CN114470219A

CN114470219A - Oral preparation for resisting helicobacter pylori

Info

Publication number: CN114470219A
Application number: CN202210174136.9A
Authority: CN
Inventors: 陈志良
Original assignee: Guangdong Qimei Biotechnology Co ltd
Current assignee: Guangdong Qimei Biotechnology Co ltd
Priority date: 2022-02-24
Filing date: 2022-02-24
Publication date: 2022-05-13

Abstract

The invention discloses an anti-helicobacter pylori oral preparation, which belongs to the field of oral cavity and comprises the following raw materials in parts by weight: 8-20 parts of organic colloidal bismuth agent, 8-20 parts of dormant microbial agent, 5-16 parts of sterile water, 6-20 parts of hydrogen peroxide, 5-18 parts of rhizoma acori graminei, 10-28 parts of sulforaphane, 6-22 parts of vitamin complex, 10-26 parts of chlorhexidine gluconate, 10-26 parts of frankincense and 8-28 parts of clove. The oral cavity is temporarily eliminated by combining a low-concentration broad-spectrum bactericide, the anaerobic environment for breeding the helicobacter pylori easily is avoided, the mucous membrane of the oral cavity is not damaged, the focus of the oral cavity is disinfected later, the subsequent inhibitor is assisted to enter, the sterilization efficiency is improved, the vitamins are firstly utilized to avoid the wound of the oral cavity, the helicobacter pylori is led to be bred, the strong oxidizing property of the sulforaphane is combined, the focus is sterilized, cancer cells are prevented and treated, the lysozyme is integrated, the final sterilization is completed, beneficial bacteria are prevented from being killed, and beneficial microbial flora in the oral cavity is protected.

Description

Oral preparation for resisting helicobacter pylori

Technical Field

The invention relates to the field of oral cavity, in particular to an anti-helicobacter pylori oral preparation.

Background

The oral cavity (oral cavity) is the initial part of the alimentary canal, the front part is communicated with the outside through cleft mouth, the back part is continued with the pharynx through the angina, the oral cavity is provided with teeth, tongue and other organs, the front wall of the oral cavity is the lip, the side wall is the cheek, the top is the palate, the bottom of the oral cavity is the mucous membrane and muscle and other structures, the oral cavity is divided into the oral vestibule (oral cavity) at the front outer part and the inherent oral cavity (oral cavity) at the back inner part through the upper dental arch and the lower dental arch; when the upper and lower teeth are occluded, the vestibule of the oral cavity is communicated with the inherent oral cavity by a gap behind the third molar, and when the teeth of a patient are closed clinically, an opener or a cannula can be arranged in the passage to inject medicines or nutrients, and simultaneously, the tongue is prevented from being bitten.

The helicobacter pylori diseases include gastritis, peptic ulcer, lymphoproliferative gastric lymphoma, etc. caused by helicobacter pylori infection.

The prevention and control of gastric cancer has attracted increasing attention, and studies have shown that H.pylori lives in the pylorus region of the human stomach, is one of the most common bacterial pathogens, and that most of the world's population is infected with H.pylori, in some countries almost 90% of people are infected with this bacterium, which is usually the case in young adults, up to 50% under 5 years old, and this bacterial infection first causes chronic gastritis, and causes gastric ulcer and gastric atrophy, the severe cases develop into gastric cancer, according to statistics, the atrophic gastritis and gastric cancer incidence rate of people who are infected with helicobacter pylori for the first time and have an early age are high, the helicobacter pylori infection and the gastric cancer death rate show parallel relationship, the helicobacter pylori parasitizes in gastric mucosa tissues, 67-80% of gastric ulcers and 95% of duodenal ulcers are caused by helicobacter pylori, and the common symptoms of patients with chronic gastritis and peptic ulcers are: after eating, the upper abdomen is full, uncomfortable or painful, other adverse symptoms are often accompanied, such as eructation, abdominal distension, acid regurgitation, anorexia and the like, and some patients can also have recurrent severe abdominal pain, a small amount of upper gastrointestinal bleeding and the like.

At present, oral helicobacter pylori preparations are often used in a toothpaste mode, firstly, the prevention significance of the mode is greater than the treatment significance, the living environment of the helicobacter pylori in the oral cavity is essentially inhibited, the effect is not good, after the helicobacter pylori is propagated in a large amount in the oral cavity, only drug control treatment can be carried out under general conditions unless combined antibiotics are used, the treatment is often limited by the reason of allergy, the formulation of a treatment scheme is complex, and the rapid radical treatment is difficult.

Disclosure of Invention

1. Technical problem to be solved

Aiming at the problems in the prior art, the invention aims to provide an anti-helicobacter pylori oral preparation which adopts natural plants as raw materials, solves the problems of narrow treatment range, poor antibacterial effect and incapability of controlling helicobacter pylori to invade the digestive tract.

2. Technical scheme

In order to solve the problems, the invention adopts the following technical scheme:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 8-20 parts of organic colloidal bismuth agent, 8-20 parts of dormant microbial agent, 5-16 parts of sterile water, 6-20 parts of hydrogen peroxide, 5-18 parts of rhizoma acori graminei, 10-28 parts of sulforaphane, 6-22 parts of vitamin complex, 10-26 parts of chlorhexidine gluconate, 10-26 parts of frankincense and 8-28 parts of clove.

As a further scheme of the invention: 10-18 parts of organic colloidal bismuth agent, 10-28 parts of dormant microbial agent, 6-14 parts of sterile water, 8-18 parts of hydrogen peroxide, 6-16 parts of rhizoma acori graminei, 12-26 parts of sulforaphane, 8-20 parts of vitamin complex, 12-24 parts of chlorhexidine gluconate, 12-24 parts of frankincense and 10-26 parts of clove.

As a further scheme of the invention: 12-16 parts of organic colloidal bismuth agent, 12-26 parts of dormant microbial agent, 8-12 parts of sterile water, 10-16 parts of hydrogen peroxide, 8-14 parts of rhizoma acori graminei, 14-26 parts of sulforaphane, 10-18 parts of vitamin complex, 14-22 parts of chlorhexidine gluconate, 14-22 parts of frankincense and 12-24 parts of clove.

As a further scheme of the invention: 13-15 parts of organic colloidal bismuth agent, 12-16 parts of dormant microbial agent, 10-12 parts of sterile water, 12-14 parts of hydrogen peroxide, 10-12 parts of rhizoma acori graminei, 16-24 parts of sulforaphane, 12-16 parts of vitamin complex, 15-21 parts of chlorhexidine gluconate, 15-21 parts of frankincense and 13-23 parts of clove.

As a further scheme of the invention: 14 parts of organic colloidal bismuth agent, 14 parts of dormant microbial preparation, 11 parts of sterile water, 13 parts of hydrogen peroxide, 11 parts of rhizoma acori graminei, 19 parts of sulforaphane, 14 parts of multivitamin, 18 parts of chlorhexidine gluconate, 18 parts of frankincense and 18 parts of clove.

The oral preparation for resisting helicobacter pylori according to any one of claims 1 to 5, wherein the sulforaphane is one or more of radish, broccoli and cabbage, which are pulverized, mixed, concentrated and extracted in any proportion.

The oral preparation for resisting helicobacter pylori according to any one of claims 1 to 5, wherein the vitamin complex is lysozyme, vitamin C and vitamin B12 which are mixed with one or more of lysozyme, vitamin C and vitamin B12 in any proportion.

A method for processing an anti-helicobacter pylori oral preparation comprises the following steps:

the method comprises the following steps: firstly, the hydrolyzed capsule is utilized to carry out sealing treatment on the organic colloidal bismuth agent, vacuum packaging is carried out after the drying is kept, and then the residual raw materials are utilized to respectively prepare the broad-spectrum bactericide and the inhibitor;

step two: the broad-spectrum bactericide utilizes hydrogen peroxide and sterile water to prepare a low-concentration broad-spectrum bactericide, and then is sealed and stored;

step three: the inhibitor is prepared by mixing rhizoma Acori Graminei, sulforaphane, dormant microbial preparation, compound vitamin, chlorhexidine gluconate, Olibanum and flos Caryophylli, dissolving in sterile water, and making into aqua.

As a further scheme of the invention: according to the operation steps in the first step and the third step, the low-concentration broad-spectrum bactericide is 10% in concentration, and the rhizoma acori graminei is crushed, cured, dissolved and separated, and the rhizoma acori graminei extracting solution is extracted and mixed.

As a further scheme of the invention: mixing the sulforaphane with absolute ethyl alcohol according to the operation steps in the first step and the third step, and then mixing with sterile water.

3. Advantageous effects

Compared with the prior art, the invention has the advantages that:

(1) according to the scheme, the anaerobic environment for breeding the helicobacter pylori is eliminated in the oral cavity temporarily by combining the low-concentration broad-spectrum bactericide, the mucous membrane of the oral cavity is not damaged, the focus of the oral cavity is disinfected afterwards, and the subsequent inhibitor is assisted to enter, so that the sterilization efficiency is improved.

(2) According to the scheme, the inhibitor prepared from natural raw materials is used for preventing the oral cavity from being wounded by vitamins to cause breeding of helicobacter pylori, secondly, strong oxidizing property of sulforaphane is combined to realize sterilization of focuses and treatment and prevention of cancer cells, and secondly, lysozyme is collected to finish final sterilization, so that beneficial bacteria are prevented from being killed, and beneficial microbial flora in the oral cavity is protected.

Drawings

FIG. 1 is a schematic diagram showing the detection of the blood agar medium helicobacter pylori sterilization test of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.

Example 1:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 8 parts of organic colloidal bismuth agent, 8 parts of dormant microbial agent, 5 parts of sterile water, 6 parts of hydrogen peroxide, 5 parts of grassleaf sweelflag rhizome, 10 parts of sulforaphane, 6 parts of vitamin complex, 10 parts of chlorhexidine gluconate, 10 parts of frankincense and 8 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa and precipitates on the ulcer surface to form a protective film covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, coma due to fever, amnesia, deafness, chest distress, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle-abscess pyogenic infections, traumatic injury, calamus water infusion (1: 3), has different degrees of inhibitory action on trichophyton violaceum, trichophyton concentricum, yellow ringworm of the orchid, ozoke ringworm, small rust ringworm, wool-like small spore ringworm, epidermophyton groin, epidermophyton rubrum, kaufman-wolfe epidermophyton, mitrocardia stellata and other dermatophytes in test tubes, rhizoma acori graminei decoction can promote secretion of digestive juice and abnormal fermentation of gastrointestinal tract and relieve intestinal canal smooth muscle spasm, asarone in rhizoma acori graminei can resist isolated intestinal canal effect caused by barium chloride, Vitamin (Vitamin) is a trace organic substance obtained from food for maintaining normal physiological functions of human and animals, the vitamin plays an important role in the growth, metabolism and development processes of human bodies, the vitamin is not involved in forming human body cells in vivo and also provides energy for human bodies, the deficiency of the vitamin is easy to cause inflammation of mouth and tongue, lysozyme (lysozyme) is also called muramidase or N-acetylmuramidase glycohydrolase and is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, lysozyme can decompose cell wall insoluble mucopolysaccharide into soluble glycopeptide by mainly destroying beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls, so that the cell walls are ruptured to escape contents to dissolve the bacteria, the lysozyme can be directly combined with virus protein with virus to form a complex with DNA, RNA and apoprotein to inactivate viruses, and the lysozyme is widely present in various tissues of human bodies, the enzyme is also contained in egg white of birds and poultry, tears of mammals, saliva, blood plasma, milk and other liquids of mammals, and microorganisms, wherein the egg white is most abundant, the egg white can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the quantity of streptococcus salivarius in the oral cavity of a halitosis person is less, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the oral cavity microecology: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

Specifically, the sulforaphane is extracted from one or more of radish, broccoli and cabbage by pulverizing, mixing and concentrating at any ratio.

Specifically, the compound vitamin is one or more of lysozyme, vitamin C and vitamin B12 which are mixed according to any proportion.

the method comprises the following steps: firstly, the hydrolytic capsule is utilized to carry out sealing treatment on the organic colloidal bismuth agent, vacuum packaging is carried out after the drying is kept, then the residual raw materials are utilized to respectively prepare the broad spectrum bactericide and the inhibitor, and the step two is as follows: and (3) preparing a low-concentration broad-spectrum bactericide by using hydrogen peroxide and sterile water, and then sealing and storing the mixture, wherein the low-concentration broad-spectrum bactericide is 10 percent in concentration, and the third step is as follows: the inhibitor is prepared by mixing rhizoma Acori Graminei, sulforaphane, dormant microbial preparation, vitamin complex, chlorhexidine gluconate, Olibanum and flos Caryophylli, dissolving in sterile water, making into aqua, mixing sulforaphane with sewage and ethanol, and mixing with sterile water.

Example 2:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 20 parts of organic colloidal bismuth agent, 20 parts of dormant microbial agent, 16 parts of sterile water, 20 parts of hydrogen peroxide, 18 parts of rhizoma acori graminei, 28 parts of sulforaphane, 22 parts of vitamin complex, 26 parts of chlorhexidine gluconate, 26 parts of frankincense and 28 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa to precipitate on the ulcer surface to form a protective film covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, coma due to fever, amnesia, deafness, chest distress, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle-abscess pyogenic infections, traumatic injury, calamus water infusion (1: 3), has different degrees of inhibition effects on trichophyton violaceum, trichophyton concentricum, trichophyton schoenliensis, ozoken odoratum, trichophyton ferrugineum, trichophyton lanugineum, trichophyton lanuginosum, epidermophyton ventricosum inguinarum, epidermophyton rubrum, chefmann-wolff epidermophyton, nocardia stellata and other dermatophytes in test tubes, rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of gastrointestinal tract, and has the effect of relieving smooth muscle spasm of intestinal canal, asarone in vitro functions of resisting barium chloride, Vitamin (Vitamin E) is a kind of organic substances which are obtained from food and are necessary for maintaining normal physiological functions of human and animals, the lysozyme (lysozyme) is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, mainly breaks beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls to decompose insoluble mucopolysaccharide in cell walls into soluble glycopeptides so as to break the cell walls and escape contents to dissolve the bacteria, can be directly combined with virus proteins with negative charges to form a complex with DNA, RNA and apoprotein to inactivate viruses, and widely exists in various tissues of a human body, the enzyme is also contained in egg white of birds and poultry, tears of mammals, saliva, blood plasma, milk and other liquids of mammals, and microorganisms, wherein the egg white is most abundant, the egg white can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the quantity of streptococcus salivarius in the oral cavity of a halitosis person is less, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the oral cavity microecology: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

Example 3:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 10 parts of organic colloidal bismuth agent, 10 parts of dormant microbial preparation, 6 parts of sterile water, 8 parts of hydrogen peroxide, 6 parts of grassleaf sweelflag rhizome, 12 parts of sulforaphane, 8 parts of vitamin complex, 12 parts of chlorhexidine gluconate, 12 parts of frankincense and 10 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa and precipitates on the ulcer surface to form a protective film covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, coma due to fever, amnesia, deafness, chest distress, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle-abscess pyogenic infections, traumatic injury, calamus water infusion (1: 3), has different degrees of inhibition effects on trichophyton violaceum, trichophyton concentricum, trichophyton schoenliensis, ozoken odoratum, trichophyton ferrugineum, trichophyton lanugineum, trichophyton lanuginosum, epidermophyton ventricosum inguinarum, epidermophyton rubrum, chefmann-wolff epidermophyton, nocardia stellata and other dermatophytes in test tubes, rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of gastrointestinal tract, and has the effect of relieving smooth muscle spasm of intestinal canal, asarone in vitro functions of resisting barium chloride, Vitamin (Vitamin E) is a kind of organic substances which are obtained from food and are necessary for maintaining normal physiological functions of human and animals, the vitamin plays an important role in the growth, metabolism and development processes of human bodies, the vitamin is not involved in forming human body cells in vivo and also provides energy for human bodies, the deficiency of the vitamin is easy to cause inflammation of mouth and tongue, lysozyme (lysozyme) is also called muramidase or N-acetylmuramidase glycohydrolase and is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, lysozyme can decompose cell wall insoluble mucopolysaccharide into soluble glycopeptide by mainly destroying beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls, so that the cell walls are ruptured to escape contents to dissolve the bacteria, the lysozyme can be directly combined with virus protein with virus to form a complex with DNA, RNA and apoprotein to inactivate viruses, and the lysozyme is widely present in various tissues of human bodies, the enzyme is also contained in egg white of birds and poultry, tears of mammals, saliva, blood plasma, milk and other liquids of mammals, and microorganisms, wherein the egg white is most abundant, the egg white can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the quantity of streptococcus salivarius in the oral cavity of a halitosis person is less, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the oral cavity microecology: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

the method comprises the following steps: firstly, sealing the organic colloidal bismuth agent by utilizing a hydrolysis capsule, keeping the organic colloidal bismuth agent dry, then carrying out vacuum packaging, and then respectively preparing a broad spectrum bactericide and an inhibitor by utilizing the rest raw materials, wherein the second step is as follows: and (3) preparing a low-concentration broad-spectrum bactericide by using hydrogen peroxide and sterile water, and then sealing and storing the mixture, wherein the low-concentration broad-spectrum bactericide is 10 percent in concentration, and the third step is as follows: the inhibitor is prepared by mixing rhizoma Acori Graminei, sulforaphane, dormant microbial preparation, vitamin complex, chlorhexidine gluconate, Olibanum and flos Caryophylli, dissolving in sterile water, making into aqua, mixing sulforaphane with sewage and ethanol, and mixing with sterile water.

Example 4:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 12 parts of organic colloidal bismuth agent, 12 parts of dormant microbial preparation, 8 parts of sterile water, 10 parts of hydrogen peroxide, 8 parts of grassleaf sweelflag rhizome, 14 parts of sulforaphane, 10 parts of vitamin complex, 14 parts of chlorhexidine gluconate, 14 parts of frankincense and 12 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa and precipitates on the ulcer surface to form a protective film covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, coma due to fever, amnesia, deafness, chest distress, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle-abscess pyogenic infections, traumatic injury, calamus water infusion (1: 3), has different degrees of inhibition effects on trichophyton violaceum, trichophyton concentricum, trichophyton schoenliensis, ozoken odoratum, trichophyton ferrugineum, trichophyton lanugineum, trichophyton lanuginosum, epidermophyton ventricosum inguinarum, epidermophyton rubrum, chefmann-wolff epidermophyton, nocardia stellata and other dermatophytes in test tubes, rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of gastrointestinal tract, and has the effect of relieving smooth muscle spasm of intestinal canal, asarone in vitro functions of resisting barium chloride, Vitamin (Vitamin E) is a kind of organic substances which are obtained from food and are necessary for maintaining normal physiological functions of human and animals, the lysozyme (lysozyme) is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, mainly breaks beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls to decompose insoluble mucopolysaccharide in cell walls into soluble glycopeptides so as to break the cell walls and escape contents to dissolve the bacteria, can be directly combined with virus proteins with negative charges to form a complex with DNA, RNA and apoprotein to inactivate viruses, and widely exists in various tissues of a human body, the enzyme is also contained in egg white of birds and poultry, tears of mammals, saliva, blood plasma, milk and other liquids of mammals, and microorganisms, wherein the egg white is most abundant, the egg white can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the quantity of streptococcus salivarius in the oral cavity of a halitosis person is less, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the oral cavity microecology: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

Example 5:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 13 parts of organic colloidal bismuth agent, 12 parts of dormant microbial agent, 10 parts of sterile water, 12 parts of hydrogen peroxide, 10 parts of grassleaf sweelflag rhizome, 16 parts of sulforaphane, 12 parts of vitamin complex, 15 parts of chlorhexidine gluconate, 15 parts of frankincense and 13 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa and precipitates on the ulcer surface to form a protective film for covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, the rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of gastrointestinal tracts by oral administration, and has the effect of relieving smooth muscle spasm of intestinal tracts, and asarone in the rhizoma acori graminei can resist isolated intestinal tracts caused by barium chloride. Vitamins (vitamines) are a kind of trace organic substances which are necessary to be obtained from food for human and animal to maintain normal physiological functions, and play an important role in the growth, metabolism and development of human body, and are not involved in constituting human body cells nor providing energy to human body in vivo, and lack of vitamins liable to inflammation of mouth and tongue, lysozyme (also called muramidase) or N-acetylmuramidase (N-acetylmuramidase glycohydrolase), which is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, mainly breaks beta-1, 4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in cell wall to decompose insoluble cell wall mucopolysaccharide into soluble glycopeptide, leading to rupture of cell wall contents and escape of the content, and makes bacteria dissolve, and lysozyme can be directly combined with virus protein with negative charge, the enzyme is widely present in various tissues of human bodies, egg white of birds and poultry, tears, saliva, blood plasma, milk and other liquids of mammals, microorganisms also contain the enzyme, wherein the egg white content is most abundant, the enzyme can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, the streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the streptococcus salivarius in the oral cavity of a halitosis person is fewer in number, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the microecology of the oral cavity: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

Example 6:

an anti-helicobacter pylori oral preparation comprises the following raw materials in parts by weight: 14 parts of organic colloidal bismuth agent, 14 parts of dormant microbial preparation, 11 parts of sterile water, 13 parts of hydrogen peroxide, 11 parts of grassleaf sweelflag rhizome, 19 parts of sulforaphane, 14 parts of vitamin complex, 18 parts of chlorhexidine gluconate, 18 parts of frankincense and 18 parts of clove, and gastric ulcer is mainly caused by damage and loss of defense capability of gastric mucosa, so that the gastric ulcer is treated by selecting medicaments capable of promoting gastric mucosa repair and strengthening the defense capability of gastric mucosa clinically, a large number of medicaments for protecting the gastric mucosa are provided, and the most common colloidal bismuth agent has the main advantages of less adverse reaction and capability of effectively preventing the recurrence of the gastric ulcer, and the colloidal bismuth agent mainly forms bismuth salt and adhesive concretion with mucin of the ulcer surface of the gastric mucosa and precipitates on the ulcer surface to form a protective film covering the gastric mucosa, and the protective film can prevent gastric acid and pepsin from further stimulating the ulcer surface of the gastric wall, meanwhile, the bismuth preparation can resist helicobacter pylori, forms a compound with gastric mucosa epidermal growth factor, promotes epithelization regeneration and healing of ulcer surfaces, and needs to be noted that the colloidal bismuth preparation is easy to cause acute renal failure when being used in excess, so patients with renal insufficiency are prohibited from taking the bismuth preparation, sterile water is used for dissolving and mixing raw materials, the anaerobic environment in the oral cavity can be destroyed in a short time through hydrogen peroxide, on one hand, the oral cavity is disinfected, on the other hand, the beneficial microbial environment in the oral cavity is not destroyed on a large scale, on the other hand, the characteristics of pyloric anaerobism are utilized to complete local killing, on the other hand, the acorus gramineus and the acorus gramineus have the effects of resolving dampness and stimulating appetite, opening orifices and eliminating phlegm, refreshing and benefiting intelligence, and are used for treating epigastric fullness without hunger, vomiting and diarrhea, coma and epilepsy, deafness, vital energy regulating qi, amnesia, dispelling wind, eliminating dampness, treating epilepsy and phlegm syncope, coma due to fever, amnesia, deafness, chest distress, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle-abscess pyogenic infections, traumatic injury, calamus water infusion (1: 3), has different degrees of inhibition effects on trichophyton violaceum, trichophyton concentricum, trichophyton schoenliensis, ozoken odoratum, trichophyton ferrugineum, trichophyton lanugineum, trichophyton lanuginosum, epidermophyton ventricosum inguinarum, epidermophyton rubrum, chefmann-wolff epidermophyton, nocardia stellata and other dermatophytes in test tubes, rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of gastrointestinal tract, and has the effect of relieving smooth muscle spasm of intestinal canal, asarone in vitro functions of resisting barium chloride, Vitamin (Vitamin E) is a kind of organic substances which are obtained from food and are necessary for maintaining normal physiological functions of human and animals, the vitamin plays an important role in the growth, metabolism and development processes of human bodies, the vitamin is not involved in forming human body cells in vivo and also provides energy for human bodies, the deficiency of the vitamin is easy to cause inflammation of mouth and tongue, lysozyme (lysozyme) is also called muramidase or N-acetylmuramidase glycohydrolase and is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, lysozyme can decompose cell wall insoluble mucopolysaccharide into soluble glycopeptide by mainly destroying beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls, so that the cell walls are ruptured to escape contents to dissolve the bacteria, the lysozyme can be directly combined with virus protein with virus to form a complex with DNA, RNA and apoprotein to inactivate viruses, and the lysozyme is widely present in various tissues of human bodies, the enzyme is also contained in egg white of birds and poultry, tears of mammals, saliva, blood plasma, milk and other liquids of mammals, and microorganisms, wherein the egg white is most abundant, the egg white can be divided into four types according to different sources, namely plant lysozyme, animal lysozyme, microorganism lysozyme and egg white lysozyme, helicobacter pylori can be killed in a targeted manner, streptococcus salivarius belongs to normal flora in the oral cavity, and compared with healthy people, the quantity of streptococcus salivarius in the oral cavity of a halitosis person is less, researches show that the streptococcus salivarius can produce certain bacteriocin, has an inhibiting effect on bacteria related to the oral cavity, and improves the oral cavity microecology: the probiotics contained in the product can be planted in the oral cavity, supplement the lack of the active probiotics in the oral cavity, improve the micro-ecological balance of the oral cavity and prevent respiratory discomfort: BLIS K12 oral cavity probiotics can inhibit the growth and reproduction of pathogenic bacteria through the micro-ecological mode of regulation, thereby prevent and treat pharyngolaryngitis, respiratory tract discomfort such as rhinitis, glucose chlorhexidine can be used to gingivitis, pharyngolaryngitis and canker sore etc., the frankincense product has more obvious analgesia, the uterus pill that takes frankincense as the first medicine has stronger antibacterial action than multiple antibiotics, and can kill the trichomonas effectively, in vitro, clove has inhibitory action to the growth of staphylococcus and tubercle bacillus, clove water decoction and powder have stronger antibacterial action to hemolytic streptococcus, its antibacterial action and not influenced by heating, the experiment proves: the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil has a stronger antibacterial ability than the clove oil, in vitro experiments prove that the clove alcohol extract has an inhibiting effect on the white larynx bacillus, the anthrax bacillus, the paratyphoid bacillus, the dysentery bacillus, the staphylococcus aureus, the white staphylococcus and the vibrio cholerae, and the clove oil and the eugenol can completely prevent the growth of the brucella when the ratio of the clove oil to the eugenol is 1: 16000-1: 64000 in a test tube; the growth of the mycobacterium avium can be completely inhibited at 1: 8000; in-vitro tests prove that the clove has an inhibiting effect on staphylococcus aureus, pneumonia bacillus, dysentery bacillus, escherichia coli, proteus and tuberculosis bacillus at a concentration of 1: 2000-1: 8000, water, alcohol and ether leachate of clove and volatile oil thereof have an obvious antifungal effect on pathogenic fungi, the leachate at a low concentration has an inhibiting effect on ringworm of the orchid, candida albicans and the like, and the clove oil and eugenol have an antibacterial effect on various trichophytons, ringworm of the abdomen and epidermophyton inguinale at a concentration of 1: 8000-1: 16000 in a test tube.

Example 1, example 2, example 3, example 4, example 5 and example 6 are different in the content of the components of the internal components thereof, and the preparation methods thereof are the same.

To further illustrate the beneficial effects of the present invention, the present inventors selected two anti-helicobacter pylori formulations, selected a toothpaste named anti-helicobacter pylori, purchased a linked https:// detail.1688.com/offer/651980484790. htmlpsm ═ a312h.2018_ new _ sem.dh _002.3.179476f 38703 03 4D & transcel ═ p4p & clickid ═ 3da03e13 f3446886d999e2006bdc1d & sessionid &.5 f4d7678 569a688e 757a091, described below briefly as the first inhibitor, selected a bacteriostatic at the same time, purchased a linked https:// detail.468.46/fb/64589942:. 3124 a091 ═ t, prepared as a control test results for the following three groups of natural inhibitors 4452, and wo 3852 b 569 b, wherein the test results were obtained for the case control of the present invention, the case of the invention, the test results of the total inhibition of No. wo 449, No. wo 25 b, No. wo 567 b, No. 59 b, No. 3,62, No. 4,62, No. wo, No. 4,62, No. 5,62, No. 4,62, No. 5,4,62, No. 4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4, and No. where the following test were made simultaneously, and the test results of the invention, the test results of the invention, the test results of the invention, a test, the test, a test results of the invention, a test results of the invention, and the test, the test results of the test, and the test results of the test, the test results of the, the test of helicobacter pylori respiration is carried out by adopting C14, and the experimental data are detailed in Table 1:

TABLE 1 Experimental data sheet

	Bacteriostatic conditions	Control of the disease condition	Adaptability
				First inhibitor	In general	Is not controlled	Little adverse reaction
Second inhibitor	In general	Is not controlled	Little adverse reaction
				Example 1	The effect is obvious	Complete degradation of	No adverse reaction
Example 2	The effect is obvious	Complete degradation of	No adverse reaction
				Example 3	The effect is obvious	Complete degradation of	No adverse reaction
Example 4	The effect is obvious	Complete degradation of	No adverse reaction
				Example 5	The effect is obvious	Complete degradation of	No adverse reaction
Example 6	The effect is obvious	Complete degradation of	No adverse reaction

From the above experimental data, examples 1-6 had better antibacterial conditions and the disease condition was controlled to a certain extent, no discomfort was produced, and the experimental time was controlled at 30 days:

the first case is: using the first inhibitor, C102 positive Hp (+) was detected initially, C98 positive Hp (+) was detected 15 days after treatment, and C90 positive Hp (+) was detected thirty days after treatment;

case two: initial assay for C110-positive Hp (+) with the first inhibitor, 15 days post-treatment with C100-positive Hp (+) and thirty days post-treatment with C98-positive Hp (+);

case three: initial detection of C90 positive Hp (+) with a second inhibitor, 15 days post-treatment with C92 positive Hp (+) and thirty days post-treatment with C93 positive Hp (+);

case four: initial assay for C113-positive Hp (+) with a second inhibitor, 15 days post-treatment with C111-positive Hp (+) and thirty days post-treatment with C101-positive Hp (+);

case five: using the example formulation, C106 positive Hp (+) was detected initially, C96 positive Hp (+) was detected 15 days after treatment, and negative C31, Hp (-) was detected thirty days after treatment;

six cases: using the example formulation for initial detection of C104 positive Hp (+), C60 positive Hp (+) after 15 days of treatment, and negative C30, Hp (-) thirty days after thirty days of treatment;

case seven: the blank was initially tested for C104 positive Hp (+), 15 days later for C106 positive Hp (+), and thirty days later for C109 positive Hp (+).

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to cover the technical scope of the present invention, the technical solutions and the modifications thereof according to the present invention within the technical scope of the present invention.

Claims

1. An anti-helicobacter pylori oral preparation is characterized by comprising the following raw materials in parts by weight: 8-20 parts of organic colloidal bismuth agent, 8-20 parts of dormant microbial agent, 5-16 parts of sterile water, 6-20 parts of hydrogen peroxide, 5-18 parts of rhizoma acori graminei, 10-28 parts of sulforaphane, 6-22 parts of vitamin complex, 10-26 parts of chlorhexidine gluconate, 10-26 parts of frankincense and 8-28 parts of clove.

2. The oral preparation for resisting helicobacter pylori according to claim 1, wherein the oral preparation comprises 10-18 parts of organic colloidal bismuth agent, 10-28 parts of dormant microbial agent, 6-14 parts of sterile water, 8-18 parts of hydrogen peroxide, 6-16 parts of rhizoma acori graminei, 12-26 parts of sulforaphane, 8-20 parts of vitamin complex, 12-24 parts of chlorhexidine gluconate, 12-24 parts of frankincense and 10-26 parts of clove.

3. The oral preparation for resisting helicobacter pylori according to claim 2, wherein the oral preparation comprises 12-16 parts of organic colloidal bismuth agent, 12-26 parts of dormant microbial agent, 8-12 parts of sterile water, 10-16 parts of hydrogen peroxide, 8-14 parts of rhizoma acori graminei, 14-26 parts of sulforaphane, 10-18 parts of vitamin complex, 14-22 parts of chlorhexidine gluconate, 14-22 parts of frankincense and 12-24 parts of clove.

4. The oral preparation for resisting helicobacter pylori according to claim 3, wherein the oral preparation comprises 13-15 parts of organic colloidal bismuth agent, 12-16 parts of dormant microbial agent, 10-12 parts of sterile water, 12-14 parts of hydrogen peroxide, 10-12 parts of rhizoma acori graminei, 16-24 parts of sulforaphane, 12-16 parts of vitamin complex, 15-21 parts of chlorhexidine gluconate, 15-21 parts of frankincense and 13-23 parts of clove.

5. The oral preparation for resisting helicobacter pylori according to claim 4, wherein the oral preparation comprises 14 parts of organic colloidal bismuth agent, 14 parts of dormant microorganism agent, 11 parts of sterile water, 13 parts of hydrogen peroxide, 11 parts of rhizoma acori graminei, 19 parts of sulforaphane, 14 parts of vitamin complex, 18 parts of chlorhexidine gluconate, 18 parts of frankincense and 18 parts of clove.

6. The oral preparation for resisting helicobacter pylori according to any one of claims 1 to 5, wherein the sulforaphane is one or more of radish, broccoli and cabbage, which are pulverized, mixed, concentrated and extracted in any proportion.

7. The oral preparation for resisting helicobacter pylori according to any one of claims 1 to 5, wherein the vitamin complex is lysozyme, vitamin C, vitamin B12 in any proportion.

8. A processing method of an oral preparation for resisting helicobacter pylori is characterized by comprising the following steps:

s1: firstly, the hydrolyzed capsule is utilized to carry out sealing treatment on the organic colloidal bismuth agent, vacuum packaging is carried out after the drying is kept, and then the residual raw materials are utilized to respectively prepare the broad-spectrum bactericide and the inhibitor;

s2: the broad-spectrum bactericide utilizes hydrogen peroxide and sterile water to prepare a low-concentration broad-spectrum bactericide, and then is sealed and stored;

s3: the inhibitor is prepared by mixing rhizoma Acori Graminei, sulforaphane, dormant microbial preparation, compound vitamin, chlorhexidine gluconate, Olibanum and flos Caryophylli, dissolving in sterile water, and making into aqua.

9. The method for processing the anti-helicobacter pylori oral preparation according to claim 8, comprising the following steps: according to the operation steps of S1-S3, the low-concentration broad-spectrum bactericide is 10% in concentration, and the rhizoma acori graminei is crushed, cured, dissolved and separated, and the rhizoma acori graminei extracting solution is extracted and mixed.

10. The method for processing an anti-helicobacter pylori oral preparation according to claim 8, comprising the steps of: the sulforaphane according to the procedure of S1-S3 was mixed with absolute ethanol and then mixed with sterile water.