CN114456396A - Polymer modified zinc oxide and preparation method and application thereof - Google Patents
Polymer modified zinc oxide and preparation method and application thereof Download PDFInfo
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- CN114456396A CN114456396A CN202210108282.1A CN202210108282A CN114456396A CN 114456396 A CN114456396 A CN 114456396A CN 202210108282 A CN202210108282 A CN 202210108282A CN 114456396 A CN114456396 A CN 114456396A
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Abstract
The invention relates to polymer modified zinc oxide and a preparation method and application thereof. The preparation method comprises the following steps: dissolving a water-soluble polymer in water to obtain a polymer solution; adding nano zinc oxide colloid into the polymer solution, stirring, mixing and reacting to obtain reaction liquid; and centrifuging the reaction solution, and collecting the precipitate to obtain the polymer modified zinc oxide. According to the preparation method of the polymer modified zinc oxide, the water-soluble polymer is dissolved to obtain the polymer solution, the nano zinc oxide colloid and the polymer solution are stirred, mixed and reacted, the water-soluble polymer is combined on the surface of the nano zinc oxide, and the polymer modified zinc oxide is obtained through centrifugal treatment, so that the antibacterial effect can be enhanced.
Description
Technical Field
The invention relates to the technical field of nano materials, in particular to polymer modified zinc oxide and a preparation method and application thereof.
Background
Harmful bacteria are important factors that harm human health, and thus development and utilization of antibacterial materials to inhibit and kill harmful bacteria are an important aspect to improve human health. The traditional antibacterial materials such as antibiotics, quaternary ammonium salts and the like not only cause the resistance of microorganisms, but also cause serious environmental pollution. The nano material has the characteristics of stronger transmembrane capacity, function of inhibiting efflux, difficulty in inducing bacterial drug resistance and the like, and is expected to become a novel antibacterial material.
The nano zinc oxide (ZnO) has special performance and new application which are incomparable with common zinc oxide in the aspects of magnetism, light, electricity and the like due to the special surface effect, small-size effect, macroscopic quantum tunnel effect and the like. In a neutral environment, the nano zinc oxide shows remarkable antibacterial property without illumination, and because the zinc oxide has rich raw material sources and low price and is also a mineral element necessary for a human body, the nano zinc oxide becomes one of the hot spots for the research of inorganic antibacterial agents. However, when the nano zinc oxide is used as a single antibacterial material, the antibacterial performance has certain limitation.
Disclosure of Invention
Accordingly, there is a need for a polymer modified zinc oxide, and a preparation method and an application thereof, so as to improve antibacterial effect.
One of the purposes of the invention is to provide a preparation method of polymer modified zinc oxide, and the scheme is as follows:
a preparation method of polymer modified zinc oxide is characterized by comprising the following steps:
dissolving a water-soluble polymer in water to obtain a polymer solution;
adding the nano zinc oxide colloid into the polymer solution, stirring, mixing and reacting to obtain a reaction solution;
and step three, carrying out centrifugal treatment on the reaction liquid, and collecting precipitates to obtain the polymer modified zinc oxide.
In one embodiment, the water soluble polymer is selected from one or more of polyethylene glycol, polyglycolic acid, polyvinylpyrrolidone, and polyvinyl alcohol.
In one embodiment, the mass ratio of the water-soluble polymer to the nano zinc oxide in the nano zinc oxide colloid is 1: 0.5-1: 4.
In one embodiment, the mass ratio of the water-soluble polymer to the nano zinc oxide in the nano zinc oxide colloid is 1: 0.8-1: 3.
In one embodiment, the concentration of the polymer solution is 0.016 mg/mL-0.06 mg/mL.
In one embodiment, the nano zinc oxide colloid has a mass concentration of 4 × 10-3mol/L～8×10-3mol/L。
In one embodiment, the nano zinc oxide colloid has a particle size of 30nm to 50 nm.
In one embodiment, in the second step, the stirring speed is 500rpm to 700 rpm.
In one embodiment, in the second step, the reaction time is 2-4 h.
In one embodiment, in the third step, the centrifugation rate is 6000rpm to 10000 rpm.
One of the purposes of the invention is to provide a polymer modified zinc oxide, and the scheme is as follows:
a polymer modified zinc oxide prepared by the preparation method of any one of the above embodiments.
The invention also aims to provide application of the polymer modified zinc oxide as an antibacterial material.
Compared with the prior scheme, the polymer modified zinc oxide and the preparation method thereof have the following beneficial effects:
according to the preparation method of the polymer modified zinc oxide, the water-soluble polymer is dissolved to obtain the polymer solution, the nano zinc oxide colloid and the polymer solution are stirred and mixed to react, the water-soluble polymer is combined on the surface of the nano zinc oxide, and the polymer modified zinc oxide is obtained through centrifugal treatment, so that the antibacterial effect can be enhanced.
Drawings
FIG. 1 is a photograph of polymer-modified zinc oxide prepared in example 1.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The preparation method of the polymer modified zinc oxide provided by the embodiment of the invention comprises the following steps:
step one, dissolving a water-soluble polymer in water to obtain a polymer solution.
And step two, adding the nano zinc oxide colloid into the polymer solution, stirring, mixing and reacting to obtain a reaction solution.
And step three, carrying out centrifugal treatment on the reaction liquid, and collecting precipitates to obtain the polymer modified zinc oxide.
According to the preparation method of the polymer modified zinc oxide, the water-soluble polymer is dissolved to obtain the polymer solution, the nano zinc oxide colloid and the polymer solution are stirred, mixed and reacted, the water-soluble polymer is combined on the surface of the nano zinc oxide, and the polymer modified zinc oxide is obtained through centrifugal treatment, so that the antibacterial effect can be enhanced.
Alternatively, the water-soluble polymer may be selected from, but not limited to, one or more of polyethylene glycol (PEG), polyglycolic acid (PGA), polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA).
One of the technical cores of the invention lies in the selection of the water-soluble polymer, and the above example modifies the zinc oxide through the preferable water-soluble polymer, so that the zinc oxide has excellent antibacterial performance compared with the traditional nano zinc oxide.
In one example, the water-soluble polymer is selected from one of polyethylene glycol (PEG), polyglycolic acid (PGA), polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA).
In one example, the concentration of the polymer solution is 0.016 mg/mL-0.06 mg/mL.
In one example, the nano zinc oxide colloid has a mass concentration of 4 × 10-3mol/L～8×10-3mol/L。
In one example, the mass ratio of the water-soluble polymer to the nano zinc oxide in the nano zinc oxide colloid is 1: 0.5-1: 4.
Further, in one example, the mass ratio of the water-soluble polymer to the nano zinc oxide in the nano zinc oxide colloid is 1: 0.8-1: 3.
The above examples can enhance the antibacterial effect of the product by further optimizing the mass ratio of the water-soluble polymer and the nano zinc oxide.
In one example, the nano zinc oxide colloid has a nano zinc oxide particle size of 30nm to 50 nm.
In one example, in the second step, the stirring speed is 500rpm to 700 rpm. In some specific examples, in the second step, the stirring rate is 500rpm, 550rpm, 600rpm, 650rpm, 700rpm, or the like.
In one example, in the second step, the reaction time is 2-4 h. In some specific examples, in the second step, the reaction time is 2h, 2.3h, 2.6h, 2.9h, 3.2h, 3.6h, and the like.
In one example, in the third step, the centrifugation rate is 6000rpm to 10000 rpm. In some specific examples, the rate of the centrifugation process is 6000rpm, 7000rpm, 8000rpm, 9000rpm, 10000rpm, and the like.
Further, the invention also provides polymer modified zinc oxide which is prepared by the preparation method illustrated in the above example.
According to the preparation method of the polymer modified zinc oxide, the water-soluble polymer is dissolved to obtain the polymer solution, the nano zinc oxide colloid and the polymer solution are stirred, mixed and reacted, the water-soluble polymer is combined on the surface of the nano zinc oxide, and the polymer modified zinc oxide is obtained through centrifugal treatment, so that the antibacterial effect can be enhanced.
Furthermore, the invention also provides application of the polymer modified zinc oxide as an antibacterial material.
The following examples are provided to further illustrate the present invention, but the present invention is not limited to the following examples, and it should be understood that the scope of the present invention is summarized by the appended claims, and a person skilled in the art should realize that certain changes made to the embodiments of the present invention, in light of the inventive concept, are intended to be covered by the spirit and scope of the claims of the present invention.
Example 1
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyvinylpyrrolidone (PVP) in water, and stirring for 20min to completely dissolve the PVP to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 0.8. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 2
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyvinylpyrrolidone (PVP) in water, and stirring for 20min to completely dissolve the PVP to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 3
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyvinylpyrrolidone (PVP) in water, and stirring for 20min to completely dissolve the PVP to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1.25. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 4
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyvinylpyrrolidone (PVP) in water, and stirring for 20min to completely dissolve the PVP to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1.7. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 5
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyvinylpyrrolidone (PVP) in water, and stirring for 20min to completely dissolve the PVP to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 3. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 6
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 0.5. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 7
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, absorbing the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 0.8. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 8
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 9
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1.25. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 10
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 1.7. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 11
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 2.5. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Example 12
This example prepares a polymer modified zinc oxide and a method for preparing the same.
The preparation method of this example includes the following steps:
step 1, preparing nano zinc oxide colloid, weighing 5mg of nano zinc oxide, adding into 10mL of water, and uniformly stirring at the speed of 550rpm for 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
And 2, preparing a polymer solution, dissolving polyethylene glycol (PEG) in water, and stirring for 20min to completely dissolve the polyethylene glycol (PEG) to obtain the polymer solution. The volume of the polymer solution was 6 mL.
And 3, sucking the nano zinc oxide colloid prepared in the step 1 by using a rubber head dropper, and slowly adding the nano zinc oxide colloid into the polymer solution prepared in the step 2, wherein the mass ratio of the polymer solution to the nano zinc oxide colloid is 1: 3. Stirring, mixing and reacting for 2h to obtain a reaction solution.
And 4, centrifuging the reaction solution in the step 3 at the centrifugation speed of 8000 rpm. And collecting the precipitate to obtain the polymer modified zinc oxide.
Comparative example 1
The comparative example provides a nano zinc oxide colloid, and the preparation method comprises the following steps:
6mg of nano zinc oxide is weighed and added into 20mL of water and stirred evenly at the speed of 550rpm, and the stirring time is 40 min. The quantity concentration of the nano zinc oxide colloid is 0.004 mol/L.
Comparative example 2
The comparative example provides a nano zinc oxide colloid, and the preparation method comprises the following steps:
9mg of nano zinc oxide is weighed and added into 20mL of water and stirred evenly at the speed of 550rpm, and the stirring time is 40 min. The quantity concentration of the nano zinc oxide colloid is 0.006 mol/L.
Comparative example 3
The comparative example provides a nano zinc oxide colloid, and the preparation method comprises the following steps:
12mg of nano zinc oxide is weighed and added into 20mL of water and stirred evenly at the speed of 550rpm, and the stirring time is 40 min. The mass concentration of the nano zinc oxide colloid is 0.008 mol/L.
Example 1 photographs of polymer-modified zinc oxide obtained after centrifugation are shown in fig. 1.
The products obtained in examples 1 to 12 and comparative examples 1 to 3 were subjected to an antibacterial test, and the Minimum Inhibitory Concentrations (MIC) of the products against Escherichia coli and Staphylococcus aureus were respectively tested. The test results are shown in table 1.
TABLE 1
According to the preparation method of the polymer modified zinc oxide, the water-soluble polymer is dissolved to obtain the polymer solution, the nano zinc oxide colloid and the polymer solution are stirred, mixed and reacted, the water-soluble polymer is combined on the surface of the nano zinc oxide, and the polymer modified zinc oxide is obtained through centrifugal treatment, so that the antibacterial effect can be enhanced.
Compared with the traditional nano zinc oxide, the nano zinc oxide modified by the macromolecule has excellent antibacterial performance, the preparation method is simple and easy, and the safety is high.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A preparation method of polymer modified zinc oxide is characterized by comprising the following steps:
dissolving a water-soluble polymer in water to obtain a polymer solution;
adding the nano zinc oxide colloid into the polymer solution, stirring, mixing and reacting to obtain a reaction solution;
and step three, carrying out centrifugal treatment on the reaction liquid, and collecting precipitates to obtain the polymer modified zinc oxide.
2. The method for preparing polymer-modified zinc oxide according to claim 1, wherein the water-soluble polymer is one or more selected from polyethylene glycol, polyglycolic acid, polyvinylpyrrolidone, and polyvinyl alcohol.
3. The method for preparing polymer-modified zinc oxide according to claim 1, wherein the mass ratio of the water-soluble polymer to the nano zinc oxide in the nano zinc oxide colloid is 1: 0.5-1: 4.
4. The method of claim 1, wherein the concentration of the polymer solution is 0.016 mg/mL-0.06 mg/mL.
5. The method of claim 1, wherein the nano zinc oxide colloid is present in an amount of 4 x 10-3mol/L～8×10-3mol/L。
6. The method for preparing polymer-modified zinc oxide according to claim 1, wherein in the second step, the stirring speed is 500rpm to 700 rpm.
7. The method for preparing polymer modified zinc oxide according to claim 1, wherein in the second step, the reaction time is 2-4 h.
8. The method for preparing polymer modified zinc oxide according to any one of claims 1 to 7, wherein in the third step, the speed of the centrifugal treatment is 8000rpm to 10000 rpm.
9. A polymer-modified zinc oxide, which is produced by the production method according to any one of claims 1 to 8.
10. Use of the polymer modified zinc oxide of claim 9 as an antimicrobial material.
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