CN102600098A - Glucosamine sustained release preparation and preparation method thereof - Google Patents
Glucosamine sustained release preparation and preparation method thereof Download PDFInfo
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- CN102600098A CN102600098A CN2012100704119A CN201210070411A CN102600098A CN 102600098 A CN102600098 A CN 102600098A CN 2012100704119 A CN2012100704119 A CN 2012100704119A CN 201210070411 A CN201210070411 A CN 201210070411A CN 102600098 A CN102600098 A CN 102600098A
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- glucosamine
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Abstract
A glucosamine sustained release preparation consists of various main and auxiliary raw materials including, by weight ratio, from 30 to 90% of glucosamine, from 1 to 50% of sustained release materials, from 1 to 20% of other auxiliary materials and from 3 to 5% of stomach soluble coating films. The glucosamine includes glucosamine hydrochloride, sulfate, phosphate, hydriodate and glucosamine mixture; the sustained release materials selectively include one or a combination of more than one of stearic acid, gelatin, glycerin monostearate, dextrin, methylcellulose, microcrystalline cellulose and ethyl cellulose; and the other auxiliary materials are selected from microcrystalline cellulose, silica, magnesium stearate and glycerin monostearate. The glucosamine is stably released by the aid of skeleton sustained release technology, the immunity of a patient suffering from osteoarthrosis is improved by means of supplementing the glucosamine, and pain of the patient is released. A preparation method is simple in process, fine in reproducibility and high in production efficiency, prepared tablets are released uniformly, and stability is good.
Description
Technical field
The present invention relates to field of health care food, be specifically related to a kind of glucosamine slow releasing preparation and preparation method thereof.
Background technology
Glucosamine is a kind of natural amino monosaccharide, is the important component part of the extremely strong proteoglycan of hydrophilic, and the collagen protein in its ability synthesized human very easily is absorbed by the body.It has certain physiologically active, can produce the proteoglycan and the collagen of normal polymer structure through stimulating chondrocyte, is the essential material of synthetic proteins polysaccharide and the base substance of synthesizing amino polysaccharide.Become the constituent in the articular cartilage, and can act on articular cartilage specifically, recover the normal metabolic function of chondrocyte, stimulate the proteoglycan that chondrocyte produces has normal how former body structure, safeguard the morphosis of cartilage matrix.In addition, can also suppress to damage ultra oxyradical, collagenase and the phospholipase A of cartilage matrix II Collagen Type VI
2Generation, thereby delay the pathological process and the PD of osteoarthritis, improve joint motion, alleviating pain, and do not have significant side effects.D-glucosamine is " street cleaner " in the articular cavity, can not only suppress the inflammatory reaction of nonspecific factor, removes pain, and can eliminate harmful enzyme in the articular cavity, improves the immunity of joint and body.Through replenishing the raising that D-glucosamine brings immunity, be the important prerequisite of eliminating arthritis.
Summary of the invention
The object of the present invention is to provide a kind of glucosamine slow releasing preparation and preparation method thereof, utilize the skeleton slow release method that glucosamine is steadily discharged, the osteoarthrosis patient is through replenishing the raising that glucosamine brings immunity; Alleviating pain; And method for preparing technology is simple, favorable reproducibility, and production efficiency is high, is fit to industrialized mass; The tablet that makes discharges homogeneous, good stability.
The present invention sets up sustained-release matrix through joining with hydroxypropyl emthylcellulose 15000 centipoises and carbomer amount by a certain percentage in the tablet; Make slow releasing preparation according to the drug release determination method; Adopt dissolution method first device to measure, make these article reach various slow release effect at 1 hour, 4 hours, 8 hours, 10 hours, 12 hours each time points.
The present invention is achieved in that a kind of glucosamine slow releasing preparation, it is characterized in that the weight proportion of each main auxiliary material is following: glucosamine: 30 ~ 90%, and slow-release material: 1 ~ 50%, other adjuvants: 1 ~ 20%, gastric solubleness coating membrane: 3 ~ 5%; Described glucosamine is its hydrochlorate, sulfate, phosphate, hydriodate and its mixture; Described slow-release material is selected from: the combination of one or more in stearic acid, gelatin, glyceryl monostearate, dextrin, methylcellulose, microcrystalline Cellulose, ethyl cellulose, hydroxy methocel, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate, acrylic resin, polyvinyl alcohol, crospolyvinylpyrrolidone, carbomer, the carbopol; Described other adjuvants are selected from: microcrystalline Cellulose, silicon dioxide, magnesium stearate, glyceryl monostearate, dextrin, cellulose acetate, polyvinyl alcohol, crospolyvinylpyrrolidone, carbopol.
A kind of glucosamine slow releasing preparation of the present invention is characterized in that its slow release pattern is a matrix type.
The method for preparing of a kind of glucosamine slow releasing preparation of the present invention is characterized in that: processing according to the following steps:
1), takes by weighing each main auxiliary material mix homogeneously, discharging by prescription;
2), the above-mentioned material that mixes is carried out tabletting with suitable punch die, average sheet heavily is controlled between 1.17g ± 5%;
3), with sheet wicking surface bag one deck gastric solubleness coating, make unilateral bright and clean;
4), release degree that the tablet that makes was carried out 1 hour, 4 hours, 8 hours, 10 hours, 12 hours detects, the glucosamine dissolution that records is respectively: 12.2%, 20.5%, 40.90%, 72.88%, 93.07%.
The present invention utilizes the skeleton slow release method that glucosamine is steadily discharged; The raising that the osteoarthrosis patient brings immunity through additional glucosamine, alleviating pain, and method for preparing technology is simple, favorable reproducibility; Production efficiency is high; Be fit to industrialized mass, the tablet that makes discharges homogeneous, good stability.
The specific embodiment
Below will combine embodiment to specify the present invention, embodiments of the invention only are used to technical scheme of the present invention is described, and non-limiting essence of the present invention.
Embodiment 1:
1000 glucosamine extended release tablet formulations:
Glucosamine hydrochloride 850g
Microcrystalline Cellulose 40g
Hydroxypropyl emthylcellulose 15000 centipoise 20g
Carbomer 20g
Silica 1 0g
Magnesium stearate 10g
Gastric solubleness coating membrane 50g.
Method for preparing:
1,, adds the magnesium stearate mix homogeneously of formula ratio then, discharging with glucosamine hydrochloride, microcrystalline Cellulose, hydroxypropyl emthylcellulose 15000 centipoises, carbomer, the silicon dioxide mix homogeneously of formula ratio;
2, the above-mentioned material that mixes is carried out tabletting with suitable punch die, average sheet heavily is controlled between 0.95g ± 5%;
3, with sheet wicking surface bag one deck gastric solubleness coating membrane, make unilateral bright and clean;
The release degree that the tablet that makes was carried out 1 hour, 4 hours, 8 hours detects, and the glucosamine dissolution that records is respectively: 27.2%, 68.5%, 99.0%.
Embodiment 2:
1000 glucosamine extended release tablet formulations:
Glucosamine hydrochloride 700g
Microcrystalline Cellulose 70g
Hydroxypropyl emthylcellulose 15000 centipoise 100g
Carbomer 60g
Silica 1 0g
Magnesium stearate 10g
Gastric solubleness coating membrane 50g.
Method for preparing:
1,, adds the magnesium stearate mix homogeneously of formula ratio then, discharging with glucosamine hydrochloride, microcrystalline Cellulose, hydroxypropyl emthylcellulose 15000 centipoises, carbomer, the silicon dioxide mix homogeneously of formula ratio;
2, the above-mentioned material that mixes is carried out tabletting with suitable punch die, average sheet heavily is controlled between 0.95g ± 5%;
3, with sheet wicking surface bag one deck gastric solubleness coating membrane, make unilateral bright and clean;
The release degree that the tablet that makes was carried out 1 hour, 4 hours, 8 hours, 10 hours detects, and the glucosamine dissolution that records is respectively: 18.5%, 30.2%, 60.5%, 96.0%.
Embodiment 3:
1000 glucosamine extended release tablet formulations:
Glucosamine hydrochloride 600g
Microcrystalline Cellulose 70g
Hydroxypropyl emthylcellulose 15000 centipoise 180g
Carbomer 100g
Silica 1 0g
Magnesium stearate 10g
Gastric solubleness coating membrane 30g.
Method for preparing:
1,, adds the magnesium stearate mix homogeneously of formula ratio then, discharging with glucosamine hydrochloride, microcrystalline Cellulose, hydroxypropyl emthylcellulose 15000 centipoises, carbomer, the silicon dioxide mix homogeneously of formula ratio;
2, the above-mentioned material that mixes is carried out tabletting with suitable punch die, average sheet heavily is controlled between 0.97g ± 5%;
3, with sheet wicking surface bag one deck gastric solubleness coating membrane, make unilateral bright and clean;
The release degree that the tablet that makes was carried out 1 hour, 4 hours, 8 hours, 10 hours, 12 hours detects, and the glucosamine dissolution that records is respectively: 12.2%, 20.5%, 40.90%, 72.88%, 93.07%.
Claims (3)
1. glucosamine slow releasing preparation is characterized in that the weight proportion of each main auxiliary material is following: glucosamine: 30 ~ 90%, and slow-release material: 1 ~ 50%, other adjuvants: 1 ~ 20%, gastric solubleness coating membrane: 3 ~ 5%; Described glucosamine is its hydrochlorate, sulfate, phosphate, hydriodate and its mixture; Described slow-release material is selected from: the combination of one or more in stearic acid, gelatin, glyceryl monostearate, dextrin, methylcellulose, microcrystalline Cellulose, ethyl cellulose, hydroxy methocel, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate, acrylic resin, polyvinyl alcohol, crospolyvinylpyrrolidone, carbomer, the carbopol; Described other adjuvants are selected from: microcrystalline Cellulose, silicon dioxide, magnesium stearate, glyceryl monostearate, dextrin, cellulose acetate, polyvinyl alcohol, crospolyvinylpyrrolidone, carbopol.
2. a kind of glucosamine slow releasing preparation according to claim 1 is characterized in that its slow release pattern is a matrix type.
3. according to the method for preparing of claim 1 and 2 described a kind of glucosamine slow releasing preparation, it is characterized in that: processing according to the following steps:
1), takes by weighing each main auxiliary material mix homogeneously, discharging by prescription;
2), the above-mentioned material that mixes is carried out tabletting with suitable punch die, average sheet heavily is controlled between 1.17g ± 5%;
3), with sheet wicking surface bag one deck gastric solubleness coating, make unilateral bright and clean;
4), release degree that the tablet that makes was carried out 1 hour, 4 hours, 8 hours, 10 hours, 12 hours detects, the glucosamine dissolution that records is respectively: 12.2%, 20.5%, 40.90%, 72.88%, 93.07%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2012100704119A CN102600098A (en) | 2012-03-17 | 2012-03-17 | Glucosamine sustained release preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100704119A CN102600098A (en) | 2012-03-17 | 2012-03-17 | Glucosamine sustained release preparation and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823211A (en) * | 2017-11-22 | 2018-03-23 | 中国人民解放军第二军医大学 | Application of the gucosamine in preparing ionising radiation and causing induced lung injury protective agents |
| CN108420824A (en) * | 2017-02-15 | 2018-08-21 | 徐天宏 | A kind of product that treating diabetes and its preparation and application |
| CN114344314A (en) * | 2022-01-05 | 2022-04-15 | 山东润德生物科技有限公司 | Preparation process and application of glucosamine composition |
| CN114343184A (en) * | 2020-12-29 | 2022-04-15 | 江苏艾兰得营养品有限公司 | Preparation method of ammonia sugar composite functional tablet |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634087A (en) * | 2004-10-14 | 2005-07-06 | 浙江海力生制药有限公司 | Sustained release formulation of glucosamine salt, its preparation and usage |
-
2012
- 2012-03-17 CN CN2012100704119A patent/CN102600098A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634087A (en) * | 2004-10-14 | 2005-07-06 | 浙江海力生制药有限公司 | Sustained release formulation of glucosamine salt, its preparation and usage |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420824A (en) * | 2017-02-15 | 2018-08-21 | 徐天宏 | A kind of product that treating diabetes and its preparation and application |
| CN107823211A (en) * | 2017-11-22 | 2018-03-23 | 中国人民解放军第二军医大学 | Application of the gucosamine in preparing ionising radiation and causing induced lung injury protective agents |
| CN114343184A (en) * | 2020-12-29 | 2022-04-15 | 江苏艾兰得营养品有限公司 | Preparation method of ammonia sugar composite functional tablet |
| CN114344314A (en) * | 2022-01-05 | 2022-04-15 | 山东润德生物科技有限公司 | Preparation process and application of glucosamine composition |
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Application publication date: 20120725 |