CN114364790A - T细胞的产生方法 - Google Patents

T细胞的产生方法 Download PDF

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Publication number
CN114364790A
CN114364790A CN202080059142.9A CN202080059142A CN114364790A CN 114364790 A CN114364790 A CN 114364790A CN 202080059142 A CN202080059142 A CN 202080059142A CN 114364790 A CN114364790 A CN 114364790A
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cells
cell
tcr
population
icos
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Chinese (zh)
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C·盖根
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Adaptimmune Ltd
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Adaptimmune Ltd
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/165—Vascular endothelial growth factor [VEGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Hematology (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
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CN202080059142.9A 2019-08-20 2020-08-20 T细胞的产生方法 Pending CN114364790A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1911958.5A GB201911958D0 (en) 2019-08-20 2019-08-20 Methods of t cell production
GB1911958.5 2019-08-20
PCT/EP2020/073332 WO2021032836A1 (en) 2019-08-20 2020-08-20 Methods of t cell production

Publications (1)

Publication Number Publication Date
CN114364790A true CN114364790A (zh) 2022-04-15

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ID=68099410

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080059142.9A Pending CN114364790A (zh) 2019-08-20 2020-08-20 T细胞的产生方法

Country Status (9)

Country Link
US (1) US20220267729A1 (https=)
EP (1) EP4017966A1 (https=)
JP (1) JP2022545416A (https=)
KR (1) KR20220047376A (https=)
CN (1) CN114364790A (https=)
AU (1) AU2020332059A1 (https=)
CA (1) CA3150425A1 (https=)
GB (1) GB201911958D0 (https=)
WO (1) WO2021032836A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022241558A1 (en) * 2021-05-18 2022-11-24 The University Of British Columbia A method for producing blood progenitor and progenitor t cells, resulting cells and methods and uses thereof
GB202205572D0 (en) 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
GB202208545D0 (en) 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
IL320084A (en) * 2022-10-05 2025-06-01 Garuda Therapeutics Inc Pluripotent T cell populations derived from stem cells and their progenitors
GB202318950D0 (en) 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171148A1 (en) * 2002-12-10 2004-09-02 Schmitt Thomas M. Cell preparations comprising cells of the T cell lineage and methods of making and using them
WO2011097477A1 (en) * 2010-02-04 2011-08-11 The Trustees Of The University Of Pennsylvania Icos critically regulates the expansion and function of inflammatory human th17 cells
CN110325633A (zh) * 2016-09-23 2019-10-11 艾达普特免疫有限公司 免疫抑制抗性增强的t细胞
US20200010560A1 (en) * 2017-03-15 2020-01-09 Oxford Biomedica (Uk) Limited Method
US20200179451A1 (en) * 2017-07-19 2020-06-11 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
US20240124841A1 (en) * 2021-02-18 2024-04-18 Adaptimmune Limited Methods of producing haemogenic endothelial cells from pluripotent stem cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018005274A (es) * 2015-10-30 2019-09-19 The Regents Of The Universtiy Of California Metodos para la generacion de celulas-t a partir de celulas madre y metodos inmunoterapeuticos que utilizan las celulas-t.
EP3572502B1 (en) * 2017-01-20 2023-01-11 Kyoto University Method for producing cd8alpha +beta + cytotoxic t cells
CA3056942A1 (en) * 2017-03-29 2018-10-04 Sunnybrook Research Institute Engineered t-cell modulating molecules and methods of using same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171148A1 (en) * 2002-12-10 2004-09-02 Schmitt Thomas M. Cell preparations comprising cells of the T cell lineage and methods of making and using them
WO2011097477A1 (en) * 2010-02-04 2011-08-11 The Trustees Of The University Of Pennsylvania Icos critically regulates the expansion and function of inflammatory human th17 cells
CN110325633A (zh) * 2016-09-23 2019-10-11 艾达普特免疫有限公司 免疫抑制抗性增强的t细胞
US20200010560A1 (en) * 2017-03-15 2020-01-09 Oxford Biomedica (Uk) Limited Method
US20200179451A1 (en) * 2017-07-19 2020-06-11 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
US20240124841A1 (en) * 2021-02-18 2024-04-18 Adaptimmune Limited Methods of producing haemogenic endothelial cells from pluripotent stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G RICHTER等: "ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion", 《ONKOLOGIE》, vol. 27, no. 1, 29 February 2004 (2004-02-29), pages 91 - 95 *

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Publication number Publication date
US20220267729A1 (en) 2022-08-25
WO2021032836A1 (en) 2021-02-25
KR20220047376A (ko) 2022-04-15
JP2022545416A (ja) 2022-10-27
CA3150425A1 (en) 2021-02-25
AU2020332059A1 (en) 2022-03-24
EP4017966A1 (en) 2022-06-29
GB201911958D0 (en) 2019-10-02

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