CN114344557A - Hydrocolloid dressing containing cyclodextrin and preparation method thereof - Google Patents
Hydrocolloid dressing containing cyclodextrin and preparation method thereof Download PDFInfo
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- CN114344557A CN114344557A CN202210023202.2A CN202210023202A CN114344557A CN 114344557 A CN114344557 A CN 114344557A CN 202210023202 A CN202210023202 A CN 202210023202A CN 114344557 A CN114344557 A CN 114344557A
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- cyclodextrin
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- 238000002360 preparation method Methods 0.000 title claims abstract description 26
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a hydrocolloid dressing containing cyclodextrin and a preparation method thereof, and relates to the technical field of hydrocolloid dressings. The hydrocolloid dressing containing cyclodextrin mainly comprises the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride. The hydrocolloid dressing containing the cyclodextrin takes a double-spiral structure of xanthan gum as a framework, takes beta-cyclodextrin and polyacrylic acid as monomers, can also be taken as connecting substances of the beta-cyclodextrin and the xanthan gum, and takes azodiisopropyl imidazoline hydrochloride as an initiator to prepare the hydrocolloid dressing which has a hydrophobic channel, strong mechanical strength and can absorb wound odor in a matching way, so that the expected effect is achieved. In addition, the preparation method of the hydrocolloid dressing containing cyclodextrin can scientifically and reasonably set preparation conditions, so that the yield of the hydrocolloid dressing is high, and the hydrocolloid dressing is suitable for batch production.
Description
Technical Field
The invention relates to the technical field of hydrocolloid dressings, and particularly relates to a hydrocolloid dressing containing cyclodextrin and a preparation method thereof.
Background
Hydrocolloid dressings are those made by processing a mixture of an elastic polymeric hydrogel with synthetic rubber and an adhesive. Hydrocolloid dressings are widely used for superficial burns, partial cortical burns, donor-cortical wounds, post-operative wounds, skin abrasions, leg ulcers, pressure sores and the like, due to their characteristics of absorbing wound exudate, forming a closed wound, debriding and the like. In addition, the hydrocolloid dressing is suitable for children and the like.
However, hydrocolloid dressings have the characteristic of poor mechanical strength, are easy to break and have low use value when being influenced by external force.
Based on this, it is important to develop a hydrocolloid dressing with strong mechanical strength.
Disclosure of Invention
The invention aims to provide a hydrocolloid dressing containing cyclodextrin, which not only has stronger air permeability, but also has stronger mechanical property, is convenient to transport, store and carry, and has higher use value.
The invention also aims to provide a preparation method of the hydrocolloid dressing containing cyclodextrin, which can enable the yield of the hydrocolloid dressing to be higher and the cost performance to be lower.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the invention provides a hydrocolloid dressing containing cyclodextrin, which mainly comprises the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride.
On the other hand, the invention provides a preparation method of a hydrocolloid dressing containing cyclodextrin, which mainly comprises the following steps:
dissolving xanthan gum in water, heating to 80-95 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then mixing the mixed solution with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and reacting to prepare colloid; sintering the alginate fiber at 180-220 deg.C for 10-15 min, and grinding to obtain powder; mixing the powder and the colloid, homogenizing to obtain a mixture, and drying to obtain the hydrocolloid dressing.
The hydrocolloid dressing containing cyclodextrin and the preparation method thereof provided by the embodiment of the invention have at least the following beneficial effects:
on one hand, the invention provides a hydrocolloid dressing containing cyclodextrin, which mainly comprises the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride. The hydrocolloid dressing containing the cyclodextrin takes a double-spiral structure of xanthan gum as a framework, takes beta-cyclodextrin and polyacrylic acid as monomers, can also be taken as a connecting substance of the beta-cyclodextrin and the xanthan gum, and takes azodiisopropyl imidazoline hydrochloride as an initiator to prepare the hydrocolloid dressing with a hydrophobic channel and stronger mechanical strength in a matching way, thereby achieving the expected effect. Moreover, the hydrocolloid dressing containing cyclodextrin can effectively adsorb wound odor, and has good use effect.
On the other hand, the invention also provides a preparation method of the hydrocolloid dressing containing the cyclodextrin, and the preparation method can scientifically and reasonably set preparation conditions, so that the yield of the hydrocolloid dressing is higher, and the hydrocolloid dressing is suitable for batch production.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides a hydrocolloid dressing containing cyclodextrin, which mainly comprises the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride. The functions of the raw materials are as follows:
beta-cyclodextrin: beta-cyclodextrin is a white to yellowish powder, slightly sweet in taste, slightly sour in flavor, soluble in water, insoluble in ethanol and other organic solvents, with a slight aroma characteristic of pectin. Moreover, the beta-cyclodextrin has no hygroscopicity, so that when the beta-cyclodextrin is used as a raw material of the dressing, the stability of the dressing can be effectively enhanced, the storage life is prolonged, and the effect is good.
In addition, the beta-cyclodextrin is in a cone-shaped three-dimensional cylindrical shape, has a hollow structure, and shows the performances of hydrophilicity on the outer side of the cylinder and hydrophobicity on the inner side of the cylinder. Based on the situation, the beta-cyclodextrin and the colloid are combined, so that the beta-cyclodextrin is embedded among colloid molecules, a plurality of hydrophobic areas are formed among dressings, and the air permeability of the hydrocolloid dressings is further enhanced.
In addition, when the beta-cyclodextrin is combined with the colloid, the length of the colloid chain can be further increased, so that the mechanical property of the dressing is improved, the hydrophilic property of the dressing can be enhanced, and the absorption effect of the dressing on seepage is enhanced.
Xanthan gum: the xanthan gum is also called xanthan gum, is a microbial extracellular polysaccharide prepared by fermenting carbohydrate with xanthomonas campestris, and has good rheological property, water solubility, acid resistance, alkali resistance and heat resistance. Meanwhile, the xanthan gum is formed by reversely winding a side chain around a main chain framework and forming a rod-shaped double-spiral structure through a hydrogen bond system.
In the application, a rodlike double-spiral structure of xanthan gum is used as a framework, then phenolic hydroxyl groups and pyruvic acid groups in the xanthan gum are used as main reaction sites, and a macromolecular colloid is formed through ion exchange, so that the mechanical strength of the macromolecular colloid is enhanced, and an expected effect is achieved.
In addition, when the xanthan gum is used as an auxiliary material, the original advantageous characteristics of the xanthan gum can be kept, the mechanical strength of the xanthan gum can be enhanced, and the expected effect is achieved.
Polyacrylic acid: polyacrylic acid is also called acrylic acid homopolymer, and is weakly acidic, colorless or light yellow. Because polyacrylic acid is rich in a plurality of carboxylic acid functional groups, when the polyacrylic acid is used as one of raw materials of the dressing, the beta-cyclodextrin and the xanthan gum can be connected, so that the molecular structure of the hydrocolloid dressing not only has a hydrophobic channel, but also has a strong mechanical structure, and the use value is high.
Azodiisopropyl imidazoline hydrochloride: the azodiisopropyl imidazoline hydrochloride has the characteristics of being soluble in water and insoluble in organic solvents such as ethanol, toluene and the like, and can decompose two cationic free radicals in water, thereby achieving the effects of activating functional groups and initiating reaction. It is worth mentioning here that azodiisopropyl imidazoline hydrochloride does not cause side reaction in the reaction process, and the decomposition product is nontoxic and has good use effect.
In conclusion, the hydrocolloid dressing containing the cyclodextrin takes the double-spiral structure of the xanthan gum as a framework, takes the beta-cyclodextrin and the polyacrylic acid as monomers, can also be taken as connecting substances of the beta-cyclodextrin and the xanthan gum, and takes the azodiisopropyl imidazoline hydrochloride as an initiator to prepare the hydrocolloid dressing which has a hydrophobic channel and strong mechanical strength in a matching way, so as to achieve the expected effect. Moreover, the hydrocolloid dressing containing cyclodextrin can effectively adsorb wound odor, and has good use effect.
In the invention, the hydrocolloid dressing containing cyclodextrin also comprises 3-5 parts by weight of alginate fibers. The alginate fiber is a renewable green fiber with good biocompatibility, hygroscopicity and a certain antibacterial property. Furthermore, the alginate fiber is rich in seaweed components, so when the alginate fiber is used as one of raw materials of the hydrocolloid dressing, the hydrocolloid dressing can exert moisture absorption performance through contacting with the skin, and release the seaweed components, so that the skin has better moist feeling and tactile feeling.
In addition, in this application, when regarding alginate fiber as hydrocolloid dressing, can promote hydrocolloid dressing's hydrophilic performance to reinforcing hydrocolloid dressing is to the absorption effect of surface of a wound sepage, and then makes the surface of a wound be in airtight moist environment, does benefit to the surface of a wound healing.
It should be noted that, in the present application, the raw materials used in the hydrocolloid dressing are all biodegradable and have better biocompatibility, so the safety factor and environmental protection are better.
The invention also provides a preparation method of the hydrocolloid dressing containing cyclodextrin, which mainly comprises the following steps:
dissolving xanthan gum in water, heating to 80-95 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then mixing the mixed solution with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and reacting to prepare colloid; sintering the alginate fiber at 180-220 deg.C for 10-15 min, and grinding to obtain powder; mixing the powder and the colloid, homogenizing to obtain a mixture, and drying to obtain the hydrocolloid dressing.
Specifically, after dissolving xanthan gum in water, heating to 80-95 ℃, adding beta-cyclodextrin to fully disperse the beta-cyclodextrin in the solution, and initially reacting with pyruvic acid in the xanthan gum.
When the beta-cyclodextrin and the xanthan gum are uniformly mixed, polyacrylic acid can be added to prepare a mixed solution. When polyacrylic acid is added, the system temperature is still maintained at 80-95 ℃, so that the dispersion effect of the three raw materials in the mixed solution is better.
It should be noted here that the system can be maintained at 80-95 ℃ by means of water bath heating, so that the system temperature is stable and the preparation effect is good.
In the application, the ratio of xanthan gum to water is (10-13):1g/L before temperature rise, so that the copolymerization reaction can smoothly occur in a solvent, and the copolymerization effect is good. When moisture content is higher, the drying cost of hydrocolloid dressing is higher to make hydrocolloid dressing's price/performance ratio lower, and when moisture content is lower, in the water bath in-process, can influence going on smoothly of copolymerization behind the moisture loss, thereby influence hydrocolloid dressing's yield.
After the mixed solution is prepared, the mixed solution can be mixed with the initiator in the application in an oxygen-free environment to initiate copolymerization reaction, and colloid is prepared.
In the application, the oxygen-free environment can be selected as a nitrogen environment, so that the influence of oxygen in the system on the copolymerization reaction is avoided, and the yield is reduced.
In the application, the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride and reacts for 4 to 6 hours at the temperature of between 100 and 110 ℃ to prepare the colloid. Under such conditions, the copolymer can be smoothly produced. When the temperature is higher, the air pressure in the system is higher, and the cost of energy is higher; when the temperature is low, the environment cannot provide energy required by the reaction for the system, the reaction is incomplete, and the yield of the product is low.
In the present application, stirring may be performed during the reaction, and the stirring speed is 40rpm to 60 rpm. In the reaction process, the reaction is completed and the raw materials in the system are reacted with each other, and the mixture is stirred. When the stirring speed is high, the reaction process is easily broken, and when the stirring speed is low, the desired effect is not obtained.
In the application, the alginate fibers are sintered for 10min to 15min at the temperature of 180 ℃ to 220 ℃, and then ground to prepare powder. After the alginate fibers are sintered under the conditions, on one hand, the specific surface area of the alginate fibers can be increased, the effect between the alginate fibers and the colloid is improved, on the other hand, the number of pores of the alginate fibers can be increased, so that the air permeability of the hydrocolloid dressing is enhanced, and the use value is high.
Then, the powder is mixed with the colloid and homogenized to obtain a mixture. Wherein, the homogeneity can make the powder more evenly disperse in the colloid, forms the parcel structure, avoids hydrocolloid dressing quality discrepancy.
In the application, the homogenizing pressure is 3MPa-5MPa, and the homogenizing time is 30min-60 min. Xanthan gum has a high viscosity and a poor homogenization effect when the homogenization pressure is low, while unformed dressings are easily destroyed when the homogenization pressure is higher.
In the application, the particle size of the powder can be 500nm-800nm, so that the powder in the hydrocolloid dressing is uniformly dispersed, and the action effect is better.
And then drying the prepared mixture to prepare the hydrocolloid dressing with proper viscosity for external application.
In the application, the viscosity of the hydrocolloid dressing can be 60-75 pas, so that the situation that the hydrocolloid dressing has pain (pain is caused when the hydrocolloid dressing is torn off) when the viscosity is high and falls or is not sealed (the wound surface is not sealed) when the viscosity is low is avoided.
In the application, the mixture can be spun by an electrostatic spinning process and then ground to prepare a dressing layer. The dressing layer is prepared from the filamentous mixture prepared by electrostatic spinning, so that the air-permeable structure of the hydrocolloid dressing can be effectively enhanced, the moisture retention of the hydrocolloid dressing can be enhanced, and the application value is higher.
In the application, in the spinning process, the voltage is 25kv-30kv, and the flow rate of the mixture is 10mL/min-15 mL/min.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
35g of beta-cyclodextrin, 100g of xanthan gum, 70g of polyacrylic acid and 0.8g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water at a ratio of 12:1g/L, dissolving, heating to 85 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to obtain a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 5 hours at the temperature of 105 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 50 rpm. And drying the colloid to obtain the hydrocolloid dressing.
Example 2
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
50g of beta-cyclodextrin, 110g of xanthan gum, 90g of polyacrylic acid, 50g of alginate fiber and 1g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water according to the proportion of 13:1g/L, dissolving, heating to 95 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 4 hours at the temperature of 110 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 60 rpm.
Sintering alginate fiber at 220 deg.C for 10min, and grinding to obtain powder with particle size of 800 nm; mixing the powder and the colloid, homogenizing under 5MPa for 30min to obtain a mixture, and drying to obtain the hydrocolloid dressing with viscosity of 60Pa & s.
Example 3
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
20g of beta-cyclodextrin, 90g of xanthan gum, 50g of polyacrylic acid, 30g of alginate fiber and 0.5g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water at a ratio of 12:1g/L, dissolving, heating to 80 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 4 hours at the temperature of 100 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 40 rpm.
Sintering alginate fiber at 180 deg.C for 15min, and grinding to obtain powder with particle size of 500 nm; mixing the powder and the colloid, homogenizing under 3MPa for 60min to obtain a mixture, and drying to obtain the hydrocolloid dressing with the viscosity of 75Pa & s.
Example 4
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
30g of beta-cyclodextrin, 95g of xanthan gum, 60g of polyacrylic acid, 35g of alginate fiber and 0.6g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water in a ratio of 10.5:1g/L, dissolving, heating to 85 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 5 hours at the temperature of 105 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 50 rpm.
Sintering the alginate fiber at 200 deg.C for 12min, and grinding to obtain powder with particle size of 600 nm; mixing the powder and the colloid, and homogenizing under 4MPa for 50min to obtain a mixture; and (3) carrying out electrostatic spinning on the mixture under the condition of 25kv, wherein the flow rate of the mixture is 13mL/min, preparing a dressing layer, and adjusting the viscosity to 65Pa s to obtain the hydrocolloid dressing.
Example 5
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
35g of beta-cyclodextrin, 100g of xanthan gum, 70g of polyacrylic acid, 40g of alginate fiber and 0.8g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water at a ratio of 12:1g/L, dissolving, heating to 85 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to obtain a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 5 hours at the temperature of 105 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 50 rpm.
Sintering the alginate fiber at 200 deg.C for 12min, and grinding to obtain powder with particle size of 600 nm; mixing the powder and the colloid, and homogenizing under 4MPa for 50min to obtain a mixture; and (3) carrying out electrostatic spinning on the mixture under the condition of 28kv, wherein the flow rate of the mixture is 10mL/min, preparing a dressing layer, and adjusting the viscosity to 65Pa s to obtain the hydrocolloid dressing.
Example 6
The purpose of this example is to provide a hydrocolloid dressing containing cyclodextrin, including the following raw materials:
35g of beta-cyclodextrin, 100g of xanthan gum, 70g of polyacrylic acid, 40g of alginate fiber and 0.8g of azodiisopropyl imidazoline hydrochloride.
The preparation method of the hydrocolloid dressing containing cyclodextrin comprises the following steps:
mixing xanthan gum and water at a ratio of 12:1g/L, dissolving, heating to 85 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to obtain a mixed solution; then the mixed solution is mixed with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and the mixture reacts for 5 hours at the temperature of 105 ℃ to prepare colloid, and the colloid is stirred in the reaction process, and the stirring speed is 50 rpm.
Sintering the alginate fiber at 200 deg.C for 12min, and grinding to obtain powder with particle size of 600 nm; mixing the powder and the colloid, and homogenizing under 4MPa for 50min to obtain a mixture; and (3) carrying out electrostatic spinning on the mixture under the condition of 30kv, wherein the flow rate of the mixture is 15mL/min, preparing a dressing layer, and adjusting the viscosity to 65Pa s to obtain the hydrocolloid dressing.
Example 7
The hydrocolloid dressing prepared in example 1 was compounded with a non-woven fabric (non-adhesive) to prepare an external patch.
Example 8
The hydrocolloid dressing prepared in example 3 was compounded with a non-woven fabric (non-adhesive) to prepare an external patch.
Example 9
The hydrocolloid dressing prepared in example 4 was compounded with a non-woven fabric (non-adhesive) to prepare an external patch.
Examples of effects
The hydrocolloid dressings prepared in examples 1 to 6 were used as samples and tested for mechanical strength, water absorption, air permeability and stability, the results of which are shown in table 1.
The test method specifically comprises the following steps:
mechanical strength: carrying out compression and cyclic compression tests on the sample on an instron5848, wherein the compression rate is 0.5 mm/min;
water absorption performance: reference is made to YY/T0471.1-2004 standard;
air permeability: reference is made to YY/T0148-2006 standard;
stability: placing the sample in a hydrochloric acid solution (the pH value is 4.3) to be soaked for 3 hours, and observing whether the sample changes; placing the sample at 40 ℃ for 24h, and observing the change of the sample;
the comparative example setup was as follows:
comparative example 1: the difference from the example 3 is that the content of xanthan gum is increased by 50g without beta-cyclodextrin, the other parameters are the same, and the preparation steps are consistent;
comparative example 2: the difference from example 3 is that the xanthan gum was replaced with gelatin, the remaining parameters were the same, and the preparation procedure was consistent.
Table 1 hydrocolloid dressing test results
As can be seen from the above table, in the present application, since the hydrocolloid dressing uses xanthan gum as a framework, the mechanical strength is strong, and when β -cyclodextrin is contained therein, the air permeability effect is strong, and the use value is high. Meanwhile, the water absorption performance and the stability are good, and the water absorption agent is suitable for use.
In summary, in one aspect, the invention provides a hydrocolloid dressing containing cyclodextrin, which mainly comprises the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride. The hydrocolloid dressing containing the cyclodextrin takes a double-spiral structure of xanthan gum as a framework, takes beta-cyclodextrin and polyacrylic acid as monomers, can also be taken as a connecting substance of the beta-cyclodextrin and the xanthan gum, and takes azodiisopropyl imidazoline hydrochloride as an initiator to prepare the hydrocolloid dressing with a hydrophobic channel and stronger mechanical strength in a matching way, thereby achieving the expected effect. Moreover, the hydrocolloid dressing containing cyclodextrin can effectively adsorb wound odor, and has good use effect.
On the other hand, the invention also provides a preparation method of the hydrocolloid dressing containing the cyclodextrin, and the preparation method can scientifically and reasonably set preparation conditions, so that the yield of the hydrocolloid dressing is higher, and the hydrocolloid dressing is suitable for batch production.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The hydrocolloid dressing containing cyclodextrin is characterized by comprising the following raw materials in parts by weight: 2-5 parts of beta-cyclodextrin, 9-11 parts of xanthan gum, 5-9 parts of polyacrylic acid and 0.05-0.1 part of azodiisopropyl imidazoline hydrochloride.
2. Hydrocolloid dressing containing cyclodextrin as claimed in claim 1, characterized in that it further comprises 3-5 parts by weight of alginate fibres.
3. A method of preparing a hydrocolloid dressing containing cyclodextrin as claimed in claim 2, comprising the steps of:
dissolving xanthan gum in water, heating to 80-95 ℃, adding beta-cyclodextrin, mixing, and adding polyacrylic acid solution to prepare a mixed solution; then mixing the mixed solution with azodiisopropyl imidazoline hydrochloride in an oxygen-free environment, and reacting to prepare colloid;
sintering the alginate fibers at 180-220 ℃ for 10-15 min, and grinding to obtain powder; and mixing and homogenizing the powder and the colloid to obtain a mixture, and drying to obtain the hydrocolloid dressing.
4. The method of claim 3, wherein the ratio of xanthan gum to water is (10-13):1g/L before warming.
5. The preparation method according to claim 3, wherein the colloid is prepared by mixing the mixed solution with azodiisopropyl imidazoline hydrochloride and reacting at 100-110 ℃ for 4-6 h.
6. The production method according to claim 5, wherein stirring is performed during the reaction, and the stirring speed is 40rpm to 60 rpm.
7. The method according to claim 3, wherein the particle size of the powder is 500nm to 800 nm.
8. The method according to claim 3, wherein the homogenization pressure is 3MPa to 5MPa, and the homogenization time is 30min to 60 min.
9. The method according to any one of claims 3 to 8, wherein the mixture is spun by an electrospinning process and then ground to prepare a coating layer.
10. The method of claim 9, wherein the voltage is 25kv to 30kv and the flow rate of the mixture is 10mL/min to 15mL/min during spinning.
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