CN114391815A - Method and system for stroke rehabilitation analysis by using near-infrared brain function imaging device - Google Patents
Method and system for stroke rehabilitation analysis by using near-infrared brain function imaging device Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
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- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
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- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
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- A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
- A61B2505/09—Rehabilitation or training
Abstract
The invention provides a method and a system for stroke rehabilitation analysis by using a near-infrared brain function imaging device, wherein the near-infrared brain function imaging device is provided with a head cap worn on the head of a subject, the head cap is provided with a plurality of probes used for transmitting and/or receiving near-infrared signals so as to acquire the near-infrared signals of a plurality of corresponding channels, and the method comprises the following steps: under the condition that the object executes a plurality of groups of upper limb movement and rest alternate tasks, acquiring a plurality of segments of near-infrared signals of all channels of bilateral brain areas at least corresponding to the upper limb movement by utilizing the plurality of probes, wherein each segment of near-infrared signal corresponds to each group of tasks; determining a stroke rehabilitation analysis result of the object according to at least a plurality of collected near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement; and displaying the determined stroke rehabilitation analysis result of the subject, which is beneficial to eliminating interference and improving analysis accuracy.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a method and a system for stroke rehabilitation analysis by using a near-infrared brain function imaging device.
Background
Near infrared spectral brain function imaging (fNIRS) is a new brain function imaging technique. By using multi-channel sensing composed of near infrared light and a transmitting probe-receiving probe, based on a nerve-blood oxygen coupling mechanism, the fNIRS can penetrate through the skull to detect and image the change of activation of brain activity with high time resolution, and effectively perform visualization and quantitative evaluation on brain functions. Currently, near-infrared spectral brain function imaging technology can be used for assessing stroke rehabilitation, however, the inventor finds that near-infrared signals of a large brain area of a subject, which usually needs to be continuously acquired for tens of minutes, are serious in signal intensity drift and frequency band interference, and the effect is not good although wavelet transformation is used for reducing noise interference. In addition, in the prior art, the stroke rehabilitation analysis is performed by using the near infrared signal of the object during the rehabilitation training exercise, and the stroke rehabilitation analysis performed by keeping the rehabilitation training exercise task for tens of minutes or even tens of minutes is difficult for some severe stroke patients, the compliance of the patients is not high, and the evaluation accuracy is also seriously influenced.
Disclosure of Invention
The invention is provided for solving the technical problems in the prior art. The invention aims to provide a method and a system for stroke rehabilitation analysis by using a near-infrared brain function imaging device, which are particularly suitable for severe stroke patients, can complete analysis and evaluation in a short time so as to improve the efficiency, and can reduce signal drift and frequency band interference so as to improve the accuracy of an analysis result.
According to a first aspect of the present invention, there is provided a method of stroke rehabilitation analysis with a near-infrared brain function imaging device having a head cap for wearing on a subject's head, the head cap being provided with a plurality of probes for transmitting and/or receiving near-infrared signals to acquire near-infrared signals of a plurality of corresponding channels, the method comprising: under the condition that the object executes a plurality of groups of upper limb movement and rest alternate tasks, acquiring a plurality of segments of near-infrared signals of all channels of bilateral brain areas at least corresponding to the upper limb movement by utilizing the plurality of probes, wherein each segment of near-infrared signal corresponds to each group of tasks; determining a stroke rehabilitation analysis result of the object according to at least a plurality of collected near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement; and
displaying the determined stroke rehabilitation analysis result of the subject.
According to a second aspect of the present invention, there is provided a stroke rehabilitation analyzing system including: the head cap is used for being worn on the head of a subject and is provided with a plurality of probes for transmitting and/or receiving near-infrared signals so as to acquire the near-infrared signals of a plurality of corresponding channels; a processor configured to: under the condition that the object executes a plurality of groups of upper limb movement and rest alternate tasks, enabling the plurality of probes to collect a plurality of segments of near-infrared signals of all channels of bilateral brain areas at least corresponding to the upper limb movement, wherein each segment of near-infrared signal corresponds to each group of tasks; determining a stroke rehabilitation analysis result of the object according to at least a plurality of collected near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement; and a display configured to: displaying the determined stroke rehabilitation analysis result of the subject.
According to a third aspect of the present invention, a computer-readable storage medium has stored thereon computer program instructions, which, when executed by a processor, cause the processor to execute the method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to various embodiments of the present invention.
Compared with the prior art, the embodiment of the invention has the beneficial effects that:
when the apoplexy patient carries out the recovered analysis of apoplexy, carry out array upper limbs motion and rest task in turn, be favorable to reducing the frequency band interference and reduce the drift, the rest phase provides the blood oxygen concentration benchmark of current group for can obtain real-time, accurate blood oxygen concentration change condition, and then obtain more accurate recovered analysis result of apoplexy. Based on the analysis method, the assessment of the stroke rehabilitation analysis can be completed in a short time, the method is particularly suitable for patients with severe stroke, the object compliance is high, the near infrared signals of all channels of bilateral brain areas corresponding to the upper limb movement rather than generalized brain areas are acquired in a targeted mode, the upper limb movement can generate signals with high intensity in the corresponding brain areas, more concentrated and consistent near infrared signals with high intensity can be obtained along with the upper limb movement, the stroke rehabilitation analysis result is determined according to the signals, and the interference elimination and the accuracy improvement are facilitated.
The foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to limit the invention as claimed.
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In the drawings, which are not necessarily drawn to scale, like reference numerals may describe similar components in different views. Like reference numerals having letter suffixes or different letter suffixes may represent different examples of similar components. The drawings illustrate various embodiments generally by way of example and not by way of limitation, and together with the description and claims serve to explain the disclosed embodiments. The same reference numbers will be used throughout the drawings to refer to the same or like parts, where appropriate. Such embodiments are illustrative, and are not intended to be exhaustive or exclusive embodiments of the present apparatus or method.
Fig. 1 shows a flowchart of a method for stroke rehabilitation analysis using a near-infrared brain function imaging device according to an embodiment of the present invention.
FIG. 2 shows a graphical representation of a representative HbO2 distribution curve (201), a representative HbR distribution curve (202), and a representative HbT (203) distribution curve obtained in accordance with an embodiment of the present invention with a time axis control display.
Fig. 3 shows a diagram of an activation map obtained by stroke rehabilitation analysis using a near-infrared brain function imaging apparatus according to an embodiment of the present invention.
Fig. 4 shows a graph of a stroke rehabilitation analysis result obtained by performing a stroke rehabilitation analysis using a near-infrared brain function imaging device while displaying a stroke rehabilitation index of the subject according to an embodiment of the present invention.
Fig. 5 shows a schematic diagram of a stroke rehabilitation analysis system according to an embodiment of the invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments. The following detailed description of embodiments of the invention is provided in connection with the accompanying drawings and the detailed description of embodiments of the invention, but is not intended to limit the invention.
The use of "first," "second," and similar terms in the present application does not denote any order, quantity, or importance, but rather the terms first, second, and the like are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element preceding the word covers the element listed after the word, and does not exclude the possibility that other elements are also covered. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
All terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs unless specifically defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.
Fig. 1 shows a flowchart of a method for stroke rehabilitation analysis using a near-infrared brain function imaging device according to an embodiment of the present invention. The near-infrared brain function imaging device is provided with a head cap which is worn on the head of a subject, the head cap is provided with a plurality of probes which are used for transmitting and/or receiving near-infrared signals so as to acquire the near-infrared signals of a plurality of corresponding channels, and the near-infrared signals can represent the blood oxygen concentration change of cerebral cortex. In the process of utilizing the near-infrared brain function imaging device to carry out stroke rehabilitation analysis, the near-infrared light and the transmitting probe-receiving probe on the head cap form multi-channel sensing, the near-infrared signals of a plurality of corresponding channels are collected, and the brain function condition of a stroke patient is effectively visualized and quantitatively evaluated based on a nerve-blood oxygen coupling mechanism.
As shown in fig. 1, step S101 discloses acquiring, with the plurality of probes, segments of near-infrared signals of respective channels of bilateral brain regions corresponding at least to upper limb movement, in a case where the subject performs an array of alternating tasks of upper limb movement and rest. Each section of near-infrared signal corresponds to each group of tasks, each group of tasks comprises an upper limb movement stage and a rest stage, namely each section of near-infrared signal comprises the upper limb movement stage and the rest stage. For each channel, a group of upper limb movement and rest alternating tasks correspondingly acquire a section of near-infrared signals which are continuous in a time domain, and compared with the acquisition of the near-infrared signals which are continuous for tens of minutes, baseline drift can be avoided, and the stability of each section of near-infrared signals is ensured. The brain region may be a motion region corresponding to the motion of an upper limb, and the object includes, but is not limited to, a patient with mild stroke, a patient with moderate stroke, a patient with severe stroke, and the like, which is not particularly limited in the present invention. It will be appreciated that some stroke patients have impaired motor zones and difficulty performing some motor movements, such as grasping movements, bending and stretching movements, and the like, and generally need to perform corresponding rehabilitation tasks according to the order to improve the motor functions of the stroke patients.
It should be noted that the training time of the rehabilitation training task performed by the stroke patient is at least ten minutes, even tens of minutes, and the ideal training effect can be achieved. The sum of the duration time of the plurality of groups of tasks is shorter than the training time of the rehabilitation training task of the object, the duration time of the upper limb movement of each group can be tens of seconds or tens of seconds, the duration time of the rest phase can also be tens of seconds or tens of seconds, the sum of the duration time of the execution of the plurality of groups of tasks can be several minutes, such as 3 minutes, 5 minutes and the like, and is far shorter than the training time of the rehabilitation training task executed by the object, so that the compliance of a patient is higher, the obtained near infrared signals can be processed to obtain more stable and accurate near infrared signals corresponding to each group of tasks, the stroke rehabilitation analysis is carried out based on the near infrared signals of each group of tasks or representative near infrared signals obtained based on the near infrared signals of each group of tasks, and the accuracy of the analysis can be improved.
It is understood that the upper limb movement performed by the subject for stroke rehabilitation analysis may be the same or different from the movement performed by the subject for the rehabilitation training task, that is, the rehabilitation training task performed by the subject may be the upper limb movement, or may be other movements, such as limb linkage movement, grasping movement, and the like, which is not limited in this respect.
When the subject performs several groups of alternating tasks of upper limb movement and resting, the so-called several groups include, but are not limited to, 1 group, 2 groups, 3 groups, 4 groups, etc., the number of groups to be specifically performed may be determined based on the requirements of the doctor or the analysis requirements, and the present invention is not limited thereto. For example, when stroke rehabilitation analysis is performed on a hemiplegia critical patient, the patient wears a head cap of a near-infrared brain function imaging device, and the critical patient performs upper limb movement for several seconds and then performs rest for several seconds into one group and 3 groups in total under the request of a doctor, and a probe on the head cap is used for collecting near-infrared signals for subsequent analysis. Wherein, the time for performing the upper limb movement and the time for performing the rest can be the same or different, for example, the patient can perform the upper limb movement for 15 seconds and then rest for 20 seconds. The rest phase of every group provides the blood oxygen concentration benchmark of current group, and the blood oxygen concentration value during the upper limbs motion based on the blood oxygen concentration benchmark of current group and current group can obtain the blood oxygen concentration change data of current group, and the real-time is better, can show the influence that reduces the drift, can obtain comparatively accurate reliable apoplexy rehabilitation analysis result based on this. In this embodiment, the patient performs the upper limb movement specifically under the guidance of the doctor, or the patient may perform the upper limb movement based on the prompt of the near-infrared brain function imaging device. When the alternation of the upper limb movement and the rest is executed, the patient can be done by lying or standing, for example, the patient can not stand for the rehabilitation analysis process of the patient with severe stroke, and the patient can be done by lying on the bed due to the simple analysis method of the embodiment. Therefore, the method provided by the embodiment is not only suitable for patients with mild stroke, but also is especially suitable for patients with severe stroke, and the compliance of the method to the patients is high. Of course, for the patient with mild stroke who can walk in a standing manner, there are many options for the execution mode, and the patient can finish the operation in a standing manner or finish the operation in a lying manner. The method provided by the embodiment has high training compliance and small execution difficulty, and greatly improves the efficiency of executing the rehabilitation analysis.
Specifically, the plurality of probes are used for acquiring a plurality of segments of near-infrared signals of channels of bilateral brain regions at least corresponding to upper limb movement, and the number and the types of the probes on the headgear are not specifically limited as long as the probes can be used for acquiring the near-infrared signals meeting the requirements. When the near-infrared brain function imaging device is used, the channel formed by the probes on the acquisition head cap corresponds to brain areas on two sides of the head of a user, and the physiological state of the brain areas on two sides corresponding to the movement of upper limbs is determined according to the acquired near-infrared data. The positioning of the bilateral brain areas can be realized by positioning software or other methods.
In the process of rehabilitation training of patients, the training time is long, and the training time can vary from tens of minutes to one hour based on the condition of the patients. However, according to the stroke rehabilitation analysis method provided by the embodiment, the duration of the patient or other study object performing the array task is shorter than the training time for performing the rehabilitation training exercise, so that the frequency band interference is less, and compared with the method of continuously acquiring the near infrared signal for tens of minutes, the drift can be significantly reduced. The embodiment can complete the evaluation within a few minutes, improves the analysis efficiency and can reduce the burden of the object.
In step S102, a stroke rehabilitation analysis result of the subject may be determined according to at least the collected near-infrared signals of the channels corresponding to the bilateral brain regions of the upper limb movement. Next, in step S103, the determined stroke rehabilitation analysis result of the subject may be displayed. The blood oxygen concentration in the human tissue changes according to the metabolic activity of the human body, and the change can be measured by using the near infrared light, so that the HbO2 distribution curve, the HbR distribution curve, the HbT distribution curve and the like in the time domain of each channel can be determined based on the plurality of pieces of near infrared signals as the stroke rehabilitation analysis result of the subject. Therefore, the hemodynamic activity of the cerebral cortex can be directly detected in real time, and the activity condition of the brain can be reversely deduced by observing the hemodynamic change, namely the neurovascular coupling rule. In the above embodiment, the stroke rehabilitation analysis is performed by using the near-infrared brain function imaging device, and several sets of tasks are adopted, each set of tasks has alternating upper limb movement and rest, the duration is several seconds, for example, 10 to 30 seconds, the frequency band interference to the attribute of the near-infrared signal is less, and the drift is significantly reduced compared with the continuous acquisition for more than ten minutes, the evaluation can be completed within several minutes, the compliance of the subject is higher, the rest stage of each set provides the blood oxygen concentration reference of the current set, the data of the blood oxygen concentration change of the current set can be obtained based on the blood oxygen concentration reference of the current set and the blood oxygen concentration value during the upper limb movement of the current set, the real-time performance is better, the influence of the drift can be significantly reduced, a more accurate and reliable stroke rehabilitation analysis result can be obtained based on the basis, and the near-infrared signals of each channel corresponding to the bilateral brain region of the upper limb movement rather than the generalized brain region are acquired in a targeted manner, the upper limbs motion can produce the great signal of intensity in corresponding brain district, can obtain the bigger near-infrared signal of more concentrated unanimous intensity along with the upper limbs motion, confirms the recovered analysis result of apoplexy according to this, is favorable to eliminating the interference and promotes the degree of accuracy.
It will be appreciated that the solution disclosed in the present invention may be used for analyzing the rehabilitation status of stroke patients who have improved their motor function by performing rehabilitation training tasks, and also for analyzing the rehabilitation status of stroke patients who do not need to perform rehabilitation training tasks, e.g. stroke patients who after a therapeutic intervention are considered by a doctor to be not needed to perform rehabilitation training tasks.
In some embodiments, determining the stroke rehabilitation analysis result of the subject from at least the acquired segments of near-infrared signals corresponding to the channels of the bilateral brain regions of the upper limb movement specifically comprises: for each channel, a correction is made to eliminate drift effects based on the signal strength at the beginning of each of the segments of the near-infrared signal for that channel. Specifically, in the acquisition process, the base lines of the near-infrared signals corresponding to each group of tasks can drift, and by registering the signal intensity of the starting positions of the near-infrared signals of the channels, the drift influence can be eliminated, and the accuracy of the analysis result is improved.
In some embodiments, the corrected near-infrared signals of the channel may be averaged to serve as a representative near-infrared signal of the channel, so that a stable and accurate representative near-infrared signal may be quickly obtained, and the stroke rehabilitation analysis result of the subject may be determined based on the representative near-infrared signal of each channel, which is beneficial to reducing workload and further improving accuracy of the analysis result. The representative near-infrared signal is intended to reflect the overall situation of the near-infrared signals of each channel, so that large deviation is avoided, and large errors are caused in judgment.
In some embodiments, as shown in fig. 2, the stroke rehabilitation analysis result of the subject includes a representative HbO2 distribution curve 201, a representative HbR distribution curve 202, and a representative HbT distribution curve 203 on a time domain of each channel of each brain region, and the representative HbO2 distribution curve 201, the representative HbR distribution curve 202, and the representative HbT distribution curve 203 on the time domain are displayed in comparison on the same time axis. The so-called representative profile can be obtained in various ways. For example, a representative channel may be selected, and a profile (or a time-domain average profile) of the representative channel may be acquired as the representative profile. For another example, a distribution curve of each channel may be obtained, and a representative curve (for example, but not limited to, an average curve) may be obtained as the representative distribution curve.
The representative HbO2 distribution curve 201, the representative HbR distribution curve 202, and the representative HbT distribution curve 203 can be displayed in comparison on the same time axis for the physician to visually assess how effective the blood oxygen response is. The blood oxygen concentration changes with the progress of the upper limb movement. For example, when a physician gives a right-handed finger movement to a subject, it consumes oxygen and energy in the cerebral cortex tissue corresponding to the brain region. At this time, the overcompensation mechanism of the cerebral blood supply system will greatly input blood containing abundant oxyhemoglobin into the local area, thereby causing the blood oxygen concentration of the local area to increase. When a subject executes a task, the near-infrared brain function imaging device is used for acquiring the blood oxygen concentration change of brain areas at two sides of the brain, the correlation degree of the hemodynamic activity and the task design is higher, the brain area can be inferred to be activated in a task state, and the blood oxygen response effect is better.
As shown in FIG. 2, the blood oxygen concentration value shows a trend of rising first and falling after reaching the peak in the time domain of the set of tasks, and this regular distribution curve shows that the blood oxygen response effect is better. The blood oxygen response effect can be used as a reference factor for stroke rehabilitation analysis, and other analysis results with high rehabilitation level can be overturned. For example, even if the activation map shows a high level of recovery but the blood oxygen effect is not normal, it cannot be determined that the analysis result of the activation map is reliable, and the doctor can make a note of how effective the blood oxygen response is for subsequent diagnosis. The poor blood oxygen response effect may be caused by low self-healing level, and may also be caused by detection failure of the near infrared device or improper operation in the acquisition process. In some embodiments, a prompt may be displayed to the physician when the blood oxygenation response is not effective.
In some embodiments, the acquiring the segments of near-infrared signals of the channels corresponding to at least the bilateral brain regions of the upper limb movement further comprises acquiring the segments of near-infrared signals of the channels corresponding to the bilateral brain regions of the upper limb movement and the peripheral brain regions, and the determining the stroke rehabilitation analysis result of the subject according to the acquired segments of near-infrared signals of the channels corresponding to at least the bilateral brain regions of the upper limb movement specifically comprises: determining an activation map of the brain region of the subject according to the collected near-infrared signals of the channels of the bilateral brain regions and the peripheral brain regions corresponding to the upper limb movement, wherein the distribution regularity of the color blocks in the activation map represents the stroke rehabilitation level of the subject, and the higher the distribution regularity is, the higher the stroke rehabilitation level of the subject is.
Specifically, as shown in fig. 3, the activation map not only shows the activation condition of the brain region corresponding to the upper limb movement, but also shows the activation condition of the adjacent peripheral related brain region, and the regularity of the color block distribution in the brain region corresponding to the upper limb movement and the adjacent peripheral related brain region can allow the doctor to clearly determine the stroke rehabilitation level. When patient's apoplexy rehabilitation level is higher, it has regular response to upper limbs motion to mean the brain district, and activation map distribution regularity is high this moment, and the user can judge the recovered effect of apoplexy fast based on regularly distributed's color lump. When the stroke rehabilitation level of a patient is low, the brain area has a lag or even no response to the response of the upper limb movement, even if the upper limb movement is executed, the brain area has a lag or even no response, which shows that the brain area is not quickly activated or even not activated by the upper limb movement, the distribution regularity of the activation map is poor, and the user can quickly judge that the stroke rehabilitation level is low based on the color blocks which are not uniformly distributed or irregular, so that the stroke rehabilitation analysis is required to be further performed.
In some embodiments, as shown in fig. 3, the activation map may be displayed on a partial two-dimensional brain image, that is, an incomplete two-dimensional brain image, as long as the partial two-dimensional brain image includes a brain region to be presented, so that the activation map may be highlighted in a limited display area, which facilitates a doctor to clearly view the condition of the activation map and make a more accurate judgment.
The method provided by the embodiment presents the activation map of the brain area to the user, the color blocks in the activation map and the response of the brain area to the upper limb movement present regular correlation, and the user can intuitively and quickly judge the stroke rehabilitation level by observing whether the color blocks of the activation map present regular distribution, so that the stroke rehabilitation analysis efficiency is improved, and the workload of the user is reduced.
In some embodiments, the stroke rehabilitation analysis result of the subject further comprises an activation map of a brain region of the subject, wherein the distribution regularity of the color blocks in the activation map represents the stroke rehabilitation level of the subject, the higher the distribution regularity is, the higher the stroke rehabilitation level of the subject is, and the activation map comprises a 2D activation map and/or a 3D activation map, so that the user can intuitively and quickly judge the stroke rehabilitation level.
Fig. 4 shows a graph of a stroke rehabilitation analysis result obtained by performing a stroke rehabilitation analysis using a near-infrared brain function imaging device while displaying a stroke rehabilitation index of the subject according to an embodiment of the present invention. As shown in fig. 4, the step of displaying the determined stroke rehabilitation analysis result of the subject specifically includes displaying an activation map of a brain region of the subject in a first region 401, and displaying a representative HbO2 distribution curve (a curve at a middle position of an upper limb movement region), a representative HbR distribution curve (a curve at a lower position of the upper limb movement region), and a representative HbT distribution curve (a curve at an upper position of the upper limb movement region) in a time domain in a second region 402 other than the first region 401. For example, the second region 402 may further include a right motion region 4021 and a left motion region 4022, and the right motion region 4021 and the left motion region 4022 each display a representative HbO2 distribution curve (a curve of a middle position of the upper limb motion region), a representative HbR distribution curve (a curve of a lower position of the upper limb motion region), and a representative HbT distribution curve (a curve of an upper position of the upper limb motion region) in the time domain, respectively.
The combined presentation of the map and the three distribution curves can be activated, the actual requirements of doctors can be met, and the comprehensive consideration of the doctors to all layers of stroke rehabilitation analysis results is facilitated. For example, a doctor can check the distribution curve to evaluate the blood oxygen response effect, and if the blood oxygen response effect is good, then check the activation map, the activation map not only reflects the activation condition of the brain area corresponding to the movement of the upper limbs, but also presents the activation condition of the related brain areas around, and the regular distribution of the color blocks can enable the doctor to clearly judge the stroke rehabilitation level. If the blood oxygen response effect and the distribution regularity of the activation map are good, the high stroke rehabilitation level can be determined with higher reliability. However, when the blood oxygen response effect is poor, the doctor does not need to view and analyze the activation map, and unnecessary workload of the doctor is reduced.
In some embodiments, the representative HbO2 distribution curve, the representative HbR distribution curve and the representative HbT distribution curve in the time domain may be displayed first, and the doctor may selectively view the activation map according to the blood oxygen response effect embodied by the distribution curves, so that the interface is clearer and simpler, the information obtained by the doctor is more concentrated, and the doctor can judge the analysis result conveniently.
In some embodiments, returning to fig. 3, the regularity of distribution of the color patches in the activation map includes the degree of dispersion and the degree of mutation of the color patches, and the higher the degree of dispersion and the degree of mutation, the lower the regularity of distribution. The active color blocks of the active map are regularly distributed, the dispersion degree is high, for example, the active color blocks are distributed at different positions, the mutation degree is high, for example, the active color blocks are not smoothly changed into the inactive color blocks, but are jumped and mutated into the inactive color blocks, the dispersion degree and the mutation degree of the color blocks are high in sensitivity and easy to identify for human eyes, the workload of a doctor is reduced, and the accuracy and the efficiency of identification are ensured.
In some embodiments, the stroke rehabilitation analysis result of the subject further comprises a stroke rehabilitation index of the subject, the stroke rehabilitation index comprising a left brain region activation degree and a right brain region activation degree of the subject. The activation degree can be determined based on the signal during the movement of the upper limb and the reference signal during the rest period, which is beneficial to eliminating interference and improving accuracy. The blood oxygen concentration reference of the current group is provided during the rest period, and the timely and effective activation degree can be obtained based on the signals of the upper limb of the current group during the movement and the reference signals of the current group during the rest period, so that the accuracy of the stroke rehabilitation analysis result is improved.
In particular, determining a stroke rehabilitation analysis result of the subject from at least acquired segments of near-infrared signals of channels of bilateral brain regions corresponding to an upper limb movement comprises determining a left brain region activation degree of the subject based on signal intensities of representative near-infrared signals of at least part of channels of a left brain region within a first preset time window during the upper limb movement and within a second preset time window during rest. For example, the subject is asked to perform a set of tasks, perform upper limb movements within 0-20s, perform rest within 20-40s, a first predetermined time window may be understood as a time period within 0-20s, e.g. 5-20s, and a second predetermined time window may be understood as a time period within 20-40s, e.g. 25-40 s. If the signal intensity when performing upper limb movement is far higher than the signal intensity when performing rest, the activation degree of the left brain area can be determined to be higher, and reference can also be provided for judging the recovery condition of the stroke. This embodiment is merely exemplary and is not intended to limit the scope of the specific comparison. The method of comparing the signal intensities is not particularly limited.
Similar to the method for determining the left brain region activation degree, the right brain region activation degree of the subject is determined based on the signal intensity of the representative near-infrared signal of at least part of the channels of the right brain region within a first preset time window during the movement of the upper limb and the signal intensity within a second preset time window during the rest period.
In some other embodiments, further to the layout of the stroke rehabilitation index 403 in fig. 4, determining the stroke rehabilitation analysis result of the subject based on the representative near-infrared signals of the channels further includes determining the bilateral brain area balance 4033 based on a ratio of a difference between the left brain area activation 4031 and the right brain area activation 4032 and a sum of the left brain area activation 4031 and the right brain area activation 4032. The smaller the balance 4033 of the brain areas on the two sides is, the smaller the difference between the activation 4031 of the left brain area and the activation 4032 of the right brain area is, and the larger deviation does not occur in the left brain area and the right brain area, which indicates that the rehabilitation condition of the patient is better. Specifically, for example, if the condition of the left brain area of a stroke patient is good and the right brain area belongs to the affected side, after a period of rehabilitation exercise training, when analyzing the rehabilitation condition of the right brain area of the patient, it is found that the difference between the activation 4031 of the left brain area and the activation 4032 of the right brain area is large and the balance of the two brain areas is relatively large, and the doctor can consider that the rehabilitation condition of the right brain area of the patient is poor. If the rehabilitation condition of the left brain area and the rehabilitation condition of the right brain area of the stroke patient are better in the rehabilitation process, the difference between the activation 4031 of the left brain area and the activation 4032 of the right brain area is smaller, so that the balance 4033 of the two brain areas determined by the method is also smaller, and the balance of the rehabilitation conditions of the two brain areas is balanced.
Three stroke rehabilitation indexes of the left brain area activation 4031, the right brain area activation 4032 and the two side brain area balance 4033 are provided for doctors to analyze the stroke rehabilitation level of an object, so that the accuracy of a stroke rehabilitation analysis result is further improved, and the reliability of the result is improved.
In other embodiments, reference values of the activation degrees and the balance degrees of the two brain areas may be provided to the doctor, and the sizes of the left brain area activation degree 4031, the right brain area activation degree 4032, and the balance degrees of the two brain areas 4033 may be defined based on actual conditions, for example, may be set when the apparatus is shipped from a factory to provide a criterion for stroke rehabilitation indexes. In other embodiments, a modifiable manner may be provided for the user, for example, a doctor may set different patients, degrees of illness, and the like to realize personalized treatment, so as to further improve accuracy and reliability of the stroke rehabilitation analysis result. The index sizes of the left brain region activation 4031 and the right brain region activation 4032 may be the same or different, and are not particularly limited.
In some embodiments, as shown in fig. 4, the stroke rehabilitation analysis result of the subject further includes stroke rehabilitation indicators of the subject, including a left brain region activation 4031, a right brain region activation 4032, and a two brain region balance 4033 of the subject; displaying the determined stroke rehabilitation analysis result of the subject specifically includes: in the first zone 401 and the third zone 403 other than the second zone 402, stroke rehabilitation index of the subject is displayed together. For example, fig. 4 shows that the left brain region activation 4031, the right brain region activation 4032, and the bilateral brain region balance 4033 are displayed in the third region 403 while the activation map is displayed in the first region 401.
In the analysis process, the three analysis results are displayed in a partition and combined mode, so that a doctor can integrate the three analysis results to obtain a more accurate stroke rehabilitation level, and the accuracy of the stroke rehabilitation analysis results is improved. For a specific display mode, the user interface may simultaneously display the left brain region activation 4031, the right brain region activation 4032, and the bilateral brain region balance 4033, or may include an instruction when the user gives an instruction to display which analysis result, and the system responds to display the analysis result based on the instruction, for example, when the user wants to obtain the left brain region activation 4031, after performing a corresponding selection, the interactive interface displays the left brain region activation 4031; when the user wants to compare with the apoplexy rehabilitation index based on the obtained right side brain area activation 4032, the user gives an instruction for selecting the apoplexy rehabilitation index, so that the apoplexy rehabilitation index is displayed by the user. The interactive interface may display the required analysis result based on the selection of the user, and the specific display mode is not particularly limited.
In some embodiments, the duration of the upper limb movement of each group is 5-50 seconds, such as 5 seconds, 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, etc., preferably 10-40 seconds. The duration of the rest of each group is 5-50 seconds, such as 5 seconds, 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, etc., preferably 10-40 seconds. Each group of tasks is executed in a shorter time, frequency band interference is less for the attribute of the near infrared signals, and compared with a method of continuously acquiring for more than ten minutes, the drift is obviously reduced, the whole evaluation can be completed in a few minutes, and the compliance of the object is higher. In addition, in the embodiment, the total time for executing each group of tasks including the movement and the rest of the upper limbs is 10-100 seconds, and in the range, the near infrared signals which are accurate and effective for the rehabilitation analysis of the stroke can be obtained, so that more interference is avoided, and the accuracy of evaluation is reduced. The time quantum that this embodiment provided, contained the useful frequency channel of aassessment to the recovered analysis result of apoplexy, both satisfied the demand to the aassessment of the recovered analysis result of apoplexy, can reduce patient's the execution degree of difficulty again, and patient's acceptance is high, can improve patient's degree of cooperation.
Specifically, for example, the duration of the upper limb movement of the subject is 15 seconds, the subject takes a rest for 20 seconds, and the total of 5 groups is executed, so that the analysis of the stroke rehabilitation status of the subject can be completed within 3 minutes for reference of a doctor, so that the doctor can give the corresponding rehabilitation advice to the subject according to the analysis, the work efficiency is greatly improved, and the burden of the subject is reduced. For example, some patients with severe stroke can only perform simple exercises for a short time after recovering for a while, and at this time, the patients cannot perform exercises for tens of minutes or even tens of minutes. However, the severe stroke patient can greatly reduce the difficulty of movement of the patient by adopting the method of the embodiment, and a more efficient analysis method is provided for realizing rehabilitation analysis of the severe stroke patient.
In addition, in another embodiment, the upper limb movement includes alternate flexion and extension movements of the upper limb while keeping the fingers in the grip, and the upper limb movement is not only simple and can reduce the difficulty of movement of the subject, but also is beneficial to providing enough stimulation for the corresponding brain area and collecting more concentrated and consistent near-infrared signals with higher intensity for subsequent analysis. The alternate bending and stretching movement of the upper limbs is performed while the fingers are kept to be grasped, compared with the movement of moving the fingers and the movement of twisting a simple large arm joint, the method can be widely applied to various stroke patients, the discrimination of different rehabilitation levels is better, and the executability and the compliance of the patients are also better; the execution of the upper limb movement can be associated with the exercise equipment, and the definition of a uniform movement mode can simplify the exercise equipment, reduce the cost and also be beneficial to enhancing the robustness of the analyzed rehabilitation level.
Fig. 5 shows a schematic diagram of a stroke rehabilitation analysis system according to an embodiment of the invention. As shown in fig. 5, the stroke rehabilitation analyzing system includes a near-infrared brain function imaging device 500, the near-infrared brain function imaging device 500 at least has a head cap 501, the head cap 501 is used for being worn on the head of a subject 505, and the head cap 501 is provided with a plurality of probes 506 for transmitting and/or receiving near-infrared signals so as to acquire near-infrared signals of a plurality of corresponding channels. For example, the headgear 501 may have a plurality of probes 506 for transmitting and/or receiving near-infrared signals. For another example, the headgear 501 may be provided with a plurality of mounting locations for detachably mounting respective ones of the probes 506, and in use, the probes 506 may be mounted to the headgear 501 via the mounting locations.
The complete configuration of the near-infrared brain function imaging apparatus 500 is not shown in fig. 5, but only some of the components relevant to the embodiment of the present invention are shown, wherein each of the plurality of probes 506 may be configured as a transmitting probe (S) or a receiving probe (D), and each pair of paired probes forms one channel. In some embodiments, one transmitting probe may correspond to multiple receiving probes, or vice versa, with a receiving probe corresponding to multiple transmitting probes, in a paired relationship depending on the specific requirements of the deployment location of the probes, the brain functional region to be detected, and the like.
In some embodiments, the near-infrared brain function imaging apparatus 500 further includes a processor 502, and the processor 502 may be a processing device including one or more general purpose processing devices, such as a microprocessor, Central Processing Unit (CPU), Graphics Processing Unit (GPU), or the like. More specifically, the processor may be a Complex Instruction Set Computing (CISC) microprocessor, Reduced Instruction Set Computing (RISC) microprocessor, Very Long Instruction Word (VLIW) microprocessor, processor running other instruction sets, or processors running a combination of instruction sets. The processor may also be one or more special-purpose processing devices such as an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA), a Digital Signal Processor (DSP), a system on a chip (SoC), or the like. The processor 502 may be configured to cause the plurality of probes 506 to acquire segments of near-infrared signals corresponding to at least channels of bilateral brain regions of upper limb movement, if the subject performs sets of alternating tasks of upper limb movement and resting. Determining a stroke rehabilitation analysis result of the subject according to at least the collected near-infrared signals of the channels of the bilateral brain areas corresponding to the upper limb movement.
In some embodiments, the near-infrared brain function imaging device 500 may also include a memory 503 and a display 504. Wherein the memory 503 is configured to store a program that causes the processor 502 to execute a procedure of a method for stroke rehabilitation analysis using a near-infrared brain function imaging device (such as, but not limited to, processing of a stroke rehabilitation analysis on acquired near-infrared signals) and data generated and/or needed during execution.
The memory 503 may be a non-transitory computer-readable medium, such as Read Only Memory (ROM), Random Access Memory (RAM), phase change random access memory (PRAM), Static Random Access Memory (SRAM), Dynamic Random Access Memory (DRAM), Electrically Erasable Programmable Read Only Memory (EEPROM), other types of Random Access Memory (RAM), flash memory or other forms of flash memory, cache, registers, static memory, compact disc read only memory (CD-ROM), Digital Versatile Discs (DVD) or other optical storage, magnetic cassettes or other magnetic storage devices, or any other possible non-transitory medium for storing information or instructions that may be accessed by a computer device or the like. When the instructions stored on the memory 503 are executed by the processor 502, methods according to the teachings herein may be performed.
The display 504 may be configured to display the determined stroke rehabilitation analysis result of the subject, and the display 504 may employ an LED, an OLED, or the like, which is not particularly limited.
The near-infrared brain function imaging apparatus 500 according to various embodiments of the present invention may be used to construct a stroke rehabilitation analysis system by itself (including a head cap and a host), or by a host other than a head cap (mainly used to store and analyze near-infrared data).
In some embodiments, the stroke rehabilitation analysis system may further include a motor configured to be used by the subject to perform sets of alternating upper limb movement and rest tasks, the processor 502 further configured to: sending control information to the exercise machine such that the exercise machine is in an actuatable state during upper limb movement and in a non-actuatable state during rest. With the assistance of the sports apparatus, the subject can complete the task of alternating the movement and the rest of the upper limbs, and the movement difficulty is further reduced.
In some embodiments, a computer readable storage medium having stored thereon computer program instructions which, when executed by a processor, cause the processor to perform a method for stroke rehabilitation analysis using a near-infrared brain function imaging device according to various embodiments of the present invention. The computer-readable medium may include volatile or non-volatile, magnetic, semiconductor-based, tape-based, optical, removable, non-removable, or other types of computer-readable media or computer-readable storage devices. For example, a computer-readable medium may be a storage device or a storage module having stored therein computer instructions, as disclosed. In some embodiments, the computer readable medium may be a disk or flash drive having computer instructions stored thereon.
Various modifications and alterations may be made to the method, apparatus and system of the present invention. Other embodiments may be devised by those skilled in the art in view of the description and practice of the disclosed systems and related methods. The individual claims of the invention can be understood as independent embodiments and any combination between them also serves as an embodiment of the invention and these embodiments are considered to be included in the invention.
The examples are to be considered as illustrative only, with a true scope being indicated by the following claims and their equivalents.
Claims (13)
1. Method for stroke rehabilitation analysis with a near-infrared brain function imaging device having a headgear for wearing on the head of a subject, the headgear being provided with a plurality of probes for transmitting and/or receiving near-infrared signals for acquiring near-infrared signals of a plurality of corresponding channels, characterized in that the method comprises:
under the condition that the object executes a plurality of groups of upper limb movement and rest alternate tasks, acquiring a plurality of segments of near-infrared signals of all channels of bilateral brain areas at least corresponding to the upper limb movement by utilizing the plurality of probes, wherein each segment of near-infrared signal corresponds to each group of tasks;
determining a stroke rehabilitation analysis result of the object according to at least a plurality of collected near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement; and
displaying the determined stroke rehabilitation analysis result of the subject.
2. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to claim 1, wherein the stroke rehabilitation analysis result of the subject includes a representative HbO2 distribution curve, a representative HbR distribution curve, and a representative HbT distribution curve in a time domain of each channel of each brain region, and the representative HbO2 distribution curve, the representative HbR distribution curve, and the representative HbT distribution curve in the time domain are displayed in comparison on the same time axis.
3. The method for stroke rehabilitation analysis using a near-infrared brain function imaging device according to claim 1 or 2, wherein acquiring the segments of near-infrared signals of the channels of the bilateral brain regions corresponding to at least the movement of the upper limbs further comprises acquiring the segments of near-infrared signals of the channels of the bilateral brain regions and the peripheral brain regions corresponding to the movement of the upper limbs,
determining a stroke rehabilitation analysis result of the subject according to at least the collected near-infrared signals of the channels of the bilateral brain regions corresponding to the upper limb movement specifically comprises:
determining an activation map of the brain area of the subject according to the collected near-infrared signals of all channels of the bilateral brain areas and the peripheral brain areas corresponding to the upper limb movement, wherein the distribution regularity of color blocks in the activation map represents the stroke rehabilitation level of the subject, and the higher the distribution regularity is, the higher the stroke rehabilitation level of the subject is.
4. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to claim 2, wherein the stroke rehabilitation analysis result of the subject further includes an activation map of the brain region of the subject, the distribution regularity of the color blocks in the activation map characterizes the stroke rehabilitation level of the subject, the higher the distribution regularity, the higher the stroke rehabilitation level of the subject, the activation map includes a 2D activation map and/or a 3D activation map,
displaying the determined stroke rehabilitation analysis result of the subject specifically includes: an activation map of a brain region of the subject is displayed in a first region, and a representative HbO2 distribution curve, a representative HbR distribution curve, and a representative HbT distribution curve in a time domain are displayed together in a second region other than the first region.
5. The method for stroke rehabilitation analysis with the near-infrared brain function imaging device according to claim 4, wherein the distribution regularity of the color patches in the activation map includes a degree of dispersion and a degree of mutation of the color patches, and the distribution regularity is lower as the degree of dispersion and the degree of mutation are higher.
6. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device of claim 1, wherein the stroke rehabilitation analysis result of the subject further includes stroke rehabilitation indicators of the subject, the stroke rehabilitation indicators including left brain region activation and right brain region activation of the subject; wherein the content of the first and second substances,
determining a stroke rehabilitation analysis result of the object according to at least acquired near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement, specifically comprising:
determining a left brain region activation degree of the subject based on signal strength of representative near-infrared signals of at least partial channels of the left brain region within a first preset time window during upper limb movement and signal strength within a second preset time window during rest; and
determining a right brain region activation degree of the subject based on signal strengths of representative near-infrared signals of at least partial channels of the right brain region within a first preset time window during upper limb movement and within a second preset time window during rest.
7. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device of claim 6, wherein the stroke rehabilitation index of the subject further comprises:
and determining the balance degree of the brain areas on two sides based on the ratio of the difference of the activation degree of the left brain area and the activation degree of the right brain area to the sum of the activation degree of the left brain area and the activation degree of the right brain area.
8. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to claim 4, wherein the stroke rehabilitation analysis result of the subject further includes stroke rehabilitation indicators of the subject, the stroke rehabilitation indicators including left brain region activation, right brain region activation and both brain region balance of the subject;
displaying the determined stroke rehabilitation analysis result of the subject specifically includes: in a third region other than the first region and the second region, stroke rehabilitation indicators of the subject are displayed together.
9. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to any of claims 1, 7, 8, characterized in that the duration of the upper limb movement of each group is 5-50 seconds and the duration of the rest of each group is 5-50 seconds.
10. The method for stroke rehabilitation analysis with a near-infrared brain function imaging device according to any of claims 1, 7, 8, characterized in that the upper limb movement comprises alternating flexion and extension movements of the upper limb while keeping the fingers in grip.
11. A stroke rehabilitation analysis system, comprising:
the head cap is used for being worn on the head of a subject and is provided with a plurality of probes for transmitting and/or receiving near-infrared signals so as to acquire the near-infrared signals of a plurality of corresponding channels;
a processor configured to:
under the condition that the object executes a plurality of groups of upper limb movement and rest alternate tasks, enabling the plurality of probes to collect a plurality of segments of near-infrared signals of all channels of bilateral brain areas at least corresponding to the upper limb movement, wherein each segment of near-infrared signal corresponds to each group of tasks;
determining a stroke rehabilitation analysis result of the object according to at least a plurality of collected near-infrared signals of channels of bilateral brain areas corresponding to upper limb movement; and
a display configured to: displaying the determined stroke rehabilitation analysis result of the subject.
12. The stroke rehabilitation analyzing system of claim 11, further comprising a motion instrument configured to be used by the subject to perform sets of alternating tasks of upper limb movement and resting;
the processor is further configured to: sending control information to the exercise machine such that the exercise machine is in an actuatable state during upper limb movement and in a non-actuatable state during rest.
13. A computer readable storage medium having stored thereon computer program instructions which, when executed by a processor, cause the processor to perform the method of stroke rehabilitation analysis with a near-infrared brain function imaging device of any of claims 1-10.
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| PCT/CN2023/078118 WO2023179305A1 (en) | 2022-03-25 | 2023-02-24 | Method and system for performing stroke rehabilitation analysis by using near-infrared brain function imaging device |
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| CN117045205B (en) * | 2023-10-10 | 2024-02-13 | 慧创科仪(北京)科技有限公司 | Near infrared data analysis device, analysis method and storage medium |
| CN117398074B (en) * | 2023-12-13 | 2024-04-05 | 慧创科仪(北京)科技有限公司 | Near infrared data-based brain function rehabilitation training method and device |
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