lowest position, the moving pipe is unscrewed from the inner pipe, the elastic rope is in a stretching state, and the rope is in a tensioning state, so that the other end of the sprinkler head is abutted against the inner side wall of the cylinder; when the barrel moves to the lowest position, the moving pipe moves to the highest position, the moving pipe is screwed with the inner pipe in a loosening mode, the top of the moving pipe is abutted to the elastic limiting part, the elastic limiting part is in a compression state, and the rope is in a tensioning state.

7. The apparatus for purifying cephalosporin fermentation solution as claimed in claim 6, characterized in that the elastic limiting element comprises a third plate sleeved outside the fixing rod, the third plate is fixed with the fixing rod, a fourth plate is positioned below the third plate, the fourth plate is sleeved outside the fixing rod, a second spring is connected between the fourth plate and the third plate, when the movable tube moves to the highest position, the top of the movable tube is abutted against the fourth plate, and the second spring is in a compressed state.

8. The apparatus for purifying cephalosporin fermentation solution according to claim 6, characterized in that a water spray pipe is arranged below the water spray head, the water spray pipe is communicated with the annular pipe and sprays water toward the inner side wall of the cylinder.

9. Use of a device for the purification of a cephalosporin fermentation broth according to any of claims 1-8, characterized by the following steps: