CN114392397A - Degradable biological material and preparation method thereof - Google Patents

Degradable biological material and preparation method thereof Download PDF

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CN114392397A
CN114392397A CN202210060460.8A CN202210060460A CN114392397A CN 114392397 A CN114392397 A CN 114392397A CN 202210060460 A CN202210060460 A CN 202210060460A CN 114392397 A CN114392397 A CN 114392397A
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water
parts
fixedly connected
pipe
shell
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田明秀
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/06—Filters with filtering elements which move during the filtering operation with rotary cylindrical filtering surfaces, e.g. hollow drums
    • B01D33/11—Filters with filtering elements which move during the filtering operation with rotary cylindrical filtering surfaces, e.g. hollow drums arranged for outward flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/58—Handling the filter cake in the filter for purposes other than for regenerating the filter cake remaining on the filtering element
    • B01D33/60—Handling the filter cake in the filter for purposes other than for regenerating the filter cake remaining on the filtering element for washing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a degradable biological material and a preparation method thereof, wherein the biological material is prepared from the following raw materials in parts by weight: 1-2 parts of 1, 4-butanediol, 4-6 parts of lysine hydrochloride, 15-18 parts of toluene, 8-10 parts of isopropanol, 30-40 parts of N, N-dimethylacetamide, 6-8 parts of nano calamine powder, 4-6 parts of casein, 4-6 parts of acrylic acid, 8-10 parts of potassium persulfate, 10-12 parts of polyether glycol and 10-12 parts of dibutyltin dilaurate; the nano particles can be prepared by the raw materials in the formula, and are introduced into the polymerization reaction of casein and acrylic acid, amino groups and the like contained in the nano particles can form hydrogen bonds with hydroxyl groups, amino groups and the like in the casein and the acrylic acid, so that the mechanical property and the degradation property of the biological material are improved.

Description

Degradable biological material and preparation method thereof
Technical Field
The invention belongs to the technical field of biological materials, and particularly relates to a degradable biological material and a preparation method thereof.
Background
As an important means of modern medicine and an important basis and component part of medical appliances, the biological material is used for diagnosis and treatment of diseases, repair, replacement or function improvement of tissues and organs, so that a large number of patients struggling at the edges of residual and dead pain can be recovered.
One chinese patent publication No. CN101175513B discloses a biomaterial and a method of making the same, comprising (a) providing a first slurry composition comprising a liquid carrier, an inorganic material, and an organic material; (b) providing a mould for the pulp; (c) allowing the slurry to settle in the mould; (d) cooling the slurry precipitated in the mold to a temperature at which the liquid carrier is converted into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material containing inorganic material and organic material; (f) removing the material from the mold.
In the prior art, with the rapid development of medical systems, the existing biological materials can not meet the current treatment requirements gradually, and the mechanical property and the degradation property of the biological materials are still to be improved so as to achieve more ideal curative effects.
Therefore, the invention provides a degradable biological material and a preparation method thereof.
Disclosure of Invention
To remedy the deficiencies of the prior art, at least one of the technical problems set forth in the background is addressed.
The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to a degradable biological material, which consists of the following raw materials in parts by weight:
1-2 parts of 1, 4-butanediol
4-6 parts of lysine hydrochloride
15-18 parts of toluene
8-10 parts of isopropanol
30-40 parts of N, N-dimethylacetamide
6-8 parts of nano calamine powder
4-6 parts of casein
4-6 parts of acrylic acid
8-10 parts of potassium persulfate
10-12 parts of polyether glycol
10-12 parts of dibutyltin dilaurate;
the nano particles can be prepared by the raw materials in the formula, and are introduced into the polymerization reaction of casein and acrylic acid, amino groups and the like contained in the nano particles can form hydrogen bonds with hydroxyl groups, amino groups and the like in the casein and the acrylic acid, so that the mechanical property and the degradation property of the biological material are improved.
A preparation method of a degradable biological material is used for preparing the degradable biological material, and the biological material is prepared by the following steps:
s1: adding 1, 4-butanediol and lysine hydrochloride into toluene, stirring and reacting for 22-24 hours under a high temperature condition, centrifuging to obtain a precipitate, then adding the precipitate into isopropanol, stirring and dispersing uniformly, standing for 10-12 hours under a low temperature condition, centrifuging to obtain the precipitate to obtain a lysine monomer precipitate;
s2: the lysine monomer sediment is introduced into the filter screen cylinder of the washing equipment, high-pressure water is injected into a water supply pipe to wash the lysine monomer, the filter screen cylinder is driven to rotate by a motor to generate centrifugal force, water in the lysine monomer is thrown out together with impurities, a water beating pipe rotates outside the water supply pipe, the sprayed water is scattered, the water flow washing area is increased, and the washing effect is improved;
s3: uniformly mixing lysine monomers and nano calamine powder, carrying out post-treatment to obtain nano particles, adding casein, acrylic acid and potassium persulfate into water, stirring and reacting under a nitrogen environment, then adding the nano particles, and carrying out post-treatment to obtain modified nano particles;
s4: adding polyether glycol and the modified nanoparticles into N, N-dimethylacetamide, uniformly oscillating by ultrasonic waves, and carrying out coaxial electrostatic spinning to obtain the finished degradable biological material.
Preferably, the water washing apparatus comprises a housing; a filter screen cylinder is rotatably connected inside the shell; a motor is arranged on one side of the shell; a rotating shaft is rotatably connected inside the shell, one end of the rotating shaft is fixedly connected with an output shaft of the motor, and the other end of the rotating shaft is fixedly connected with the filter screen cylinder; the inner wall of the filter screen cylinder is fixedly connected with a helical blade; a water pumping pipe is fixedly connected inside the filter screen cylinder and is made of a grid material; a water supply pipe is arranged in the water fetching pipe, and the water fetching pipe is rotatably connected with the water supply pipe; one end of the water supply pipe is a blind end, and the other end of the water supply pipe extends out of the shell and is fixedly connected with the shell; a plurality of water spraying holes are uniformly formed in the water supply pipe; leading-in to filter screen cylinder with the lysine monomer deposit that generates, and inject the high pressure water into the delivery pipe, and then the water under high pressure outwards spouts through the hole for water spraying of evenly arranging, wash lysine monomer, drive filter screen cylinder through the motor and rotate simultaneously, produce centrifugal force, throw away the moisture in the lysine monomer together with impurity, it rotates in the delivery pipe outside to beat the water pipe, break up spun water, increase rivers wash the area, improve the free cleaning performance of lysine, because lysine monomer receives the action of gravity, most all is located filter screen cylinder bottom, can take lysine monomer to the take the altitude through helical blade, thereby reduce the accumulational thickness of lysine monomer in filter screen cylinder bottom, be convenient for rivers wash it, further improve the cleaning performance.
Preferably, the blind end of the water supply pipe is connected with a blocking block in a sliding manner, and a spring is fixedly connected between the blocking block and the blind end of the water supply pipe; a plurality of blocking rings are connected in the water supply pipe in a sliding manner; connecting rods are fixedly connected between the blocking blocks and the blocking rings; the water spray holes are sealed by the blocking blocks and the blocking rings; after the water under high pressure got into the delivery pipe, because all hole for water spraying all sealed by sprue and stifled ring, the delivery pipe can not go out water at this moment, later rivers reach sprue department and promote the sprue to slide in the delivery pipe, drive stifled ring through the connecting rod simultaneously and slide, all hole for water spraying this moment and open simultaneously, this operation can be so that the water pressure of each hole for water spraying department equals to reach the purpose that the water yield is the same, the water yield of avoiding each hole for water spraying is different, lead to wasing inhomogeneous problem.
Preferably, a plurality of scraping strips are uniformly distributed on the outer side of the water pipe, and the scraping strips are made of elastic materials; the free end of the scraping strip is close to the inner wall of the filter screen cylinder; through setting up a plurality of strips of scraping, the filter screen section of thick bamboo drives the strip of scraping through beating the water pipe and rotates together, and then scrapes the strip and dial the lysine monomer of filter screen bobbin base portion and scatter, make its can be even with rivers contact, avoid a large amount of lysine monomers to bond together, lead to the problem that inside lysine monomer can't be washed by rivers.
Preferably, a plurality of driving shells are uniformly distributed on the outer side of the water fetching pipe; a balancing weight is connected in the guide shell in a sliding manner; an arc-shaped elastic sheet is fixedly connected to one side of the guide shell, which is far away from the water pumping pipe, and the arc-shaped elastic sheet is bent towards the balancing weight; the scraping strips are uniformly and fixedly connected to one side of the arc-shaped elastic sheet away from the balancing weight; lead the shell and rotate along with the pipe of fetching water, when leading the shell and moving the top, the effect of centrifugal force is overcome to the balancing weight, so the balancing weight can not strike arc shell fragment, when leading the shell and moving the below, the gravity that the balancing weight received is the same with centrifugal force direction, so the balancing weight can strike arc shell fragment and make its deformation, and then arc shell fragment reverse bend, it outwards opens the swing to drive the scraping strip, this operation makes equipment operation in-process, the swing that the scraping strip can the intermittent type formula, further dial the lysine monomer on the filter screen section of thick bamboo inner wall and scatter, avoid a large amount of lysine monomers to bond together, lead to the problem that inside lysine monomer can't be washed by rivers.
Preferably, the guide shell is positioned between the adjacent water spraying holes, and the guide shell does not shield the water spraying holes; through will leading the movable shell setting between adjacent hole for water spraying, can avoid leading the movable shell to shelter from the hole for water spraying, lead to the problem that the water is smooth.
Preferably, one side of the arc-shaped elastic sheet close to the balancing weight is fixedly connected with an elastic air bag; the scraping strip is of a hollow structure and is communicated with the elastic air bag through the guide hole; through setting up the elasticity gasbag for when the balancing weight is strikeed towards arc elasticity, can extrude the elasticity gasbag earlier, and make the air in the elasticity gasbag pass through the guide hole and get into inside the scraping strip, finally by the free end blowout of scraping the strip, further blow away the lysine monomer, avoid a large amount of lysine monomers to bond together, lead to the unable problem that is washed by rivers of inside lysine monomer.
Preferably, a pressure chamber is fixedly connected to the position, close to the rotating shaft, of the bottom of the shell through a support; the inner part of the pressure chamber is rotatably connected with a packing auger through a support, and the packing auger is driven by a power assembly; the top of the pressure chamber is communicated with a guide pipe, and the other end of the guide pipe extends out of the shell and is wound outside the motor; drive the auger through power component and rotate, can outwards take the sewage of shell bottom out, reach the purpose of automatic blowdown, simultaneously through winding the pipe in the motor outside, the inside rivers of pipe can also play when the motor, and the problem of avoiding the motor to influence equipment work efficiency because of the high temperature prolongs the life of motor for the radiating effect of motor.
Preferably, the power assembly comprises a first bevel gear, and the first bevel gear is fixedly connected to the top end of the auger; a transmission shaft is rotatably connected in the pressure chamber; one end of the transmission shaft is fixedly connected with a second bevel gear, and the first bevel gear is meshed with the second bevel gear; the other end of the transmission shaft extends out of the pressure chamber and is fixedly connected with a first gear; a second gear is fixedly connected to the outer side of the rotating shaft, and the first gear is meshed with the second gear; when the motor drives the rotating shaft to rotate, the auger is driven to rotate through the matching between the two pairs of gears, the power generated during the operation of the motor is ingeniously utilized, the energy utilization rate is improved, the operation steps are simplified, water pumping by other equipment such as a water pump is avoided, and the operation cost of the device is reduced.
The invention has the following beneficial effects:
1. according to the degradable biological material and the preparation method thereof, the nano particles can be prepared by the raw materials in the formula, and are introduced into the polymerization reaction of casein and acrylic acid, and the amino groups and the like contained in the nano particles can form hydrogen bonds with hydroxyl groups, amino groups and the like in the casein and the acrylic acid, so that the mechanical property and the degradation property of the biological material are improved;
2. the degradable biological material and the preparation method thereof are characterized in that the generated lysine monomer precipitate is introduced into a filter screen cylinder, high-pressure water is injected into a water supply pipe to wash the lysine monomer, the filter screen cylinder is driven to rotate by a motor to generate centrifugal force, water in the lysine monomer is thrown out together with impurities, a water beating pipe rotates outside the water supply pipe, the sprayed water is scattered, the water flow washing area is increased, and the washing effect of the lysine monomer is improved.
Drawings
The invention will be further described with reference to the accompanying drawings in which:
FIG. 1 is a schematic flow diagram of a preparation process of the present invention;
FIG. 2 is a perspective view of the present invention;
FIG. 3 is a cross-sectional view of the present invention;
FIG. 4 is an enlarged view of a portion of FIG. 3 at A;
FIG. 5 is a partial enlarged view of FIG. 4 at B;
FIG. 6 is a cross-sectional view of the present invention;
FIG. 7 is an enlarged view of a portion of FIG. 6 at C;
in the figure: the device comprises a shell 1, a filter screen cylinder 2, a motor 3, a rotating shaft 4, a helical blade 5, a water pipe 6, a water supply pipe 7, a water spray hole 8, a blocking block 9, a spring 10, a blocking ring 11, a connecting rod 12, a scraping strip 13, a guide shell 14, a balancing weight 15, an arc-shaped elastic sheet 16, an elastic air bag 17, a guide hole 18, a pressure chamber 19, a packing auger 20, a guide pipe 21, a first bevel gear 22, a transmission shaft 23, a second bevel gear 24, a first gear 25 and a second gear 26.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
A degradable biological material is prepared from the following raw materials in parts by weight:
1-2 parts of 1, 4-butanediol
4-6 parts of lysine hydrochloride
15-18 parts of toluene
8-10 parts of isopropanol
30-40 parts of N, N-dimethylacetamide
6-8 parts of nano calamine powder
4-6 parts of casein
4-6 parts of acrylic acid
8-10 parts of potassium persulfate
10-12 parts of polyether glycol
10-12 parts of dibutyltin dilaurate;
the nano particles can be prepared by the raw materials in the formula, and are introduced into the polymerization reaction of casein and acrylic acid, amino groups and the like contained in the nano particles can form hydrogen bonds with hydroxyl groups, amino groups and the like in the casein and the acrylic acid, so that the mechanical property and the degradation property of the biological material are improved.
Example one
As shown in fig. 1, a method for preparing a degradable biomaterial according to an embodiment of the present invention is used to prepare the degradable biomaterial, and the method comprises the following steps:
s1: adding 1, 4-butanediol and lysine hydrochloride into toluene, stirring and reacting for 22-24 hours under a high temperature condition, centrifuging to obtain a precipitate, then adding the precipitate into isopropanol, stirring and dispersing uniformly, standing for 10-12 hours under a low temperature condition, centrifuging to obtain the precipitate to obtain a lysine monomer precipitate;
s2: the lysine monomer sediment is introduced into the filter screen cylinder 2 of the washing equipment, high-pressure water is injected into the water supply pipe 7 to wash the lysine monomer, the filter screen cylinder 2 is driven to rotate by the motor 3 to generate centrifugal force, water in the lysine monomer is thrown out together with impurities, the water beating pipe 6 rotates outside the water supply pipe 7 to break up the sprayed water, the water flow washing area is increased, and the washing effect is improved;
s3: uniformly mixing lysine monomers and nano calamine powder, carrying out post-treatment to obtain nano particles, adding casein, acrylic acid and potassium persulfate into water, stirring and reacting under a nitrogen environment, then adding the nano particles, and carrying out post-treatment to obtain modified nano particles;
s4: adding polyether glycol and the modified nanoparticles into N, N-dimethylacetamide, uniformly oscillating by ultrasonic waves, and carrying out coaxial electrostatic spinning to obtain the finished degradable biological material.
As shown in fig. 2 to 4, the water washing apparatus includes a housing 1; a filter screen cylinder 2 is rotatably connected inside the shell 1; a motor 3 is arranged on one side of the shell 1; a rotating shaft 4 is rotatably connected inside the shell 1, one end of the rotating shaft 4 is fixedly connected with an output shaft of the motor 3, and the other end of the rotating shaft 4 is fixedly connected with the filter screen cylinder 2; the inner wall of the filter screen cylinder 2 is fixedly connected with a helical blade 5; a water pumping pipe 6 is fixedly connected inside the filter screen cylinder 2, and the water pumping pipe 6 is made of a grid material; a water supply pipe 7 is arranged in the water fetching pipe 6, and the water fetching pipe 6 is rotatably connected with the water supply pipe 7; one end of the water supply pipe 7 is a blind end, and the other end of the water supply pipe extends out of the shell 1 and is fixedly connected with the shell 1; a plurality of water spraying holes 8 are uniformly formed in the water supply pipe 7; leading-in filter screen section of thick bamboo 2 with the lysine monomer deposit that generates, and inject the high pressure water into delivery pipe 7, and then the water under high pressure outwards spouts through the hole for water spraying 8 of evenly arranging, wash the lysine monomer, drive filter screen section of thick bamboo 2 through motor 3 simultaneously and rotate, produce centrifugal force, throw away the moisture in the lysine monomer together with impurity, it rotates in the delivery pipe 7 outside to beat water pipe 6, break up spun water, increase rivers wash the area, improve the free cleaning performance of lysine, because the lysine monomer receives the action of gravity, most all are located filter screen section of thick bamboo 2 bottom, can take the lysine monomer to the take-up height through helical blade 5, thereby reduce the accumulational thickness of lysine monomer in filter screen section of thick bamboo 2 bottom, the rivers of being convenient for wash it, further improve the cleaning performance.
A blocking block 9 is connected in the blind end of the water supply pipe 7 in a sliding manner, and a spring 10 is fixedly connected between the blocking block 9 and the blind end of the water supply pipe 7; a plurality of blocking rings 11 are connected in the water supply pipe 7 in a sliding manner; a connecting rod 12 is fixedly connected between the blocking block 9 and the blocking rings 11; the water spray holes 8 are sealed by the blocking blocks 9 and the blocking rings 11; after water under high pressure got into delivery pipe 7, because all hole for water spraying 8 all are sealed by sprue 9 and stifled ring 11, delivery pipe 7 can not go out water at this moment, later rivers reach sprue 9 department and promote sprue 9 and slide in delivery pipe 7, it slides to drive stifled ring 11 simultaneously through connecting rod 12, all hole for water spraying 8 open simultaneously this moment, this operation can be so that the water pressure of each hole for water spraying 8 department equals, in order to reach the same mesh of water yield, avoid the water yield of each hole for water spraying 8 different, lead to wasing inhomogeneous problem.
A plurality of scraping strips 13 are uniformly distributed on the outer side of the water injection pipe 6, and the scraping strips 13 are made of elastic materials, wherein the elastic materials can be rubber, silica gel and other materials; the free end of the scraping strip 13 is close to the inner wall of the filter screen cylinder 2; through setting up a plurality of scrapers 13, filter screen cylinder 2 drives through water pipe 6 and scrapes strip 13 and rotate together, and then scrapes strip 13 and dial the lysine monomer of filter screen cylinder 2 bottoms and scatter, make its can be even with rivers contact, avoid a large amount of lysine monomers to bond together, lead to the problem that inside lysine monomer can't be washed by rivers.
A plurality of driving shells 14 are uniformly distributed on the outer side of the water pumping pipe 6; a balancing weight 15 is connected in the guide shell 14 in a sliding manner; an arc-shaped elastic sheet 16 is fixedly connected to one side of the guide shell 14, which is far away from the water injection pipe 6, and the arc-shaped elastic sheet 16 is bent towards the balancing weight 15; the scraping strips 13 are uniformly and fixedly connected to one side of the arc-shaped elastic sheet 16 away from the balancing weight 15; guide shell 14 and rotate along with pipe 6 of beating water, when guide shell 14 moves the top, the effect of centrifugal force is overcome to balancing weight 15, event balancing weight 15 can not strike arc shell fragment 16, when guide shell 14 moves the below, the gravity that balancing weight 15 received is the same with centrifugal force direction, event balancing weight 15 can strike arc shell fragment 16 and make its deformation, and then arc shell fragment 16 reverse bending, drive scraping strip 13 outwards opens the swing, this operation makes the equipment operation in-process, scraping strip 13 can the swing of intermittent type formula, further dial lysine monomer on 2 inner walls of filter screen cylinder, avoid a large amount of lysine monomer to bond together, lead to the problem that inside lysine monomer can't be washed by rivers.
The guide shell 14 is positioned between the adjacent water spraying holes 8, and the guide shell 14 does not shield the water spraying holes 8; by arranging the guide shell 14 between the adjacent water spraying holes 8, the problem that the water spraying holes 8 are blocked by the guide shell 14 to cause unsmooth water outlet can be avoided.
As shown in fig. 5, an elastic airbag 17 is fixedly connected to one side of the arc-shaped elastic sheet 16 close to the counterweight block 15; the scraping strip 13 is of a hollow structure, and the scraping strip 13 is communicated with the elastic air bag 17 through a guide hole 18; through setting up elasticity gasbag 17 for balancing weight 15 when striking towards arc elasticity, can extrude elasticity gasbag 17 earlier, and make the air in the elasticity gasbag 17 pass through guide hole 18 and get into inside scraping strip 13, finally by the free end blowout of scraping strip 13, further blow away the lysine monomer, avoid a large amount of lysine monomers to bond together, lead to the unable problem that is washed by rivers of inside lysine monomer.
Example two
As shown in fig. 6 to 7, a first comparative example, in which another embodiment of the present invention is: a pressure chamber 19 is fixedly connected to the position, close to the rotating shaft 4, of the bottom of the shell 1 through a support; the packing auger 20 is rotatably connected inside the pressure chamber 19 through a support, and the packing auger 20 is driven by a power assembly; the top of the pressure chamber 19 is communicated with a conduit 21, and the other end of the conduit 21 extends out of the shell 1 and is wound outside the motor 3; drive auger 20 through power component and rotate, can outwards take the sewage of shell 1 bottom out, reach the purpose of automatic blowdown, simultaneously through winding pipe 21 in the 3 outsides of motor, the inside rivers of pipe 21 can also play when motor 3, avoid motor 3 to influence the problem of equipment work efficiency because of the high temperature for the radiating effect of motor 3, prolong motor 3's life.
The power assembly comprises a first bevel gear 22, and the first bevel gear 22 is fixedly connected to the top end of the auger 20; a transmission shaft 23 is rotatably connected in the pressure chamber 19; one end of the transmission shaft 23 is fixedly connected with a second bevel gear 24, and the first bevel gear 22 is meshed with the second bevel gear 24; the other end of the transmission shaft 23 extends out of the pressure chamber 19 and is fixedly connected with a first gear 25; a second gear 26 is fixedly connected to the outer side of the rotating shaft 4, and the first gear 25 is meshed with the second gear 26; when the motor 3 drives the rotating shaft 4 to rotate, the auger 20 is driven to rotate through the matching between the two pairs of gears, the power generated when the motor 3 operates is ingeniously utilized, the energy utilization rate is improved, the operation steps are simplified, water pumping by other equipment such as a water pump is avoided, and the operation cost of the device is reduced.
The working principle is as follows: the generated lysine monomer sediment is guided into the filter screen cylinder 2, high-pressure water is injected into the water supply pipe 7, the high-pressure water is sprayed out through the uniformly arranged water spraying holes 8, the lysine monomer is washed, meanwhile, the filter screen cylinder 2 is driven to rotate through the motor 3 to generate centrifugal force, moisture in the lysine monomer is thrown out together with impurities, the water beating pipe 6 rotates outside the water supply pipe 7 to break up the sprayed water, the water flow washing area is increased, the washing effect of the lysine monomer is improved, most of the lysine monomer is positioned at the bottom of the filter screen cylinder 2 under the action of gravity, and the lysine monomer can be brought to a certain height through the spiral blade 5, so that the accumulation thickness of the lysine monomer at the bottom of the filter screen cylinder 2 is reduced, the lysine monomer is convenient to be washed by water flow, and the washing effect is further improved; after high-pressure water enters the water supply pipe 7, all the water spray holes 8 are sealed by the blocking blocks 9 and the blocking rings 11, so that the water supply pipe 7 cannot discharge water, then the water flow reaches the blocking blocks 9 and pushes the blocking blocks 9 to slide in the water supply pipe 7, meanwhile, the blocking rings 11 are driven to slide through the connecting rods 12, all the water spray holes 8 are opened at the same time, the operation can enable the water pressure at all the water spray holes 8 to be equal, the purpose of the same water discharge is achieved, and the problem of uneven cleaning caused by different water discharge of all the water spray holes 8 is solved; by arranging the plurality of scraping strips 13, the filter screen cylinder 2 drives the scraping strips 13 to rotate together through the water injection pipe 6, and then the scraping strips 13 scatter lysine monomers at the bottom of the filter screen cylinder 2, so that the lysine monomers can be uniformly contacted with water flow, and the problem that the lysine monomers in the filter screen cylinder cannot be washed by the water flow due to the fact that a large number of lysine monomers are bonded together is solved; the guide shell 14 rotates along with the water pumping pipe 6, when the guide shell 14 moves to the upper part, the counterweight block 15 overcomes the action of centrifugal force, so the counterweight block 15 cannot impact the arc-shaped elastic sheet 16, when the guide shell 14 moves to the lower part, the gravity and the centrifugal force applied to the counterweight block 15 are the same in direction, so the counterweight block 15 can impact the arc-shaped elastic sheet 16 and deform the arc-shaped elastic sheet 16, further the arc-shaped elastic sheet 16 is reversely bent to drive the scraping strip 13 to outwards open and swing, in the operation process of the equipment, the scraping strip 13 can intermittently swing to further disperse the lysine monomers on the inner wall of the filter screen cylinder 2, and the problem that the lysine monomers in the inner part cannot be washed by water flow due to the fact that a large amount of lysine monomers are bonded together is avoided; the guide shell 14 is arranged between the adjacent water spraying holes 8, so that the problem of unsmooth water outlet caused by the fact that the water spraying holes 8 are shielded by the guide shell 14 can be avoided; by arranging the elastic air bag 17, when the balancing weight 15 is impacted towards the arc-shaped elasticity, the elastic air bag 17 is firstly extruded, air in the elastic air bag 17 enters the interior of the scraping strip 13 through the guide hole 18 and is finally sprayed out from the free end of the scraping strip 13, and lysine monomers are further blown away, so that the problem that the lysine monomers in the interior cannot be washed by water flow due to the fact that a large number of lysine monomers are bonded together is solved; the auger 20 is driven to rotate by the power assembly, so that the sewage at the bottom of the shell 1 can be extracted outwards, the aim of automatic sewage discharge is achieved, meanwhile, the guide pipe 21 is wound outside the motor 3, and when water in the guide pipe 21 flows through the motor 3, the effect of radiating the motor 3 can be achieved, the problem that the working efficiency of equipment is influenced due to overhigh temperature of the motor 3 is avoided, and the service life of the motor 3 is prolonged; when the motor 3 drives the rotating shaft 4 to rotate, the auger 20 is driven to rotate through the matching between the two pairs of gears, the power generated when the motor 3 operates is ingeniously utilized, the energy utilization rate is improved, the operation steps are simplified, water pumping by other equipment such as a water pump is avoided, and the operation cost of the device is reduced.
The front, the back, the left, the right, the upper and the lower are all based on figure 1 in the attached drawings of the specification, according to the standard of the observation angle of a person, the side of the device facing an observer is defined as the front, the left side of the observer is defined as the left, and the like.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience in describing the present invention and for simplifying the description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the scope of the present invention.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. A degradable biomaterial, characterized by: the biological material comprises the following raw materials in parts by weight:
1-2 parts of 1, 4-butanediol
4-6 parts of lysine hydrochloride
15-18 parts of toluene
8-10 parts of isopropanol
30-40 parts of N, N-dimethylacetamide
6-8 parts of nano calamine powder
4-6 parts of casein
4-6 parts of acrylic acid
8-10 parts of potassium persulfate
10-12 parts of polyether glycol
10-12 parts of dibutyltin dilaurate.
2. A method for preparing a degradable biomaterial according to claim 1, wherein the method comprises the steps of: the biological material is prepared by the following steps:
s1: adding 1, 4-butanediol and lysine hydrochloride into toluene, stirring and reacting for 22-24 hours under a high temperature condition, centrifuging to obtain a precipitate, then adding the precipitate into isopropanol, stirring and dispersing uniformly, standing for 10-12 hours under a low temperature condition, centrifuging to obtain the precipitate to obtain a lysine monomer precipitate;
s2: the lysine monomer sediment is led into the interior of a filter screen cylinder (2) of a washing device, high-pressure water is injected into a water supply pipe (7) to wash the lysine monomer, the filter screen cylinder (2) is driven to rotate through a motor (3) to generate centrifugal force, water in the lysine monomer is thrown out together with impurities, a water beating pipe (6) rotates on the outer side of the water supply pipe (7), the sprayed water is scattered, the water flow washing area is increased, and the washing effect is improved;
s3: uniformly mixing lysine monomers and nano calamine powder, carrying out post-treatment to obtain nano particles, adding casein, acrylic acid and potassium persulfate into water, stirring and reacting under a nitrogen environment, then adding the nano particles, and carrying out post-treatment to obtain modified nano particles;
s4: adding polyether glycol, modified nanoparticles and dibutyltin dilaurate into N, N-dimethylacetamide, uniformly oscillating by ultrasonic waves, and carrying out coaxial electrostatic spinning to obtain the finished degradable biological material.
3. The method for preparing a degradable biomaterial according to claim 2, wherein the method comprises the following steps: the water washing device comprises a housing (1); a filter screen cylinder (2) is rotatably connected in the shell (1); a motor (3) is arranged on one side of the shell (1); a rotating shaft (4) is rotatably connected inside the shell (1), one end of the rotating shaft (4) is fixedly connected with an output shaft of the motor (3), and the other end of the rotating shaft (4) is fixedly connected with the filter screen cylinder (2); the inner wall of the filter screen cylinder (2) is fixedly connected with a helical blade (5); a water pumping pipe (6) is fixedly connected inside the filter screen cylinder (2), and the water pumping pipe (6) is made of a grid material; a water supply pipe (7) is arranged in the water pumping pipe (6), and the water pumping pipe (6) is rotatably connected with the water supply pipe (7); one end of the water supply pipe (7) is a blind end, and the other end of the water supply pipe extends out of the shell (1) and is fixedly connected with the shell (1); a plurality of water spraying holes (8) are uniformly formed in the water supply pipe (7).
4. The method for preparing a degradable biomaterial according to claim 3, wherein the method comprises the following steps: a plugging block (9) is connected in the blind end of the water supply pipe (7) in a sliding manner, and a spring (10) is fixedly connected between the plugging block (9) and the blind end of the water supply pipe (7); a plurality of blocking rings (11) are connected in the water supply pipe (7) in a sliding way; connecting rods (12) are fixedly connected between the blocking blocks (9) and the blocking rings (11); the water spray holes (8) are sealed by the blocking blocks (9) and the blocking rings (11).
5. The method for preparing a degradable biomaterial according to claim 3, wherein the method comprises the following steps: a plurality of scraping strips (13) are uniformly distributed on the outer side of the water injection pipe (6), and the scraping strips (13) are made of elastic materials; the free end of the scraping strip (13) is close to the inner wall of the filter screen cylinder (2).
6. The method for preparing a degradable biomaterial according to claim 5, wherein the method comprises the following steps: a plurality of driving shells (14) are uniformly distributed on the outer side of the water injection pipe (6); a balancing weight (15) is connected in the guide shell (14) in a sliding way; an arc-shaped elastic sheet (16) is fixedly connected to one side, away from the water inlet pipe (6), of the guide shell (14), and the arc-shaped elastic sheet (16) bends towards the balancing weight (15); the scraping strips (13) are uniformly and fixedly connected to one side of the arc-shaped elastic sheet (16) far away from the balancing weight (15).
7. The method for preparing a degradable biomaterial according to claim 6, wherein the method comprises the following steps: the guide shell (14) is positioned between the adjacent water spraying holes (8), and the guide shell (14) does not shield the water spraying holes (8).
8. The method for preparing a degradable biomaterial according to claim 7, wherein the method comprises the following steps: an elastic air bag (17) is fixedly connected to one side of the arc-shaped elastic sheet (16) close to the balancing weight (15); the scraping strip (13) is of a hollow structure, and the scraping strip (13) is communicated with the elastic air bag (17) through a guide hole (18).
9. The method for preparing a degradable biomaterial according to claim 3, wherein the method comprises the following steps: a pressure chamber (19) is fixedly connected to the position, close to the rotating shaft (4), of the bottom of the shell (1) through a support; the packing auger (20) is rotatably connected inside the pressure chamber (19) through a support, and the packing auger (20) is driven by a power assembly; the top of the pressure chamber (19) is communicated with a guide pipe (21), and the other end of the guide pipe (21) extends out of the shell (1) and is wound outside the motor (3).
10. The method for preparing a degradable biomaterial according to claim 9, wherein the method comprises the following steps: the power assembly comprises a first bevel gear (22), and the first bevel gear (22) is fixedly connected to the top end of the packing auger (20); a transmission shaft (23) is rotatably connected in the pressure chamber (19); one end of the transmission shaft (23) is fixedly connected with a second bevel gear (24), and the first bevel gear (22) is meshed with the second bevel gear (24); the other end of the transmission shaft (23) extends out of the pressure chamber (19) and is fixedly connected with a first gear (25); a second gear (26) is fixedly connected to the outer side of the rotating shaft (4), and the first gear (25) is meshed with the second gear (26).
CN202210060460.8A 2022-01-19 2022-01-19 Degradable biological material and preparation method thereof Pending CN114392397A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318264A (en) * 2021-05-28 2021-08-31 瑞聚再生(厦门)医学科技有限公司 Degradable polyurethane biomaterial and preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318264A (en) * 2021-05-28 2021-08-31 瑞聚再生(厦门)医学科技有限公司 Degradable polyurethane biomaterial and preparation method and application thereof

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