CN114450010A - 耳用制剂、方法和装置 - Google Patents

耳用制剂、方法和装置 Download PDF

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Publication number
CN114450010A
CN114450010A CN202080068395.2A CN202080068395A CN114450010A CN 114450010 A CN114450010 A CN 114450010A CN 202080068395 A CN202080068395 A CN 202080068395A CN 114450010 A CN114450010 A CN 114450010A
Authority
CN
China
Prior art keywords
formulation
days
000cps
ear
mineral oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080068395.2A
Other languages
English (en)
Chinese (zh)
Inventor
D·I·赫普勒
G·L·登普西
D·A·埃克勒本
N·E·保尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dekra Veterinary Products Co
Original Assignee
Piedmont Animal Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piedmont Animal Health filed Critical Piedmont Animal Health
Priority to CN202510552853.4A priority Critical patent/CN120284977A/zh
Priority to CN202511023282.1A priority patent/CN120837502A/zh
Publication of CN114450010A publication Critical patent/CN114450010A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0662—Ears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
CN202080068395.2A 2019-10-11 2020-10-08 耳用制剂、方法和装置 Pending CN114450010A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202510552853.4A CN120284977A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置
CN202511023282.1A CN120837502A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962914301P 2019-10-11 2019-10-11
US62/914,301 2019-10-11
PCT/US2020/054770 WO2021072063A1 (en) 2019-10-11 2020-10-08 Otic formulations, methods and devices

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202511023282.1A Division CN120837502A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置
CN202510552853.4A Division CN120284977A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置

Publications (1)

Publication Number Publication Date
CN114450010A true CN114450010A (zh) 2022-05-06

Family

ID=75383696

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202080068395.2A Pending CN114450010A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置
CN202510552853.4A Pending CN120284977A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置
CN202511023282.1A Pending CN120837502A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202510552853.4A Pending CN120284977A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置
CN202511023282.1A Pending CN120837502A (zh) 2019-10-11 2020-10-08 耳用制剂、方法和装置

Country Status (6)

Country Link
US (3) US11986483B2 (enExample)
EP (1) EP4041153A4 (enExample)
JP (2) JP7680653B2 (enExample)
CN (3) CN114450010A (enExample)
AU (2) AU2020361511B2 (enExample)
WO (1) WO2021072063A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4041153A4 (en) * 2019-10-11 2023-10-25 Piedmont Animal Health Inc. OTIC FORMULATIONS, METHODS AND DEVICES

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070078116A1 (en) * 2003-08-20 2007-04-05 Fairfield Clinical Trials, Llc Method of treatment of otitis externa
CN101039668A (zh) * 2004-08-13 2007-09-19 先灵-普劳有限公司 包含抗菌素、三唑和皮质类固醇的药物制剂
US20100036000A1 (en) * 2008-07-21 2010-02-11 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
CN102612372A (zh) * 2009-11-11 2012-07-25 拜耳公司 用于快速治疗外耳炎的方法和组合物
US20130178801A1 (en) * 2012-01-10 2013-07-11 Entrx LLC Otic formulations, methods and devices
US20160058775A1 (en) * 2013-04-12 2016-03-03 Vyome Biosciences Pvt. Ltd. Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003616B2 (en) * 2004-04-23 2011-08-23 Albert Rory J Composition for the treatment of ear infections and method
US7858115B2 (en) * 2004-06-24 2010-12-28 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
US9849126B2 (en) * 2013-01-03 2017-12-26 Entrx LLC Sterile otic formulations
EP4041153A4 (en) * 2019-10-11 2023-10-25 Piedmont Animal Health Inc. OTIC FORMULATIONS, METHODS AND DEVICES

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070078116A1 (en) * 2003-08-20 2007-04-05 Fairfield Clinical Trials, Llc Method of treatment of otitis externa
CN101039668A (zh) * 2004-08-13 2007-09-19 先灵-普劳有限公司 包含抗菌素、三唑和皮质类固醇的药物制剂
US20100036000A1 (en) * 2008-07-21 2010-02-11 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
CN102612372A (zh) * 2009-11-11 2012-07-25 拜耳公司 用于快速治疗外耳炎的方法和组合物
US20130178801A1 (en) * 2012-01-10 2013-07-11 Entrx LLC Otic formulations, methods and devices
US20160058775A1 (en) * 2013-04-12 2016-03-03 Vyome Biosciences Pvt. Ltd. Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吴钟琪: "临床症状鉴别及诊疗", 人民军医出版社, pages: 708 *

Also Published As

Publication number Publication date
CA3153832A1 (en) 2021-04-15
US20240285651A1 (en) 2024-08-29
US12491189B2 (en) 2025-12-09
JP2025098165A (ja) 2025-07-01
JP2022551499A (ja) 2022-12-09
US20260060990A1 (en) 2026-03-05
JP7680653B2 (ja) 2025-05-21
US11986483B2 (en) 2024-05-21
CN120837502A (zh) 2025-10-28
AU2020361511B2 (en) 2025-12-18
EP4041153A4 (en) 2023-10-25
CN120284977A (zh) 2025-07-11
EP4041153A1 (en) 2022-08-17
AU2020361511A1 (en) 2022-04-14
WO2021072063A1 (en) 2021-04-15
US20210106597A1 (en) 2021-04-15
AU2026201359A1 (en) 2026-03-12

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Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Country or region after: U.S.A.

Address after: Kansas, USA

Applicant after: Piedmont Animal Health Co.,Ltd.

Address before: North Carolina, USA

Applicant before: Piedmont animal health

Country or region before: U.S.A.

CB02 Change of applicant information
TA01 Transfer of patent application right

Effective date of registration: 20240513

Address after: Kansas, USA

Applicant after: DEKRA Veterinary Products Co.

Country or region after: U.S.A.

Address before: Kansas, USA

Applicant before: Piedmont Animal Health Co.,Ltd.

Country or region before: U.S.A.

TA01 Transfer of patent application right