CN114468274A - Application of traditional Chinese medicine composition in food for assisting in relieving hypertension, nutritional powder and preparation method of nutritional powder - Google Patents
Application of traditional Chinese medicine composition in food for assisting in relieving hypertension, nutritional powder and preparation method of nutritional powder Download PDFInfo
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- CN114468274A CN114468274A CN202210075642.2A CN202210075642A CN114468274A CN 114468274 A CN114468274 A CN 114468274A CN 202210075642 A CN202210075642 A CN 202210075642A CN 114468274 A CN114468274 A CN 114468274A
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- 239000008158 vegetable oil Substances 0.000 description 1
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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Abstract
The invention provides application of a traditional Chinese medicine composition in food for assisting in relieving hypertension, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight: 0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn. The special traditional Chinese medicine composition with the auxiliary blood pressure reducing effect is added on the basis of a total nutrient formula, belongs to medicine and food homologous components, has the auxiliary blood pressure reducing effect on the basis of providing balanced nutrition for patients with hypertension, and can avoid the problems of large blood pressure fluctuation of the patients due to improper diet or malnutrition due to excessive diet control.
Description
Technical Field
The invention relates to the technical field of food, in particular to nutrition powder suitable for hypertension patients based on the traditional Chinese medicine and western medicine combined nutrition and a preparation method thereof.
Background
Hypertension refers to the continuous increase of systolic pressure or (and) diastolic pressure (systolic pressure is more than or equal to 140mmHg, diastolic pressure is more than or equal to 90mmHg) at rest, and is mainly caused by genetic factors, weight factors, dietary factors, life style, mental factors and the like. Hypertension causes functional or organic changes in organs such as heart, blood vessels, brain and kidney, which in turn leads to diseases such as stroke, heart disease, hemangioma, renal failure, etc.
The medical food is a formula Food (FSMP) specially processed and prepared for meeting the special requirements of people with limited food intake, digestive absorption disorder, metabolic disorder or specific disease states on nutrients or diet. The product must be eaten alone or in combination with other foods under the guidance of doctors or clinical dieticians. The formula food with special medical application plays a great role in improving the nutritional status of patients, promoting the recovery of patients, shortening the hospitalization time, saving medical expenses and the like.
The homology of medicine and food is one of the most valuable contributions to human beings in Chinese original medicine. Traditional Chinese medicine always emphasizes that the medical therapy is inferior to the food therapy, and the food therapy becomes the best choice for modern people to pursue truthful and healthy diet. The pain can be removed in the process of enjoying delicious food, and the suffering of injection, medication and even operation can be avoided. The treatment rule of hypertension follows the basic principle of treatment based on syndrome differentiation of traditional Chinese medicine, and the specific treatment method is mainly soothing the liver and relieving depression and is assisted by clearing heat, regulating vital energy, promoting blood circulation and the like. Clinical literature also shows that the liver-soothing and depression-relieving method is used for treating hypertension with definite curative effect, so that the clear liver-soothing and depression-relieving method provides a micro theoretical basis for the main treatment method of early liver-qi depression of hypertension.
At present, few full-nutrition formula foods which can meet the nutritional metabolism characteristics of hypertension patients and are designed by combining the traditional Chinese medicine essence theory exist in the market. Therefore, it is important to develop a full nutritional formula that can provide the nutritional ingredients needed by hypertensive patients and control the blood pressure of patients.
Disclosure of Invention
In view of the above problems, the invention provides an application of a traditional Chinese medicine composition in food for assisting in relieving hypertension, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn.
The traditional Chinese medicine composition can relieve hypertension caused by lipid metabolism disorder, and can be used as a medicine and food homologous component. The ancient prescription considers that the disease is related to emotion, long-term mental stress or depression and anger, stagnation of liver qi, fire transformation due to depression and spleen and stomach injury due to fire are the main reasons. Therefore, the prescription takes liver calming, phlegm reducing, liver heat clearing, kidney tonifying, blood circulation promoting and diuresis promoting as the main prescription for reducing blood pressure. In the formula, flos sophorae and selfheal are mainly used for clearing liver and purging fire, and calming liver and purging fire, and eucommia ulmoides leaves are used for nourishing yang and nourishing yin; semen Raphani and fructus Citri Sarcodactylis can also be added to relieve qi, resolve phlegm, and soothe the liver and regulate qi; the hawthorn fruit is added to strengthen the effects of promoting qi circulation and removing blood stasis.
The fingered citron has certain functions of reducing blood pressure, relieving spasm and resisting aging, the fingered citron extract has the effect of inhibiting angiotensin converting enzyme, and the best effective active part for reducing blood pressure is screened out to be the fingered citron methanol extract.
The radish seed has the functions of reducing blood pressure and blood fat, and the active substance for reducing blood pressure in the radish seed is sinapine thiocyanate. The semen Raphani water soluble alkaloid can activate nitric oxide-myocardial nitric oxide synthase system, dilate blood vessel, and lower blood pressure.
Flos Sophorae Immaturus contains large amount of rutin, and has effects of increasing resistance of capillary vessel, increasing elasticity of human blood vessel wall, and preventing hypertension.
The selfheal has obvious antihypertensive activity, can effectively reduce the systolic pressure and diastolic pressure of spontaneous hypertensive rats, and has lasting effect. The selfheal has the effects of reducing the blood pressure mechanism, reducing the content of angiotensin II and increasing the content of Nitric Oxide (NO); reducing the content of endothelin-1 (ET-1) and increasing the content of Atrial Natriuretic Peptide (ANP); the inhibition of intracellular calcium ion release and extracellular calcium ion influx are involved.
The chemical component mainly containing chlorogenic acid in the eucommia ulmoides leaves has the function of reducing blood pressure, and the effect of reducing blood pressure is obvious and basically stable without adverse reaction.
The total flavonoids in fructus crataegi can be used for inhibiting extracellular Ca2+Internal flow of Ca in cells2+Releasing and activating the non-selective potassium channel and the inward rectifying potassium channel to complete the relaxation of the isolated blood vessel of the rat, so as to reduce the blood pressure.
According to one aspect of the invention, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
The invention also provides application of the traditional Chinese medicine composition in a food for reducing blood pressure by reducing low-density lipoprotein cholesterol (LDL-C) in serum and increasing high-density lipoprotein cholesterol (HDL-C), wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn.
According to one aspect of the invention, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
The invention also provides application of the traditional Chinese medicine composition in food for increasing the concentration of Nitric Oxide (NO) in blood at a molecular level to reduce blood pressure, which is characterized by comprising the following components in parts by weight: the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn.
According to one aspect of the invention, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
The invention also provides application of the traditional Chinese medicine composition in food for reducing the concentration of endothelin-1 (ET-1) in blood, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn.
According to one aspect of the invention, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
According to one aspect of the invention, the food product comprises: 6.6-53 parts of the traditional Chinese medicine composition, 808 parts of protein 101-containing materials, 56-452 parts of fat, 2260 part of carbohydrate 282-containing materials, 68-124 parts of compound mineral substances, 2.5-20 parts of compound vitamin, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerol fatty acid ester, 0.09-0.72 part of nucleotide and 0.06-0.48 part of L-carnitine. Preferably, the food contains 1-8 parts of vanilla essence and 0.3-2.2 parts of aspartame. The vanilla and aspartame primarily function as a flavoring, and those skilled in the art know that appropriate amounts can be added and subtracted as desired. Preferably, the food contains 9-72 parts of composite thickening agent.
According to one aspect of the invention, the protein is one or a combination of more than two of hydrolyzed whey protein powder, concentrated whey protein powder, soy protein isolate, whole egg powder, bovine colostrum powder, whole milk powder, lactoferrin and soy oligopeptide powder; preferably 400 parts of whey protein, 240 parts of soybean protein isolate, 16 parts of bovine colostrum powder and 240 parts of soybean oligopeptide powder.
According to one aspect of the invention, the fat is derived from one or a combination of more than two of olive oil powder, perilla seed oil powder, linseed oil powder, medium chain triglyceride powder, soybean oil powder, coconut oil portion and sunflower seed oil powder; preferably 35 parts of perilla seed oil powder, 152 parts of coconut oil powder, 400 parts of soybean oil powder, 152 parts of olive oil powder and 140 parts of medium chain triglyceride powder.
According to one aspect of the invention, the carbohydrate is derived from one or a combination of more than two of maltodextrin, soybean dietary fiber, crystalline fructose, resistant starch, resistant dextrin, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and isomalto-oligosaccharide; preferably, the maltodextrin 1640 parts, the inulin 24 parts, the crystalline fructose 40 parts, the galacto-oligosaccharide 40 parts and the isomalto-oligosaccharide 40 parts.
According to one aspect of the invention, the compound mineral is one or a combination of more than two of calcium citrate, L-calcium lactate, sodium dihydrogen phosphate, sodium citrate, magnesium gluconate, ferrous gluconate, zinc gluconate, potassium gluconate, sodium selenite, potassium iodide, anhydrous copper sulfate and manganese gluconate; preferably 24 parts of calcium citrate, 32 parts of L-calcium lactate, 32 parts of sodium dihydrogen phosphate, 16 parts of sodium citrate, 90 parts of magnesium gluconate, 16 parts of ferrous gluconate, 2 parts of zinc gluconate, 132 parts of potassium gluconate, 0.36 part of sodium selenite, 0.0024 part of potassium iodide, 0.04 part of anhydrous copper sulfate and 0.4 part of manganese gluconate.
According to one aspect of the invention, the multivitamins are derived from vitamin A and vitamin D3Vitamin E, vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12One or a combination of more than two of L-sodium ascorbate, D-calcium pantothenate, folic acid, nicotinamide, D-biotin and inositol; preferably 0.16 part of vitamin A and vitamin D30.16 part of vitamin E, 0.364 part of vitamin K10.0316 part of vitaminElement B10.044 part of vitamin B20.044 part of vitamin B60.044 part of vitamin B120.008 parts, 5.8 parts of L-sodium ascorbate, 0.124 part of D-calcium pantothenate, 0.008 parts of folic acid, 0.08 part of nicotinamide, 0.036 part of D-biotin and 13.2 parts of inositol.
According to one aspect of the invention, the composite thickening agent is derived from one or a combination of more than two of carrageenan, guar gum and Arabic gum; preferably 24 parts of carrageenan, 28 parts of guar gum and 20 parts of Arabic gum.
According to one aspect of the invention, the food product comprises: 20-40 parts of the traditional Chinese medicine composition, 300 parts of protein 220-ion, 300 parts of fat 220-ion, 600 parts of carbohydrate 500-ion, 5-10 parts of compound vitamin, 20-25 parts of compound thickener, 0.8-1.2 parts of taurine, 0.8-1.5 parts of monoglyceride, 0.1-0.5 parts of nucleotide and 0.120-0.180 parts of L-carnitine;
preferably, the vanilla also comprises 2.4 parts of vanilla essence and 0.66 part of aspartame;
preferably, the composite thickener also comprises 20 to 25 parts.
The invention also provides a nutritional powder for relieving hypertension caused by lipid metabolism disorder, which comprises the following components in parts by weight:
6.6-53 parts of the traditional Chinese medicine composition, 808 parts of protein 101-containing materials, 56-452 parts of fat, 2260 part of carbohydrate 282-containing materials, 8-64 parts of compound mineral substances, 2.5-20 parts of compound vitamin, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerol fatty acid ester, 0.09-0.72 part of nucleotide and 0.06-0.48 part of L-carnitine; the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 1.4 to 11.2 parts of hawthorn.
Preferably, the vanilla also comprises 2.4 parts of vanilla essence and 0.66 part of aspartame;
preferably, the composite thickener also comprises 9 to 72 parts.
As a preferable scheme, the nutritional powder comprises the following components in parts by weight: 20-40 parts of the traditional Chinese medicine composition, 300 parts of protein 220-ion, 300 parts of fat 220-ion, 600 parts of carbohydrate 500-ion, 50-120 parts of compound mineral substances, 5-10 parts of compound vitamin, 0.8-1.2 parts of taurine, 0.8-1.5 parts of monoglyceride, 0.1-0.5 parts of nucleotide and 0.120-0.180 parts of L-carnitine; the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn;
preferably, the vanilla also comprises 2.4 parts of vanilla essence and 0.66 part of aspartame;
preferably, the composite thickener also comprises 20 to 25 parts.
According to one aspect of the invention, the protein is one or a combination of more than two of hydrolyzed whey protein powder, concentrated whey protein powder, soy protein isolate, whole egg powder, bovine colostrum powder, whole milk powder, lactoferrin and soy oligopeptide powder; preferably 120 parts of whey protein, 72 parts of soybean protein isolate, 5 parts of bovine colostrum powder and 72 parts of soybean oligopeptide powder.
According to one aspect of the invention, the fat is derived from one or a combination of more than two of olive oil powder, perilla seed oil powder, linseed oil powder, medium chain triglyceride powder, soybean oil powder, coconut oil portion and sunflower seed oil powder; preferably 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder.
According to one aspect of the invention, the carbohydrate is derived from one or a combination of more than two of maltodextrin, soybean dietary fiber, crystalline fructose, resistant starch, resistant dextrin, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and isomalto-oligosaccharide; preferably 492 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomalto-oligosaccharide.
According to one aspect of the invention, the compound mineral is one or a combination of more than two of calcium citrate, L-calcium lactate, sodium dihydrogen phosphate, sodium citrate, magnesium gluconate, ferrous gluconate, zinc gluconate, potassium gluconate, sodium selenite, potassium iodide, anhydrous copper sulfate and manganese gluconate; preferably 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide, 0.012 part of anhydrous copper sulfate and 0.12 part of manganese gluconate.
According to one aspect of the invention, the multivitamins are derived from vitamin A and vitamin D3Vitamin E, vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of L-sodium ascorbate, D-calcium pantothenate, folic acid, nicotinamide, D-biotin and inositol; preferably 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 part, 1.75 parts of L-sodium ascorbate, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin and 3.96 parts of inositol.
According to one aspect of the invention, the composite thickening agent is derived from one or a combination of more than two of carrageenan, guar gum and Arabic gum; preferably 7 parts of carrageenan, 8 parts of guar gum and 6 parts of Arabic gum.
The invention also provides a preparation method of the nutrition powder for treating hypertension caused by lipid metabolism disorder, which comprises the following steps:
(1) the preparation of the traditional Chinese medicine composition comprises the following steps:
decocting fructus Citri Sarcodactylis, Raphani semen, flos Sophorae Immaturus, Prunellae Spica, fructus crataegi, folium Eucommiae, and fructus crataegi with water, concentrating, and drying to obtain powdered medicinal composition;
(2) accurately weighing raw and auxiliary materials:
dividing maltodextrin in the carbohydrate with the formula amount into three equal parts, dividing the materials into a material a, a material b, a material c and a material d according to the types and the properties of the raw and auxiliary materials,
a, material a: an aliquot of maltodextrin, a formula amount of protein, a formula amount of carbohydrate other than maltodextrin;
b, material preparation: an equal portion of maltodextrin and a formula amount of a complex mineral;
c, material preparation: a formula amount of fat;
d, material: an equal amount of maltodextrin, compound vitamin, taurine, monoglyceride and nucleotide, L-carnitine and pharmaceutical composition;
preferably, the first and second electrodes are formed of a metal,
a, material a: 120 parts of whey protein powder, 72 parts of soybean protein isolate, 5 parts of bovine colostrum, 72 parts of soybean oligopeptide powder, 164 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomaltooligosaccharide;
b, material preparation: 164 parts of maltodextrin, 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide and 0.12 part of manganese gluconate;
c, material preparation: 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder;
d, material: 164 parts of maltodextrin, 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 part, 1.75 parts of L-sodium ascorbate, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin, 3.96 parts of inositol, 7 parts of carrageenan, 8 parts of guar gum, 6 parts of Arabic gum, 0.66 part of aspartame, 2.4 parts of vanilla essence, 0.144 part of L-carnitine, 0.2 part of nucleotide, 0.96 part of taurine and 0.012 part of anhydrous copper sulfate, wherein the components of the pharmaceutical composition are as follows: 1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn;
(3) premixing materials a and b:
premixing the components in the material a to form premix a;
premixing the components in the material b to form a premix b;
mixing the premix a and the premix b uniformly to obtain premix ab;
(4) and (3) wet granulation:
mixing the material a and the material b, and performing wet granulation;
(5) drying and granulating:
drying the ab-mixed wet particles obtained by the mixing granulation;
(6) c, premixing materials d:
uniformly mixing the components in the material c and the components in the material d to obtain a premix cd;
(7) total mixing:
and uniformly mixing the dried ab mixed particles and the premix cd.
According to one aspect of the invention, in the preparation of the traditional Chinese medicine composition, fingered citron, radish seed, sophora flower, selfheal, hawthorn, eucommia leaf and hawthorn are cleaned and soaked for 30min, firstly decocted for 30-40min, and then decocted for 2-3 times, the obtained water decoctions are mixed and further concentrated, and the concentrated solution is spray-dried to obtain medicinal and edible component powder.
According to one aspect of the invention, the specific preparation process of the premix a is as follows: and adding the weighed material a into a single-upright lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain the premix a.
According to one aspect of the invention, the specific preparation process of the premix b is as follows: and adding the weighed b material into a single-upright lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain a premix b.
According to one aspect of the invention, the specific preparation process of the premix ab is as follows: mixing the mixed premix a and premix b, adding into a single-column lifting hopper mixer at a set rotation speed of 10-15rpm, and mixing for 50-70min to obtain premix ab.
According to one aspect of the present invention, the wet granulation process comprises:
the premix ab is put into a high-efficiency wet mixing granulator, the stirring speed is set to be 130-.
According to one aspect of the invention, the particle size of the pre-mix ab is controlled to be larger than 40 mesh;
according to one aspect of the invention, the drying process comprises the following steps:
transferring the wet granules after granulation to a boiling drying granulator for drying; preferably, the drying is stopped when the water content is 4.0 to 5.5 percent; and then transferring the materials to a lifting and overturning granulator for granulation.
According to one aspect of the invention, the specific process of the premix cd is as follows:
adding the materials c and d into a single-upright-column lifting hopper mixing machine bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain a premix cd; and/or the presence of a gas in the gas,
the total mixing is carried out by adopting a three-dimensional mixer, and the mixing speed is set to be 5-10rpm for 120 min.
Compared with the prior art, the invention has the beneficial effects that:
the special traditional Chinese medicine composition with the auxiliary blood pressure reducing effect is added on the basis of a total nutrient formula, belongs to medicine and food homologous components, has the auxiliary blood pressure reducing effect on the basis of providing balanced nutrition for patients with hypertension, and can avoid the problems of large blood pressure fluctuation of the patients due to improper diet or malnutrition due to excessive diet control.
The traditional Chinese medicine composition added in the invention belongs to medicine-food homologous components, has the function of reducing blood pressure, has exact curative effect and safe blood pressure reducing effect by supplementing the components, and can provide necessary nutrient components for patients with hypertension together with other raw materials so as to improve the nutritional status of the patients.
The fat source in the formula of the invention is perilla seed oil, soybean oil and olive oil, is rich in omega-3 polyunsaturated fatty acid, and can play a role in reducing blood pressure by protecting the function of vascular endothelium, changing the compliance of blood vessels and influencing various aspects such as sympathetic nerve and renin angiotensin aldosterone system and ion channel.
The soybean oligopeptide is added in the formula, the content is up to 6 percent, and the soybean peptide contains rich angiotensin converting enzyme inhibitory peptide and can reduce the formation of angiotensin II in blood, thereby reducing the blood pressure of patients with primary hypertension.
In the formula of the invention, inulin, galacto-oligosaccharide, isomaltooligosaccharide and other dietary fiber sources are added, so that ions can be adsorbed and exchanged with sodium ions and potassium ions in intestinal tracts, and the sodium-potassium ratio in blood is reduced, thereby playing a role in reducing blood pressure.
The formula of the invention contains various vitamins and minerals, can quickly supplement micronutrients required by a patient with hypertension, and increases the absorption rate of mineral elements after the short peptide is chelated with calcium, iron, zinc and the like.
To further illustrate the essence of the present invention, animal experiments were performed on the Chinese medicinal composition of the present invention, and clinical experiments were performed on the nutritional powder of the present invention.
First, animal experiment
(1) Animal experiment modeling
SPF grade male SD rats 80, 6 weeks old, 120 ± 20g body weight, constant temperature in the house: 20-24 ℃, humidity: 40-70%, indoor illumination condition 12h light and shade are alternated, and free diet and water intake can be realized. Rats were randomly divided into 2 groups according to body weight after 7 days of adaptive feeding. Blank control group (NC), high fat model group (HM) 72. Establishing a hyperlipemia rat model: the blank control group is perfused with 1mL/100g of normal saline, the high-fat model group is perfused with high-fat emulsion per 1mL/100g of body weight for 1 time/d for 60 days, and drinking water and basal feed are normally supplied at the same time. After the last 1 times of gavage, the animals in each group were fasted for 12h without water supply. Collecting blood from infraorbital venous plexus, separating serum, and measuring serum Total Cholesterol (TC), Triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), Nitric Oxide (NO), and endothelin-1 (ET-1).
(2) Experiment grouping
After the model building is successful, 64 high-fat model rats are randomly selected and randomly grouped, namely a high-fat model group (HM), a mixture group (HG) is a mixture of Chinese medicine extracts including fingered citron, radish seed, sophora flower, selfheal and folium cortex eucommiae, and a control group is a fingered citron group (FSG), radish seed group (LG), sophora flower group (HG), selfheal group (XG) and folium cortex eucommiae group (DG). The dose of each group was converted according to the human dose and converted according to the equivalence principle, and the dose is shown in table 1.
TABLE 1 dosage of each group for reducing blood lipid
(3) Index detection
After the last gastric lavage of each group of animals, fasting for 12h without water prohibition, carrying out abdominal anesthesia by using 10% chloral hydrate according to 400mg/kg body weight, taking about 5mL of blood from aorta, naturally coagulating the blood at room temperature, centrifuging (3000rpm, 10min, 4 ℃), taking yellow transparent supernatant as serum, and storing at-80 ℃ for later use after subpackaging.
And (3) detecting TC, TG, LDL-C, HDL-C, NO and ET-1 in rat serum, and referring to the specifications of each kit for a specific operation method.
(5) Statistical treatment
Data analysis was performed using Origin 9.1. The measured data are averaged + -SD: (
S) in two groups, the same time point comparison between two groups is performed by independent sample t test, the group comparison is performed by paired t test, P<0.05 is significant, P<0.01 is a very significant difference.
(5) Analysis and discussion of results
As shown in the figures 1-4, the mixed solution of the Chinese herbal extracts can reduce the content of low-density lipoprotein cholesterol (LDL-C) in serum of hyperlipidemic rats (P <0.05) and increase the content of high-density lipoprotein cholesterol (HDL-C) (P <0.05), and a single Chinese herbal extract also has certain effects of reducing the content of low-density lipoprotein cholesterol in serum and increasing the content of high-density lipoprotein cholesterol, but the effect is lower than that of the Chinese herbal mixture. The traditional Chinese medicine extract mixture has certain capacity of regulating lipid metabolism disorder, so that the effect of the mixture extract is more obvious than that of a single extract.
To ascertain the protective effect of the herbal extract mixture, the study also analyzed the levels of relevant factors in the blood vessels, as shown in figures 5-6, and the results indicated that: compared with a control group, the traditional Chinese medicine extract mixture has the advantages that the Nitric Oxide (NO) is increased (P <0.01), the endothelin-1 (ET-1) is decreased (P <0.01) on the molecular level, and the FSG group, the LG group, the HG group, the XG group and the DG group also have the obvious effects of increasing NO (P <0.05) and decreasing ET-1(P <0.05), and have significant differences. Compared with the effect of the traditional Chinese medicine extract mixture, the effect of the traditional Chinese medicine extract mixture is more obvious, and the beneficial regulation effect of the traditional Chinese medicine extract mixture on the vascular cell related factors is shown.
Clinical experiment of nutritious powder (food)
(1) Study object
100 hypertensive patients were selected and randomized into two groups: study group 50 persons: 27 men, 23 women; control group 50 persons: 26 men and 24 women, the age range is 45-60 years. There were no statistical differences in age, gender between the two groups of patients (P > 0.05). Inclusion criteria were: can be used for treating serious cardiovascular diseases such as secondary hypertension, acute myocardial infarction, and unstable angina pectoris caused by kidney disease and endocrine disease.
(2) Method of administration
Study group: the nutritional powder of example 1 was orally administered to hypertensive patients 3 times a day. The modulation method comprises the following steps: 120g of warm boiled water is mixed with 300mL of water to prepare 400mL of liquid.
Control group: the homogenate diet is orally taken three times a day. The homogenate diet is composed of egg powder, soybean powder, rice, millet, carrot, green vegetables, salt, vegetable oil and trace element additive, and is powder.
The modulation method comprises the following steps: mixing 300mL of boiled water into 400mL of pasty object.
(3) Detecting the index
Systolic and diastolic blood pressure changes were observed in the study and control groups before nutritional support and at 1 and 2 months as check points.
(4) Statistical treatment
Data analysis was performed using Origin 9.1. The measured data is averaged + -SD
Showing that the same time point comparison between two groups adopts independent sample t test, the intra-group comparison adopts paired t test, P<A difference of 0.05 was significant.
(5) Results
After 2 months of nutritional dry prognosis, as shown in table 2, the diastolic blood pressure of the hypertensive patients in the study group was significantly lower than that before nutritional intervention (P < 0.05); compared with the control group, the hypertension diastolic pressure of the patients in the study group is obviously lower than that of the control group, and the significance is realized (P < 0.05). The systolic blood pressure of the hypertension patients in the study group is obviously different from that before the intervention (P < 0.05); the magnitude of the reduction in systolic blood pressure was greater in the study group of hypertensive patients compared to the control group (P < 0.05).
TABLE 2 comparative analysis of blood pressure of two groups of hypertensive patients
Note: p <0.05 compared to control; compared with before intervention#P＜0.05。
The results show that the nutrition powder for the hypertension patients has obvious nutrition intervention effect, can reduce the diastolic pressure and the systolic pressure of the hypertension patients to a certain extent, and improves the blood pressure condition of the patients. In the research process, no anaphylactic reaction, gastrointestinal tract and other adverse reactions occur, and the product can be taken by hypertensive patients at ease.
Drawings
FIG. 1 is a graph comparing TC levels in hyperlipidemic rats,
wherein: # denotes P <0.05 compared to the blank control group; denotes P <0.05 compared to the HM group;
FIG. 2 is a graph comparing the levels of TG in hyperlipidemic rats,
wherein: # denotes P <0.05 compared to the blank control group; denotes P <0.05 compared to the HM group;
FIG. 3 is a graph comparing the LDL-C levels in hyperlipidemic rats,
wherein: # indicates P <0.05 compared to placebo; denotes P <0.05 compared to the HM group; denotes P <0.01 compared to the HM group;
FIG. 4 is a graph comparing HDL-C levels in hyperlipidemic rats,
wherein: # indicates P <0.05 compared to placebo; denotes P <0.05 compared to the HM group; denotes P <0.01 compared to the HM group;
FIG. 5 is a graph comparing serum NO concentration levels in hyperlipidemic rats,
wherein: # indicates P <0.05 compared to placebo; denotes P <0.05 compared to the HM group;
FIG. 6 is a graph comparing the concentration levels of ET-1 in serum from hyperlipidemic rats,
wherein: # indicates P < 0.05; denotes P <0.05 compared to the HM group; denotes P <0.01 compared to the HM group.
Detailed Description
In the following description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of one or more embodiments. It may be evident, however, that such embodiment(s) may be practiced without these specific details. In other instances, well-known structures and devices are shown in block diagram form in order to facilitate describing one or more embodiments.
Various embodiments according to the present invention will be described in detail below with reference to the accompanying drawings.
A first embodiment of the present invention shows a pharmaceutical composition, which has the property of homology of medicine and food, and is used for assisting in alleviating hypertension in this embodiment. The traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 10.8 to 18 parts of hawthorn.
The traditional Chinese medicine composition can relieve hypertension caused by lipid metabolism disorder, and can be used as a medicine and food homologous component. The ancient prescription considers that the disease is related to emotion, long-term mental stress or depression and anger, stagnation of liver qi, fire transformation due to depression and spleen and stomach injury due to fire are the main reasons. Therefore, the prescription takes liver calming, phlegm reducing, liver heat clearing, kidney tonifying, blood circulation promoting and diuresis promoting as the main prescription for reducing blood pressure. In the formula, flos sophorae and selfheal are mainly used for clearing liver and purging fire, and calming liver and purging fire, and eucommia ulmoides leaves are used for nourishing yang and nourishing yin; semen Raphani and fructus Citri Sarcodactylis can also be added to relieve qi, resolve phlegm, and soothe the liver and regulate qi; the hawthorn fruit is added to strengthen the effects of promoting qi circulation and removing blood stasis. The fingered citron has certain functions of reducing blood pressure, relieving spasm and resisting aging, the fingered citron extract has the effect of inhibiting angiotensin converting enzyme, and the best effective active part for reducing blood pressure is screened out to be the fingered citron methanol extract. The radish seed has the functions of reducing blood pressure and blood fat, and the active substance for reducing blood pressure in the radish seed is sinapine thiocyanate. The semen Raphani water soluble alkaloid can activate nitric oxide-myocardial nitric oxide synthase system, dilate blood vessel, and lower blood pressure. Flos Sophorae Immaturus contains large amount of rutin, and has effects of increasing resistance of capillary vessel, increasing elasticity of human blood vessel wall, and preventing hypertension. The selfheal has obvious antihypertensive activity, can effectively reduce the systolic pressure and diastolic pressure of spontaneous hypertensive rats, and has lasting effect. The selfheal has the effects of reducing the blood pressure mechanism, reducing the content of angiotensin II and increasing the content of Nitric Oxide (NO); reducing the content of endothelin-1 (ET-1) and increasing the content of Atrial Natriuretic Peptide (ANP); the inhibition of intracellular calcium ion release and extracellular calcium ion influx are involved. The chemical component mainly containing chlorogenic acid in the eucommia ulmoides leaves has the function of reducing blood pressure, and the effect of reducing blood pressure is obvious and basically stable without adverse reaction. The total flavonoids in fructus crataegi can be used for inhibiting extracellular Ca2+Internal flow, inhibiting intracellular Ca2+Releasing and activating the non-selective potassium channel and the inward rectifying potassium channel to complete the relaxation of the isolated blood vessel of the rat, so as to reduce the blood pressure.
The optimal formula of the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn.
The traditional Chinese medicine composition is prepared by the following steps:
cleaning fructus Citri Sarcodactylis, Raphani semen, flos Sophorae Immaturus, Prunellae Spica, fructus crataegi, folium Eucommiae and fructus crataegi as raw materials of Chinese medicinal composition, soaking for 30min, decocting for 30-40min, and repeating for 2-3 times. Mixing the obtained water decoctions, further concentrating, and spray drying the concentrated solution to obtain Chinese medicinal composition powder.
The second embodiment of the invention shows the application of the traditional Chinese medicine composition in a food for lowering low-density lipoprotein cholesterol (LDL-C) in serum and raising high-density lipoprotein cholesterol (HDL-C) to realize blood pressure reduction. The above experimental results show that, referring to fig. 1-4, the mixed solution of the Chinese herbal extracts can reduce the low-density lipoprotein cholesterol (LDL-C) content (P <0.05) in the serum of the rat with hyperlipidemia and increase the high-density lipoprotein cholesterol (HDL-C) content (P <0.05), and a single Chinese herbal extract also has a certain effect of reducing the low-density lipoprotein cholesterol and increasing the high-density lipoprotein cholesterol in the serum, but the effect is lower than that of the Chinese herbal mixture. The traditional Chinese medicine extract mixture has certain capacity of regulating lipid metabolism disorder, so that the effect of the mixture extract is more obvious than that of a single extract.
The third embodiment of the invention shows the application of the traditional Chinese medicine composition in food for increasing the concentration of Nitric Oxide (NO) in blood at a molecular level and realizing blood pressure reduction.
The fourth embodiment of the invention shows the application of the traditional Chinese medicine composition in food for reducing the concentration of endothelin-1 (ET-1) in blood.
Referring to FIGS. 5-6, the results show that: compared with a control group, the traditional Chinese medicine extract mixture has the advantages that the Nitric Oxide (NO) is increased (P <0.01), the endothelin-1 (ET-1) is decreased (P <0.01) on the molecular level, and the FSG group, the LG group, the HG group, the XG group and the DG group also have the obvious effects of increasing NO (P <0.05) and decreasing ET-1(P <0.05), and have significant differences. Compared with the effect of the traditional Chinese medicine extract mixture, the effect of the traditional Chinese medicine extract mixture is more obvious, and the beneficial regulation effect of the traditional Chinese medicine extract mixture on the vascular cell related factors is shown.
The fifth embodiment of the invention shows the application of the medicinal composition in food for assisting in relieving hypertension.
In the sixth embodiment of the invention, the traditional Chinese medicine composition is applied to food for assisting in relieving hypertension, so that a nutritional powder product is realized, and the nutritional powder product is suitable for hypertension patients or hypertension patients accompanied with other symptoms, and is particularly suitable for hypertension patients caused by metabolic disorder. The nutritional powder comprises the following components in parts by weight:
6.6-53 parts of the traditional Chinese medicine composition, 808 parts of protein 101-containing materials, 56-452 parts of fat, 2260 part of carbohydrate 282-containing materials, 8-64 parts of compound mineral substances, 2.5-20 parts of compound vitamin, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerol fatty acid ester, 0.09-0.72 part of nucleotide and 0.06-0.48 part of L-carnitine.
The traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8 to 6.4 parts of fingered citron, 1 to 8 parts of radish seed, 0.9 to 7.2 parts of sophora flower, 1 to 8 parts of selfheal, 1.5 to 12 parts of eucommia leaf and 1.4 to 11.2 parts of hawthorn.
As a preferable mode of the fifth embodiment, the nutritional powder comprises the following components in parts by weight: 20-40 parts of the traditional Chinese medicine composition, 300 parts of protein 220-ion, 300 parts of fat 220-ion, 600 parts of carbohydrate 500-ion, 50-120 parts of compound mineral substances, 5-10 parts of compound vitamin, 0.8-1.2 parts of taurine, 0.8-1.5 parts of monoglyceride, 0.1-0.5 parts of nucleotide and 0.120-0.180 parts of L-carnitine; the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
2.4 parts of vanilla essence, 0.66 part of aspartame and 9-72 parts of composite thickening agent can also be added to further adjust the taste of the nutritional powder.
Wherein the protein is derived from hydrolyzed whey protein powder,One or more of concentrated whey protein powder, soybean protein isolate, whole egg powder, bovine colostrum powder, whole milk powder, lactoferrin, and soybean oligopeptide powder; preferably 120 parts of whey protein, 72 parts of soybean protein isolate, 5 parts of bovine colostrum powder and 72 parts of soybean oligopeptide powder. The fat is selected from one or more of olive oil powder, perilla seed oil powder, linseed oil powder, medium chain triglyceride powder, soybean oil powder, coconut oil powder and sunflower seed oil powder; preferably 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder. The carbohydrate is selected from one or more of maltodextrin, soybean dietary fiber, crystalline fructose, resistant starch, resistant dextrin, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and isomalto-oligosaccharide; preferably 492 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomalto-oligosaccharide. The compound mineral is selected from one or more of calcium citrate, L-calcium lactate, sodium dihydrogen phosphate, sodium citrate, magnesium gluconate, ferrous gluconate, zinc gluconate, potassium gluconate, sodium selenite, potassium iodide, anhydrous copper sulfate, and manganese gluconate; preferably 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide, 0.012 part of anhydrous copper sulfate and 0.12 part of manganese gluconate. The compound vitamin is derived from vitamin A and vitamin D3Vitamin E, vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of L-sodium ascorbate, D-calcium pantothenate, folic acid, nicotinamide, D-biotin and inositol; preferably 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 parts of L-sodium ascorbate1.75 parts, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin and 3.96 parts of inositol. The composite thickening agent is derived from one or the combination of more than two of carrageenan, guar gum and Arabic gum; preferably 7 parts of carrageenan, 8 parts of guar gum and 6 parts of Arabic gum.
The preparation method of the nutritional powder comprises the following steps:
(1) the preparation of the traditional Chinese medicine composition comprises the following steps:
decocting fructus Citri Sarcodactylis, Raphani semen, flos Sophorae Immaturus, Prunellae Spica, fructus crataegi, folium Eucommiae, and fructus crataegi with water, concentrating, and drying to obtain powdered medicinal composition;
(2) accurately weighing raw and auxiliary materials:
dividing maltodextrin in the carbohydrate with the formula amount into three equal parts, dividing the materials into a material a, a material b, a material c and a material d according to the types and the properties of the raw and auxiliary materials,
a, material a: an aliquot of maltodextrin, a formula amount of protein, a formula amount of carbohydrate other than maltodextrin;
b, material preparation: an equal portion of maltodextrin and a formula amount of a complex mineral;
c, material preparation: a formula amount of fat;
d, material: an equal amount of maltodextrin, compound vitamin, taurine, monoglyceride and nucleotide, L-carnitine and pharmaceutical composition;
(3) premixing materials a and b:
premixing the components in the material a to form premix a;
premixing the components in the material b to form premix b;
mixing the premix a and the premix b uniformly to obtain premix ab;
(4) and (3) wet granulation:
mixing the material a and the material b, and performing wet granulation;
(5) drying and granulating:
drying the ab-mixed wet particles obtained by the mixing granulation;
(6) c, premixing materials d:
uniformly mixing the components in the material c and the components in the material d to obtain a premix cd;
(7) total mixing:
and uniformly mixing the dried ab mixed particles and the premix cd.
For example, in the case of the optimal formulation of the nutritional powder, the a \ b \ c \ d materials are prepared as follows:
a, material a: 120 parts of whey protein powder, 72 parts of soybean protein isolate, 5 parts of bovine colostrum, 72 parts of soybean oligopeptide powder, 164 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomaltooligosaccharide;
b, material preparation: 164 parts of maltodextrin, 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide and 0.12 part of manganese gluconate;
c, material preparation: 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder;
d, material: 164 parts of maltodextrin, 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 part, 1.75 parts of L-sodium ascorbate, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin, 3.96 parts of inositol, 7 parts of carrageenan, 8 parts of guar gum, 6 parts of Arabic gum, 0.66 part of aspartame, 2.4 parts of vanilla essence, 0.144 part of L-carnitine, 0.2 part of nucleotide, 0.96 part of taurine and 0.012 part of anhydrous copper sulfate, wherein the components of the pharmaceutical composition are as follows: 1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn;
wherein the content of the first and second substances,
the specific preparation process of the premix a comprises the following steps: and adding the weighed material a into a single-upright lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain the premix a.
The specific preparation process of the premix b comprises the following steps: and adding the weighed b material into a single-upright lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain a premix b.
The specific preparation process of the premix ab comprises the following steps: mixing the mixed premix a and premix b, adding into a single-column lifting hopper mixer at a set rotation speed of 10-15rpm, and mixing for 50-70min to obtain premix ab.
The wet granulation process comprises the following specific steps: the premix ab is put into a high-efficiency wet mixing granulator, the stirring speed is set to be 130-. In this example, the particle size of the premix ab was controlled to be greater than 40 mesh;
the specific drying process comprises the following steps: transferring the wet granules after granulation to a boiling drying granulator for drying; preferably, the drying is stopped when the water content is 4.0-5.5%; and then transferring the materials to a lifting and overturning granulator for granulation.
The specific process of the premix cd is as follows: and c, adding the materials c and d into a single-upright-column lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain the premix cd.
The total mixing is carried out by adopting a three-dimensional mixer, and the mixing speed is set to be 5-10rpm for 120 min.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (15)
1. The application of a traditional Chinese medicine composition in food for assisting in relieving hypertension is characterized in that: the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8-6.4 parts of fingered citron, 1-8 parts of radish seed, 0.9-7.2 parts of sophora flower, 1-8 parts of selfheal, 1.5-12 parts of eucommia leaf and 10.8-18 parts of hawthorn;
preferably, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
2. The application of a traditional Chinese medicine composition in foods for reducing blood pressure by reducing low-density lipoprotein cholesterol (LDL-C) and increasing high-density lipoprotein cholesterol (HDL-C) in serum is characterized in that: the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8-6.4 parts of fingered citron, 1-8 parts of radish seed, 0.9-7.2 parts of sophora flower, 1-8 parts of selfheal, 1.5-12 parts of eucommia leaf and 10.8-18 parts of hawthorn;
preferably, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
3. The application of a traditional Chinese medicine composition in food for increasing the concentration of Nitric Oxide (NO) in blood at a molecular level to realize blood pressure reduction is characterized in that: the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8-6.4 parts of fingered citron, 1-8 parts of radish seed, 0.9-7.2 parts of sophora flower, 1-8 parts of selfheal, 1.5-12 parts of eucommia leaf and 10.8-18 parts of hawthorn;
preferably, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
4. The application of a traditional Chinese medicine composition in food for reducing the concentration of endothelin-1 (ET-1) in blood is disclosed, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8-6.4 parts of fingered citron, 1-8 parts of radish seed, 0.9-7.2 parts of sophora flower, 1-8 parts of selfheal, 1.5-12 parts of eucommia leaf and 10.8-18 parts of hawthorn;
preferably, the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaf and 15.8 parts of hawthorn.
5. Use according to claims 1-4, characterized in that the food product comprises: 6.6-53 parts of the traditional Chinese medicine composition, 808 parts of protein 101-containing materials, 56-452 parts of fat, 2260 part of carbohydrate 282-containing materials, 68-124 parts of compound mineral substances, 2.5-20 parts of compound vitamin, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerol fatty acid ester, 0.09-0.72 part of nucleotide and 0.06-0.48 part of L-carnitine;
preferably, the food also comprises 1-8 parts of vanilla essence and 0.3-2.2 parts of aspartame;
preferably, the food also comprises 9-72 parts of composite thickening agent;
preferably, the protein is one or the combination of more than two of hydrolyzed whey protein powder, concentrated whey protein powder, soy protein isolate, whole egg powder, bovine colostrum powder, whole milk powder, lactoferrin and soy oligopeptide powder; preferably 400 parts of whey protein, 240 parts of soybean protein isolate, 16 parts of bovine colostrum powder and 240 parts of soybean oligopeptide powder;
the fat is selected from one or more of olive oil powder, perilla seed oil powder, linseed oil powder, medium chain triglyceride powder, soybean oil powder, coconut oil powder and sunflower seed oil powder; preferably 35 parts of perilla seed oil powder, 152 parts of coconut oil powder, 400 parts of soybean oil powder, 152 parts of olive oil powder and 140 parts of medium chain triglyceride powder;
the carbohydrate is selected from one or more of maltodextrin, soybean dietary fiber, crystalline fructose, resistant starch, resistant dextrin, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and isomalto-oligosaccharide; preferably maltodextrin 1640 parts, inulin 24 parts, crystalline fructose 40 parts, galacto-oligosaccharide 40 parts, isomalto-oligosaccharide 40 parts;
the compound mineral is selected from one or more of calcium citrate, L-calcium lactate, sodium dihydrogen phosphate, sodium citrate, magnesium gluconate, ferrous gluconate, zinc gluconate, potassium gluconate, sodium selenite, potassium iodide, anhydrous copper sulfate, and manganese gluconate; preferably 24 parts of calcium citrate, 32 parts of L-calcium lactate, 32 parts of sodium dihydrogen phosphate, 16 parts of sodium citrate, 90 parts of magnesium gluconate, 16 parts of ferrous gluconate, 2 parts of zinc gluconate, 132 parts of potassium gluconate, 0.36 part of sodium selenite, 0.0024 part of potassium iodide, 0.04 part of anhydrous copper sulfate and 0.4 part of manganese gluconate;
the compound vitamin is derived from vitamin A, vitamin D3, vitamin E, and vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of L-sodium ascorbate, D-calcium pantothenate, folic acid, nicotinamide, D-biotin and inositol; preferably 0.16 part of vitamin A and vitamin D30.16 part of vitamin E, 0.364 part of vitamin K10.0316 part of vitamin B10.044 part of vitamin B20.044 part of vitamin B60.044 part of vitamin B120.008 parts, 5.8 parts of L-sodium ascorbate, 0.124 part of D-calcium pantothenate, 0.008 parts of folic acid, 0.08 part of nicotinamide, 0.036 part of D-biotin and 13.2 parts of inositol;
the composite thickening agent is derived from one or the combination of more than two of carrageenan, guar gum and Arabic gum; preferably 24 parts of carrageenan, 28 parts of guar gum and 20 parts of Arabic gum.
6. Use according to claims 1-4, characterized in that the food product comprises: 20-40 parts of the traditional Chinese medicine composition, 300 parts of protein 220-ion, 300 parts of fat 220-ion, 600 parts of carbohydrate 500-ion, 50-120 parts of compound mineral substances, 5-10 parts of compound vitamin, 20-25 parts of compound thickener, 0.8-1.2 parts of taurine, 0.8-1.5 parts of monoglyceride, 0.1-0.5 parts of nucleotide and 0.120-0.180 parts of L-carnitine;
preferably, the food also comprises 2.4 parts of vanilla essence and 066 parts of aspartame;
preferably, the food also comprises 20-25 parts of composite thickening agent.
7. The nutritional powder for relieving hypertension caused by lipid metabolism disorder is characterized by comprising the following components in parts by weight:
6.6-53 parts of the traditional Chinese medicine composition, 808 parts of protein 101-containing materials, 56-452 parts of fat, 2260 part of carbohydrate 282-containing materials, 8-64 parts of compound mineral substances, 2.5-20 parts of compound vitamin, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerol fatty acid ester, 0.09-0.72 part of nucleotide and 0.06-0.48 part of L-carnitine; the traditional Chinese medicine composition is prepared from the following components in parts by weight:
0.8-6.4 parts of fingered citron, 1-8 parts of radish seed, 0.9-7.2 parts of sophora flower, 1-8 parts of selfheal, 1.5-12 parts of eucommia leaf and 1.4-11.2 parts of hawthorn;
preferably, 1-8 parts of vanilla essence and 0.3-2.2 parts of aspartame are also included;
preferably, the composite thickener also comprises 9 to 72 parts.
8. The nutritional powder for treating hypertension caused by lipid metabolism disorder according to claim 7, wherein the nutritional powder comprises the following components in parts by weight: 20-40 parts of the traditional Chinese medicine composition, 300 parts of protein 220-ion, 300 parts of fat 220-ion, 600 parts of carbohydrate 500-ion, 50-120 parts of compound mineral substances, 5-10 parts of compound vitamin, 0.8-1.2 parts of taurine, 0.8-1.5 parts of monoglyceride, 0.1-0.5 parts of nucleotide and 0.120-0.180 parts of L-carnitine; the traditional Chinese medicine composition is prepared from the following components in parts by weight:
1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn;
preferably, the vanilla also comprises 2.4 parts of vanilla essence and 0.66 part of aspartame;
preferably, the composite thickener also comprises 20 to 25 parts.
9. The nutritional powder for alleviating hypertension caused by lipid metabolism disorder according to claim 7 or 8, wherein the protein is one or a combination of two or more of hydrolyzed whey protein powder, concentrated whey protein powder, soy protein isolate, whole egg powder, bovine colostrum powder, whole milk powder, lactoferrin, and soy oligopeptide powder; preferably 120 parts of whey protein, 72 parts of soybean protein isolate, 5 parts of bovine colostrum powder and 72 parts of soybean oligopeptide powder;
the fat is selected from one or more of olive oil powder, perilla seed oil powder, linseed oil powder, medium chain triglyceride powder, soybean oil powder, coconut oil powder and sunflower seed oil powder; preferably 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder;
the carbohydrate is selected from one or more of maltodextrin, soybean dietary fiber, crystalline fructose, resistant starch, resistant dextrin, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and isomalto-oligosaccharide; preferably 492 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomalto-oligosaccharide;
the compound mineral is selected from one or more of calcium citrate, L-calcium lactate, sodium dihydrogen phosphate, sodium citrate, magnesium gluconate, ferrous gluconate, zinc gluconate, potassium gluconate, sodium selenite, potassium iodide, anhydrous copper sulfate, and manganese gluconate; preferably 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide, 0.012 part of anhydrous copper sulfate and 0.12 part of manganese gluconate;
the compound vitamin is derived from vitamin A and vitamin D3Vitamin E, vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of L-sodium ascorbate, D-calcium pantothenate, folic acid, nicotinamide, D-biotin and inositol; preferably 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 part, 1.75 parts of L-sodium ascorbate, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin and 3.96 parts of inositol;
the composite thickening agent is derived from one or the combination of more than two of carrageenan, guar gum and Arabic gum; preferably 7 parts of carrageenan, 8 parts of guar gum and 6 parts of Arabic gum.
10. The method for preparing a nutritional powder for hypertension caused by lipid metabolism disorders according to any one of claims 7 to 9, comprising the steps of:
(1) the preparation of the traditional Chinese medicine composition comprises the following steps:
decocting fructus Citri Sarcodactylis, Raphani semen, flos Sophorae Immaturus, Prunellae Spica, fructus crataegi, folium Eucommiae, and fructus crataegi with water, concentrating, and drying to obtain powdered medicinal composition;
(2) accurately weighing raw and auxiliary materials:
dividing maltodextrin in the carbohydrate with the formula amount into three equal parts, dividing the materials into a material a, a material b, a material c and a material d according to the types and the properties of the raw and auxiliary materials,
a, material a: an aliquot of maltodextrin, a formula amount of protein, a formula amount of carbohydrate other than maltodextrin;
b, material preparation: an equal portion of maltodextrin and a formula amount of a complex mineral;
c, material preparation: a formulated amount of fat;
d, material: an equal amount of maltodextrin, compound vitamin, taurine, monoglyceride and nucleotide, L-carnitine and pharmaceutical composition;
preferably, the first and second electrodes are formed of a metal,
a, material a: 120 parts of whey protein powder, 72 parts of soybean protein isolate, 5 parts of bovine colostrum, 72 parts of soybean oligopeptide powder, 164 parts of maltodextrin, 7 parts of inulin, 12 parts of crystalline fructose, 12 parts of galacto-oligosaccharide and 12 parts of isomaltooligosaccharide;
b, material preparation: 164 parts of maltodextrin, 7 parts of calcium citrate, 10 parts of L-calcium lactate, 10 parts of sodium dihydrogen phosphate, 5 parts of sodium citrate, 27 parts of magnesium gluconate, 0.48 part of ferrous gluconate, 0.6 part of zinc gluconate, 40 parts of potassium gluconate, 0.108 part of sodium selenite, 0.0007 part of potassium iodide and 0.12 part of manganese gluconate;
c, material preparation: 10 parts of perilla seed oil powder, 46 parts of coconut oil powder, 120 parts of soybean oil powder, 46 parts of olive oil powder and 42 parts of medium chain triglyceride powder;
d, material: 164 parts of maltodextrin, 0.048 part of vitamin A and vitamin D30.048 part of vitamin E, 0.11 part of vitamin K10.009 parts, vitamin B10.013 part of vitamin B20.013 part of vitamin B60.013 part of vitamin B120.0024 part, 1.75 parts of L-sodium ascorbate, 0.037 part of D-calcium pantothenate, 0.0024 part of folic acid, 0.024 part of nicotinamide, 0.0108 part of D-biotin, 3.96 parts of inositol, 7 parts of carrageenan, 8 parts of guar gum, 6 parts of Arabic gum, 0.66 part of aspartame, 2.4 parts of vanilla essence, 0.144 part of L-carnitine, 0.2 part of nucleotide, 0.96 part of taurine and 0.012 part of anhydrous copper sulfate, wherein the components of the pharmaceutical composition are as follows: 1.92 parts of fingered citron, 2.4 parts of radish seed, 2.16 parts of sophora flower, 2.4 parts of selfheal, 3.6 parts of eucommia leaves and 15.8 parts of hawthorn;
(3) premixing materials a and b:
premixing the components in the material a to form premix a;
premixing the components in the material b to form premix b;
mixing the premix a and the premix b uniformly to obtain premix ab;
(4) and (3) wet granulation:
mixing the material a and the material b, and performing wet granulation;
(5) drying and granulating:
drying the ab-mixed wet particles obtained by the mixing granulation;
(6) c, premixing materials d:
uniformly mixing the components in the material c and the components in the material d to obtain a premix cd;
(7) total mixing:
and uniformly mixing the dried ab mixed particles and the premix cd.
11. The method for preparing the nutritional powder for hypertension caused by lipid metabolism disorder according to claim 10, wherein the preparation of the Chinese medicinal composition comprises cleaning fingered citron, radish seed, sophora flower, selfheal, hawthorn, eucommia bark leaf and hawthorn, soaking for 30min, decocting for 30-40min after intensive treatment, repeating the decocting for 2-3 times, mixing the obtained water decoctions, further concentrating, and spray drying the concentrated solution to obtain medicinal and edible component powder.
12. The method for producing a nutritional powder for hypertension caused by lipid metabolism disorders according to claim 10,
the specific preparation process of the premix a comprises the following steps: adding the weighed material a into a single-upright-column lifting hopper mixer bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain premix a; and/or the presence of a gas in the gas,
the specific preparation process of the premix b comprises the following steps: adding the weighed b material into a single-upright lifting hopper mixer bin, and mixing for 50-70min at a set rotation speed of 10-15rpm to obtain a premix b; and/or the presence of a gas in the gas,
the specific preparation process of the premix ab comprises the following steps: mixing the mixed premix a and premix b, adding into a single-column lifting hopper mixer at a set rotation speed of 10-15rpm, and mixing for 50-70min to obtain premix ab.
13. The method for preparing nutritional powder for hypertension caused by lipid metabolism disorder according to claim 10, wherein the wet granulation comprises the following specific processes:
putting the premix ab into a high-efficiency wet mixing granulator, setting the stirring speed at 130-;
preferably, the particle size of the pre-mix ab is controlled to be greater than 40 mesh.
14. The method for preparing nutritional powder for hypertension caused by lipid metabolism disorder according to claim 10, wherein the drying process comprises:
transferring the wet granules after granulation to a boiling drying granulator for drying; preferably, the drying is stopped when the water content is 4.0-5.5%; and then transferring the materials to a lifting and overturning granulator for granulation.
15. The preparation method of the nutritional powder for hypertension caused by lipid metabolism disorder according to claim 10, wherein the specific process of the premix cd is as follows:
adding the materials c and d into a single-upright-column lifting hopper mixing machine bin, and mixing for 50-70min at a set rotating speed of 10-15rpm to obtain a premix cd; and/or the presence of a gas in the gas,
and the total mixing is carried out by adopting a three-dimensional mixer, and the mixing speed is set to be 5-10rpm for 120 min.
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