CN114404308A - Fullerene moisturizing, whitening and repairing essence and preparation method thereof - Google Patents
Fullerene moisturizing, whitening and repairing essence and preparation method thereof Download PDFInfo
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- CN114404308A CN114404308A CN202111454965.4A CN202111454965A CN114404308A CN 114404308 A CN114404308 A CN 114404308A CN 202111454965 A CN202111454965 A CN 202111454965A CN 114404308 A CN114404308 A CN 114404308A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention belongs to the technical field of cosmetics and discloses a fullerene moisturizing, whitening and repairing essence and a preparation method thereof, wherein the fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials: chelating agent, glycyrrhiza glabra root extract, pH regulator, preservative, compound essential oil, thickener, centella asiatica extract, glutathione, carrageen crispus extract, antioxidant, modified fullerene, aloe barbadensis leaf extract, agave stem extract, emulsifier, emollient, humectant, polyhydric alcohol and deionized water. The fullerene moisturizing, whitening and repairing essential oil liquid has good whitening, repairing and moisturizing effects, and the modified fullerene can effectively and rapidly eliminate free radicals, brighten skin color, recover and activate the activity of the body, effectively inhibit tyrosinase activity, inhibit melanin formation, reduce pigmentation and promote skin whitening.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to fullerene moisturizing, whitening and repairing essence and a preparation method thereof.
Background
Modern women have higher and higher requirements on the efficacy of skin care products, and in numerous brands of the skin care product market, the difference between the declared efficacy of most products and the actual using effect of the products is very far, such as the efficacy requirements of moisturizing, whitening, repairing, strengthening the skin compactness and the like; with the coexistence of the young and the aged of domestic female consumption subjects, the skin care product market needs to consider consumption groups at the same time, and has the skin care product which has actual use effect and scientific sense.
CN112022776A discloses a whitening essence and a preparation method thereof, wherein the essence comprises agave stem extract, glycyrrhiza glabra root extract, niacinamide, tranexamic acid, glycerin, xanthan gum, panthenol, bioglycan-1 and deionized water, which are considered to be the closest prior art of the present invention, and the essence has a better effect of inhibiting tyrosinase; the weight ratio of panthenol to bioglycan-1 is controlled to be 1: 1-6 can improve the skin tolerance, and further can absorb the effective components in the essence to a greater extent. According to the description of the specification, the maximum inhibition rate of the complex tyrosinase reaches 70.6%, and the whitening effect of the complex tyrosinase is still to be improved.
Disclosure of Invention
The invention provides a fullerene moisturizing, whitening and repairing essence liquid and a preparation method thereof.
The invention adopts the following technical scheme for solving the technical problems:
a fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.02-0.08 part of chelating agent, 0.04-0.1 part of glycyrrhiza glabra root extract, 0.1-0.3 part of pH regulator, 0.15-0.3 part of preservative, 0.2-0.4 part of compound essential oil, 0.2-0.5 part of thickener, 0.2-0.3 part of centella asiatica extract, 0.2-0.8 part of glutathione, 0.2-1 part of carrageen crispus extract, 0.3-0.8 part of antioxidant, 0.5-1 part of modified fullerene, 0.8-1.5 parts of aloe barbadensis leaf extract, 0.7-1.5 parts of agave stem extract, 0.8-2 parts of emulsifier, 2-5 parts of emollient, 4-10 parts of humectant, 6-15 parts of polyhydric alcohol and 60-80 parts of deionized water.
As a preferable scheme, the fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.02-0.06 part of chelating agent, 0.05-0.1 part of glycyrrhiza glabra root extract, 0.15-0.3 part of pH regulator, 0.15-0.25 part of preservative, 0.2-0.3 part of compound essential oil, 0.2-0.4 part of thickener, 0.2-0.5 part of centella asiatica extract, 0.2-0.6 part of glutathione, 0.2-0.6 part of carrageen crispus extract, 0.3-0.6 part of antioxidant, 0.6-1 part of modified fullerene, 0.8-1.2 parts of aloe barbadensis leaf extract, 1-1.5 parts of agave stem extract, 0.8-1.5 parts of emulsifier, 2-4 parts of emollient, 4-8 parts of humectant, 6-12 parts of polyhydric alcohol and 65-80 parts of deionized water.
As a preferable scheme, the fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.05 part of chelating agent, 0.08 part of glycyrrhiza glabra root extract, 0.2 part of pH regulator, 0.2 part of preservative, 0.25 part of compound essential oil, 0.3 part of thickening agent, 0.3 part of centella asiatica extract, 0.4 part of glutathione, 0.5 part of carrageen crispus extract, 0.5 part of antioxidant, 0.8 part of modified fullerene, 1 part of aloe barbadensis leaf extract, 1.2 parts of agave stem extract, 1.2 parts of emulsifier, 3.5 parts of emollient, 6 parts of humectant, 10 parts of polyhydric alcohol and 73.52 parts of deionized water.
Preferably, the chelating agent is disodium edetate.
Preferably, the pH regulator is one or more of triethanolamine, arginine and citric acid.
As a most preferred embodiment, the pH adjusting agent is arginine.
As a preferable scheme, the preservative is one or more of phenoxyethanol, methyl hydroxybenzoate, sodium benzoate, potassium sorbate, DMDM hydantoin, ethylparaben, methylparaben and ethylparaben.
As a most preferred embodiment, the preservative is phenoxyethanol.
Preferably, the humectant is one or more of sodium hyaluronate, trehalose, bioglycan-1, saccharide isomerate, panthenol, beta-glucan, betaine, glycerol polyacrylate, amino acid, PCA, sodium lactate and urea.
Preferably, the humectant is prepared from sodium hyaluronate, bioglycan-1, saccharide isomerate, panthenol, beta-glucan, betaine and glycerol polyacrylate according to a weight ratio of 0.5-2: 8-15: 1-4: 2-5: 1-4: 6-12: 8 to 15.
As a most preferred scheme, the humectant is prepared from sodium hyaluronate, bioglycan-1, saccharide isomerate, panthenol, beta-glucan, betaine and glycerol polyacrylate according to the weight ratio of 1: 10: 2: 3: 2: 10: 12.
The moisturizing agent has a good moisturizing effect, the moisturizing component has a good instant moisturizing effect, the moisturizing capability to skin is strong, the moisturizing component can effectively permeate into the dermis of the skin, and the moisturizing effect is balanced from inside to outside.
Preferably, the polyhydric alcohol is two or more of glycerol, 1, 3-butanediol, 1, 3-propanediol, dipropylene glycol, polyethylene glycol, 1, 2-hexanediol, xylitol, polypropylene glycol and sorbitol.
Preferably, the polyhydric alcohol is glycerol and 1, 3-butanediol, wherein the weight ratio of the polyhydric alcohol to the 1-8: 1 to 10.
As a preferable scheme, the polyalcohol is glycerol, 1, 3-butanediol, and the weight ratio of the polyalcohol to the 1, 3-butanediol is 4: 6.
As a preferable scheme, the compound essential oil is at least two of bitter orange flower essential oil, citrus essential oil, sweet orange essential oil, rose essential oil and jasmine essential oil.
As a most preferred scheme, the compound essential oil is prepared from bitter orange flower essential oil and sweet orange essential oil according to the weight ratio of 1: 1.
As a preferable scheme, the thickening agent is one or more of carbomer, xanthan gum, carrageenan, hydroxyethyl cellulose and hydrolyzed sclerotium rolfsii gum.
As a most preferred embodiment, the thickener is carbomer 980.
As a preferable scheme, the emulsifier is two or more of C12-20 alkyl glucoside, arachidonoyl glucoside, cetearyl alcohol ether-21, cocoyl glucoside, polyglyceryl-10 pentastearate, cetearyl olive oleate, sorbitan olive oleate, lecithin, methylgluco sesquistearate, PEG-10 polydimethylsiloxane and hydrogenated lecithin.
As a preferred scheme, the emulsifier is composed of sorbitan olive oleate and hydrogenated lecithin according to the weight ratio of 1: 0.2 to 0.6.
As a most preferred solution, the emulsifier is composed of sorbitan olive oleate, hydrogenated lecithin in a weight ratio of 1: 0.5.
Preferably, the emollient is one or more selected from dimethicone, dimethiconol, cyclopentadimethicone, jojoba oil, isopropyl myristate, shea butter, meadowfoam seed oil, isononyl isononanoate, neopentyl glycol diheptanoate, squalane, glyceryl caprylate.
Preferably, the emollient is prepared from squalane, neopentyl glycol diheptanoate, dimethiconol and glyceryl caprylate in a weight ratio of 0.2-2: 0.5-2: 0.5-2: 0.2 to 1.
As a most preferred embodiment, the emollient is prepared from squalane, neopentyl glycol diheptanoate, dimethiconol, glyceryl caprylate in a weight ratio of 1: 1: 1: 0.5.
Preferably, the antioxidant is one or two of tocopherol acetate and hydrolyzed oat protein.
As a most preferred embodiment, the antioxidant is hydrolyzed oat protein.
The preparation method of the modified fullerene comprises the following steps:
s1, adding 5-10 parts by weight of concentrated nitric acid and 5-10 parts by weight of hydrogen peroxide into 70-90 parts by weight of deionized water to prepare an oxidation solution, and adding 10-20 parts by weight of octadecyl dimethyl benzyl styrene ammonium chloride into 80-90 parts by weight of deionized water to prepare a modification solution;
s2, adding 4-10 parts by weight of fullerene into 15-30 parts by weight of oxidation liquid, carrying out ultrasonic treatment for 20-35 min at 200-600W, filtering, and drying to obtain oxidized fullerene;
s3, adding 5-12 parts by weight of oxidized fullerene into 20-40 parts by weight of modified liquid, stirring at a rotating speed of 100-1000 rpm for 100-200 min, adding 1-3 parts by weight of 1, 3-butanediol and 0.1-0.5 part by weight of xanthan gum, uniformly dispersing, filtering and drying to obtain the modified fullerene.
According to the invention, the fullerene is subjected to oxidation treatment, then is subjected to modification treatment by octadecyl dimethyl benzyl styrene ammonium chloride, and then is compounded with butanediol and xanthan gum, so that the whitening effect of the fullerene is obviously improved, and the fullerene can effectively permeate and promote skin absorption.
The modified fullerene can effectively and rapidly remove free radicals, brighten skin color, recover and activate the activity of the organism, effectively inhibit tyrosinase activity, inhibit melanin formation, reduce pigmentation and promote skin whitening, can be effectively dispersed in essence liquid without agglomeration, and can be used for fully brightening skin, brightening skin color, inhibiting tyrosinase activity and achieving the whitening effect by cooperating with agave stem extract and glutathione whitening components.
As a preferred scheme, the preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing agave stem to 40-100 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 3-6 parts by weight of enzymolysis liquid, carrying out enzymolysis for 1-4 h at 50-65 ℃, and carrying out ultrasonic treatment for 15-30 min at 400-800W to obtain a mixed solution; the enzymolysis liquid is prepared by 0.5-2 parts by weight of hexadecyl trimethyl ammonium bromide, 2-8 parts by weight of glucoamylase, 4-10 parts by weight of papain and 75-90 parts by weight of deionized water;
s13, centrifuging the mixed solution, taking supernatant, adding the supernatant into deionized water to prepare sample liquid, adding the sample liquid on D101 macroporous adsorption resin at the speed of 1-2 BV/h, eluting at the speed of 1-2 BV/h, washing 1-2 BV with deionized water, washing 1-3 BV with 40-70 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
The agave stem extract with good whitening effect is prepared by crushing agave stem, performing ultrasonic-assisted enzymolysis, and performing macroporous adsorption resin treatment, and in the preparation method of the agave stem extract, the agave stem extracts prepared by different enzymolysis solutions have different whitening effects, and the agave stem extract prepared by the enzymolysis solution compounded by hexadecyl trimethyl ammonium bromide, glucoamylase, papain and deionized water has good whitening effect.
The invention also provides a fullerene moisturizing, whitening and repairing essence for preparing the fullerene moisturizing, whitening and repairing essence, which comprises the following steps:
s21, adding a chelating agent, a thickening agent, polyhydric alcohol and deionized water into an emulsifying pot, heating to 70-90 ℃, and stirring at the rotating speed of 200-1000 rpm for 20-60 min;
s22, adding the emulsifier and the emollient into the oil phase pot, heating to 70-90 ℃, and stirring at the rotating speed of 100-600 rpm for 10-50 min;
s23, pumping the materials in the oil phase pot into an emulsifying pot, and homogenizing at the rotating speed of 1000-2000 rpm for 4-8 min;
s24, cooling to 40-45 ℃, adding the glycyrrhiza glabra root extract, the pH regulator, the preservative, the compound essential oil, the centella asiatica extract, the glutathione, the carrageen crispa extract, the antioxidant, the modified fullerene, the aloe barbadensis leaf extract, the agave stem extract and the humectant into an emulsifying pot, stirring at the rotating speed of 200-800 rpm for 1-5 hours, discharging and cooling to obtain the fullerene moisturizing, whitening and repairing essence.
The invention has the beneficial effects that: the fullerene moisturizing, whitening and repairing essential oil liquid has good whitening, repairing and moisturizing effects, the modified fullerene can effectively and quickly eliminate free radicals, brighten skin color, recover and activate the self activity of an organism, effectively inhibit tyrosinase activity, inhibit melanin formation, reduce pigmentation and promote skin whitening, the modified fullerene can be effectively dispersed in the essential liquid, the agglomeration phenomenon cannot occur, and the modified fullerene cooperates with the agave stem extract and glutathione whitening components to enable the skin to be full of gloss, brighten skin color, inhibit tyrosinase activity and achieve the whitening effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the present invention, the parts are all parts by weight unless otherwise specified.
Example 1
A fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.05 part of chelating agent, 0.08 part of glycyrrhiza glabra root extract, 0.2 part of pH regulator, 0.2 part of preservative, 0.25 part of compound essential oil, 0.3 part of thickening agent, 0.3 part of centella asiatica extract, 0.4 part of glutathione, 0.5 part of carrageen crispus extract, 0.5 part of antioxidant, 0.8 part of modified fullerene, 1 part of aloe barbadensis leaf extract, 1.2 parts of agave stem extract, 1.2 parts of emulsifier, 3.5 parts of emollient, 6 parts of humectant, 10 parts of polyhydric alcohol and 73.52 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
Arginine as the pH regulator.
The preservative is phenoxyethanol.
The humectant is prepared from sodium hyaluronate, biological carbohydrate-1, saccharide isomerate, panthenol, beta-glucan, betaine and glycerol polyacrylate according to a weight ratio of 1: 10: 2: 3: 2: 10: 12.
The polyhydric alcohol is glycerol and 1, 3-butanediol according to a weight ratio of 4: 6.
The compound essential oil is prepared from bitter orange flower essential oil and sweet orange essential oil according to the weight ratio of 1: 1.
The thickener is carbomer 980.
The emulsifier is prepared from sorbitan olive oleate and hydrogenated lecithin according to the weight ratio of 1: 0.5.
The emollient is prepared from squalane, neopentyl glycol diheptanoate, dimethiconol and glyceryl caprylate in a weight ratio of 1: 1: 1: 0.5.
The antioxidant is hydrolyzed oat protein.
The preparation method of the modified fullerene comprises the following steps:
s1, adding 8 parts by weight of concentrated nitric acid and 8 parts by weight of hydrogen peroxide into 84 parts by weight of deionized water to prepare an oxidizing solution, and adding 15 parts by weight of octadecyl dimethyl benzyl styrene ammonium chloride into 85 parts by weight of deionized water to prepare a modified solution;
s2, adding 8 parts by weight of fullerene (Puyang brand Yongxin fullerene science and technology Co., Ltd.) into 20 parts by weight of oxidizing solution, carrying out ultrasonic treatment for 25min at 500W, filtering and drying to obtain oxidized fullerene;
s3, adding 10 parts by weight of oxidized fullerene into 30 parts by weight of modified liquid, stirring at 800rpm for 120min, adding 1.5 parts by weight of 1, 3-butanediol and 0.2 part by weight of xanthan gum, uniformly dispersing, filtering and drying to obtain the modified fullerene.
The modified fullerene can effectively and rapidly remove free radicals, brighten skin color, recover and activate the activity of the organism, effectively inhibit tyrosinase activity, inhibit melanin formation, reduce pigmentation and promote skin whitening, can be effectively dispersed in essence liquid without agglomeration, and can be used for fully brightening skin, brightening skin color, inhibiting tyrosinase activity and achieving the whitening effect by cooperating with agave stem extract and glutathione whitening components.
The preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing the agave stem to 80 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 4 parts by weight of enzymolysis liquid, carrying out enzymolysis for 2h at 60 ℃, and carrying out ultrasonic treatment for 20min at 500W to obtain a mixed solution; the enzymolysis liquid is prepared by 1 weight part of hexadecyl trimethyl ammonium bromide, 4 weight parts of glucoamylase, 6 weight parts of papain and 89 weight parts of deionized water;
s13, centrifuging the mixed solution at 5000rpm for 10min, taking supernatant, adding the supernatant into deionized water to prepare sample liquid (the weight ratio of the deionized water to the sample liquid is 1: 3), adding the sample liquid on D101 macroporous adsorption resin at the speed of 1.5BV/h, eluting at the speed of 1.5BV/h, washing 2BV with deionized water, washing 1.5BV with 60 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
The preparation method of the fullerene moisturizing, whitening and repairing essence comprises the following steps:
s21, adding a chelating agent, a thickening agent, polyhydric alcohol and deionized water into an emulsifying pot, heating to 85 ℃, and stirring at the rotating speed of 800rpm for 40 min;
s22, adding the emulsifier and the emollient into the oil phase pot, heating to 85 ℃, and stirring at 500rpm for 30 min;
s23, pumping the materials in the oil phase pot into an emulsifying pot, and homogenizing at 1500rpm for 5 min;
s24, cooling to 42 ℃, adding the glycyrrhiza glabra root extract, the pH regulator, the preservative, the compound essential oil, the centella asiatica extract, the glutathione, the carrageen crispa extract, the antioxidant, the modified fullerene, the aloe barbadensis leaf extract, the agave stem extract and the humectant into an emulsifying pot, stirring at the rotating speed of 500rpm for 4 hours, discharging and cooling to obtain the fullerene moisturizing, whitening and repairing essence.
Example 2
A fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.02 part of chelating agent, 0.1 part of glycyrrhiza glabra root extract, 0.1 part of pH regulator, 0.3 part of preservative, 0.2 part of compound essential oil, 0.5 part of thickening agent, 0.2 part of centella asiatica extract, 0.8 part of glutathione, 0.2 part of carrageen crispus extract, 0.8 part of antioxidant, 0.5 part of modified fullerene, 1.5 parts of aloe barbadensis leaf extract, 1 part of agave stem extract, 2 parts of emulsifier, 2 parts of emollient, 10 parts of humectant, 6 parts of polyhydric alcohol and 73.78 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
Arginine as the pH regulator.
The preservative is phenoxyethanol.
The humectant is prepared from sodium hyaluronate, biological carbohydrate-1, saccharide isomerate, panthenol, beta-glucan, betaine and glycerol polyacrylate according to a weight ratio of 1: 10: 2: 3: 2: 10: 12.
The polyhydric alcohol is glycerol and 1, 3-butanediol according to a weight ratio of 4: 6.
The compound essential oil is prepared from bitter orange flower essential oil and sweet orange essential oil according to the weight ratio of 1: 1.
The thickener is carbomer 980.
The emulsifier is prepared from sorbitan olive oleate and hydrogenated lecithin according to the weight ratio of 1: 0.5.
The emollient is prepared from squalane, neopentyl glycol diheptanoate, dimethiconol and glyceryl caprylate in a weight ratio of 1: 1: 1: 0.5.
The antioxidant is hydrolyzed oat protein.
The preparation method of the modified fullerene comprises the following steps:
s1, adding 6 parts by weight of concentrated nitric acid and 10 parts by weight of hydrogen peroxide into 84 parts by weight of deionized water to prepare an oxidizing solution, and adding 20 parts by weight of octadecyl dimethyl benzyl styrene ammonium chloride into 80 parts by weight of deionized water to prepare a modified solution;
s2, adding 8 parts by weight of fullerene into 22 parts by weight of oxidizing solution, carrying out ultrasonic treatment for 25min at 500W, filtering, and drying to obtain oxidized fullerene;
s3, adding 10 parts by weight of oxidized fullerene into 30 parts by weight of modified liquid, stirring at 800rpm for 150min, adding 2 parts by weight of 1, 3-butanediol and 0.3 part by weight of xanthan gum, uniformly dispersing, filtering and drying to obtain the modified fullerene.
The preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing the agave stem to 80 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 5 parts by weight of enzymolysis liquid, carrying out enzymolysis for 2h at 55 ℃, and carrying out ultrasonic treatment for 20min at 600W to obtain a mixed solution; the enzymolysis liquid is prepared by 1 weight part of hexadecyl trimethyl ammonium bromide, 6 weight parts of glucoamylase, 10 weight parts of papain and 83 weight parts of deionized water;
s13, centrifuging the mixed solution at 5000rpm for 10min, taking supernatant, adding the supernatant into deionized water to prepare sample liquid (the weight ratio of the deionized water to the sample liquid is 1: 3), adding the sample liquid on D101 macroporous adsorption resin at the speed of 1.5BV/h, eluting at the speed of 1.5BV/h, washing 2BV with deionized water, washing 1.5BV with 60 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
The preparation method of the fullerene moisturizing, whitening and repairing essence comprises the following steps:
s21, adding a chelating agent, a thickening agent, polyhydric alcohol and deionized water into an emulsifying pot, heating to 85 ℃, and stirring at the rotating speed of 800rpm for 40 min;
s22, adding the emulsifier and the emollient into the oil phase pot, heating to 85 ℃, and stirring at 500rpm for 30 min;
s23, pumping the materials in the oil phase pot into an emulsifying pot, and homogenizing at 1500rpm for 5 min;
s24, cooling to 42 ℃, adding the glycyrrhiza glabra root extract, the pH regulator, the preservative, the compound essential oil, the centella asiatica extract, the glutathione, the carrageen crispa extract, the antioxidant, the modified fullerene, the aloe barbadensis leaf extract, the agave stem extract and the humectant into an emulsifying pot, stirring at the rotating speed of 500rpm for 4 hours, discharging and cooling to obtain the fullerene moisturizing, whitening and repairing essence.
Example 3
A fullerene moisturizing, whitening and repairing essence is prepared from the following raw materials in parts by weight: 0.08 part of chelating agent, 0.04 part of glycyrrhiza glabra root extract, 0.3 part of pH regulator, 0.15 part of preservative, 0.4 part of compound essential oil, 0.2 part of thickening agent, 0.3 part of centella asiatica extract, 0.2 part of glutathione, 1 part of carrageen crispus extract, 0.3 part of antioxidant, 1 part of modified fullerene, 0.8 part of aloe barbadensis leaf extract, 0.7 part of agave stem extract, 0.8 part of emulsifier, 5 parts of emollient, 4 parts of humectant, 15 parts of polyhydric alcohol and 69.73 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
Arginine as the pH regulator.
The preservative is phenoxyethanol.
The humectant is prepared from sodium hyaluronate, biological carbohydrate-1, saccharide isomerate, panthenol, beta-glucan, betaine and glycerol polyacrylate according to a weight ratio of 1: 10: 2: 3: 2: 10: 12.
The polyhydric alcohol is glycerol and 1, 3-butanediol according to a weight ratio of 4: 6.
The compound essential oil is prepared from bitter orange flower essential oil and sweet orange essential oil according to the weight ratio of 1: 1.
The thickener is carbomer 980.
The emulsifier is prepared from sorbitan olive oleate and hydrogenated lecithin according to the weight ratio of 1: 0.5.
The emollient is prepared from squalane, neopentyl glycol diheptanoate, dimethiconol and glyceryl caprylate in a weight ratio of 1: 1: 1: 0.5.
The preparation method of the modified fullerene comprises the following steps:
s1, adding 10 parts by weight of concentrated nitric acid and 5 parts by weight of hydrogen peroxide into 85 parts by weight of deionized water to prepare an oxidizing solution, and adding 12 parts by weight of octadecyl dimethyl benzyl styrene ammonium chloride into 88 parts by weight of deionized water to prepare a modified solution;
s2, adding 6 parts by weight of fullerene into 24 parts by weight of oxidizing solution, carrying out ultrasonic treatment for 30min at 400W, filtering, and drying to obtain oxidized fullerene;
s3, adding 10 parts by weight of oxidized fullerene into 20 parts by weight of modified liquid, stirring at 500rpm for 120min, adding 1.2 parts by weight of 1, 3-butanediol and 0.4 part by weight of xanthan gum, uniformly dispersing, filtering and drying to obtain the modified fullerene.
The preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing the agave stem to 60 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 5 parts by weight of enzymolysis liquid, carrying out enzymolysis for 2h at 60 ℃, and carrying out ultrasonic treatment for 20min at 500W to obtain a mixed solution; the enzymolysis liquid is prepared by 1 weight part of hexadecyl trimethyl ammonium bromide, 4 weight parts of glucoamylase, 8 weight parts of papain and 77 weight parts of deionized water;
s13, centrifuging the mixed solution at 5000rpm for 10min, taking supernatant, adding the supernatant into deionized water to prepare sample liquid (the weight ratio of the deionized water to the sample liquid is 1: 3), adding the sample liquid on D101 macroporous adsorption resin at the speed of 1.5BV/h, eluting at the speed of 1.5BV/h, washing 2BV with deionized water, washing 1.5BV with 60 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
The preparation method of the fullerene moisturizing, whitening and repairing essence comprises the following steps:
s21, adding a chelating agent, a thickening agent, polyhydric alcohol and deionized water into an emulsifying pot, heating to 85 ℃, and stirring at the rotating speed of 800rpm for 40 min;
s22, adding the emulsifier and the emollient into the oil phase pot, heating to 85 ℃, and stirring at 500rpm for 30 min;
s23, pumping the materials in the oil phase pot into an emulsifying pot, and homogenizing at 1500rpm for 5 min;
s24, cooling to 42 ℃, adding the glycyrrhiza glabra root extract, the pH regulator, the preservative, the compound essential oil, the centella asiatica extract, the glutathione, the carrageen crispa extract, the antioxidant, the modified fullerene, the aloe barbadensis leaf extract, the agave stem extract and the humectant into an emulsifying pot, stirring at the rotating speed of 500rpm for 4 hours, discharging and cooling to obtain the fullerene moisturizing, whitening and repairing essence.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 uses fullerene instead of modified fullerene, and the other is the same.
Comparative example 2
Comparative example 2 is different from example 1 in that the method for producing a modified fullerene described in comparative example 2 is different from example 1, and the other steps are the same.
In this comparative example, the fullerene was subjected to oxidation treatment only.
The preparation method of the modified fullerene comprises the following steps:
s1, adding 8 parts by weight of concentrated nitric acid and 8 parts by weight of hydrogen peroxide into 84 parts by weight of deionized water to prepare an oxidizing solution;
s2, adding 8 parts by weight of fullerene into 20 parts by weight of oxidizing solution, carrying out ultrasonic treatment for 25min at 500W, filtering, and drying to obtain the modified fullerene.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain the agave stem extract, and the rest are the same.
Comparative example 4
Comparative example 4 is different from example 1 in that the agave stem extract described in comparative example 4 is prepared by the same method as example 1.
In the comparative example, the enzymatic hydrolysate was replaced with equal amounts of cellulase and pectinase.
The preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing the agave stem to 80 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 4 parts by weight of enzymolysis liquid, carrying out enzymolysis for 2h at 60 ℃, and carrying out ultrasonic treatment for 20min at 500W to obtain a mixed solution; the enzymolysis liquid is prepared from 5 parts by weight of cellulase, 6 parts by weight of pectinase and 89 parts by weight of deionized water;
s13, centrifuging the mixed solution at 5000rpm for 10min, taking supernatant, adding the supernatant into deionized water to prepare sample liquid (the weight ratio of the deionized water to the sample liquid is 1: 3), adding the sample liquid on D101 macroporous adsorption resin at the speed of 1.5BV/h, eluting at the speed of 1.5BV/h, washing 2BV with deionized water, washing 1.5BV with 60 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
To further demonstrate the effect of the present invention, the following test methods were provided:
1. tyrosinase inhibition assay (conventional method), the specific method is as follows: adding 500 mu L of 0.1M potassium phosphate solution into 0.3mg/ml tyrosine solution, adding 450 mu L of test substance (the whitening composition described in examples 1-5 and comparative examples 1-4, and deionized water as a control), mixing uniformly in a test tube, keeping the temperature at 37 ℃, adding 50 mu L tyrosinase solution (with the concentration of 1540 ng/ml), culturing for 10min at 37 ℃, testing the absorbance at 480nm by using a UV-VIS spectrophotometer, wherein the test results are shown in Table 1, and the average value of each three groups is measured.
Tyrosinase inhibition was calculated according to the following formula:
inhibition = [ (A-B)/A ]. times.l 00%
Wherein, A is the light absorption value of the standard control, and B is the light absorption value of the test solution.
TABLE 1 test results
As can be seen from Table 1, the essence of the present invention has a good whitening effect.
As can be seen from comparison of examples 1 to 3, example 1 is the best mode and has a better whitening effect.
As can be seen from comparison between example 1 and comparative examples 1 to 2, the modified fullerene of the present invention can significantly improve the whitening effect, and in the preparation method of the modified fullerene, the modified fullerene prepared by different modification methods is different in the whitening effect, and the fullerene prepared by the preparation method of the modified fullerene of the present invention can significantly improve the whitening effect.
As can be seen from the comparison of example 1 with comparative examples 3 and 4, the agave stem extract can significantly improve the whitening effect, and in the preparation method thereof, the agave stem extracts prepared from different enzymatic hydrolysates are different in the improvement of the whitening effect, and the agave stem extract prepared from the enzymatic hydrolysate provided by the invention has a good whitening effect.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The fullerene moisturizing, whitening and repairing essence is characterized by being prepared from the following raw materials in parts by weight: 0.02-0.08 part of chelating agent, 0.04-0.1 part of glycyrrhiza glabra root extract, 0.1-0.3 part of pH regulator, 0.15-0.3 part of preservative, 0.2-0.4 part of compound essential oil, 0.2-0.5 part of thickener, 0.2-0.3 part of centella asiatica extract, 0.2-0.8 part of glutathione, 0.2-1 part of carrageen crispus extract, 0.3-0.8 part of antioxidant, 0.5-1 part of modified fullerene, 0.8-1.5 parts of aloe barbadensis leaf extract, 0.7-1.5 parts of agave stem extract, 0.8-2 parts of emulsifier, 2-5 parts of emollient, 4-10 parts of humectant, 6-15 parts of polyhydric alcohol and 60-80 parts of deionized water.
2. The fullerene moisturizing, whitening and repairing essence according to claim 1, which is prepared from the following raw materials in parts by weight: 0.02-0.06 part of chelating agent, 0.05-0.1 part of glycyrrhiza glabra root extract, 0.15-0.3 part of pH regulator, 0.15-0.25 part of preservative, 0.2-0.3 part of compound essential oil, 0.2-0.4 part of thickener, 0.2-0.5 part of centella asiatica extract, 0.2-0.6 part of glutathione, 0.2-0.6 part of carrageen crispus extract, 0.3-0.6 part of antioxidant, 0.6-1 part of modified fullerene, 0.8-1.2 parts of aloe barbadensis leaf extract, 1-1.5 parts of agave stem extract, 0.8-1.5 parts of emulsifier, 2-4 parts of emollient, 4-8 parts of humectant, 6-12 parts of polyhydric alcohol and 65-80 parts of deionized water.
3. The fullerene moisturizing, whitening and repairing essence according to claim 1, which is prepared from the following raw materials in parts by weight: 0.05 part of chelating agent, 0.08 part of glycyrrhiza glabra root extract, 0.2 part of pH regulator, 0.2 part of preservative, 0.25 part of compound essential oil, 0.3 part of thickening agent, 0.3 part of centella asiatica extract, 0.4 part of glutathione, 0.5 part of carrageen crispus extract, 0.5 part of antioxidant, 0.8 part of modified fullerene, 1 part of aloe barbadensis leaf extract, 1.2 parts of agave stem extract, 1.2 parts of emulsifier, 3.5 parts of emollient, 6 parts of humectant, 10 parts of polyhydric alcohol and 73.52 parts of deionized water.
4. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the chelating agent is disodium ethylenediaminetetraacetate;
the pH regulator is one or more of triethanolamine, arginine and citric acid;
the antiseptic is one or more of phenoxyethanol, methyl hydroxybenzoate, sodium benzoate, potassium sorbate, DMDM hydantoin, ethylparaben, methyl hydroxybenzoate, and ethylparaben.
5. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the moisturizer is one or more of sodium hyaluronate, trehalose, bioglycan-1, saccharide isomerate, panthenol, beta-glucan, betaine, glycerol polyacrylate, amino acid, PCA, sodium lactate and urea;
the polyalcohol is two or more of glycerol, 1, 3-butanediol, 1, 3-propylene glycol, dipropylene glycol, polyethylene glycol, 1, 2-hexanediol, xylitol, polypropylene glycol and sorbitol;
the compound essential oil is at least two of bitter orange flower essential oil, citrus essential oil, sweet orange essential oil, rose essential oil and jasmine essential oil.
6. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the thickener is one or more of carbomer, xanthan gum, carrageenan, hydroxyethyl cellulose and hydrolyzed sclerotium rolfsii gum;
the emulsifier is two or more of C12-20 alkyl glucoside, arachidonoyl glucoside, cetearyl glucoside, ceteareth-21, cocoyl glucoside, polyglycerol-10 pentastearate, cetearyl olive oleate, sorbitan olive oleate, lecithin, methylglucose sesquistearate, PEG-10 polydimethylsiloxane and hydrogenated lecithin.
7. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the emollient is one or more of polydimethylsiloxane, dimethiconol, cyclopentadimethylsiloxane, jojoba oil, isopropyl myristate, shea butter, meadowfoam seed oil, isononyl isononanoate, neopentyl glycol diheptanoate, squalane, glyceryl caprylate;
the antioxidant is one or two of tocopherol acetate and hydrolyzed oat protein.
8. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the preparation method of the modified fullerene comprises the following steps:
s1, adding 5-10 parts by weight of concentrated nitric acid and 5-10 parts by weight of hydrogen peroxide into 70-90 parts by weight of deionized water to prepare an oxidation solution, and adding 10-20 parts by weight of octadecyl dimethyl benzyl styrene ammonium chloride into 80-90 parts by weight of deionized water to prepare a modification solution;
s2, adding 4-10 parts by weight of fullerene into 15-30 parts by weight of oxidation liquid, carrying out ultrasonic treatment for 20-35 min at 200-600W, filtering, and drying to obtain oxidized fullerene;
s3, adding 5-12 parts by weight of oxidized fullerene into 20-40 parts by weight of modified liquid, stirring at a rotating speed of 100-1000 rpm for 100-200 min, adding 1-3 parts by weight of 1, 3-butanediol and 0.1-0.5 part by weight of xanthan gum, uniformly dispersing, filtering and drying to obtain the modified fullerene.
9. The fullerene moisturizing, whitening and repairing essence according to claim 1, wherein the preparation method of the agave stem extract comprises the following steps:
s11, cleaning, drying and crushing agave stem to 40-100 meshes to obtain agave stem powder;
s12, adding 1 part by weight of agave stem powder into 3-6 parts by weight of enzymolysis liquid, carrying out enzymolysis for 1-4 h at 50-65 ℃, and carrying out ultrasonic treatment for 15-30 min at 400-800W to obtain a mixed solution; the enzymolysis liquid is prepared by 0.5-2 parts by weight of hexadecyl trimethyl ammonium bromide, 2-8 parts by weight of glucoamylase, 4-10 parts by weight of papain and 75-90 parts by weight of deionized water;
s13, centrifuging the mixed solution, taking supernatant, adding the supernatant into deionized water to prepare sample liquid, adding the sample liquid on D101 macroporous adsorption resin at the speed of 1-2 BV/h, eluting at the speed of 1-2 BV/h, washing 1-2 BV with deionized water, washing 1-3 BV with 40-70 wt% ethanol solution, collecting ethanol solution eluent, and drying to obtain the agave stem extract.
10. A fullerene moisturizing, whitening and repairing essence for preparing the fullerene moisturizing, whitening and repairing essence of any one of claims 1-9, comprising the following steps:
s21, adding a chelating agent, a thickening agent, polyhydric alcohol and deionized water into an emulsifying pot, heating to 70-90 ℃, and stirring at the rotating speed of 200-1000 rpm for 20-60 min;
s22, adding the emulsifier and the emollient into the oil phase pot, heating to 70-90 ℃, and stirring at the rotating speed of 100-600 rpm for 10-50 min;
s23, pumping the materials in the oil phase pot into an emulsifying pot, and homogenizing at the rotating speed of 1000-2000 rpm for 4-8 min;
s24, cooling to 40-45 ℃, adding the glycyrrhiza glabra root extract, the pH regulator, the preservative, the compound essential oil, the centella asiatica extract, the glutathione, the carrageen crispa extract, the antioxidant, the modified fullerene, the aloe barbadensis leaf extract, the agave stem extract and the humectant into an emulsifying pot, stirring at the rotating speed of 200-800 rpm for 1-5 hours, discharging and cooling to obtain the fullerene moisturizing, whitening and repairing essence.
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