CN114377068A - Traditional Chinese medicine preparation for treating nephrotic syndrome - Google Patents
Traditional Chinese medicine preparation for treating nephrotic syndrome Download PDFInfo
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- CN114377068A CN114377068A CN202210234199.9A CN202210234199A CN114377068A CN 114377068 A CN114377068 A CN 114377068A CN 202210234199 A CN202210234199 A CN 202210234199A CN 114377068 A CN114377068 A CN 114377068A
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Abstract
The invention provides a traditional Chinese medicine preparation for treating nephrotic syndrome, which is prepared from dandelion, sculellaria barbata, black nightshade, akebia stem, lilac daphne flower bud, eucommia bark, pyrrosia lingua, garland jute seed, rhizoma alismatis, polyporus, peony, verbena, rhubarb, motherwort herb, medicinal cyathula root, psammosilene, sticktight, rust-coloured crotalaria herb and hibiscus root. The traditional Chinese medicine has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, and inducing diuresis to reduce edema. Can be used for treating chronic nephritis, pyelonephritis, nephrotic syndrome, etc., with good therapeutic effect and no major side effect. The traditional Chinese medicine preparation comprises the following raw material medicines: the eucommia ulmoides can reduce proteinuria, promote adrenal cortex function, improve hormone level in vivo, improve glomerular blood flow and the like, and has the effect of assisting in reducing renal hypertension.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating nephrotic syndrome.
Background
Nephrotic syndrome is a group of common clinical symptoms, and refers to a group of syndromes caused by various causes, mainly glomerulopathies such as increase of glomerular basement membrane permeability and concomitant decrease of glomerular filtration rate.
Nephrotic syndrome is typically characterized by "high three and low one", i.e., massive proteinuria, hypoalbuminemia, high grade edema, hyperlipidemia. By copious proteinuria is meant an increase in the permeability of the glomerular filtration membrane to plasma proteins resulting in an increase in the protein content of the urine when the molecular and charge barriers, and in particular the charge barrier, of the glomerular filtration membrane are compromised, and when the distal convoluted tubule resorption is exceeded, copious proteinuria is formed. Hypoalbuminemia refers to the loss of a large amount of albumin from urine, promoting the compensatory synthesis of albumin in the liver, and the insufficient increase in hepatic albumin synthesis to overcome the loss, and furthermore, hypo-eating, insufficient protein intake, malabsorption or loss due to gastrointestinal mucosal edema are also causes of hypoalbuminemia. High edema refers to hypoalbuminemia causing a decrease in plasma colloid osmotic pressure and the entry of water from the vascular lumen into the interstitial space. Hyperlipidemia refers to hypercholesterolemia or hypertriglyceridemia, increased concentrations of LDL, VLDL and lipoproteins in serum, often coexisting with hypoalbuminemia, whose mechanism of occurrence is associated with increased lipoprotein synthesis by the liver and decreased lipoprotein decomposition.
Nephrotic syndrome with complicated etiology, including chronic glomerulonephritis, nephrotic nephropathy of renal degeneration type, lipoid nephropathy, nephropathy in systemic lupus erythematosus, amyloidosis, multiple myeloma, glomerulosclerosis in diabetes, allergic purpura, renal venous thrombosis, etc., can cause nephrotic syndrome. The nephrotic syndrome is characterized by edema, oliguria, frequent infection history of upper respiratory tract infection, skin infection and the like before onset of disease, and accompanied symptoms of fatigue, anorexia, pallor, listlessness and the like, and serious patients have serous cavity hydrops and anuria.
The nephrotic syndrome has long attack time and is not easy to cure, great physical and psychological burden is brought to patients, the existing medical level has no obvious specific treatment scheme for treating the nephrotic syndrome, the existing treatment medicine has long treatment course, low cure rate and great side effect, and the pain of the patients is increased.
Disclosure of Invention
Aiming at the situations, in order to overcome the defects of the prior art, the invention aims to provide the traditional Chinese medicine preparation for treating nephrotic syndrome, which can effectively solve the problems of poor treatment effect and great side effect of nephrotic syndrome.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that:
the traditional Chinese medicine preparation for treating nephrotic syndrome is characterized by comprising the following raw materials in parts by weight: 10-15 parts of dandelion, 11-15 parts of sculellaria barbata, 8-12 parts of black nightshade, 4-8 parts of akebia stem, 8-12 parts of lilac daphne flower bud, 8-13 parts of eucommia ulmoides, 6-11 parts of pyrrosia lingua, 9-11 parts of garland sesame seed, 5-10 parts of rhizoma alismatis, 6-12 parts of grifola, 4-9 parts of peony, 5-11 parts of verbena, 3-6 parts of rheum officinale, 10-12 parts of leonurus, 6-9 parts of medicinal cyathula root, 9-15 parts of psammophyte goldenrod herb, 8-15 parts of bidens bipinnata, 10-18 parts of rust-coloured crotalaria herb and 12-18 parts of hibiscus root.
The preferable weight ratio of each active component is as follows: 10 parts of dandelion, 11 parts of sculellaria barbata, 8 parts of black nightshade, 4 parts of akebia stem, 8 parts of lilac daphne flower bud, 8 parts of eucommia bark, 6 parts of pyrrosia lingua, 9 parts of garland jute seed, 5 parts of rhizoma alismatis, 6 parts of grifola, 4 parts of Chinese herbaceous peony, 5 parts of verbena, 3 parts of rheum officinale, 10 parts of motherwort, 6 parts of medicinal cyathula root, 9 parts of goldenrod, 8 parts of sticktight, 10 parts of rust-coloured crotalaria herb and 12 parts of hibiscus root.
The preferable weight ratio of each active component is as follows: 13 parts of dandelion, 14 parts of sculellaria barbata, 10 parts of black nightshade, 5 parts of akebia stem, 10 parts of lilac daphne flower bud, 11 parts of eucommia bark, 9 parts of pyrrosia lingua, 10 parts of garland jute seed, 8 parts of rhizoma alismatis, 9 parts of polyporus umbellatus, 7 parts of Chinese herbaceous peony, 9 parts of verbena, 4 parts of rheum officinale, 11 parts of motherwort, 8 parts of medicinal cyathula root, 12 parts of goldenrod, 13 parts of sticktight, 14 parts of rust-coloured crotalaria herb and 15 parts of hibiscus root.
The preferable weight ratio of each active component is as follows: 15 parts of dandelion, 15 parts of sculellaria barbata, 12 parts of black nightshade, 8 parts of akebia stem, 12 parts of lilac daphne flower bud, 13 parts of eucommia bark, 11 parts of pyrrosia lingua, 11 parts of garland jute seed, 10 parts of rhizoma alismatis, 12 parts of grifola, 9 parts of Chinese herbaceous peony, 11 parts of verbena, 6 parts of rheum officinale, 12 parts of motherwort, 9 parts of medicinal cyathula root, 15 parts of climbing fern, 15 parts of bidens pilosula, 18 parts of rust-coloured crotalaria herb and 18 parts of hibiscus root.
The traditional Chinese medicine is a tablet, and various raw materials are cleaned, dried, disinfected, powdered and mixed to prepare the tablet according to a conventional method.
The usage and dosage are as follows: it is taken with warm water, three times a day, 3 tablets each time, after meal.
The medicinal properties of the active ingredients adopted by the invention are as follows:
dandelion: clear heat and remove toxicity, induce diuresis and dissipate nodulation. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
Barbed skullcap herb: clearing away heat and toxic material, promoting blood circulation, dispelling blood stasis, and promoting urination. Belongs to heat-clearing and toxicity-removing herbs in the category of heat-clearing herbs. Can be used for treating chronic nephritis and edema.
Black nightshade: clearing away heat and toxic material, promoting blood circulation and eliminating swelling. It can be used for treating furuncle, carbuncle, erysipelas, traumatic injury, sprain, chronic tracheitis, and acute nephritis.
B, wood through: clear heart fire, induce diuresis, dredge meridians and promote lactation. Belongs to the diuresis and stranguria treatment drugs classified under the diuresis and dampness eliminating drugs. Has diuretic and antibacterial effects.
Lilac daphne flower bud: it has the actions of inducing diuresis to alleviate edema, promoting blood circulation to stop pain, clearing away heat and toxic material.
Eucommia ulmoides: has effects in tonifying liver and kidney, strengthening muscle and bone, regulating Chong and ren meridians, and preventing miscarriage. Can reduce proteinuria, promote adrenal cortex function, increase in vivo hormone level, and improve glomerular blood flow. It also has adjuvant effect on renal hypertension.
And (3) pyrrosia lingua: it has effects in promoting urination, relieving stranguria, clearing lung-heat, relieving cough, cooling blood, and stopping bleeding, and can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung heat, chronic tracheitis, and incised wound.
And (3) crowndaisy hemp seed: clear heat and cool blood, activate blood, remove toxicity and promote eruption. The natural alkannin compounds and their derivatives in radix Arnebiae have cytotoxic effect and anti-tumor effect of different degrees.
Rhizoma alismatis: has effects in cooling blood, dredging channels, clearing away heat and toxic materials, relieving itching, expelling intestinal parasites, and relieving flatulence. And has effects of promoting blood circulation for removing blood stasis, and relieving cough.
And (3) polyporus umbellatus: induce diuresis to alleviate edema, clear heat and remove toxicity. Can be used for treating abdominal edema, edema of face and foot, carbuncle, furuncle, and snake and insect bite; ascites due to late schistosomiasis.
Peony: has effects of dispersing stagnated liver qi, promoting blood circulation, relieving pain, relieving restlessness, and promoting urination.
Verbena: has effects in cooling blood, dredging channels, clearing away heat and toxic materials, relieving itching, expelling intestinal parasites, and relieving flatulence. And has effects of promoting blood circulation for removing blood stasis, and relieving cough. The verbena is a special traditional Chinese medicine capable of preventing cancers, can effectively prevent canceration of cells, can also inhibit regeneration of cancer cells, and obviously reduces the incidence rate of the cancers. In addition, verbena is a common drug for treating cancer, and can relieve the symptoms of cancer patients.
Rhubarb: purge heat and unblock intestines, cool blood and remove toxicity, dispel stasis and dredge meridians. For: constipation due to damp-heat, abdominal pain due to stagnation, dysentery with difficulty, jaundice due to damp-heat, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, abdominal pain due to intestinal abscess, carbuncle, furuncle, amenorrhea due to blood stasis, traumatic injury, and external treatment for scald due to water and fire; upper gastrointestinal hemorrhage.
Motherwort: promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema, clearing away heat and toxic materials.
Radix cyathulae: radix Cyathulae has effects of promoting blood circulation, dredging channels, dispelling pathogenic wind, removing dampness, promoting joint movement, and inducing diuresis for treating stranguria.
And (3) golden sand grass: clearing away heat; removing dampness; relaxing tendons and activating collaterals; stopping bleeding. Major urinary tract infection; urinary calculus; edema due to nephritis; hepatitis; dysentery; conjunctival congestion with swelling and pain; rheumatic arthralgia; numbness of the bones and muscles; traumatic fractures; bleeding due to trauma.
Bidens pilosa L: clearing away heat, removing toxic material, dissipating blood stasis and relieving swelling. It can be used for treating malaria, diarrhea, dysentery, hepatitis, acute nephritis, gastralgia, dysphagia, acute appendicitis, laryngopharynx swelling and pain, traumatic injury, and snake and insect bite.
Rust-colored crotalaria herb: nourishing kidney and liver, relieving cough and asthma, promoting diuresis and removing toxic substance. Yunnan Chinese herbal medicine: "diminish inflammation, induce diuresis". Can be used for treating dysuria, whitish and turbid urine, nephritis, lymphadenitis, parotitis, tonsillitis, chronic bronchitis, and asthma. "south medicine" Chinese herbal medicine: the main treatment is as follows: deficiency of liver and kidney, tinnitus, deafness, dizziness, blurred vision; menorrhagia; cough and asthma, chronic bronchitis; chronic nephritis, cystitis; furuncle. "
Lotus root: clearing away heat and toxic materials; cool blood and relieve swelling. Beginning of superficial infection with pyogenic infections; ecthyma; conjunctival congestion with swelling and pain; pulmonary abscess; cough and asthma; dysentery with reddish white feces; leucorrhea of women; pyelonephritis.
The traditional Chinese medicine has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, and inducing diuresis to reduce edema. Can be used for treating chronic nephritis, pyelonephritis, nephrotic syndrome, etc., with good therapeutic effect and no major side effect. The traditional Chinese medicine preparation comprises the following raw material medicines: the eucommia ulmoides can reduce proteinuria, promote adrenal cortex function, improve hormone level in vivo, improve glomerular blood flow and the like, has the effect of assisting reduction of renal hypertension, and has a good treatment effect on the nephrotic syndrome.
Detailed Description
In order to make the content of the present invention more clearly understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Wherein like parts are designated by like reference numerals. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions, and the terms "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.
Example 1:
taking 10 parts of dandelion, 11 parts of sculellaria barbata, 8 parts of black nightshade, 4 parts of akebia stem, 8 parts of lilac daphne flower bud, 8 parts of eucommia bark, 6 parts of pyrrosia lingua, 9 parts of garland jute seed, 5 parts of rhizoma alismatis, 6 parts of polyporus umbellatus, 4 parts of Chinese herbaceous peony, 5 parts of verbena, 3 parts of rheum officinale, 10 parts of motherwort, 6 parts of radix cyathulae, 9 parts of goldenrod, 8 parts of sticktight, 10 parts of rust-coloured crotalaria herb and 12 parts of hibiscus root, cleaning the raw materials, drying, sterilizing, grinding and mixing, preparing the raw materials into tablets according to a conventional method, and taking the tablets in a fixed amount.
The usage and dosage are as follows: it is taken with warm water, three times a day, 3 tablets each time, after meal.
Example 2:
taking 13 parts of dandelion, 14 parts of sculellaria barbata, 10 parts of black nightshade, 5 parts of akebia stem, 10 parts of lilac daphne flower bud, 11 parts of eucommia bark, 9 parts of pyrrosia lingua, 10 parts of garland jute seed, 8 parts of rhizoma alismatis, 9 parts of polyporus umbellatus, 7 parts of Chinese herbaceous peony, 9 parts of verbena, 4 parts of rheum officinale, 11 parts of motherwort, 8 parts of radix cyathulae, 12 parts of goldenrod, 13 parts of sticktight, 14 parts of rust-coloured crotalaria herb and 15 parts of hibiscus root, cleaning the raw materials, drying, sterilizing, grinding and mixing, preparing the raw materials into tablets according to a conventional method, and taking the tablets in a fixed amount.
The usage and dosage are as follows: it is taken with warm water, three times a day, 3 tablets each time, after meal.
Example 3:
taking 15 parts of dandelion, 15 parts of sculellaria barbata, 12 parts of black nightshade, 8 parts of akebia stem, 12 parts of lilac daphne flower bud, 13 parts of eucommia bark, 11 parts of pyrrosia lingua, 11 parts of garland jute seed, 10 parts of rhizoma alismatis, 12 parts of grifola, 9 parts of Chinese herbaceous peony, 11 parts of verbena, 6 parts of rheum officinale, 12 parts of motherwort, 9 parts of radix cyathulae, 15 parts of climbing fern, 15 parts of sticktight, 18 parts of rust-coloured crotalaria herb, and 18 parts of hibiscus root, cleaning the raw materials, drying, sterilizing, grinding and mixing, preparing the raw materials into tablets according to a conventional method, and taking the tablets in a fixed amount.
The usage and dosage are as follows: it is taken with warm water, three times a day, 3 tablets each time, after meal.
The treatment method comprises the following steps:
the preparation is taken with warm water, three times a day, 3 tablets each time, and the treatment time is calculated according to the patient's condition, the preparation is taken by patients with mild diseases for about 3 months, and the preparation is taken by patients with severe diseases for more than 12 months.
Treatment effect judgment standard:
and (3) complete alleviation: less than 0.3 g/day of urine protein, 3 consecutive days, edema, blood lipid, nephrotic syndrome sign are completely eliminated, the plasma albumin is more than 35 g/day, and the renal function is normal.
Partial mitigation: 0.31-2.0 g/day of urine protein, 3 consecutive days, nephrotic syndrome is completely eliminated, and renal function is improved.
And (4) invalidation: the urinary protein is more than 2.0 g/day, the sign of nephrotic syndrome is not eliminated, and the renal function is not improved.
The traditional Chinese medicine preparation has good absorption effect and obvious curative effect, is beneficial to timely alleviating symptoms of patients, can clear away heat and toxic materials, induce diuresis to reduce edema, reduce proteinuria and blood fat and blood sugar through various raw material medicines in the traditional Chinese medicine preparation, and can effectively treat nephrotic syndrome.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (5)
1. The traditional Chinese medicine preparation for treating nephrotic syndrome is characterized by comprising the following raw materials in parts by weight: 10-15 parts of dandelion, 11-15 parts of sculellaria barbata, 8-12 parts of black nightshade, 4-8 parts of akebia stem, 8-12 parts of lilac daphne flower bud, 8-13 parts of eucommia ulmoides, 6-11 parts of pyrrosia lingua, 9-11 parts of garland sesame seed, 5-10 parts of rhizoma alismatis, 6-12 parts of grifola, 4-9 parts of peony, 5-11 parts of verbena, 3-6 parts of rheum officinale, 10-12 parts of leonurus, 6-9 parts of medicinal cyathula root, 9-15 parts of psammophyte goldenrod herb, 8-15 parts of bidens bipinnata, 10-18 parts of rust-coloured crotalaria herb and 12-18 parts of hibiscus root.
2. The traditional Chinese medicine preparation for treating nephrotic syndrome according to claim 1, characterized in that the active ingredients comprise the following raw materials in parts by weight: 10 parts of dandelion, 11 parts of sculellaria barbata, 8 parts of black nightshade, 4 parts of akebia stem, 8 parts of lilac daphne flower bud, 8 parts of eucommia bark, 6 parts of pyrrosia lingua, 9 parts of garland jute seed, 5 parts of rhizoma alismatis, 6 parts of grifola, 4 parts of Chinese herbaceous peony, 5 parts of verbena, 3 parts of rheum officinale, 10 parts of motherwort, 6 parts of medicinal cyathula root, 9 parts of goldenrod, 8 parts of sticktight, 10 parts of rust-coloured crotalaria herb and 12 parts of hibiscus root.
3. The traditional Chinese medicine preparation for treating nephrotic syndrome according to claim 1, characterized in that the active ingredients comprise the following raw materials in parts by weight: 13 parts of dandelion, 14 parts of sculellaria barbata, 10 parts of black nightshade, 5 parts of akebia stem, 10 parts of lilac daphne flower bud, 11 parts of eucommia bark, 9 parts of pyrrosia lingua, 10 parts of garland jute seed, 8 parts of rhizoma alismatis, 9 parts of polyporus umbellatus, 7 parts of Chinese herbaceous peony, 9 parts of verbena, 4 parts of rheum officinale, 11 parts of motherwort, 8 parts of medicinal cyathula root, 12 parts of goldenrod, 13 parts of sticktight, 14 parts of rust-coloured crotalaria herb and 15 parts of hibiscus root.
4. The traditional Chinese medicine preparation for treating nephrotic syndrome according to claim 1, characterized in that the active ingredients comprise the following raw materials in parts by weight: 15 parts of dandelion, 15 parts of sculellaria barbata, 12 parts of black nightshade, 8 parts of akebia stem, 12 parts of lilac daphne flower bud, 13 parts of eucommia bark, 11 parts of pyrrosia lingua, 11 parts of garland jute seed, 10 parts of rhizoma alismatis, 12 parts of grifola, 9 parts of Chinese herbaceous peony, 11 parts of verbena, 6 parts of rheum officinale, 12 parts of motherwort, 9 parts of medicinal cyathula root, 15 parts of climbing fern, 15 parts of bidens pilosula, 18 parts of rust-coloured crotalaria herb and 18 parts of hibiscus root.
5. The Chinese medicinal preparation for treating nephrotic syndrome according to any one of claims 1 to 4, wherein the Chinese medicament is a tablet.
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| CN101229292A (en) * | 2008-01-10 | 2008-07-30 | 程立国 | Chinese traditional medicine preparation for treating nephropathy, preparation method and applications thereof |
| CN103393851A (en) * | 2013-08-10 | 2013-11-20 | 常玲玲 | Chinese medicinal preparation for treating nephrotic syndrome and preparation method |
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| CN101229292A (en) * | 2008-01-10 | 2008-07-30 | 程立国 | Chinese traditional medicine preparation for treating nephropathy, preparation method and applications thereof |
| CN103393851A (en) * | 2013-08-10 | 2013-11-20 | 常玲玲 | Chinese medicinal preparation for treating nephrotic syndrome and preparation method |
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Application publication date: 20220422 |