TWI708589B - System for predicting cardiovascular and brain function in combination with physiological detection device and method thereof - Google Patents

Abstract

A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

Description

System and method for monitoring cardiovascular and brain function combined with physiological detection device

The present invention relates to a system and method for monitoring cardiovascular and brain functions combined with a physiological detection device, in particular to a smart wearable device for real-time monitoring of personal physiological data, and the physiological data is converted into a measurement through a preset function and program Parameters to monitor the user’s likelihood of suffering from cardiovascular diseases and neurodegenerative diseases.

At present, common cardiovascular examinations include: blood draw, electrocardiogram, ultrasound, nuclear medicine myocardial perfusion, computer tomography and cardiac catheterization. Among them: blood sampling is mainly to measure blood sugar and cholesterol; cardiac ultrasound mainly observes the heart structure and movement state, but because the coronary arteries are very small, it is sometimes difficult to accurately determine whether there is obstruction; although the accuracy of nuclear medicine myocardial perfusion (90 %) is higher than exercise electrocardiogram (70%), but there will be problems with radioactivity and longer examination time; the two advanced examinations of computed tomography and cardiac catheterization are because there is no health insurance payment and the only problems that are invasive examinations are It will only be used for advanced examinations after the disease is diagnosed.

Nuclear medicine cardiography is currently widely used in the monitoring of cardiovascular diseases to monitor sudden cardiac death and prognosis assessment of heart failure. At the same time, clinical studies have also found that nuclear medicine cardiography can also be used It is used to evaluate the distribution and function of sympathetic nerves to distinguish some neurodegenerative diseases (including Parkinson's disease and Lewy body dementia) at an early stage. In addition, in the literature, we can also observe that in the physiological data of clinical patients, the heart rate, pulse pressure, and the heart/mediastinum count ratio (H/M ratio) has a certain degree of relevance. The above physiological data is connected to the heart/mediastinum ratio calculated from nuclear medicine cardiography images, which can be used to monitor sudden cardiac death, prognosis assessment of heart failure, Parkinson’s disease and Lewy body loss. Mental illness and other diseases.

Like nuclear medicine myocardial perfusion, nuclear medicine cardiography also has the problems of radioactivity and long examination time; moreover, although the results of cardiography can be used to monitor cardiovascular diseases, evaluate prognosis and distinguish certain neurodegenerative diseases, the above must be achieved. Purpose, the quantification and standardization of image data is very important; the quantification of image data and the standardization between different devices have been successfully established abroad, but the circle selection of the quantitative data of nuclear medical images at the source may still be subject to the person responsible for image interpretation The difference affects the final result, and it takes more time to quantify the image data manually.

But with the advancement of technology and the vigorous development of wearable devices, as long as smart wearable devices such as apple watch, Xiaomi bracelet, ASUS VivoWatch BP, JSmax sports bracelet, etc., you can monitor heart rate, ECG, blood pressure and Physiological data such as blood oxygen; therefore, the collection of big data of the human body is much easier than in the past. Combined with the advancement of artificial intelligence technology, in the future, as long as a large amount of physiological data is combined with image data to calculate more accurate models, it can be collected directly through wearable devices in the future. The physiological data accurately monitors the risk of heart and neurodegenerative diseases.

In the US 7,413,546B2 patent case, it is disclosed that a collection of cardiovascular data is used to calculate the display as a technical means of monitoring the health of the body. In the US 20170172423A1 patent, a technology of a neck sensor that can detect physiological data is disclosed, but it does not link the acquired physiological data to nuclear medicine imaging and disease monitoring.

In view of the above-mentioned shortcomings of the conventional cardiovascular and brain function detection devices and evaluation methods, the inventors studied and improved ways to address these shortcomings, and finally came up with the present invention.

The main purpose of the present invention is to provide a system for monitoring cardiovascular and brain functions combined with a physiological detection device, which uses a wearable physiological detection device to detect personal physiological data and transmit the physiological data to a computing function The electronic device has built-in application programs of preset functions and calculation formulas in the electronic device, which can convert the physiological data into measurement parameters to monitor the possibility and risk of cardiovascular disease and neurodegenerative disease. Compared with traditional professional testing instruments and analysis methods, it has low investment cost, high economic efficiency and reference analysis accuracy.

Another object of the present invention is to provide a system for monitoring cardiovascular and brain functions combined with a physiological detection device, which can completely avoid radioactive material damage to the body during the detection process, and does not require professional image interpretation knowledge. Not only is it extremely safe and easy to use, but in the future, the accumulation of big data can increase the accuracy of research and judgment, which may replace some of the current physiological examination items.

Another object of the present invention is to provide a method for monitoring cardiovascular and brain functions in conjunction with a physiological detection device, which mainly collects physiological data such as heart rate and pulse pressure of the user, and pre-empts The set function relationship is converted into a clearance rate value, and then converted into a stroke volume index value through a preset function relationship, and the stroke volume index value is converted into an early or delayed heart/mediastinum through a preset function relationship The early or delayed heart/mediastinum ratio can be inserted into the heart disease monitoring chart to monitor the risk of heart disease. The early or delayed heart/mediastinum ratio can be inserted into the neurodegenerative disease monitoring chart to monitor whether there is neurological disease. Degenerative diseases, and the early or delayed heart/mediastinum ratio is inserted into the neurodegenerative disease brain imaging map to monitor the risk of brain degeneration.

In order to obtain a more detailed understanding of the above-mentioned purposes, effects and features of the present invention, the following descriptions are given with reference to the following drawings:

1: Wearable physiological detection device

11: host

111: Micro Processing Unit

112: memory unit

113: Sensing signal receiving module

114: Communication control module

115: application firmware

116: data storage unit

117: Switch operation module

12: External sensing components

2: electronic device

21: Central Processing Unit

22: Memory module

23: Communication module

24: Application

25: Database

26: Operation module

27: display module

S11: Receive physiological data such as heart rate and pulse pressure

S12: Use heart rate or pulse pressure data to calculate the clearance rate value

S13: Use the clearance rate value to calculate the stroke volume index value

S14: Use the stroke volume index value to calculate the early heart/mediastinum ratio or the delayed heart/mediastinum ratio

S15: Use the early heart/mediastinum ratio or the delayed heart/mediastinum ratio to monitor the risk of heart disease

S16: Use the early heart/mediastinum ratio or the delayed heart/mediastinum ratio to monitor for neurodegenerative diseases

S17: Monitor brain images based on the early heart/mediastinum ratio or delayed heart/mediastinum ratio

Figure 1 is a block diagram of a feasible structure of the wearable physiological detection device of the present invention.

Figure 2 is a block diagram of a feasible structure of the electronic device of the present invention.

Figure 3 is a function diagram of the relationship between the clearance rate and the pulse pressure of the present invention.

Figure 4 is a graph of the relationship between clearance rate and heart rate of the present invention.

Figure 5 is a graph showing the relationship between clearance rate and stroke volume index of the present invention.

Figure 6 is a graph showing the relationship between the early heart/mediastinum ratio and the stroke volume index of the present invention.

Figure 7 is a graph showing the relationship between the delayed heart/mediastinum ratio and the stroke volume index of the present invention.

Figure 8 is a flow chart of the method for monitoring cardiovascular and brain functions performed by the electronic device of the present invention.

Figure 9 is the heart disease monitoring diagram of the present invention (1).

Figure 10 is the heart disease monitoring diagram of the present invention (2).

Figure 11 is the neurodegenerative disease monitoring diagram of the present invention.

Figure 12 is an image of various brain detections of normal people and patients with neurodegenerative diseases of the present invention.

Figure 13 is a schematic diagram of the present invention using the pulse pressure value to obtain the clearance rate value through the clearance rate and the pulse pressure relationship function.

Figure 14 is a schematic diagram of the present invention using the heart rate value to obtain the clearance rate value through the clearance rate and the heart rate relationship function.

Figure 15 is a schematic diagram of the present invention using the clearance rate value to obtain the stroke volume index value through the clearance rate and the stroke volume index relationship function.

Figure 16 is a schematic diagram of the present invention using the stroke volume index value to obtain the early heart/mediastinum ratio value through the relationship function of the early heart/mediastinum ratio and the stroke volume index.

Figure 17 is a schematic diagram of the present invention using the stroke volume index value to obtain the delayed heart/mediastinum ratio value through the relationship function of the delayed heart/mediastinum ratio and the stroke volume index.

Please refer to Figures 1 and 2, it can be seen that the main structure of the present invention includes: a wearable physiological detection device 1 and an electronic device 2; wherein the wearable physiological detection device 1 has a host 11 and a plurality of external sensing elements 12 The host 11 is provided with a micro-processing unit 111, a memory unit 112, a sensing signal receiving module 113, a communication control module 114, and a switching operation module 117. The external sensing element 12 is worn on the human body It detects the physiological state of the human body through optical sensing, electrical signal measurement or pressure sensing, and generates corresponding sensing signals. The sensing signal is received by the sensing signal receiving module 113, converted into various physiological data, and then sent to the micro-processing unit 111. The memory unit 112 stores in addition to the storage required for the overall operation of the wearable physiological detection device 1 In addition to the application firmware 115, a data storage unit 116 that can store the physiological data is also planned. After the micro-processing unit 111 executes the application firmware 115, it can control the communication control module 114 to paired external electronics The device 2 transmits the physiological data.

The electronic device 2 can be a personal computer, a notebook computer, a tablet computer, a mobile phone or other devices with computing functions. It has a central processing unit 21, a memory module 22, a communication module 23, and an operation module. 26 and a display module 27. The communication module 23 can be paired with the aforementioned communication control module 114 via wired or wireless means for receiving the physiological data and sending it to the central processing unit 21. The memory module In addition to storing one application in group 22 In addition to (APP) 24, there is a database 25 storing various data. The application program 24 has various calculation and derived functional formulas. The operation module 26 can perform various control actions on the central processing unit 21; The display module 27 is a display module 27 that can display various operation processes and calculation and analysis results. When the central processing unit 21 executes the application program 24, it can calculate and derive the above-mentioned physiological data through each function formula. , In order to produce the analysis and prediction results of cardiovascular and brain function tests.

Please refer to Figures 3 to 7, it can be seen that the application 24 of the present invention has the following functional formulas:

1. Relation function of clearance rate and pulse pressure: y=-0.6094x+63.325; R ² =0.3284; ρ<0.05 where: y: clearance rate (WR); x: pulse pressure (PP); R ² : coefficient of determination ( When R ^{2 is} closer to 1, it means that the ability to use x to explain y is stronger); ρ : statistical difference value ( ρ <0.05 indicates a significant difference, ρ <0.01 indicates a significant difference, ρ <0.001 indicates a very significant difference )

2. Relation function between clearance rate and heart rate: y=0.2459x+12.111; R ² =0.4008; ρ<0.01 where: y: clearance rate (WR); x: heart rate (HR); R ² : coefficient of determination (when R ² The closer to 1, the stronger the ability to use x to explain y); ρ : statistical difference value ( ρ <0.05 indicates a significant difference, ρ <0.01 indicates a very significant difference, ρ <0.001 indicates a very significant difference)

3. Relation function between clearance rate and stroke volume index: y=-0.7978x+70.826; R ² =0.3578; ρ<0.05 where: y: stroke volume index (SVI); x: clearance rate (WR); R ² : Coefficient of determination (when R ^{2 is} closer to 1, it means that the ability to use x to explain y is stronger); ρ : statistical difference value ( ρ <0.05 indicates a significant difference, ρ <0.01 indicates a significant difference, ρ <0.001 indicates There is a very significant difference)

4. The relation function between the early heart/mediastinum ratio and the stroke volume index: y=0.0162x+1.3379; R ² =0.4412; ρ<0.01 where: y: early heart/mediastinum ratio (early H/M); x: Stroke Volume Index (SVI); R ² : coefficient of determination (the closer R ^{2 is} to 1, the stronger the ability to use x to explain y); ρ : statistical difference value ( ρ <0.05 indicates a significant difference, ρ <0.01 Means a very significant difference, ρ <0.001 means a very significant difference)

5. The relationship function between delayed heart/mediastinum ratio and stroke volume index: y=0.0161x+1.0938; R ² =0.3897; ρ<0.05 where: y: delayed heart/mediastinum ratio (delayed H/M); x: Stroke Volume Index (SVI); R ² : coefficient of determination (the closer R ^{2 is} to 1, the stronger the ability to use x to explain y); ρ : statistical difference value ( ρ <0.05 indicates a significant difference, ρ <0.01 Means a very significant difference, ρ <0.001 means a very significant difference)

Please refer to Figure 8, which shows that the present invention achieves the effect of monitoring cardiovascular and brain functions. In actual application, the application 24 will execute in order: a step of "receiving physiological data such as heart rate and pulse pressure", A step of ``Calculate the clearance rate value using heart rate or pulse pressure data'', a step of ``Calculate the stroke volume index value using the clearance rate value'', and a step of ``Using the stroke volume index value to calculate the early heart/mediastinum ratio or delayed heart/longitudinal The step of “diaphragm ratio”, a step of “monitoring the risk of heart disease by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio”, and the step of “monitoring the risk of heart disease by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio” The steps of suffering from neurodegenerative diseases" and a step of "monitoring brain images by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio"; the following are only explained with reference to the structures in Figures 1 and 2: First, the In the step of "receiving physiological data such as heart rate and pulse pressure", the electronic device 2 receives human physiological data such as heart rate and pulse pressure transmitted by the wearable physiological detection device 1.

The step of "calculating the clearance rate value using heart rate or pulse pressure data" is to calculate a clearance rate value through a clearance rate and heart rate relationship function (as shown in Figure 4) from the above heart rate value; A clearance rate and pulse pressure relationship function formula (as shown in Figure 3) calculates the clearance rate value.

In the "calculating stroke volume index value using the clearance rate value" step, a stroke volume index value is calculated from the clearance rate value through a clearance rate and stroke volume index function formula (as shown in Figure 5).

The step of "Using the stroke volume index value to calculate the early heart/mediastinum ratio or the delayed heart/mediastinum ratio" step is to pass the above stroke volume index value through an early heart/mediastinum ratio and the stroke volume index relationship (such as the first Figure 6) Calculate an early heart/mediastinum ratio; the stroke volume index value is calculated by a function of the delayed heart/mediastinum ratio and the stroke volume index (as shown in Figure 7) Early delayed heart/mediastinum ratio or delayed heart/mediastinum ratio.

The step of "monitoring the risk of heart disease by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio" is to insert the early heart/mediastinum ratio or the delayed heart/mediastinum ratio into the heart disease monitoring chart (such as In Figures 9 and 10), the risk of heart disease is monitored by comparison.

The "use the early heart/mediastinum ratio or the delayed heart/mediastinum ratio to monitor whether there is a neurodegenerative disease" step, the early heart/mediastinum ratio or the delayed heart/mediastinum ratio are respectively included in the neurodegenerative disease monitoring In the figure (shown in Figure 11), the risk of neurodegenerative diseases is monitored by comparison.

The step of "monitoring brain images by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio" step is to insert the early heart/mediastinum ratio or the delayed heart/mediastinum ratio into a normal person and neurodegeneration, respectively Various brain detection images of patients with diseases (as shown in Figure 12) are used to compare and monitor the risk of brain degeneration.

[Implementation Mode One]

When the electronic device 2 receives the pulse pressure transmitted by the wearable physiological detection device 1 is 70 mmHg.

As shown in Figure 13, from the position of the pulse pressure (PP) of 70mmHg (horizontal axis), draw a vertical line to intersect the clearance rate and pulse pressure relationship curve, and then draw a horizontal line from the intersection point to the clearance rate (WR) axis (Vertical axis), record the removal rate at this point as WRi=20.667%.

As shown in Figure 15, from the position where the clearance rate (WR) is WRi=20.667% (horizontal axis), draw a vertical line to cross the clearance rate and stroke volume index curve, and then draw a horizontal line from the intersection to the heart At the stroke volume index (SVI) axis (vertical axis), record the stroke volume index at this point as SVIi=54.34ml‧beat ^-1 ‧m ^-2 .

As shown in Figure 16, from the (horizontal axis) position where the stroke volume index is SVIi=54.34ml‧beat ^-1 ‧m ^-2 , draw a vertical line to intersect the early heart/mediastinum ratio relationship curve. Draw a horizontal line at the intersection point to the early heart/mediastinum ratio (vertical axis), and record the early heart/mediastinum ratio at this point as early H/Mi=2.22; as shown in Figure 17, the stroke volume index is SVIi= 54.34ml‧beat ^-1 ‧m ^-2 (horizontal axis), draw a vertical line to intersect the delayed heart/mediastinum ratio relationship curve, and then draw a horizontal line from the intersection point to the delayed heart/mediastinum ratio (vertical axis) At this point, record the delayed heart/mediastinum ratio as delayed H/Mi=1.97.

As shown in Figure 9, substituting delayed H/Mi=1.97, it is possible to monitor the heart disease death rate of about 1%, the death rate of about 2%, and the two-year event rate of about 15%.

As shown in Figure 10, substituting age and delayed H/Mi=1.97, the risk of death from heart disease at five years can be monitored at approximately 5%.

As shown in Figure 11, by substituting delayed H/Mi=1.97, it is possible to monitor the absence of Parkinson's disease, dementia, Lewy body dementia, and simple autonomic failure.

As shown in Figure 12, substitute the delaved H/Mi=1.97 to monitor and use 123I-IBZM or 123I-FP-CIT or 123I-Ioflupane or 99mTc-TRODAT or 11C-RTI 32 or 11C-DTBZ or 18F-DOPA Or the nuclear medical imaging of the brain obtained by 18F-FP-CIT, the striatum has a higher level of dopamine than those with Parkinson's disease (the position indicated by the arrow in Figure 12).

As shown in Figure 12, substituting delayed H/Mi=1.97, you can monitor the brain slice image, which will contain more paminergic neurons (the position indicated by the postmorterm arrow in Figure 14 is healthy black).

Substituting delayed H/Mi=1.97 as shown in Figure 12, you can monitor that the local cerebral blood flow in the bilateral basal ganglia, thalamus, and cerebellar dentate nucleus in the eZIS image is not high.

As shown in Figure 12, substituting delayed H/Mi=1.97, the fMRI images can be monitored. The images are in the right inferior temporal, middle temporal, fusiform parahippocampal gyri ), Right inferior parietal gyrus (Right inferior parietal gyrus), pons, midbrain, and right orbital frontal cortex aggregation is lower than that of patients with Parkinson's disease (Figure 16 fMRI AD), in the left/right cuneiform cortex (Left/Right cuneus cortices), Left/Right supplementary motor areas (Left/Right supplementary motor areas), Left putamen, Left cuneus cortex, Left inferior parietal gyrus), the left lateral premotor cortex (Left lateral premotor cortex) accumulation is higher than that of Parkinson's disease patients (fMRI EJ in Figure 12).

[Embodiment 2]

When the electronic device 2 receives the heart rate transmitted by the wearable physiological detection device 1 is 150 beats per minute.

As shown in Figure 14, from the position of the heart rate (HR) of 150/M (horizontal axis), draw a vertical line to cross the clearance rate and heart rate curve, and then draw a horizontal line from the intersection to the clearance rate (WR) axis (Vertical axis), record the removal rate at this point as WRii=48.996%.

As shown in Figure 15, from the position where the clearance rate (WR) is WRii=48.996% (horizontal axis), draw a vertical line to cross the clearance rate and stroke volume index curve, and then draw a horizontal line from the intersection to the heart At the stroke volume index (SVI) axis (vertical axis), record the stroke volume index at this point as SVIii=31.737ml‧beat ^-1 ‧m ^-2 .

As shown in Figure 16, from the (horizontal axis) position where the stroke volume index is SVIii=31.737ml‧beat ^-1 ‧m ^-2 , draw a vertical line to intersect the early heart/mediastinum ratio relationship curve. Draw a horizontal line at the intersection point to the early heart/mediastinum ratio (vertical axis), and record the early heart/mediastinum ratio at this point as early H/Mi=1.85; as shown in Figure 17, the stroke volume index is SVIii= 31.737ml‧beat ^-1 ‧m ^-2 (horizontal axis), draw a vertical line to intersect the delayed heart/mediastinum ratio curve, and then draw a horizontal line from the intersection point to the delayed heart/mediastinum ratio (vertical axis) At this point, record the delayed heart/mediastinum ratio as delayed H/Mi=1.60.

As shown in Figure 9, substituting delayed H/Mi=1.60, it is possible to monitor the heart disease death rate of about 6.7%, the death rate of 10.1%, and the two-year event rate of about 37%.

65歲時，五年時心臟病死亡風險約為20%，年齡<65歲時，五年時心臟病死亡風險約為11%。 As shown in Figure 10, insert age and delayed H/Mi=1.60 to monitor age

At the age of 65, the risk of death from heart disease at five years is approximately 20%, and at the age of <65, the risk of death from heart disease at five years is approximately 11%.

As shown in Figure 11, by substituting delayed H/Mi=1.60, the risk of Parkinson's disease, dementia, Lewy body dementia, and simple autonomic failure can be monitored.

As shown in Figure 12, substituting delayed H/Mi=1.60, you can use 123I-IBZM or 123I-FP-CIT or 123I-Ioflupane or 99mTc-TRODAT or 11C-RTI 32 or 11C-DTBZ or 18F-DOPA Or the nuclear medicine image of the brain obtained by 18F-FP-CIT, the dopamine expression in the striatum is lower than that of normal people (the position indicated by the arrow in Figure 12).

As shown in Figure 12, by substituting delayed H/Mi=1.60, the brain slice image can be monitored, which will contain fewer paminergic neurons (postmorterm in Figure 14).

As shown in Figure 12, substituting delayed H/Mi=1.60, you can monitor the local cerebral blood flow in the bilateral basal ganglia, thalamus, and cerebellar dentate nucleus in eZIS images.

As shown in Figure 12, substituting delayed H/Mi=1.60, the fMRI image can be monitored. The image is in Right inferior temporal, middle temporal, and fusiform parahippocampal gyration Curve fusiform parahippocampal gyri, Right inferior parietal gyrus, pontine, midbrain, and right orbital frontal cortex aggregation will be higher than normal people (Figure 13 16 fMRI AD), in the left/right cuneiform lobe Left/Right cuneus cortices, Left/Right supplementary motor areas, Left putamen, Left cuneus cortex, Left inferior parietal gyrus, Left lateral The aggregation of premotor cortex will be lower than that of normal people (Figure 12, 16 fMRI EJ).

In summary, the system and method for monitoring cardiovascular and brain functions of the present invention combined with a physiological detection device can indeed achieve low investment costs, easy analysis and determination, and better analysis accuracy. It is indeed a novelty. For advanced inventions, I filed for invention patents in accordance with the law; however, the content of the above description is only a description of the preferred embodiments of the present invention, including all changes, modifications, changes or equivalents extended by the technical means and scope of the present invention Any replacement should also fall within the scope of the patent application of the present invention.

S11: Receive physiological data such as heart rate and pulse pressure

S12: Use heart rate or pulse pressure data to calculate the clearance rate value

S13: Use the clearance rate value to calculate the stroke volume index value

S14: Use the stroke volume index value to calculate the early heart/mediastinum ratio or the delayed heart/mediastinum ratio

S15: Use the early heart/mediastinum ratio or the delayed heart/mediastinum ratio to monitor the risk of heart disease

S16: Use the early heart/mediastinum ratio or the delayed heart/mediastinum ratio to monitor for neurodegenerative diseases

S17: Monitor brain images based on the early heart/mediastinum ratio or delayed heart/mediastinum ratio

Claims (9)

A system device for monitoring cardiovascular and brain functions combined with a physiological detection device, comprising: a wearable physiological detection device with a host and at least one external sensing element. The host is provided with a micro-processing unit, a memory unit, and a A sensing signal receiving module and a communication control module. The external sensing element is worn on the human body to detect a preset physiological state of the human body and generate a corresponding sensing signal, which is received by the sensing signal receiving module After the sensing signal is converted into various physiological data, it is sent to the micro-processing unit. The memory unit stores the firmware required for the overall operation of the wearable physiological detection device. The micro-processing unit executes the firmware , Can control the communication control module to transmit the physiological data to the paired external electronic device; an electronic device with computing function, equipped with a central processing unit, a memory module and a communication module, the communication module is The physiological data can be received through the aforementioned paired communication control module and sent to the central processing unit. In addition to storing an application program (APP) in the memory module, there is also a database for storing various data. The application program has various calculation and derivation function formulas. When the central processing unit executes the application program, the above-mentioned physiological data can be calculated and deduced through each function formula to generate a test for cardiovascular and brain function Analyze the monitoring results. The system device for monitoring cardiovascular and brain functions combined with a physiological detection device as described in item 1 of the scope of patent application, wherein the host has a switching operation module for controlling switching of different physiological detection items and actions, and A data storage unit capable of storing the physiological data is provided in the memory unit. The system device for monitoring cardiovascular and brain functions combined with a physiological detection device as described in item 1 of the scope of patent application, wherein the external sensing element is set on the head or neck or wrist or arm or foot or other human arterial flow By the part. As described in item 1 of the scope of patent application, the combined physiological detection device monitors cardiovascular and A system device for brain functions, wherein the electronic device has an operation module that performs various control actions on the central processing unit; and a display module that can display each operation process and calculation and analysis results. For example, the system device for monitoring cardiovascular and brain functions combined with a physiological detection device as described in item 1 of the scope of patent application, wherein the electronic device is a personal computer or a notebook computer or a tablet computer or a mobile phone. The system device for monitoring cardiovascular and brain functions combined with a physiological detection device as described in item 1 of the scope of patent application, wherein the external sensing element performs physiological detection through optical sensing, electrical signal measurement, or pressure sensing. . The system for monitoring cardiovascular and brain functions combined with a physiological detection device as described in item 1 of the scope of patent application, wherein the communication control module and the communication module transmit signals via wireless means. A monitoring method for monitoring cardiovascular and brain functions combined with a physiological detection device, at least including: a step of "receiving physiological data such as heart rate and pulse pressure" in which the electronic device receives the heart rate and pulse transmitted by the wearable physiological detection device Physiological data such as pressure; a step of "calculating clearance rate value using heart rate or pulse pressure data", the above heart rate value is calculated through a clearance rate and heart rate relationship function to calculate a clearance rate value; the above pulse pressure value is calculated through a clearance rate and The pulse pressure relation function formula calculates the clearance rate value; a step of "calculating the stroke volume index value using the clearance rate value" step is to calculate a stroke volume index from the clearance rate value through a function formula of the clearance rate and stroke volume index Numerical value; a step of "calculating the early heart/mediastinum ratio or delayed heart/mediastinum ratio using the stroke volume index value", the above-mentioned stroke volume index value is calculated by a relationship between the early heart/mediastinum ratio and the stroke volume index Calculate an early heart/mediastinum ratio; use the stroke volume index value to calculate an early delayed heart/mediastinum ratio or a delayed heart/mediastinum ratio by using a function of delayed heart/mediastinum ratio and stroke volume index ； A step of "monitoring heart function by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio", insert the early heart/mediastinum ratio or the delayed heart/mediastinum ratio into a cardiac function monitoring chart, respectively, for Cardiac function monitoring; a step of "monitoring nerve function by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio", and the early heart/mediastinum ratio or the delayed heart/mediastinum ratio is inserted into a nerve function respectively Monitoring chart for neurological function monitoring; a step of "monitoring brain imaging by the early heart/mediastinum ratio or the delayed heart/mediastinum ratio", respectively, the early heart/mediastinum ratio or the delayed heart/mediastinum ratio Insert a normal person and various brain detection image maps to monitor brain images. As described in item 8 of the scope of patent application, the monitoring method for monitoring cardiovascular and brain functions combined with a physiological detection device, wherein the clearance rate and pulse pressure relationship function: y=-0.6094x+63.325; R ² =0.3284; ρ <0.05 where: y: clearance rate (WR); x: pulse pressure (PP); ρ : statistical difference value. The relationship between clearance rate and heart rate: y=0.2459x+12.111; R ² =0.4008; ρ <0.01 Among them: y: clearance rate (WR); x: heart rate (HR) The relationship between the clearance rate and stroke volume index: y=-0.7978x+70.826; R ² =0.3578; ρ <0.05 where: y: heartbeat Volume Index (SVI); x: Clearance Rate (WR) The relationship between the early heart/mediastinum ratio and the stroke volume index: y=0.0162x+1.3379; R ² =0.4412; ρ <0.01 where: y: early heart /Mediastinum ratio (early H/M); x: stroke volume index (SVI) The relationship between the delayed heart/mediastinum ratio and the stroke volume index: y=0.0161x+1.0938; R ² =0.3897; ρ < 0.05 where: y: delayed heart/mediastinum ratio (delayed H/M); x: stroke volume index (SVI).

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