CN114376723B - Irreversible electroporation ablation needle, needle channel ablation device and ablation device - Google Patents
Irreversible electroporation ablation needle, needle channel ablation device and ablation device Download PDFInfo
- Publication number
- CN114376723B CN114376723B CN202210298309.8A CN202210298309A CN114376723B CN 114376723 B CN114376723 B CN 114376723B CN 202210298309 A CN202210298309 A CN 202210298309A CN 114376723 B CN114376723 B CN 114376723B
- Authority
- CN
- China
- Prior art keywords
- needle
- ablation
- electrode
- irreversible electroporation
- electroporation ablation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002679 ablation Methods 0.000 title claims abstract description 93
- 238000004520 electroporation Methods 0.000 title claims abstract description 49
- 230000002427 irreversible effect Effects 0.000 title claims abstract description 49
- 238000010438 heat treatment Methods 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 22
- 239000004020 conductor Substances 0.000 claims description 4
- 230000005684 electric field Effects 0.000 claims description 4
- 230000035699 permeability Effects 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 27
- 238000000034 method Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 238000004088 simulation Methods 0.000 abstract description 9
- 210000004881 tumor cell Anatomy 0.000 abstract description 9
- 230000005674 electromagnetic induction Effects 0.000 abstract description 7
- 238000005452 bending Methods 0.000 abstract description 4
- 238000003782 apoptosis assay Methods 0.000 abstract description 3
- 230000037427 ion transport Effects 0.000 abstract description 3
- 239000012528 membrane Substances 0.000 abstract description 3
- 230000005522 programmed cell death Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 14
- BGPVFRJUHWVFKM-UHFFFAOYSA-N N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] Chemical compound N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] BGPVFRJUHWVFKM-UHFFFAOYSA-N 0.000 description 12
- 238000011282 treatment Methods 0.000 description 10
- 230000009471 action Effects 0.000 description 7
- 230000006907 apoptotic process Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 230000030833 cell death Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000013632 homeostatic process Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 229910001289 Manganese-zinc ferrite Inorganic materials 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- JIYIUPFAJUGHNL-UHFFFAOYSA-N [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mn++].[Mn++].[Mn++].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Zn++].[Zn++] Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mn++].[Mn++].[Mn++].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Zn++].[Zn++] JIYIUPFAJUGHNL-UHFFFAOYSA-N 0.000 description 1
- 238000011298 ablation treatment Methods 0.000 description 1
- CFQGDIWRTHFZMQ-UHFFFAOYSA-N argon helium Chemical compound [He].[Ar] CFQGDIWRTHFZMQ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000010001 cellular homeostasis Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 210000000277 pancreatic duct Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
The invention provides an irreversible electroporation ablation needle, a needle channel ablation device and an ablation device, comprising: the first needle is provided with a first needle head, and a first electrode is connected to the first needle; the second needle is provided with the second syringe needle on it, the second needle is around establishing first needle outside and at least some are the bending form setting, the second needle is connected with the second electrode, first electrode with second electrode polarity is opposite, and is suitable for and connects alternating current power supply, and when forming the return circuit between first needle and the second needle, because at least some of second needle can be the bending form setting, can know by the electromagnetic induction law, can be in the inside magnetic field that produces of second needle. The formed magnetic field can affect the ion transport capacity of the tumor cell membrane, can cause programmed cell death, and can destroy the tumor. Therefore, the method does not need to additionally adopt methods such as finite element simulation and the like to carry out simulation operation on the region to be ablated, and can effectively realize the ablation effect on the tumor.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an irreversible electroporation ablation needle, a needle channel ablation device and an ablation device.
Background
Cancer is a serious threat to human health and life, and the clinical application adopts accurate treatment technologies such as targeting, immunization, minimally invasive intervention and the like besides three conventional treatment means of traditional operation, radiotherapy and chemotherapy. Among them, the local ablation technique is becoming one of the new means for tumor therapy with the advantages of shortening the hospitalization time and causing little damage to the patient's body, etc.
Local ablation includes thermal ablation and cold ablation. The thermal ablation comprises radio frequency ablation, microwave ablation, argon-helium knife ablation, focused ultrasound ablation and other laser ablation, and the traditional ablation technology adopts temperature ablation, so that the tumor becomes an ablation forbidden zone when approaching important tissues such as gastrointestinal tract, bile duct, urethra, nerve and the like, and the curative effect of large blood vessels is influenced by the heat sedimentation effect.
In order to avoid the non-thermal ablation treatment technology, an irreversible electroporation (IRE) ablation technology is provided, which uses a tissue ablation technology that generates permanent nanopores in a cell membrane by a short-time and strong electric field to disturb cell homeostasis and then allows cells to die. The method causes cell apoptosis rather than cell necrosis caused by other ablation technologies based on thermal fusion and radiation, and can well protect important tissues of surrounding vascular nerves, bile ducts, pancreatic ducts, intestinal ducts, ureters and other complex parts from being influenced.
The difficulty of IRE ablation is the arrangement of the electrode needle, the research on the IRE ablation technology at present is generally a universal method for searching the arrangement of the electrode needle, an electric field generated when the electrode needle discharges is simulated by using a finite element simulation method, and the method is time-consuming and is not beneficial to online adjustment. Secondly, the general ablation simulation usually ignores the shape and size of the region to be ablated, does not consider the influence of obstacles on the simulation process, and the practicability of the simulation result is poor. Furthermore, it is often necessary to give the result of the distribution of the electrode needles artificially after having obtained the shape and position of the area to be ablated. Because the shape of the region to be ablated is irregular and diverse, technicians often need a longer time to adjust the position of the planar electrode needle and the depth of the electrode needle to achieve full coverage of the region to be ablated, which has higher professional requirements on the technicians and greatly limits the application of the IRE ablation technique.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to overcome the defects that the irreversible electroporation ablation needle in the prior art is complex in arrangement mode and difficult to realize the comprehensive coverage of the region to be ablated in the using process.
To this end, the present invention provides an irreversible electroporation ablation needle comprising: the first needle is provided with a first needle head, and the first needle is suitable for being connected with a first electrode; the second needle is provided with a second needle head, the second needle is wound on the outer side of the first needle, at least one part of the second needle is arranged in a bent shape, the second needle is suitable for being connected with a second electrode, and the first electrode and the second electrode have opposite polarities and are suitable for being connected with an alternating current power supply; the first needle and the second needle are made of conductive materials, and are arranged in a hollow shape; the medicine adding part is connected with the first needle and/or the second needle, and a medicine cavity used for storing medicines is formed in the medicine adding part.
The invention provides an irreversible electroporation ablation needle, which further comprises: and the auxiliary heating needles are arranged on the outer side of the first needle and are in contact with the first needle.
The irreversible electroporation ablation needle provided by the invention is characterized in that a plurality of auxiliary heating needles are annularly arranged on the outer side of the first needle.
According to the irreversible electroporation ablation needle provided by the invention, the heat conductivity coefficient of the auxiliary heating needle is greater than that of the first needle.
The irreversible electroporation ablation needle provided by the invention is characterized in that the first needle is provided with a plurality of layers along the radial direction of the first needle, wherein at least one layer is a magnetic conduction layer, and the magnetic permeability of the magnetic conduction layer is more than or equal to 18000H/m.
The irreversible electroporation ablation needle provided by the invention is outward along the radial direction, and the first needle comprises a magnetic conduction layer, an elastic layer and a rigid layer which are nested with each other.
The invention provides an irreversible electroporation ablation needle, which further comprises: a magnet disposed at least a portion of the second needle.
Furthermore, the magnet is arranged in the second needle, and the invention also comprises a reversing device matched with the magnet, which is respectively connected with the first electrode and the second electrode and is suitable for being connected with a power supply.
The irreversible electroporation ablation needle provided by the invention is characterized in that a plurality of magnets are arranged close to the end part of the first needle.
The irreversible electroporation ablation needle provided by the invention is characterized in that the second needle is spirally arranged, and the magnet is arranged at the inflection point of the second needle.
The irreversible electroporation ablation needle provided by the invention has the advantages that the corresponding ends of the first needle and the second needle are respectively connected with the handle, and the handles are suitable for being connected with an alternating current power supply.
The invention also provides a needle channel ablation device, which comprises: the invention provides an irreversible electroporation ablation needle; a temperature sensor acting at the first needle position; and the temperature acquisition module is used for acquiring the temperature signal detected by the temperature sensor.
The invention also provides an ablation device which comprises the ablation electrode needle or needle track ablation device provided by the invention.
The technical scheme of the invention has the following advantages:
1. the invention provides an irreversible electroporation ablation needle, which comprises: the first needle is provided with a first needle head, and a first electrode is connected to the first needle; the second needle is provided with a second needle head, the second needle is wound on the outer side of the first needle, at least one part of the second needle is arranged in a bent shape, the second needle is connected with a second electrode, and the first electrode and the second electrode have opposite polarities and are suitable for being connected with an alternating current power supply; the first needle and the second needle are made of conductive materials, and are arranged in a hollow shape; the medicine adding part is connected with the first needle and/or the second needle, and a medicine cavity used for storing medicines is formed in the medicine adding part.
In the invention, when a loop is formed between the first needle and the second needle, at least one part of the second needle is arranged in a bent shape, so that a magnetic field can be generated in the second needle after current flows through the second needle according to the law of electromagnetic induction. The formed magnetic field can affect the ion transport capacity of the tumor cell membrane, can cause programmed cell death, and can destroy the tumor. Based on the apoptosis mechanism, tumor cells undergo continuous apoptosis in organisms, resulting in cell changes and finally cell death. In the present invention, apoptosis is not a passive process, but an active process. In order to maintain homeostasis, cells under the control of genes die out of order by themselves. Typically, when a cell detects an aged or defective cell, it will deliver a chemical that causes the cell to self-rupture, resulting in cell death. The irreversible electroporation ablation needle provided by the invention can be used for causing cancer cells to die under the action of a strong magnetic field.
By the irreversible electroporation ablation needle, the effect of the magnetic field on the tumor ablation waiting area is realized, and the tumor ablation effect can be effectively realized without additionally adopting methods such as finite element simulation and the like to perform simulation operation on the tumor ablation waiting area.
2. The invention provides an irreversible electroporation ablation needle, which further comprises: and the auxiliary heating needles are arranged on the outer side of the first needle and are in contact with the first needle.
At present, blood stopping in puncture surgery mainly adopts compression hemostasis, and the defects are that external blood stops, but whether blood in an internal needle channel stops or not is a troublesome problem for medical care personnel; secondly, the problem of tumor cell diffusion is prevented, and the tumor can be brought out along the needle channel when the needle is withdrawn, so that the tumor cell diffusion is caused.
According to the invention, when the second needle is electrified, a magnetic field is formed, and the first needle positioned in the magnetic field and the auxiliary heating needle positioned outside the first needle can induce current under the action of the magnetic field through the electromagnetic induction law, so that the current further forms heat, the auxiliary heating needle is heated firstly, and then the auxiliary heating needle further heats the first needle. Through the arrangement mode, a high-temperature environment can be formed at the position of the wound of the tumor, so that tumor cells and the like are killed, and the problems of tumor planting and the like are effectively avoided.
3. The invention provides an irreversible electroporation ablation needle, which further comprises: a magnet disposed at least at a portion of the second needle.
In the invention, after the second needle is electrified, a magnetic field is formed in the second needle, and at the moment, a positive electrode and a negative electrode are correspondingly formed in the second needle. Further, a magnet is arranged on at least one part of the second needle, the magnet has certain polarity, and the magnet can act with the magnetic field after the magnetic field is formed, so that the second needle is further driven to stretch or contract.
The above scheme as a whole can control the size of the action area of the second needle inside the tumor by adjusting the current or the polarity of the magnet after being applied inside the tumor, thereby accurately adjusting the treatment area according to the sizes of different tumors.
4. The magnet is arranged in the second needle, and the reversing device is respectively connected with the first electrode and the second electrode and is suitable for being connected with a power supply.
Through setting up the switching-over equipment, can adjust the flow direction that enters into the inside electric current of second needle, can further control the inside magnetic field direction that forms of second needle through adjusting the electric current flow direction, because the polarity of magnet self is fixed, after the inside electric current flow direction that flows through of second needle changes, the direction of the power between its and the second needle also can change, second needle self also can contract again this moment and become the expansion, perhaps there is the expansion to become the contraction, thereby the size accuracy adjustment treatment area according to the tumour.
5. The irreversible electroporation ablation needle provided by the invention is characterized in that the second needle is spirally arranged, and the magnet is arranged at the inflection point of the second needle. Can accept magnet self effectively in the inflection point position to improve the fixed effect to magnet self, avoid the magnet to take place to slide in second needle is inside, influence final removal effect.
6. The invention provides a needle track ablation device, which comprises: the invention provides an irreversible electroporation ablation needle; a temperature sensor acting at the first needle position; and the temperature acquisition module is used for acquiring the temperature signal detected by the temperature sensor.
Can form magnetic field when the second needle after accomplishing the circular telegram, through the electromagnetic induction law, the first needle that is arranged in magnetic field can respond to the play electric current under the effect in magnetic field, and the electric current further forms the heat, heats the auxiliary heating needle, rises to after the certain degree when the temperature, can realize the purpose that the needle was said and is melted. Simultaneously, through the combination of temperature sensor and temperature acquisition module, can carry out real-time supervision to the intensification condition of first needle self, avoid the high or too low harmful effects who brings of temperature.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural view of an irreversible electroporation ablation needle provided by the present invention;
FIG. 2 is a schematic view of the connection between the first and second needles and the handle according to the present invention;
FIG. 3 is a schematic structural view of another irreversible electroporation ablation needle provided in the present invention;
FIG. 4 is a schematic view of a first configuration of an irreversible electroporation ablation needle having a magnet according to the present invention;
FIG. 5 is a schematic view of a second configuration of an irreversible electroporation ablation needle having a magnet according to the present invention;
FIG. 6 is a schematic view of a third configuration of an irreversible electroporation ablation needle having a magnet according to the present invention;
fig. 7 is a cross-sectional view of a first needle provided by the present invention.
Description of reference numerals in the examples:
A. an inflection point;
1. a first needle; 11. a first needle; 2. a second needle; 21. a second needle; 3. an auxiliary heating needle; 1a, a magnetic conduction layer; 1b, an elastic layer; 1c, a rigid layer; 4. a magnet; 5. a handle; 6. a first conductive line; 7. a second conductive line.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
This embodiment provides an irreversible electroporation ablation needle, which can be rotatably inserted into a soft tumor for treating liver tumor, pancreatic tumor, etc. As shown in fig. 1 to 7, the irreversible electroporation ablation needle includes:
a first needle 1, on which a first needle head 11 is arranged, the first needle 1 being adapted to be connected to a first electrode;
specifically, as shown in fig. 1, the first needle extends along the horizontal direction, and the first needle is disposed in a sharp shape and can pierce the tissue during the treatment.
Further, the shape of the first needle is not limited, and optionally, the first needle is linearly arranged, and in this embodiment, the length of the first needle is 40 centimeters.
A second needle 2, on which a second needle head 21 is arranged, the second needle is wound around the outer side of the first needle, at least one part of the second needle is arranged in a bending shape, the second needle is connected with a second electrode, the polarity of the first electrode is opposite to that of the second electrode, and the first electrode and the second electrode are suitable for being connected with an alternating current power supply;
specifically, as shown in fig. 1 and 2, the second needle 2 is wound around the outside of the first needle, and the second needle is disposed in a sharp shape to facilitate puncturing tissue.
In this embodiment, the first needle and the second needle may be disposed in a solid shape; as a variant, at least one of the first and second needles is arranged in a hollow shape to enable a dosing operation during the treatment.
Further, the second needle 2 itself is at least partially arranged in a curved shape, which may be arranged in a partial area in a curved shape. In this embodiment, as shown in fig. 1, the entire needle may be spirally disposed at an outer position of the first needle.
In this embodiment, a loop is formed between the first needle and the second needle. In order to realize the functions, one of the first needle and the second needle is connected with a positive pole of a power supply, and the other needle is connected with a negative pole of the power supply. Preferably, the first needle is connected to a negative electrode of a power supply, and the second needle is connected to a positive electrode of the power supply. Since tissue fluid is present inside the tissue such as a tumor, a circuit can be formed although a gap is present between the first needle and the second needle.
In this embodiment, in order to realize the power supply operation, as shown in fig. 1, a first lead wire 6 is connected to the first pin, and a second lead wire 7 is connected to the second pin. By providing the first wire and the second wire, the ease of connection with the power supply can be improved.
Further, the first pin and the second pin are made of conductive materials, for example, materials with good conductivity such as stainless steel, copper and silver are adopted. Meanwhile, in the embodiment, the power supply adopts an alternating current power supply and a high-voltage power supply. By adopting high-voltage alternating current, the electric field intensity in the area where the first needle and the second needle are located can reach 500V/cm to 30000V/cm.
When forming the return circuit between first needle and the second needle, because at least a part of second needle can be the bending form setting, can know by the electromagnetic induction law, can produce magnetic field in second needle inside behind the second needle when the electric current flows through the second needle. As shown in fig. 1, the second needle is connected to the positive power supply electrode, the first needle is connected to the negative power supply electrode, and as can be seen from the "right-hand rule", the N pole is formed in the right region of the second needle, the S pole is formed in the left region of the second needle, and the magnetic field space from right to left is formed inside the second needle.
In this embodiment, the formed magnetic field will affect the ion transport capacity of the tumor cell membrane, which may cause programmed cell death, thereby realizing the destruction of the tumor. Based on the apoptosis mechanism, tumor cells undergo continuous apoptosis in organisms, resulting in cell changes and finally cell death. Apoptosis is not a passive process, but an active process. In order to maintain homeostasis, the cells controlled by the gene die in an orderly manner autonomously. Typically, when a cell detects an aged or defective cell, it will deliver a chemical that causes the cell to self-rupture, resulting in cell death.
Through the irreversible electroporation ablation needle provided by the embodiment, cancer cells die under the action of a strong magnetic field, so that the operation of arranging a plurality of irreversible electroporation ablation needles after fussy simulation is not needed again, and the treatment efficiency is effectively improved.
In this embodiment, the first needle and the second needle are arranged in a hollow shape; the medicine adding part is connected with the first needle and/or the second needle 2, and a medicine cavity for storing medicines is formed in the medicine adding part.
Specifically, the medicine that is used for placing diseases such as carrying on tumour in adding medicine portion, add medicine portion can directly link to each other with first needle, also can directly link to each other with the second needle, can also connect first needle and second needle simultaneously. Through the connection action, the medicine can be directly conveyed to the affected part through the first needle and the second needle, and the effect of auxiliary treatment is achieved. Meanwhile, the structure of the medicine adding part is not limited as long as the operation of putting and storing the medicine can be realized.
In this embodiment, the method further includes: and the auxiliary heating needles 3 are arranged on the outer side of the first needle and are in contact with the first needle.
Specifically, can form magnetic field when the second needle is accomplishing the circular telegram after, through the electromagnetic induction law, when the second needle flows through the high frequency current of reversal, can produce closed magnetic line of force along the direction of radius of second needle, the theory of operation of similar electromagnetism stove, can produce alternating magnetic field under high frequency alternating current's effect, the first needle that is arranged in the magnetic field and the supplementary heating needle 3 that is arranged in first needle outside can be out of the electric current of induction under the effect in magnetic field, the electric current further forms the heat, at first heat supplementary heating needle 3, then supplementary heating needle 3 further heats first needle.
Further, the number and arrangement of the auxiliary irreversible electroporation ablation needles are not limited as long as induced heating and heat transfer can be realized. Preferably, a plurality of the auxiliary heating needles 3 are annularly arranged on the outer side of the first needle, so that the heating efficiency of the first needle is effectively improved.
Further, the auxiliary heating pin 3 has a thermal conductivity greater than that of the first pin. In this embodiment, the auxiliary heating needle 3 and the first needle are made of a metal material. The following combinations may be employed: the auxiliary heating needle 3 can be made of copper, and the first needle is made of stainless steel.
The embodiment can form a high-temperature environment at the position of the wound of the tumor by the arrangement mode, thereby killing tumor cells and the like, and effectively avoiding the problems of tumor planting and the like.
In this embodiment, as shown in fig. 7, the first needle is provided with a plurality of layers along the radial direction of the first needle, at least one of the layers is a magnetic conduction layer 1a, and the magnetic permeability of the magnetic conduction layer 1a is greater than or equal to 18000H/m.
Specifically, the magnetic conduction layer 1a is made of manganese-zinc ferrite, and has the advantages of large magnetic conductivity and capability of inducing a larger magnetic field after the second needle is electrified.
Further, as shown in fig. 7, outward in the radial direction, the first needle includes a magnetically permeable layer 1a, an elastic layer 1b, and a rigid layer 1c nested with each other. Specifically, the magnetic conduction layer 1a is arranged on the innermost layer, the rigid layer 1c is arranged on the outermost layer, and a first needle is formed in a layer-by-layer coating mode.
The elastic layer 1b can increase the elasticity of the first needle, so that the needle is not easy to shape after being bent, and the needle can rebound quickly to be original. Specifically, the elastic layer 1b is a nickel titanium alloy layer, and the preferred thickness thereof is 0.1 mm;
the rigid layer 1c itself is a chrome layer, preferably 0.1mm thick, which has the benefit of increasing the smoothness of the outer surface of the needle, making it easier for the needle to penetrate into the tissue, while the chrome layer increases the hardness of the outer surface of the needle, which in this embodiment has a hardness value of HV 600.
Further, this embodiment further includes: a magnet 4 disposed at least at a portion of the second needle.
As shown in fig. 1, 5 and 6, when the second needle is energized, a magnetic field is formed inside the second needle, and at this time, a positive electrode and a negative electrode are correspondingly formed inside the second needle. At the moment, the magnet 4 is arranged on at least one part of the second needle, the magnet 4 has certain polarity, and the magnet 4 can act with the magnetic field after the magnetic field is formed, so that the second needle is further driven to stretch or contract. The shape of the second needle is dynamically adjusted by utilizing the principle that like poles of the induced magnetic field and the magnet repel each other and opposite poles attract each other.
Explained in conjunction with fig. 5 and 6, in fig. 5 and 6, the magnet 4 having the polarity of S is used.
In fig. 5, the second needle is connected with the positive pole of the power supply, and at this time, an N pole is formed below the second needle, and an S pole is formed above the second needle, and the N pole located below and the magnet 4 of the S pole attract each other, and at this time, as shown by an arrow, the second needle contracts downward;
in fig. 6, the second needle is connected with a negative pole of a power supply, an S pole is formed below the second needle at this time, an N pole is formed above the second needle, the S pole positioned below and the magnet 4 of the S pole repel each other, and at this time, as shown by an arrow, the second needle is pulled upwards;
through the scheme, the strength of the magnetic field is adjusted by adjusting the voltage value, so that the size of the action area of the second needle in the tumor can be controlled, and the treatment area can be accurately adjusted according to the sizes of different tumors. Therefore, when the focal tissue is ablated, a doctor can control the ablation area of the spiral needle rod through the electrified voltage, and the treatment position is optimized through the scheme, so that the needle rod is finely attached to the focal tissue and conforms to the size of the focal.
In this embodiment, in order to realize the stretching and contracting operation of the second needle, the following embodiments may be adopted:
as a first embodiment, when the polarity of the power source connected to the first and second needles is not changed, the direction in which the magnet 4 is stressed can be adjusted by manually adjusting the magnet 4. For example, when the polarity of the magnet 4 is N, the second needle is in a contracted state, and when the polarity of the magnet 4 is changed to S, the second needle is changed to a stretched state under the condition that the current direction is inconvenient;
as a second embodiment, the stretched or contracted state of the second needle can be adjusted by changing the direction of the current. Correspondingly, the embodiment also comprises a reversing device which is respectively connected with the first electrode and the second electrode and is suitable for being connected with a power supply;
through foretell mode of setting up, can stabilize the magnetic pole inside the second needle, through the power polarity that adjustment first needle and second needle are connected, alright the flow direction of adjustment current to adjust the magnetic field direction of the inside formation of second needle, and then adjust the shape of second needle.
In the present embodiment, the number and the positions of the magnets 4 are not limited: as for the setting position, it may be provided at an end position of the second needle, or may be provided at a middle position, it may be provided at a partial region, or may be provided at a plurality of intervals over the entire length region of the second needle. Preferably, in this embodiment, the second needle is spirally disposed, and the magnet 4 is disposed at an inflection point a of the second needle.
Specifically, as shown in fig. 4, since the second needle is spirally disposed, the inflection point a is disposed at a position where the direction of the second needle is changed.
Further, in this embodiment, the first needle and the second needle are respectively connected to a handle 5 at their corresponding ends, and the handle 5 is adapted to be connected to an ac power source. Can improve the effect of restrainting of receipts to first needle and second needle through setting up handle 5 to improve the stability of first needle and second needle, and then effectively improve the job stabilization nature of irreversible electroporation ablation needle self.
In this embodiment, as shown in fig. 1, the first needle is a straight needle, and the second needle is spirally disposed. The formula of the magnetic field induced by the second needle is as follows:
where n is the number of turns of the second needle,
the magnetic permeability of the first needle, D the diameter of the second needle, and I the value of the current flowing in the second needle.
The general working process of the irreversible electroporation ablation needle provided by the embodiment is as follows:
the first needle and the second needle enter a part to be ablated in a rotating mode, the first needle and the second needle are electrified, and the current type is high-voltage alternating current. And adjusting the voltage of the high-voltage alternating current to control the extension length of the second needle inside the part to be ablated so as to adjust the working area.
Example 2
The present embodiments provide a needle track ablation device comprising:
the irreversible electroporation ablation needle provided in example 1;
a temperature sensor acting at the first needle position;
the setting position of the temperature sensor is not limited, and the temperature sensor can be arranged on the second needle in a clamping, welding and other modes, so that the temperature of the first needle can be monitored in real time;
and the temperature acquisition module is used for acquiring the temperature signal detected by the temperature sensor.
When the temperature is too low, the current flowing through the irreversible electroporation ablation needle can be controlled to be increased so as to increase the heat productivity of the first needle in the irreversible electroporation ablation needle; when the temperature is too high, the current flowing through the irreversible electroporation ablation needle can be reduced, so that the damage to other tissues caused by the too high temperature can be avoided.
The needle track ablation device that this embodiment provided at first can realize the action of melting to the tumour, secondly, can form magnetic field when the second needle after accomplishing the circular telegram, through the electromagnetic induction law, the first needle that is arranged in magnetic field can respond to the play electric current under the effect in magnetic field, and the electric current further forms the heat, heats the auxiliary heating needle, after the temperature rises to certain degree, can realize the purpose that the needle track melts. Simultaneously, through the combination of temperature sensor and temperature acquisition module, can carry out real-time supervision to the intensification condition of first needle self, avoid the high or low harmful effects who brings of temperature excessively.
Example 3
The present embodiment provides an ablation device including the ablation electrode needle provided in embodiment 1 or the needle track ablation device provided in embodiment 2.
The ablation device provided by the embodiment can comprise a power supply device, wherein the power supply device is connected with an external commercial power, and the commercial power can be converted into high-voltage power through the power supply device and further transmitted to the position of the irreversible electroporation ablation needle.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (8)
1. An irreversible electroporation ablation needle, comprising:
the device comprises a first needle (1), a second needle (11) and a third needle, wherein the first needle (1) is provided with a first needle head (11), and the first needle (1) is suitable for being connected with a first electrode;
the second needle (2) is provided with a second needle head (21), the second needle (2) is wound on the outer side of the first needle (1), at least one part of the second needle is arranged in a bent shape, the second needle (2) is suitable for being connected with a second electrode, the polarities of the first electrode and the second electrode are opposite, the first electrode and the second electrode are suitable for being connected with an alternating current power supply, and the electric field intensity in the area where the first needle and the second needle are located can reach 500V/cm to 30000V/cm;
the first needle (1) and the second needle (2) are made of conductive materials, and the first needle and the second needle are arranged in a hollow shape;
medicine portion, with first needle and/or second needle (2) link to each other, it has the medicine chamber that is used for the storage medicine to form in the medicine portion, still includes: a plurality of auxiliary heating needles (3), set up first needle (1) the outside and with first needle (1) contacts, and is a plurality of auxiliary heating needle (3) are cyclic annular setting and are in the outside of first needle (1), the coefficient of heat conductivity of auxiliary heating needle (3) is greater than the coefficient of heat conductivity of first needle (1).
2. The irreversible electroporation ablation needle according to claim 1, characterized in that along the radial direction of the first needle (1), the first needle (1) is provided with several layers, at least one of which is a magnetically conductive layer (1 a), the magnetic permeability of the magnetically conductive layer (1 a) being equal to or higher than 18000H/m.
3. The irreversible electroporation ablation needle according to claim 2, characterized in that the first needle (1) comprises a magnetically conductive layer (1 a), an elastic layer (1 b) and a rigid layer (1 c) nested one inside the other, radially outwards.
4. The irreversible electroporation ablation needle as claimed in claim 1, further comprising:
magnet (4), second needle (2) are the heliciform setting, magnet (4) set up and are in the inflection point position of second needle (2), still include: and the reversing equipment is respectively connected with the first electrode and the second electrode and is suitable for being connected with a power supply.
5. The irreversible electroporation ablation needle according to claim 4, characterized in that several of said magnets (4) are arranged near the end of the first needle (1).
6. The irreversible electroporation ablation needle according to claim 1 or 4, characterized in that the corresponding ends of the first needle (1) and the second needle (2) are respectively connected with a handle (5), and the handle (5) is suitable for connecting an alternating current power supply.
7. A needle track ablation device, comprising:
the irreversible electroporation ablation needle of any one of claims 1-6;
a temperature sensor acting at the first needle (1) position;
and the temperature acquisition module is used for acquiring the temperature signal detected by the temperature sensor.
8. An ablation device comprising the irreversible electroporation ablation needle of any one of claims 1 to 6 or the needle track ablation device of claim 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210298309.8A CN114376723B (en) | 2022-03-25 | 2022-03-25 | Irreversible electroporation ablation needle, needle channel ablation device and ablation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210298309.8A CN114376723B (en) | 2022-03-25 | 2022-03-25 | Irreversible electroporation ablation needle, needle channel ablation device and ablation device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114376723A CN114376723A (en) | 2022-04-22 |
| CN114376723B true CN114376723B (en) | 2022-07-15 |
Family
ID=81205633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210298309.8A Active CN114376723B (en) | 2022-03-25 | 2022-03-25 | Irreversible electroporation ablation needle, needle channel ablation device and ablation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114376723B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
| CN114711955B (en) * | 2022-05-11 | 2022-11-01 | 上海安通医疗科技有限公司 | Electric control ablation catheter for radial artery |
| WO2023249987A1 (en) * | 2022-06-22 | 2023-12-28 | Mayo Foundation For Medical Education And Research | Methods and tools for myocardial tissue |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631243A (en) * | 2011-02-15 | 2012-08-15 | 成功大学 | Therapeutic device for electromagnetic thermotherapy |
| CN109561922A (en) * | 2016-05-13 | 2019-04-02 | 台湾恩宁股份有限公司 | Tumour ablation system |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040254572A1 (en) * | 2003-04-25 | 2004-12-16 | Mcintyre Jon T. | Self anchoring radio frequency ablation array |
| US20050209661A1 (en) * | 2004-03-22 | 2005-09-22 | Solatronix, Inc. | System and method for generating electromagnetic fields of varying shape based on a desired target |
| CN101495056B (en) * | 2006-06-12 | 2011-06-08 | 京畿州海莱乌医院 | Electrode introducer device |
| DE102007061767A1 (en) * | 2007-06-08 | 2008-12-11 | Wulfsberg, Jens Peter, Prof. Dr.-Ing. | Bipolar electrodes for high-frequency surgery has a current path's tissue-penetration depth dependent on output and insulated control coils for electromagnetic field generation |
| US9561066B2 (en) * | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
| ATE548986T1 (en) * | 2009-11-30 | 2012-03-15 | Sorin Crm Sas | CUTLERY FOR DRILLING THE CARDIAC SEPTUM AND IMPLANTING A TRANSSEPTAL PROBE, ESPECIALLY A PROBE FOR DETECTING/STIMULATING A DEPRESSION TO THE LEFT OF THE HEART |
| US20160184001A1 (en) * | 2014-12-29 | 2016-06-30 | Metal Industries Research And Development Centre | Thermal ablation needle |
| CN207168575U (en) * | 2017-01-20 | 2018-04-03 | 战跃福 | A kind of microwave melt needle |
| CN208693439U (en) * | 2018-04-24 | 2019-04-05 | 丁荣 | A kind of tumour ablation needle |
| CN110179537B (en) * | 2019-04-28 | 2020-12-08 | 华中科技大学 | Multi-claw active conformal ablation needle with magnetic control |
| US10667855B1 (en) * | 2019-05-10 | 2020-06-02 | Trod Medical Us, Llc | Dual coil ablation devices |
-
2022
- 2022-03-25 CN CN202210298309.8A patent/CN114376723B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631243A (en) * | 2011-02-15 | 2012-08-15 | 成功大学 | Therapeutic device for electromagnetic thermotherapy |
| CN109561922A (en) * | 2016-05-13 | 2019-04-02 | 台湾恩宁股份有限公司 | Tumour ablation system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114376723A (en) | 2022-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114376723B (en) | Irreversible electroporation ablation needle, needle channel ablation device and ablation device | |
| US20220313355A1 (en) | Catheter electrodes for energy management | |
| KR100243744B1 (en) | Apparatus for ablation of a selected mass | |
| ES2349063T3 (en) | THERMAL TREATMENT SYSTEM IN A BIOLOGICAL AREA OF A PATIENT'S BODY. | |
| JP6297970B2 (en) | Ablation apparatus, system and method | |
| CN1191873C (en) | Cooled-wet electrode | |
| CN101553180A (en) | Device and method for destruction of cancer cells | |
| JP7191694B2 (en) | Device for electromagnetic ablation of tissue | |
| CN102711645A (en) | Systems, apparatuses, and methods for treating tissue and controlling stenosis | |
| CN105744907A (en) | Thoracoscopic methods for treatment of bronchial disease | |
| US20180028267A1 (en) | Radio-frequency electrical membrane breakdown for the treatment of benign prostatic hyperplasia | |
| JPH09506808A (en) | Liquid cooling and liquid perfusion catheter tip | |
| WO2021239028A1 (en) | Electric refrigeration-based ablation system employing flexible electric refrigeration probe and flexible electric refrigeration probe | |
| JP2014522714A (en) | Method and apparatus for treating cancer | |
| KR101415900B1 (en) | Reiterating type bipolar electrode for high frequency thermotherapy | |
| CN112888390B (en) | Inferred maximum temperature monitoring for irrigated ablation therapy | |
| JP7019232B1 (en) | Asymmetric microwave ablation needle with peristaltic function to treat osteosarcoma | |
| US11759519B2 (en) | Hyperthermic cancerous tissue ablation | |
| WO2001006943A1 (en) | Electromagnetic scalpel for the heating of biological tissue | |
| CN107157573A (en) | The mapping ablation catheter and ablating device and device application method of a kind of interpolar discharge | |
| CN213374764U (en) | Spherical cap type energy-gathering radio frequency radiator | |
| CN114767256A (en) | Ablation catheter and device with variable electrode spacing | |
| CN108578893B (en) | Magnetic hysteresis heating treatment device for ultrasonic positioning in cavity | |
| CN113729912A (en) | Electric cold ablation device, system and method using flexible structure | |
| CN117958959B (en) | Water-cooling radio frequency electrode structure for nerve tissue ablation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240812 Address after: Room 405, Building 2, No. 36 Doukou Road, Hengqin, Zhuhai City, Guangdong Province 519060 Patentee after: True Health (Guangdong Hengqin) Medical Technology Co.,Ltd. Country or region after: China Address before: 100176 Room 405, 4 / F, building 2, 99 Kechuang 14th Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: Beijing Weidao Medical Technology Co.,Ltd. Country or region before: China |
|
| TR01 | Transfer of patent right |