CN114371281A - Rocking mechanism in protein tracing instrument - Google Patents

Abstract

The invention provides a swing mechanism in a protein track plotter, which comprises a film bearing device, a connecting rod mechanism and a rotating mechanism, wherein the rotating mechanism is a driving part in the swing mechanism and is used for providing kinetic energy for the swing mechanism; the rotating mechanism is connected with the connecting rod mechanism and can drive the connecting rod mechanism to move; the connecting rod mechanism is connected with the film bearing device, and the rotating mechanism can drive the film bearing device to move through the connecting rod mechanism, so that the film bearing device can swing repeatedly. The swing structure of the invention has low requirements on the motor in the rotating mechanism, and compared with the motor in the traditional protein tracing instrument, the motor adopted by the invention does not need large rotating torque; meanwhile, the invention does not need to carry out complex control on the motor, such as the accurate control of the rotating speed of the motor, the control of the rotating direction and the like.

Description

Rocking mechanism in protein tracing instrument

Technical Field

The invention relates to the technical field of medical instruments, in particular to a swing mechanism in a protein tracing instrument.

Background

Immunoblotting (Western Blot, also known as Western blotting) is a method for detecting a certain protein in a complex sample based on the specific binding of antigen-antibody. The method is a new immune biochemical technology developed on the basis of gel electrophoresis and solid-phase immunoassay. Immunoblotting has become a common technique for protein analysis due to its high resolution of gel electrophoresis and high specificity and sensitivity of solid phase immunoassays. Immunoblotting is most commonly used for detection of protein properties, expression and distribution, such as antibody or antigen detection of viruses, quality determination of polypeptide molecules, and qualitative or semi-quantitative detection of tissue antigens.

At present, western blot related tests are usually carried out on an automatic western blot instrument, and the western blot instrument separates proteins to be tested by adopting different electrophoresis methods according to properties, such as molecular weight, molecular size, electric charge, isoelectric point and the like of the proteins; transferring the proteins in the gel to the polyvinylidene fluoride membrane by current; the principle that the antibody and the antigen are specifically combined is utilized, and the target protein is obtained by taking the antibody as a probe. It is noted that the membrane should be "blocked" by the addition of a non-specific protein, such as bovine serum albumin, prior to the addition of the antibody to prevent non-specific binding of the antibody to the membrane.

After the membrane and the reagent are placed into the automatic protein blotting instrument, the membrane and the antigen are subjected to sufficient fusion reaction through the reciprocating swing of a swing mechanism of the instrument, and an accurate detection result is obtained. However, the traditional swing mechanism has the problems that the required rotating moment is large, the adaptability of the swing mechanism is insufficient, the reagent is easy to shake out from the automatic protein tracing instrument and the like, and therefore, a new swing structure needs to be designed to overcome the defects.

Disclosure of Invention

The invention aims to provide a swing mechanism in a protein plotter, which solves the problems in the background technology.

The technical scheme adopted by the invention is that the rocking mechanism in the protein blotting instrument is used for fully fusing and reacting a membrane and an antigen in the automatic protein blotting instrument through reciprocating rocking of the rocking mechanism, so that an accurate detection result is obtained. The swing mechanism comprises a film bearing device, a connecting rod mechanism and a rotating mechanism, wherein the rotating mechanism is a driving part in the swing mechanism, is generally controlled by a motor and is used for providing kinetic energy for the swing mechanism; the rotating mechanism is connected with the connecting rod mechanism and can drive the connecting rod mechanism to move; link mechanism with the membrane bears the device and links to each other, and all detections in the protein tracing appearance, steps such as liquid feeding, incubation, combination, application of sample, washing are all gone on in the membrane bears the device, slewing mechanism can pass through link mechanism drives the motion of membrane bearing device realizes the membrane bears the device repeatedly sways, reciprocal rocking that the membrane bore the device can make sample and reagent fully fuse and react, and then reach the purpose that the accuracy detected.

Further, the membrane carrier has a pivot point about which it can rotate, typically on the mid-plane of the membrane carrier for uniform fusion of the membrane and antigen within the instrument. The rotary supporting points are also positioned on the fixed plate, the membrane bearing device is connected with the fixed plate in a rotating fit mode through the rotary supporting points, and in order to ensure the installation stability and the rotation stability of the membrane bearing device on the fixed plate, the rotary supporting points are provided with two rotary supporting points. As an optimized technical scheme, a fixing seat is arranged on the fixing plate, two supporting lugs are arranged on the fixing seat, through holes are formed in the two supporting lugs and used for installing pins, a supporting plate is further sleeved on the pins and connected with the membrane bearing device. The pin is the pivot point of the film carrier and the fixing base, and is also the center of rotation of the film carrier and the fixing base.

Further, in order to promote the rotation fluency of the rotation fulcrum position, sliding parts are arranged between the pin and the two support lugs and between the pin and the support plate, the most common sliding part is a rolling bearing, the rolling bearing has the advantages of low manufacturing cost, stable operation and the like, but the problem that lubricating oil or lubricating grease needs to be frequently supplemented exists, the operation is more complicated, particularly in a western blotting instrument, the rotation fulcrum position of the membrane bearing device needs to be rotated at high frequency, and the operation needs to be regularly maintained by technical personnel and is too complicated. In the present embodiment, the sliding member is a sliding bearing (press fit bearing) made of a special engineering plastic, such as the sliding bearing of germany iglidur, which has a series of characteristics of high wear resistance, dust resistance, dirt resistance, no lubrication, no maintenance, and the like, and is suitable for the device.

Further, the link mechanism comprises a first connecting structure, a second connecting structure is connected to the first connecting structure in a rotating fit mode, a third connecting structure is connected to the second connecting structure in a rotating mode, the first connecting structure is connected with the rotating mechanism, and the third connecting structure is connected with the film bearing device. The first connecting structure, the second connecting structure and the third connecting structure can be three connecting rods, adjacent connecting rods are connected in a rotating fit mode, and the simplest rotating fit connecting mode is that the rotating fit position of the adjacent connecting rods is inserted through a rotating shaft. In the working process, the rotating shaft and the connecting rod connected with the rotating shaft can frequently rotate, the technical scheme similar to the rotating fulcrum can be adopted, and the sliding bearing made of special engineering plastics is arranged at the rotating part. In this embodiment, since the first connecting structure is connected to the motor in the rotating mechanism, if the first connecting structure is a connecting rod, when the motor works, the rotating shaft of the motor may receive extremely uneven load due to the gravity and the centrifugal force of the first connecting structure, which may affect the service life of the motor.

Further, the film bearing device is generally rectangular, and in order to enable the film bearing device to be stressed uniformly when a motor in the rotating mechanism is started, the third connecting structure is located on a middle vertical plane of the film bearing device in the long edge direction. It should be noted that the third connecting structure is arranged eccentrically, i.e. the third connecting structure cannot be located on the connecting line between the two rotation fulcrums, because the rotating mechanism cannot drive the film carrier to perform a swinging motion when the third connecting structure is located on the connecting line between the two rotation fulcrums. Further, the greater the distance from the third connecting structure to the pivot point, i.e., the greater the eccentric distance, the smaller the maximum rocking amplitude of the film carrier device, all other things being equal.

Further, for the convenience of counting the number of times of swaying that the device inner membrance bore the weight of and make, link mechanism is last to be equipped with an opto-coupler separation blade, and what correspond with it still is equipped with an opto-coupler response structure in the device, along with slewing mechanism starts to drive link mechanism motion, the every round that turns of motor in the slewing mechanism, link mechanism is last the opto-coupler separation blade is just once (shelters from once) the count is carried out to opto-coupler response structure. Further, the opto-coupler separation blade install in on the second connection structure, work as when the membrane bears the weight of the device and is in horizontal position, opto-coupler separation blade right-hand member just in time shelters from the opto-coupler inductor, and the opto-coupler inductor is in the necessarily route of opto-coupler separation blade motion in-process.

Further, a motor in the rotating mechanism is kept fixed, so that parameters such as amplitude, frequency and angle of each swing of the film bearing and manufacturing are kept consistent. In this embodiment, the fixed plate is stationary, so the rotating mechanism can be mounted on the fixed plate. As the preferred technical scheme, install first mounting panel on the fixed plate, first mounting panel is L shape, motor can be installed to first mounting panel, the output shaft of motor is connected first connection structure. The optical coupling induction structure is characterized in that a second mounting plate is arranged on the first mounting plate and used for mounting the optical coupling induction structure.

Further, when the film carrier is manufactured in a horizontal state, the rotating mechanism is located at a lower side position of the third connecting structure.

Furthermore, a rotating shaft of a motor in the rotating mechanism is located at a position right below the third connecting structure, namely, a connecting line between the third connecting structure and the rotating shaft of the motor is in a vertical state.

In conclusion, the beneficial effects of the invention are as follows:

the swing structure of the invention has low requirements on the motor in the rotating mechanism, and compared with the motor in the traditional protein tracing instrument, the motor adopted by the invention does not need large rotating torque; meanwhile, the invention does not need to carry out complex control on the motor, such as the accurate control of the rotating speed of the motor, the control of the rotating direction and the like; in addition, the motor adopted by the invention can select a conventional stepping motor, and the delicate steering change and the rotating speed control of the swing structure can be realized by carrying out simple unidirectional rotation, so that the production cost of the protein tracing instrument can be greatly increased; moreover, the swing structure is provided with multi-gear speed regulation, and can be used for being suitable for various working environments or meeting different working requirements; finally, the sliding bearings made of special engineering plastics are adopted as the revolute pairs in the invention, and the sliding bearings have a series of characteristics of high wear resistance, dust resistance, dirt resistance, lubrication free, maintenance free and the like, so that technicians do not need to maintain regularly, the maintenance cost is reduced, and the service life of the whole device is greatly prolonged.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for the embodiments or the prior art descriptions will be briefly introduced below, and it is obvious that the drawings in the following description are only one embodiment of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic view of a rocking mechanism in a western blotting apparatus according to the present invention in one orientation;

FIG. 2 is a schematic view of the rocking mechanism in a western blotter of the present invention in another orientation;

FIG. 3 is an exploded view of the rocking mechanism in a western blotter of the present invention at the position of the pivot point;

FIG. 4 is a graph of the rotational speed imparted to part 1 in a motion simulation;

FIG. 5 is a graph of the rotational speed achieved for part 3 in a motion simulation;

FIG. 6 is a schematic view of a motion simulation with part 3 in a horizontal position;

FIG. 7 is a schematic view of a motion simulation in which the part 3 is in a near right limit condition;

FIG. 8 is a schematic view of the motion simulation with the part 3 again in a nearly horizontal position;

fig. 9 is a schematic view of the part 3 in a nearly left-side limit state in the motion simulation.

Detailed Description

In order to make the technical problems, technical solutions and advantages of the present invention more apparent, the embodiments of the present invention are described in detail below with reference to the accompanying drawings, it should be noted that the embodiments are only detailed descriptions of the present invention and should not be considered as limitations of the present invention, and all features disclosed in the embodiments of the present invention or all steps in a disclosed method or process can be combined in any way except for mutually exclusive features and/or steps.

The embodiment provides a wabbler mechanism in protein tracing appearance for to putting into membrane and reagent in the automatic protein tracing appearance, rocking through wabbler mechanism's reciprocal and letting the abundant fusion reaction of membrane and antigen in the instrument, and then obtain accurate testing result. The swing mechanism comprises a film bearing device 10, a connecting rod mechanism 20 and a rotating mechanism 30, wherein the rotating mechanism 30 is a driving part in the swing mechanism, is generally controlled by a motor and is used for providing kinetic energy for the swing mechanism; the rotating mechanism 30 is connected with the link mechanism 20, and the rotating mechanism 30 can drive the link mechanism 20 to move; the connecting rod mechanism 20 is connected with the membrane bearing device 10, all the steps of detection, liquid adding, incubation, combination, sample adding, cleaning and the like in the western blot instrument are carried out in the membrane bearing device 10, the rotating mechanism 30 can drive the membrane bearing device 10 to move through the connecting rod mechanism 20, the membrane bearing device 10 can swing repeatedly, the reciprocating swing of the membrane bearing device 10 can enable a sample and a reagent to be fully fused and reacted, and the aim of accurate detection is further fulfilled.

Referring to fig. 1, the membrane carrier 10 has a pivot 11 about which the membrane carrier 10 can pivot, and the pivot 11 is generally located on a vertical plane (a perpendicular bisector in the drawing, and a vertical plane in three dimensions) of the membrane carrier 10 in order to uniformly fuse the membrane and the antigen in the apparatus. The pivot 11 is also located on the fixing plate 12, the membrane carrier 10 is connected with the fixing plate 12 in a pivot fit manner through the pivot 11, and in order to ensure the installation stability and the rotation stability of the membrane carrier 10 on the fixing plate 12, two pivots 11 are provided, as shown in fig. 2. Specifically, be equipped with fixing base 121 on the fixed plate 12, be equipped with two on the fixing base 121 and support ear 122, all be equipped with through-hole 123 in two support ears 122, through-hole 123 is used for installing round pin 124, it is equipped with backup pad 125 still to overlap on the round pin 124, backup pad 125 connect in membrane load device 10. The pin 124 is the rotation pivot 11 of the film carrier 10 and the fixing seat 121, and is also the rotation center of the two.

Referring to fig. 1, the link mechanism 20 includes a first connecting structure 21, a second connecting structure 22 is connected to the first connecting structure 21 in a rotating fit manner, and a third connecting structure 24 is connected to the second connecting structure 22 in a rotating fit manner, wherein the first connecting structure 21 is connected to the rotating mechanism 30, and the third connecting structure 24 is connected to the film carrier 10. The first connecting structure 21, the second connecting structure 22 and the third connecting structure 24 may be three connecting rods, adjacent connecting rods are connected in a rotating fit manner, and the simplest rotating fit connecting manner is that a rotating shaft is inserted into a rotating fit position of the adjacent connecting rods. In this embodiment, since the first connecting structure 21 is connected to the motor in the rotating mechanism 30, if the first connecting structure 21 is a connecting rod, when the motor is in operation, the rotating shaft of the motor may receive extremely uneven load due to the gravity and centrifugal force of the first connecting structure 21, which may affect the service life of the motor, as a preferred technical solution, the first connecting structure 21 is disc-shaped, so that the gravity is distributed as uniformly as possible, which may reduce the uneven load received by the rotating shaft of the motor, and the disc-shaped first connecting structure 21 and the second connecting structure 22 rotatably and fittingly connected thereto form a structure similar to an eccentric wheel.

Preferably, the film carrier 10 is generally rectangular, and in order to make the film carrier 10 uniformly stressed when the motor in the rotating mechanism 30 is started, the third connecting structure 24 is located on a middle vertical plane of the film carrier 10 along the long side direction, as shown in fig. 2. It should be noted that the third connecting structure 24 is disposed eccentrically, as shown in fig. 1, that is, the third connecting structure 24 cannot be located on the connecting line between the two rotation fulcrums 11, because the rotating mechanism 30 cannot drive the film carrier 10 to perform a swinging motion when the third connecting structure 24 is located on the connecting line between the two rotation fulcrums 11. Further, the greater the distance from the third connecting structure 24 to the pivot point 11, i.e., the greater the eccentric distance, the smaller the maximum swing amplitude of the film carrier 10, all other things being equal.

In the automatic egg white imprinting appearance of conventionality, the servo motor that uses, its servo motor's output shaft and the rotation fulcrum 11 that the membrane bore manufacturing 10 are connected, in order to realize the action of swaing, need to input forward pulse, reverse pulse signal to servo motor, very loaded down with trivial details, servo motor's high price has improved the cost of egg white imprinting appearance greatly simultaneously. In the present invention, under the action of the link mechanism 20, the motor in the rotating mechanism 30 only needs to rotate in one direction to control the film carrier 10 to perform a swing operation, and there is no need to repeatedly input a forward pulse and a reverse pulse signal, which is much more convenient; meanwhile, after repeated forward pulse and reverse pulse signals are not required to be input, the rotating precision of the motor during working is not required, the servo motor can be replaced by a common stepping motor, the cost of the stepping motor is far lower than that of the servo motor, and the manufacturing cost of the automatic protein tracing machine is obviously reduced.

Preferably, for the convenience of counting the number of times of swinging that the inner membrane of the device bears and makes 10, be equipped with an opto-coupler separation blade 14 on link mechanism 20, correspond to it, still be equipped with an opto-coupler induction structure 15 in the device, along with slewing mechanism 30 starts the drive link mechanism 20 moves, every round of motor in slewing mechanism 30, on link mechanism 20 opto-coupler separation blade 14 just once (shelter from once) opto-coupler induction structure 15 carries out a count. Further, as shown in fig. 1, the optical coupling blocking piece 14 is installed on the second connecting structure 22, when the film carrying device 10 is located at a horizontal position, the right end of the optical coupling blocking piece 14 just covers the optical coupling inductor 15, and the optical coupling inductor 15 is located on a necessary path in the movement process of the optical coupling blocking piece 14.

Preferably, the motor in the rotating mechanism 30 is kept stationary to ensure that the parameters of amplitude, frequency, angle, etc. of each oscillation of the film carrier manufacturing 10 are kept consistent. In this embodiment, the fixed plate 12 is stationary, so the rotating mechanism 30 can be mounted on the fixed plate 12. Specifically, install first mounting panel 16 on fixed plate 12, first mounting panel 16 is L shape, motor 17 can be installed to first mounting panel 16, the output shaft of motor 17 first connection structure 21. And a second mounting plate 18 is arranged on the first mounting plate 16, and the second mounting plate 18 is used for mounting the optical coupling induction structure 15.

Preferably, the rotating mechanism 30 is located at a lower side position of the third connecting structure 24 when the film carrier manufacturing 10 is in a horizontal state. Further, the rotating shaft of the motor 17 in the rotating mechanism 30 is located at a position right below the third connecting structure 24, that is, a connecting line between the third connecting structure 24 and the rotating shaft of the motor 17 is in a vertical state.

Preferably, the present invention has at least four rotation pairs, which are a rotation pair of a motor in the rotation mechanism 30, a rotation pair between the first connection structure 21 and the second connection structure 22, a rotation pair between the second connection structure 22 and the third connection structure 24, and a rotation pair at the position of the rotation fulcrum 11. These revolute pairs all require high frequency rotation during operation of the western blotting apparatus, for example, at the position of the fulcrum 11, the membrane carrier 10 is repeatedly swung around the fulcrum 11, in order to improve the smoothness of rotation, sliding elements 13 are provided between the pin 124 and the two support lugs 122, and between the pin 124 and the support plate 125, most commonly the sliding elements 13 are rolling bearings, it has the advantages of low cost, stable operation, and the like, but also has the problem of frequent need of lubricating oil or lubricating grease, is more complicated, if the lubricating oil or the lubricating grease is not added in time, the bearing materials can be peeled off, the bearing flanges can be scratched, resulting in overheating of the rollers, extreme localized heating that can generate metal flow in the bearing, altering the original material and geometry of the bearing, eventually leading to excessive roller tilting, cage damage and complete bearing lock-up. Therefore, in these environments of high-frequency rotation, if a rolling bearing is selected, a technician is required to check and maintain the rolling bearing regularly, which is cumbersome.

In the present embodiment, the sliding member 13 is a sliding bearing (press-fit bearing) made of a special engineering plastic, and the thermoplastic base plastic material meeting the requirement is screened, and the material is usually added with reinforcing fibers to enhance the compressive strength, and is also added with solid grease for optimizing the wear resistance. These solid lubricating particles "embedded" in the matrix material are of paramount importance for the requirements of "dry running". In operation, sliding bearings typically release thousands of solid lubricant particles stored in a matrix material, due to pressure and motion, onto the contact surfaces of the shaft and bearing, sufficient to provide sufficient solid lubrication of the contact surfaces to achieve dry running. The sliding bearing made of engineering plastics has a series of characteristics of high wear resistance, dust resistance, dirt resistance, lubrication free, maintenance free and the like, is particularly suitable for the device, technical personnel do not need to maintain regularly, maintenance cost is reduced, and the service life of the whole device is greatly prolonged. In particular, the plain bearing of iglidur, germany, can be used. Here, the rotation pair at the position of the rotation fulcrum 11 is taken as an example, and the rotation pairs at other positions can adopt the similar structure.

In the automatic egg white mark appearance among the prior art the operation that sways that membrane load device 10 carried out is controlled by servo motor input forward pulse, reverse pulse signal, works as when membrane load device 10 moves to extreme position to one side, need switch over at once and input a reverse pulse signal and make it move to the opposite side, avoid membrane load device 10 excessively moves to one side, the condition that the reagent spills out appears. Then, when the two pulse signals are switched, there is a moment of sudden change of the signals, at this moment, the membrane carrier 10 suddenly moves in the reverse direction, but the reagent in the membrane carrier 10 has inertia to move in the original direction, the opposite impact of the two is very easy to cause the reagent in the membrane carrier 10 to splash, in order to solve this problem, a technician usually starts to reduce the input pulse signal when the membrane carrier 10 moves to a limit position quickly, so that the sudden change process is as gentle as possible, and after the membrane carrier 10 passes the limit position, starts to amplify a reverse pulse signal, so that the whole control process of accelerating the membrane carrier 10 to reversely swing … … is very tedious, and the manufacturing cost of the device is increased again.

In order to highlight the advantages of the rocking mechanism of the present invention, motion simulation is performed on several core components in the rocking mechanism, referring to fig. 4-9, a component 1 corresponds to the first connecting structure 21, a component 2 corresponds to the second connecting structure 22, a component 3 corresponds to the membrane carrier 10, a component 4 corresponds to the fixing plate 12, an arrow 5 corresponds to the speed (vector) of the edge position of the membrane carrier 10, the length of the arrow 5 corresponds to the speed, and the direction of the arrow 5 corresponds to the speed direction.

Now, the part 1 is endowed with an angular speed of 15r/min, namely 15 turns per minute, and the attached figure 4 is a power (angular speed) input curve of the part 1; figure 5 is a graph of the power (angular velocity) output of the part 4 about its fulcrum.

Referring to fig. 6, the state is the moving speed of the edge of the part 3 (arrow 5 position, the same below) when the part is in the horizontal state; referring to fig. 7, the state is the moving speed of the edge of the part 3 at the nearly right limit state after 1 second from the state of fig. 6; referring to fig. 8, the state is the state of fig. 7, after 1 second, the moving speed of the edge of the part 3 is nearly horizontal; referring to fig. 9, the state is the moving speed of the edge of the part 3 at the nearly left limit state after 1 second from the state of fig. 8.

As can be clearly seen in conjunction with fig. 5 and the schematic views of fig. 6-9 in various states: when the part 3 is in a horizontal state, referring to fig. 6 and 8, the reagent in the part is not easy to leak because the part 3 is stably placed, and at this time, a larger rotation speed is expected to be given to the part 3, which is helpful for allowing the membrane in the part 3 to perform a sufficient fusion reaction with the antigen, in the present invention, the arrow 5 corresponding to fig. 6 and 8 is longer, the corresponding instantaneous speed in fig. 5 is close to the maximum value of the rotation speed, and the swing mechanism of the present invention can just give a larger movement speed to the part 3 when the part 3 is in the horizontal state, namely, a larger angular speed is given to the position of the rotation fulcrum of the part 3 (the rotation fulcrum 11 of the membrane bearing device 10); when the component 3 is in the left limit state or the right limit state, referring to fig. 7 and 9, the reagent in the component is easy to leak because the component 3 is in the inclined state, and in the two states, the component 3 immediately swings reversely, which promotes the reagent to leak, so that in order to avoid the leakage, a small rotating speed is expected to be given to the component 3, so that the conversion process is as gentle as possible, whereas in the invention, the arrow 5 corresponding to fig. 7 and 9 is short, and the corresponding instantaneous rotating speed in fig. 5 is close to 0, so that the speed reduction near the limit position is perfectly realized, and the required speed of the invention can be well realized.

Through the swing structure of the invention, the higher requirement on the motor in the rotating mechanism 30 is not required any more, and meanwhile, according to the lever principle, because the rotating mechanism 30 drives the third connecting structure 24, and the third connecting structure 24 is arranged eccentrically, compared with the traditional swing mechanism motor which is directly output to the rotating fulcrum 11, the motor in the invention does not need a large rotating moment; in addition, the invention does not need to carry out complex control on the motor, such as the control on the rotating speed and the rotating direction of the motor at each moment, and only needs to select the conventional stepping motor under a delicate mechanical structure, thereby being capable of greatly reducing the production cost of the protein track plotter. Preferably, the swing structure provided by the invention is provided with multi-gear speed regulation, and is suitable for various working environments or different working requirements.

The above description is only an embodiment of the invention, but the scope of the invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the invention, and therefore, the scope of the invention should be subject to the scope defined by the claims.

Claims (10)

1. A swing mechanism in a protein track plotter is characterized by comprising a film bearing device, a connecting rod mechanism and a rotating mechanism, wherein the rotating mechanism is a driving part in the swing mechanism and is used for providing kinetic energy for the swing mechanism; the rotating mechanism is connected with the connecting rod mechanism and can drive the connecting rod mechanism to move; the connecting rod mechanism is connected with the film bearing device, and the rotating mechanism can drive the film bearing device to move through the connecting rod mechanism, so that the film bearing device can swing repeatedly.

2. The wobble mechanism of claim 1, wherein the film carrier has a pivot point about which the film carrier can rotate.

3. The wobble mechanism of claim 2, wherein the pivot point is located on a vertical plane of the membrane carrier.

4. The rocking mechanism in a protein track plotter of claim 2, wherein the pivot is located on a fixed plate, and the membrane bearing device is connected with the fixed plate in a rotationally matched manner through the pivot.

5. The mechanism of claim 4, wherein the fixed plate is provided with a fixed seat, the fixed seat is provided with two support ears, the two support ears are provided with through holes, the through holes are used for installing pins, the pins are further sleeved with support plates, the support plates are also provided with through holes, the support plates are connected with the film bearing device, and the pins are located on the rotation fulcrums of the fixed seat and the film bearing device.

6. The mechanism of claim 5, wherein a sliding member is provided between the pin and the support lug and/or between the pin and the support plate, wherein the sliding member is a rolling bearing or a sliding bearing made of engineering plastic.

7. The wobble mechanism of claim 1, wherein the linkage comprises a first linkage, a second linkage, and a third linkage; the first connecting structure is connected with the second connecting structure in a rotating fit mode, the second connecting structure is connected with the third connecting structure in a rotating fit mode, the first connecting structure is connected with the rotating mechanism, and the third connecting structure is connected with the film bearing device.

8. The wobble mechanism of claim 7, wherein said first connecting structure is disk-shaped.

9. The wobble mechanism of claim 7, wherein the third attachment structure is located on a vertical plane perpendicular to the longitudinal axis of the film carrier.

10. The wobble mechanism of claim 7, wherein the rotation mechanism is located on the underside of the third attachment structure when the film carrier is manufactured horizontally.

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