CN114344314A - Preparation process and application of glucosamine composition - Google Patents
Preparation process and application of glucosamine composition Download PDFInfo
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- CN114344314A CN114344314A CN202210005382.1A CN202210005382A CN114344314A CN 114344314 A CN114344314 A CN 114344314A CN 202210005382 A CN202210005382 A CN 202210005382A CN 114344314 A CN114344314 A CN 114344314A
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Abstract
The invention discloses a preparation process and application of a glucosamine composition, wherein the method comprises the following steps: (1) mixing gelatin solution and glucosamine or pharmaceutically acceptable salt thereof, and stirring to obtain glucosamine solution. (2) And (3) feeding the glucosamine glue solution into granulation equipment for granulation to obtain glucosamine particles. (3) And uniformly mixing the glucosamine particles, the ethyl cellulose powder and the ethanol to ensure that the ethyl cellulose is coated on the surfaces of the glucosamine particles to form a hydrated gel layer, and then drying to obtain the glucosamine composition. The glucosamine is dispersed in the gelatin to prepare the glucosamine particles, and the glucosamine particles can gradually release the glucosamine in the glucosamine particles along with digestion after entering gastric juice, so that the aim of controlled release is fulfilled, the glucosamine in the glucosamine particles is gradually released, the stability of the concentration of the glucosamine in the gastric juice is further maintained, the long-term drug effect is kept, and the treatment effect is improved.
Description
Technical Field
The invention belongs to the technical field of glucosamine preparations, and particularly relates to a preparation process and application of a glucosamine composition.
Background
Glucosamine is an important component of proteoglycan with extremely strong hydrophilicity, can promote the growth of a large amount of joint synovial fluid for human bodies, thereby constantly lubricating the layer surface of the joint cartilage, repairing the damaged cartilage, reducing the abrasion and relieving the joint pain, and also has a good repairing effect on the joint cartilage damage caused by long-term taking of anti-inflammatory drugs. Currently, glucosamine is prepared into products in various dosage forms for patients to take. However, glucosamine is characterized by unstable chemical properties, easy moisture absorption and deterioration after long-term exposure to air, and loss of glucosamine products due to oxidative decomposition and discoloration, which can reduce the effective drug loading of glucosamine products. In addition, the prior glucosamine product is difficult to maintain stable drug supply for a long time after being taken, but is decomposed in the stomach in a short time, so that the concentration of glucosamine in gastric juice is rapidly increased, the stomach is easily stimulated to have uncomfortable feeling, the treatment effect is poor, and the glucosamine does not exert the due effect.
Disclosure of Invention
In view of the problems in the prior art, the invention provides a preparation process and application of a glucosamine composition, wherein the glucosamine composition can be gradually released after entering the stomach, and the stable output of the glucosamine concentration in gastric juice for a long time is ensured. Specifically, the technical scheme of the invention is as follows:
firstly, the invention discloses a preparation method of a glucosamine composition, which comprises the following steps:
(1) mixing gelatin solution and glucosamine or pharmaceutically acceptable salt thereof, and stirring to obtain glucosamine solution.
(2) Feeding the glucosamine glue solution into granulation equipment for granulation to obtain glucosamine particles; wherein: the granulation apparatus comprises: the device comprises a solidification tank, an extrusion cylinder, a driving motor, a rotating shaft, a cutting knife, an air pressure pressurization pipe and a pressure stabilizing valve. The extruding cylinder and the driving motor are fixed on the top surface of the solidification tank, the conical extruding opening of the extruding cylinder is located below the ethanol liquid level in the inner cavity of the solidification tank, the upper end of the rotating shaft is connected with the motor shaft of the driving motor, and the rotating shaft is located in the inner cavity of the solidification tank. The cutting knife is horizontally fixed on the rotating shaft, and the cutting knife is positioned below the conical extrusion port of the extrusion barrel and is arranged adjacently to the conical extrusion port. The air pressure pressurization pipe and the pressure stabilizing valve are both arranged on the top surface of the extrusion barrel and communicated with the inner cavity of the extrusion barrel, a feeding pipe is further arranged on the top surface of the extrusion barrel, and a switch valve is arranged on the feeding pipe. And the lower part of the side wall of the solidification tank and the conical bottom are respectively provided with a filtering port and a discharge port. When in granulation, the glucosamine glue solution is sent into an extrusion cylinder from a feeding pipe, and hot air is blown into the extrusion cylinder through an air pressure pressurization pipe, so that the glucosamine glue solution is extruded from an extrusion port under the assistance of the self weight and the air pressure of the glucosamine glue solution, cut into granules by a cutting knife rotating along with the rotating shaft, solidified in ethanol solution, and then the glucosamine granules are led out from a discharge port and dried for later use.
(3) And uniformly mixing the glucosamine particles, the ethyl cellulose powder and the ethanol to ensure that the ethyl cellulose is coated on the surfaces of the glucosamine particles to form a hydrated gel layer, and then drying to obtain the glucosamine composition.
Further, in the step (1), the preparation method of the gelatin glue solution comprises the following steps: and soaking the gelatin granules in cold water for 10-15 minutes, heating in a water bath to 50-55 ℃, preserving heat, and continuously stirring until the gelatin is melted into a gelatin solution to obtain the gelatin-containing material.
Further, in the step (1), the pharmaceutically acceptable salt of glucosamine includes at least one of glucosamine hydrochloride, glucosamine sulfate and glucosamine double salt.
Further, in the step (1), the mass ratio of the gelatin glue solution to the glucosamine or the pharmaceutically acceptable salt thereof is 2.5-3.7: 1, mixing the glucosamine and the gelatin, the glucosamine can be dispersed in gelatin liquid, so that the glucosamine particles obtained after granulation have the slow-release characteristic.
Further, in the step (2), the rotating shaft is also connected with a paddle which is positioned below the cutting knife, so that the cut glucosamine particles are dispersed, and the glucosamine particles are prevented from being bonded together before solidification.
Further, in step (2), the pressure maintaining valve includes: pressure release pipe, slide bar, floater and keeping off the head. Wherein: the pressure release pipe is vertically fixed on the top surface of the extrusion cylinder and is communicated with the inner cavity of the extrusion cylinder. The sliding rod is vertically fixed at the center of the pressure release pipe, the floating ball is sleeved on the sliding rod in a sliding mode, and the floating ball is supported at the upper end opening of the pressure release pipe to be sealed.
Furthermore, the floating ball is a stainless steel or plastic hollow ball, and the floating ball can be pushed upwards to separate after the air pressure in the extrusion cylinder exceeds the weight of the floating ball, so that the air pressure in the extrusion cylinder is released in time.
Furthermore, a support rod is fixed at the lower port of the pressure release pipe, and the lower end of the slide rod is fixed on the support rod.
Further, in the step (2), an external port of the air pressure pressurization pipe is connected with a blower, and a heater is arranged in the blower so as to heat the introduced air, and then the air is sent into the extrusion cylinder to be used as the extrusion power of the glue solution, and the glue solution is helped to maintain the temperature, so that good fluidity is maintained.
Further, the heater is an electric heating net, and the air can be heated to a preset temperature by setting heating power. Preferably, the air temperature is 50-55 ℃.
Further, the air blower is connected with the filter so as to filter the introduced air and prevent the ammonia sugar glue solution from being polluted.
Further, the top wall of the solidification tank is connected with the pressure stabilizing valve to ensure that the air pressure in the solidification tank is normal.
Further, in the step (3), the proportion of the glucosamine particles, the ethyl cellulose powder and the ethanol is 1 part by weight: 3.2-3.7 parts by weight: 5.5 to 7.5 parts by weight, and an appropriate proportion can be selected according to needs.
Further, in the steps (2) and (3), the drying temperature is controlled to be 30-35 ℃, and the time is 5-10 min, so that ethanol in the coating layer outside the glucosamine particles is removed.
Further, in the steps (2) and (3), the mass fraction of the ethanol is not less than 95% or is selected to be absolute ethanol, so that the glucosamine in the glucosamine particles can be prevented from being lost due to dissolution.
The invention further discloses application of the glucosamine composition obtained by the preparation method in the fields of chemical industry, biology, medical treatment and the like.
Compared with the prior art, the invention has the following beneficial effects: the glucosamine is dispersed in the gelatin to prepare the glucosamine particles, and the glucosamine particles can be gradually released along with digestion after entering gastric juice, thereby achieving the purpose of controlled release. Meanwhile, the coating layer formed by coating the ethyl cellulose on the surface of the glucosamine particles can be hydrated to form a hydration layer after entering the gastric juice and meeting water, so that the glucosamine particles float in the gastric juice, and the hydration layer also plays a slow release role as a skeleton, so that the glucosamine in the glucosamine particles is gradually released through the skeleton, the stability of the concentration of the glucosamine in the gastric juice is further maintained, the long-term drug effect is kept, and the treatment effect is improved.
Furthermore, in order to realize the preparation of the glucosamine particles, the invention provides special granulation equipment, the device conveys the glucosamine glue solution into an extrusion cylinder and then extrudes the glucosamine glue solution into an ethanol solution by using hot air as power, and the technical advantage is that two components, namely the glucosamine and the gelatin in the glucosamine glue solution are not dissolved in the ethanol, so that the loss caused by dissolving the glucosamine can not be caused, and meanwhile, the gelatin on the surface layer of the glucosamine is quickly solidified into a shell under the denaturation action of the ethanol, so that the particles cut by a cutting knife can be effectively prevented from being bonded with each other. Simultaneously, utilize the fast rotatory cutting knife of money and the cooperation of extruding cylinder to carry out grain cutting high-efficiently to solidify the shaping fast in the ethanol environment, high-efficient swift.
Furthermore, in order to ensure the pressure balance in the extrusion cylinder during granulation, the invention also provides a pressure stabilizing valve which utilizes the acting force between the self weight of the floating ball and the air pressure to balance the air pressure in the extrusion cylinder, and plays an important role in the process of adopting hot air as extrusion power, because in order to avoid that the ethanol in the solidification tank flows backwards into the extrusion cylinder after the extrusion is finished, the gas needs to be continuously introduced into the extrusion cylinder to ensure that the pressure in the extrusion cylinder is always kept positive, but the continuously introduced gas can cause the gas to finally overcome the hydraulic pressure of the ethanol in the solidification tank and enter the solidification tank. After the pressure stabilizing valve is adopted, compared with the work required to be done for overcoming the hydraulic pressure of the ethanol in the solidification tank, the floating ball in the pressure stabilizing valve is easier to overcome, so that the gas continuously introduced into the extrusion cylinder can be released through the pressure stabilizing valve again, and the floating ball in the pressure stabilizing valve has the effect of adjusting the opening size of the pressure release pipe at any time by even more the pressure in the extrusion cylinder, so that the pressure in the extrusion cylinder can be always kept balanced, the positive pressure in the extrusion cylinder is kept, and the reverse flow of the ethanol in the solidification tank can be avoided. And when the glucosamine glue solution is added into the extrusion cylinder, the extruded enterprise can also discharge the glucosamine glue solution through the pressure stabilizing valve in time, so that the air pressure in the extrusion cylinder is not influenced by the ammonia sugar glue solution. And the hot air is adopted as the extrusion power to ensure the good fluidity of the glucosamine gel solution.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
FIG. 1 is a schematic structural view of a granulation apparatus in an embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a pressure maintaining valve in an embodiment of the invention.
Fig. 3 is a schematic structural diagram of a pressure relief tube in an embodiment of the invention.
The scores in the above figures represent: the device comprises a solidification tank 1, an extrusion cylinder 2, a driving motor 3, a rotating shaft 4, a cutting knife 5, an air pressure pressurization pipe 6, a pressure stabilizing valve 7, a pressure releasing pipe 7.1, a sliding rod 7.2, a floating ball 7.3, a stopper 7.4, a supporting rod 7.5, a feeding pipe 8, a switch valve 9, a filtering port 10, a discharging port 11, a blade 12, an air blower 13 and an air filter 14.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. The invention will now be further illustrated by specific examples.
Example 1
With reference to fig. 1 to 3, a granulation apparatus for granulating a glucosamine sol is illustrated, comprising: the device comprises a solidification tank 1, an extrusion cylinder 2, a driving motor 3, a rotating shaft 4, a cutting knife 5, an air pressure pressurization pipe 6 and a pressure stabilizing valve 7.
Wherein: and the lower part of the side wall of the solidification tank 1 and the conical bottom are respectively provided with a filter opening 10 and a discharge opening 11. The extruding cylinder 2 and the driving motor 3 are both fixed on the top surface of the solidification tank 1, the conical extruding opening of the extruding cylinder 2 is positioned below the ethanol liquid level in the inner cavity of the solidification tank 1, the upper end of the rotating shaft 4 is connected with the motor shaft of the driving motor 3, and the rotating shaft 4 is positioned in the inner cavity of the solidification tank 1. The rotating shaft 4 is also connected with a paddle 12, and the paddle 12 is positioned below the cutting knife 5, so that the cut glucosamine particles are dispersed, and are prevented from being bonded together before solidification.
The cutting knife 5 is a stainless steel blade, one end of the cutting knife is horizontally fixed on the rotating shaft 4, and the cutting knife 5 is positioned below the conical extrusion port of the extrusion barrel 2 and is arranged adjacent to the conical extrusion port. And the air pressure pressurization pipe 6 and the pressure stabilizing valve 7 are both arranged on the top surface of the extrusion cylinder 2 and are communicated with the inner cavity of the extrusion cylinder 2. The top surface of the extrusion cylinder 2 is also provided with a feed pipe 8, and the feed pipe 8 is provided with a switch valve 9 so as to facilitate the feeding of the glucosamine solution into the extrusion cylinder 2.
Referring to fig. 2 and 3, the pressure maintaining valve 7 includes: pressure release pipe 7.1, slide bar 7.2, floater 7.3 and stop 7.4. Wherein: the pressure release pipe 7.1 is vertically fixed on the top surface of the extrusion cylinder 2 and is communicated with the inner cavity of the extrusion cylinder. A support rod 7.5 is fixed at the lower port of the pressure release pipe 7.1, the lower end of the slide rod 7.2 is fixed on the support rod 7.5, the slide rod 7.2 is vertically arranged at the center of the pressure release pipe 7.1, the floating ball 7.3 is sleeved on the slide rod 7.2 in a sliding manner, the floating ball 7.3 is supported at the upper port of the pressure release pipe 7.1 and is made into a stainless steel hollow ball by the floating ball 7.3, and the floating ball 7.3 can be pushed upwards after the air pressure in the extrusion cylinder 2 exceeds the weight of the floating ball 7.3, so that the air pressure in the extrusion cylinder 2 is released in time.
The outer port of the air pressure pressurization pipe 6 is connected with an air blower 13, an electric heating net is arranged in the air blower 13, and introduced air can be heated to a preset temperature such as 40-45 ℃ by setting heating power. Then sent into the extrusion cylinder 2 to be used as the extrusion power of the glue solution, and simultaneously, the glue solution is helpful to maintain the temperature, thereby maintaining good fluidity. The blower 13 is connected to an air filter 14 to filter the incoming air and prevent contamination of the ammonia sugar liquor. In addition, the top wall of the solidification tank 1 is connected with the pressure stabilizing valve 7 to ensure that the air pressure in the solidification tank 1 is normal.
Example 2
A preparation process of a glucosamine composition comprises the following steps:
(1) soaking gelatin granules in cold water for 10min, heating in water bath to 55 deg.C, keeping the temperature, and continuously stirring until gelatin melts into gelatin solution to obtain gelatin solution.
(2) Adding glucosamine hydrochloride into the gelatin liquid prepared in the step (1), and continuously stirring for 30min, wherein the mass ratio of the glucosamine hydrochloride to the gelatin liquid is 1: 3, obtaining the uniform glucosamine gel solution for later use.
(3) The glucosamine gel solution was sent to the granulation equipment in example 1 for granulation: when in granulation, the glucosamine liquid is fed into an extrusion cylinder 2 from a feeding pipe 8, hot air at 55 ℃ is blown into the extrusion cylinder 2 through an air pressure pressurization pipe 6 (the air flow rate is 0.5m/s), the glucosamine liquid is extruded into strips from an extrusion port of the extrusion cylinder 2 under the assistance of the self weight and the air pressure of the glucosamine liquid and is cut into granules by a cutting knife 5 rotating along with a rotating shaft 4 and is solidified in ethanol liquid, then the filtering port 10 is opened to discharge ethanol, then the discharge port 11 is opened to discharge the glucosamine granules, and the glucosamine granules are dried for 5min at 35 ℃ for standby.
(4) Mixing the glucosamine particles obtained by drying in the step (3), ethyl cellulose powder and 95% ethanol according to the weight ratio of 1 part: 3.5 parts by weight: mixing 6 parts by weight, stirring uniformly to wrap the ethyl cellulose on the surface of glucosamine particles to form a hydrated gel layer, then placing the hydrated gel layer in a drying oven at 30 ℃ for drying for 10min, and then blowing for 10min by cold air to obtain the glucosamine composition.
Example 3
A preparation process of a glucosamine composition comprises the following steps:
(1) soaking gelatin granules in cold water for 10min, heating in water bath to 50 deg.C, keeping the temperature, and continuously stirring until gelatin melts into gelatin solution to obtain gelatin solution.
(2) Adding glucosamine sulfate into the gelatin liquid prepared in the step (1), and continuously stirring for 30min, wherein the mass ratio of the glucosamine sulfate to the gelatin liquid is 1: 3.7, obtaining the uniform glucosamine gel solution for later use.
(3) The glucosamine gel solution was sent to the granulation equipment in example 1 for granulation: when in granulation, the glucosamine liquid is fed into an extrusion cylinder 2 from a feeding pipe 8, hot air at 50 ℃ is blown into the extrusion cylinder 2 through an air pressure pressurization pipe 6 (the air flow rate is 0.5m/s), the glucosamine liquid is extruded into strips from an extrusion port of the extrusion cylinder 2 under the assistance of the self weight and the air pressure of the glucosamine liquid and is cut into granules by a cutting knife 5 rotating along with a rotating shaft 4 and is solidified in ethanol liquid, then the filtering port 10 is opened to discharge ethanol, then the discharge port 11 is opened to discharge the glucosamine granules, and the glucosamine granules are dried for 10min at 30 ℃ for standby.
(4) Mixing the glucosamine particles obtained by drying in the step (3), ethyl cellulose powder and 95% ethanol according to the weight ratio of 1 part: 3.2 parts by weight: 5.5 parts by weight of the glucosamine composition is mixed and stirred evenly to ensure that the ethyl cellulose is wrapped on the surface of glucosamine particles to form a hydrated gel layer, then the hydrated gel layer is dried in a drying oven at the temperature of 30 ℃ for 10min, and then the mixture is blown by cold air for 10min to obtain the glucosamine composition.
Example 4
A preparation process of a glucosamine composition comprises the following steps:
(1) soaking the gelatin granules in cold water for 15 minutes, heating in water bath to 55 ℃, keeping the temperature, and continuously stirring until the gelatin is melted into gelatin liquid to obtain the gelatin liquid.
(2) Adding glucosamine hydrochloride into the gelatin liquid prepared in the step (1), and continuously stirring for 30min, wherein the mass ratio of the glucosamine hydrochloride to the gelatin liquid is 1: 2.5, obtaining the uniform glucosamine gel solution for later use.
(3) The glucosamine gel solution was sent to the granulation equipment in example 1 for granulation: when in granulation, the glucosamine liquid is fed into an extrusion cylinder 2 from a feeding pipe 8, hot air at 55 ℃ is blown into the extrusion cylinder 2 through an air pressure pressurization pipe 6 (the air flow rate is 0.8m/s), the glucosamine liquid is extruded into strips from an extrusion port of the extrusion cylinder 2 under the assistance of the self weight and the air pressure of the glucosamine liquid and is cut into granules by a cutting knife 5 rotating along with a rotating shaft 4 and is solidified in ethanol liquid, then the filtering port 10 is opened to discharge ethanol, then the discharge port 11 is opened to discharge the glucosamine granules, and the glucosamine granules are dried for 10min at 30 ℃ for standby.
(4) And (3) drying the glucosamine particles obtained in the step (3), ethyl cellulose powder and absolute ethyl alcohol according to the weight ratio of 1: 3.7 parts by weight: and 7.5 parts by weight of the glucosamine composition is mixed and stirred uniformly to enable the ethyl cellulose to wrap the surfaces of the glucosamine particles to form a hydrated gel layer, then the hydrated gel layer is placed in a drying oven at the temperature of 30 ℃ for drying for 10min, and then the mixture is blown by cold air for 10min to obtain the glucosamine composition.
According to the method of Chinese pharmacopoeia, dilute hydrochloric acid solution 16.4ml (equivalent to hydrochloric acid 3.84ml) is taken, water 800ml and pepsin 10g are added, after shaking up, water is added to dilute into 1000ml, and simulated gastric juice (dissolution medium) is obtained. The glucosamine formulations prepared in the above examples were placed in the simulated gastric fluid and tested for floating time, with the results shown in the following table.
| Example 2 | Example 3 | Example 4 | |
| Floating time/min | 327 | 309 | 331 |
| Glucosamine Release duration/min | 322 | 301 | 327 |
It can be seen that the glucosamine compositions prepared in examples 2, 3 and 4 have good sustained release capability, so that glucosamine can be released into simulated gastric fluid continuously for a long time, because the glucosamine compositions prepared are prepared by dispersing glucosamine in gelatin to prepare glucosamine particles, and the glucosamine particles are gradually released along with digestion after entering gastric fluid, so as to achieve the purpose of controlled release. Meanwhile, the coating layer formed by coating the ethyl cellulose on the surface of the glucosamine particles can be hydrated to form a hydration layer after entering the gastric juice and meeting water, so that the glucosamine particles float in the gastric juice, and the hydration layer also plays a slow release role as a skeleton, so that the glucosamine in the glucosamine particles is gradually released through the skeleton, the stability of the concentration of the glucosamine in the gastric juice is further maintained, the long-time drug effect is kept, and the treatment effect of the glucosamine is favorably improved.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method for preparing a glucosamine composition, comprising the steps of:
(1) mixing gelatin liquid and glucosamine or pharmaceutically acceptable salt thereof, and stirring uniformly to obtain glucosamine liquid for later use;
(2) feeding the glucosamine glue solution into granulation equipment for granulation to obtain glucosamine particles; wherein:
the granulation apparatus comprises: the device comprises a solidification tank, an extrusion cylinder, a driving motor, a rotating shaft, a cutting knife, an air pressure pressurization pipe and a pressure stabilizing valve; the extruding cylinder and the driving motor are both fixed on the top surface of the solidification tank, a conical extruding opening of the extruding cylinder is positioned below the liquid level of ethanol in the inner cavity of the solidification tank, the upper end of the rotating shaft is connected with a motor shaft of the driving motor, and the rotating shaft is positioned in the inner cavity of the solidification tank; the cutting knife is horizontally fixed on the rotating shaft, and the cutting knife is positioned below the conical extrusion port of the extrusion cylinder and is arranged adjacently; the air pressure pressurization pipe and the pressure stabilizing valve are both arranged on the top surface of the extrusion cylinder and are communicated with the inner cavity of the extrusion cylinder, the top surface of the extrusion cylinder is also provided with a feeding pipe, and the feeding pipe is provided with a switch valve; the lower part of the side wall of the solidification tank and the conical bottom are respectively provided with a filtering port and a discharge port;
when in granulation, the glucosamine glue solution is sent into an extrusion cylinder from a feeding pipe, and hot air is blown into the extrusion cylinder through an air pressure pressurization pipe, so that the glucosamine glue solution is extruded from an extrusion port under the assistance of self weight and air pressure, is cut into granules by a rotating cutting knife, is solidified in ethanol solution, and then is guided out from a discharge port and is dried for later use;
(3) and uniformly mixing the glucosamine particles, the ethyl cellulose powder and the ethanol to ensure that the ethyl cellulose is coated on the surfaces of the glucosamine particles to form a hydrated gel layer, and then drying to obtain the glucosamine composition.
2. The method for preparing a glucosamine composition according to claim 1, wherein in the step (1), the gelatin solution is prepared by: and soaking the gelatin granules in cold water for 10-15 minutes, heating in a water bath to 50-55 ℃, preserving heat, and continuously stirring until the gelatin is melted into a gelatin solution to obtain the gelatin-containing material.
3. The method for preparing a glucosamine composition according to claim 1, wherein in the step (1), the mass ratio of the gelatin solution to the glucosamine or the pharmaceutically acceptable salt thereof is 2.5-3.7: 1; preferably, in step (1), the pharmaceutically acceptable salt of glucosamine comprises at least one of glucosamine hydrochloride, glucosamine sulfate and glucosamine double salt.
4. The method for preparing a glucosamine composition according to claim 1, wherein in the step (2), a paddle is further connected to the rotating shaft and is located below the cutting knife.
5. The method for preparing a glucosamine composition according to claim 1, wherein, in the step (2), the pressure maintaining valve comprises: the pressure release pipe, the sliding rod, the floating ball and the blocking head are arranged on the sliding rod; wherein: the pressure relief pipe is vertically fixed on the top surface of the extrusion cylinder and is communicated with the inner cavity of the extrusion cylinder; the sliding rod is vertically fixed at the center of the pressure release pipe, the floating ball is sleeved on the sliding rod in a sliding manner, and the floating ball is supported at the upper end opening of the pressure release pipe to be sealed;
preferably, the floating ball is a stainless steel or plastic hollow ball;
preferably, a support rod is fixed at the lower port of the pressure release pipe, and the lower end of the slide rod is fixed on the support rod.
6. The method of claim 5, wherein the pressure-maintaining valve is connected to the top wall of the coagulation tank.
7. The method for preparing a glucosamine composition according to claim 1, wherein, in the step (2), an external port of the pneumatic pressurization pipe is connected with a blower, and a heater is disposed in the blower; preferably, the heater is an electric heating net, and more preferably, the air temperature is 50-55 ℃; preferably, the blower is connected to the filter.
8. The method for preparing a glucosamine composition according to any one of claims 1-7, wherein in step (3), the ratio of glucosamine particles, ethylcellulose powder and ethanol is 1 part by weight: 3.2-3.7 parts by weight: 5.5 to 7.5 parts by weight.
9. The method for preparing a glucosamine composition according to any one of claims 1-7, wherein in the steps (2) and (3), the drying temperature is controlled between 30 ℃ and 35 ℃ for 5min to 10 min;
preferably, in the steps (2) and (3), the mass fraction of the ethanol is not less than 95% or is selected to be absolute ethanol.
10. The glucosamine composition prepared by the preparation method of any one of claims 1-9, and the application thereof in the fields of chemical industry, biology and medical treatment.
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| CN114916667A (en) * | 2022-05-31 | 2022-08-19 | 山东润德生物科技有限公司 | Oral glucosamine product and preparation method thereof |
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| CN1634087A (en) * | 2004-10-14 | 2005-07-06 | 浙江海力生制药有限公司 | Sustained release formulation of glucosamine salt, its preparation and usage |
| CN1961887A (en) * | 2005-11-10 | 2007-05-16 | 浙江海力生制药有限公司 | Sustained releasing formulation of compound glucosamine, preparation process and application thereof |
| CN102600098A (en) * | 2012-03-17 | 2012-07-25 | 江苏艾兰得营养品有限公司 | Glucosamine sustained release preparation and preparation method thereof |
| CN102599508A (en) * | 2012-03-17 | 2012-07-25 | 江苏艾兰得营养品有限公司 | Preparation for preparing chondroitin glucosamine particles by wet method and preparation method |
| CN105920031A (en) * | 2016-04-21 | 2016-09-07 | 李媚 | Composition for joint repair and preparation method of composition |
| CN111482147A (en) * | 2019-01-25 | 2020-08-04 | 天津工业大学 | Continuous preparation method and continuous preparation device of self-assembled aerogel particles of low-dimensional material |
| CN111558334A (en) * | 2020-05-26 | 2020-08-21 | 南通醋酸纤维有限公司 | Method and device for preparing cellulose acetate particles |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114916667A (en) * | 2022-05-31 | 2022-08-19 | 山东润德生物科技有限公司 | Oral glucosamine product and preparation method thereof |
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