CN114343820B - Visual high-voltage high-frequency steep pulse of image melts tumour cell system - Google Patents
Visual high-voltage high-frequency steep pulse of image melts tumour cell system Download PDFInfo
- Publication number
- CN114343820B CN114343820B CN202210029099.2A CN202210029099A CN114343820B CN 114343820 B CN114343820 B CN 114343820B CN 202210029099 A CN202210029099 A CN 202210029099A CN 114343820 B CN114343820 B CN 114343820B
- Authority
- CN
- China
- Prior art keywords
- module
- ablation
- steep pulse
- voltage
- frequency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Electrotherapy Devices (AREA)
Abstract
The invention relates to an image visualization high-voltage high-frequency steep pulse tumor cell ablation system. The visual high-voltage high-frequency steep pulse of image melts tumour cell device includes: the device comprises an upper computer, a control module, a high-voltage high-frequency steep pulse generation module, a current signal acquisition module, an electrode module, an image acquisition module and a memory module. The invention can adjust the input parameters in real time according to the feedback result, so that the ablation treatment is more scientific and accurate. The evaluation method of the high-voltage high-frequency steep pulse ablation tumor cell device comprises the following steps: establishing a three-dimensional image containing a tumor target treatment target area, generating a needle distribution area, carrying out high-voltage high-frequency steep pulse ablation tumor cell operation and the like. The method can be used for accurately analyzing and evaluating the tumor cells by the image acquisition module and then accurately ablating the tumor cells, and has a good using effect.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to an image visualization high-voltage high-frequency steep pulse tumor cell ablation system.
Background
Tumors, especially malignant tumors, are the first killers that threaten human health. Traditional therapies for tumors generally include chemotherapy, radiotherapy, surgical resection and the like, and recently developed therapies are thermal ablation physiotherapy characterized by minimally invasive ablation as a main feature. However, the clinical application of the thermal ablation physical therapy has certain limitations due to the limitation of adaptability, contraindications, side effects of treatment, thermal effects, technical development and the like. However, in recent years, with the development of pulsed bioelectricity, electric field pulses have attracted attention for their non-thermal, minimally invasive biomedical effects.
Irreversible electroporation (IRE) is an emerging technology related to athermal ablation of tumors. The technology sends a group of high-voltage electric pulses through electrodes to form an electric field in tissues, so that irreversible electroporation is carried out on cell membranes, and tumor cells are subjected to apoptosis. The high-voltage steep pulse acts on the tissue cells to form a reticular discharge area, and the field intensity decreases towards the periphery. The instantaneous high-voltage electric field changes the cell membrane potential at the electrode, so that the cell membrane is in a polarization state, the polarization trend is conducted along the adjacent cell membranes, and extremely strong interference is generated on the generation and conduction of electrocardiosignals. When the high-voltage electric field acts on the process of the depolarization of the cardiac muscle cells, the normal depolarization process of the cardiac muscle cells is interfered.
The steep pulse treatment equipment is one of the equipment for treating tumors by adopting an irreversible electroporation technology, and in the process of treating tumors by using the steep pulse treatment equipment, parameters are easy to change due to factors such as physique and the like when a patient is treated by adopting the steep pulse treatment in the prior art, but doctors are difficult to find the change, so that the difficulty that the treatment effect is difficult to improve is caused.
Disclosure of Invention
(1) Technical problem to be solved
The embodiment of the invention provides an image visualized high-voltage high-frequency steep pulse tumor cell ablation system in a first aspect, which comprises: the device comprises an upper computer, a control module, a high-voltage high-frequency steep pulse generation module, a current signal acquisition module, an electrode module, an image acquisition module and a memory module. The invention can adjust the input parameters in real time according to the feedback result, so that the ablation treatment is more scientific and accurate.
The second aspect of the embodiment of the present invention provides an evaluation method for high-voltage high-frequency steep pulse ablation tumor cells based on the image visualization high-voltage high-frequency steep pulse ablation tumor cell apparatus according to any one of the first aspect of the embodiment of the present invention, including: establishing a three-dimensional image containing a tumor target treatment target area, generating a needle distribution area, performing high-voltage high-frequency steep pulse ablation tumor cell operation and the like. The tumor cell ablation system can accurately analyze and evaluate tumor cells by virtue of the image acquisition module and then perform accurate ablation, and has a good using effect.
(2) Technical scheme
The embodiment of the first aspect of the invention provides an image-visualized high-voltage high-frequency steep pulse tumor cell ablation system, which comprises:
the upper computer is used for inputting a current change threshold, judging whether ablation parameters need to be adjusted or not, and sending an adjustment instruction when the ablation parameters need to be adjusted; the upper computer further comprises a touch display screen, and the touch display screen is used for observing the image change condition of the ablation target in real time;
the control module is connected with the upper computer and used for receiving an instruction of the upper computer to generate control information and transmitting the image change condition of the ablation target to the touch display screen in real time;
the high-voltage high-frequency steep pulse generating module is connected with the control module and used for generating or adjusting a high-voltage high-frequency steep pulse signal by the control information of the control module;
the current signal acquisition module is respectively connected with the control module and the high-voltage high-frequency steep pulse generation module, and is used for acquiring a current signal generated by the high-voltage high-frequency steep pulse generation module in real time during ablation operation and transmitting the acquired current signal to the control module;
the electrode module is connected with the high-voltage high-frequency steep pulse generating module and used for receiving a high-voltage high-frequency steep pulse signal generated by the high-voltage high-frequency steep pulse generating module and sending the signal to a tissue area to be ablated;
the image acquisition module is connected with the control module and used for acquiring image information of a tissue area to be ablated and transmitting the acquired image information to the touch display screen through the control module;
and the memory module is respectively connected with the control module and the current signal acquisition module and is used for storing the image information acquired by the image acquisition module, the operation information of the upper computer and the current signal acquired by the current signal acquisition module.
Further, the high-voltage high-frequency steep pulse generating module comprises:
the high-voltage power supply generation module is connected with the control module and used for generating a required high-voltage power supply according to the control information received from the control module;
high frequency steep pulse signal produces the module, respectively with control module high voltage power supply produces module, current signal acquisition module and the electrode module is connected, is used for according to follow the control information that control module received will the high voltage that high voltage power supply produced the module converts required high voltage high frequency steep pulse signal into, and with high voltage high frequency steep pulse signal transmission extremely current signal acquisition module is convenient for its detection current signal and with high voltage high frequency steep pulse signal transmission to electrode module (5) be convenient for its implementation high voltage high frequency steep pulse ablation operation.
Further, the control information of the control module comprises a voltage control signal and a pulse control signal, and the control module is used for outputting the voltage control signal to control the voltage value output by the high-voltage power supply generation module; the control module is used for outputting a pulse control signal and is used for outputting a high-frequency steep pulse output by the high-frequency steep pulse signal generation module.
Further, the current signal acquisition module comprises a current sensor and is used for acquiring a current value of the high-frequency steep pulse output by the high-frequency steep pulse signal generation module and sending the current value to the upper computer through the control module.
Furthermore, the current signal acquisition module further acquires a first current value of the high-frequency steep pulse signal generation module before the ablation operation and a second current value of the high-frequency steep pulse signal generation module after the ablation operation, and compares the change values of the first current value and the second current value with the input current change threshold, and if the change values of the first current value and the second current value are smaller than the input current change threshold, the ablation parameters need to be adjusted.
Furthermore, an analog signal amplification module is further arranged between the high-voltage high-frequency steep pulse generation module and the current signal acquisition module and is used for amplifying the current signals acquired by the current signal acquisition module.
Furthermore, an analog-to-digital conversion module is further arranged between the current signal acquisition module and the control module and is used for converting the signal transmitted to the control module by the current signal acquisition module into a digital signal.
Furthermore, the image acquisition module is a high-definition camera.
Further, the memory module is a memory stored by the circulating covering type body, the data storage time is t, and t is more than 30 days and less than 60 days.
According to a second aspect of the embodiments of the present invention, an evaluation method for high-voltage high-frequency steep pulse ablation tumor cells based on the image visualization high-voltage high-frequency steep pulse ablation tumor cell apparatus of any one of the first aspect of the embodiments of the present invention includes the following steps:
acquiring a medical image through the image acquisition module, marking a tumor target in the acquired medical image, and establishing three-dimensional image data containing a tumor target treatment target area, wherein the dimensionality of the three-dimensional image data is mxnxh, m is the length of the three-dimensional image data, n is the width of the three-dimensional image data, and h is the spectral dimensionality of the three-dimensional image data; carrying out normalization processing on the three-dimensional image data: x = [ (X) m -X m0 )/(X m0 ),(X n -X n0 )/(X n0 ),(X h -X h0 )/(X h0 )]Wherein X is m ，X m0 Length coordinate, X, of three-dimensional image data n ，X n0 Is the width coordinate, X, of the three-dimensional image data h ，X h0 Spectral dimension coordinates of the three-dimensional image data;
generating a needle distribution area enveloping a tumor target treatment target area in a three-dimensional image, performing binarization operation on data after normalization processing of three-dimensional image data, and enabling X and a set threshold value X 0 Comparing when X is larger than X 0 The pixel becomes 1; when X is less than X 0 The pixel is changed into 0, according to the binary image, the area where the pixel is changed into 1 is the needle distribution area, and the electrode module is arranged in the needle distribution area to implement the operation of high-voltage high-frequency steep pulse ablation of tumor cells;
establishing an electromagnetic field distribution model, and calculating the electromagnetic field distribution of the high-voltage high-frequency steep pulse:
wherein, ω δ is k Δ xsin θ δ, ω σ is k Δ ysin θ σ, Δ x is the x-direction array unit interval, Δ y is the y-direction pixel interval, θ δ and θ σ are the scanning angle coordinates of the pixel point relative to the pixel center, M and N are the serial numbers of the pixel point in the x direction and the y direction, k is the wave number, k =2 pi/λ, M is the number of the pixel points in the x direction, N is the number of the pixel points in the y direction, (δ, σ) is the coordinate of the pixel point, a is the coordinate of the pixel point, and x is the scanning angle coordinate of the pixel point in the x direction and the y direction mn Is the amplitude weighting coefficient of the pixel point,
as a function of the distribution of the electromagnetic field,
target signals received by the pixel points;
in order to focus the phase weighting coefficients,
weighting coefficients for the scanning phases;
according to the electromagnetic field distribution, calculating the temperature field of tumor cells, setting a temperature threshold value, obtaining isothermal surface envelopes of the temperature threshold value in the three-dimensional image, sequentially traversing coordinates (X, Y, Z) of the isothermal surface envelopes, and calculating an ablation volume:
；
setting ablation parameters through the upper computer, wherein the ablation parameters represent the degree of conformity between an ablation volume and a tumor target treatment target area;
recalculating the ablation volume to satisfy the ablation parameters.
(3) Advantageous effects
The image-visualized high-voltage high-frequency steep pulse tumor cell ablation device provided by the embodiment of the invention judges whether ablation parameters need to be adjusted or not by inputting the current change threshold value through the upper computer, and sends an adjustment instruction when the ablation parameters need to be adjusted, so that the input parameters can be adjusted in real time according to a feedback result, and the ablation treatment is more scientific and accurate; meanwhile, the touch display screen can be used for observing the image change condition of the ablation target in real time, so that the change condition of the tumor cells in the ablation treatment can be observed visually through images, and the working parameters can be adjusted in time or the ablation treatment operation can be stopped conveniently.
The evaluation method for the high-voltage high-frequency steep pulse ablation of the tumor cells provided by the embodiment of the invention can be used for accurately analyzing, evaluating and then accurately ablating the tumor cells by virtue of the image acquisition module, and has a good using effect.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic diagram of a device for ablating tumor cells by high-voltage high-frequency steep pulse in an embodiment of the invention.
Fig. 2 is a schematic diagram of an upper computer in an embodiment of the present invention.
Fig. 3 is a schematic diagram of a high voltage high frequency steep pulse generating module according to an embodiment of the present invention.
Fig. 4 is a schematic diagram of a current signal acquisition module according to an embodiment of the invention.
Fig. 5 is a schematic diagram of a high-voltage high-frequency steep pulse tumor cell ablation device in another embodiment of the invention.
Fig. 6 is a schematic diagram of a high-voltage high-frequency steep pulse tumor cell ablation device in another embodiment of the invention.
Fig. 7 is a schematic diagram of a device for ablating tumor cells by high-voltage high-frequency steep pulses in an embodiment of the invention.
Fig. 8 is a flowchart of an evaluation method for ablating tumor cells by high-voltage high-frequency steep pulse in an embodiment of the invention.
In the figure: the system comprises an upper computer 1 and a touch display screen 11; a control module 2; the high-voltage high-frequency steep pulse generating module 3, the high-voltage power supply generating module 31 and the high-frequency steep pulse signal generating module 32; the current signal acquisition module 4 and the current sensor 41; an electrode module 5; an image acquisition module 6; a memory module 7; an analog signal amplification module 8; and an analog-to-digital conversion module 9.
Detailed Description
The embodiments of the present invention will be described in further detail with reference to the drawings and examples. The following detailed description of the embodiments and the accompanying drawings are provided to illustrate the principles of the invention and are not intended to limit the scope of the invention, i.e., the invention is not limited to the embodiments described, but covers any modifications, alterations, and improvements in the parts, components, and connections without departing from the spirit of the invention.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The present application will be described in detail with reference to the accompanying drawings 1-8, in conjunction with an embodiment.
Referring to fig. 1 and fig. 2, an image-visualized high-voltage high-frequency steep-pulse tumor cell ablation system according to a first aspect of the embodiment of the present invention includes:
the upper computer 1 is used for inputting a current change threshold, judging whether ablation parameters need to be adjusted or not, and sending an adjustment instruction when the ablation parameters need to be adjusted; the upper computer 1 further comprises a touch display screen 11, and the touch display screen 11 is used for observing the image change condition of the ablation target in real time;
the control module 2 is connected with the upper computer 1 and used for receiving an instruction of the upper computer 1 to generate control information and transmitting the image change condition of the ablation target to the touch display screen 11 in real time;
the high-voltage high-frequency steep pulse generating module 3 is connected with the control module 2 and is used for generating or adjusting a high-voltage high-frequency steep pulse signal by the control information of the control module 2;
the current signal acquisition module 4 is respectively connected with the control module 2 and the high-voltage high-frequency steep pulse generation module 3, and is used for acquiring a current signal generated by the high-voltage high-frequency steep pulse generation module 3 in real time during ablation operation and transmitting the acquired current signal to the control module 2;
the electrode module 5 is connected with the high-voltage high-frequency steep pulse generation module 3 and used for receiving a high-voltage high-frequency steep pulse signal generated by the high-voltage high-frequency steep pulse generation module 3 and sending the signal to a tissue area to be ablated;
the image acquisition module 6 is connected with the control module 2 and used for acquiring image information of a tissue area to be ablated and transmitting the acquired image information to the touch display screen 11 through the control module 2;
and the memory module 7 is respectively connected with the control module 2 and the current signal acquisition module 4 and is used for storing the image information acquired by the image acquisition module 6, the operation information of the upper computer 1 and the current signal acquired by the current signal acquisition module 4.
In the process of treating tumors by using the irreversible electroporation technology, a plurality of nano-scale micropores are required to be generated on a cell membrane where cells in an ablation tissue are located in an ultrashort time, so that the balance inside and outside the cells is irreversibly damaged, the cells are induced to die, and the current of the lesion tissue is correspondingly changed along with the ablation of the lesion tissue in the treatment process. Based on this, the embodiment of the present invention adopts the current signal collecting module 4 to collect the current change condition during the ablation process, and takes the change of the current signal as the ablation target for consideration.
Specifically, in the process of treating tumor focus cells by ablation, when the current change of the focus cells is found to be small and the ablation target is not judged to be reached, the ablation treatment parameters are generally not ideal, and the achieved ablation treatment cannot meet the required treatment requirements. Based on this, the first aspect of the embodiment of the invention provides an image-visualized high-voltage high-frequency steep pulse tumor cell ablation system, firstly, the upper computer 1 of the embodiment of the invention is used for inputting a current change threshold value, judging whether ablation parameters need to be adjusted or not, and sending an adjustment instruction when the ablation parameters need to be adjusted, so that the input parameters can be adjusted in real time according to a feedback result, the ablation treatment is more scientific and accurate, the ablation efficiency can be accelerated, and the operation time can be reduced; meanwhile, the upper computer 1 of the embodiment of the invention further comprises a touch display screen 11, and the touch display screen 11 can be used for observing the image change condition of the ablation target in real time, so that the change condition of the tumor cells in the ablation treatment can be observed visually through images, and the working parameters can be adjusted in time or the ablation treatment operation can be stopped conveniently.
In practice, the number of electrode modules 5 may be selected based on the type, shape, size, malignancy of the tumor to be treated, for example, the electrode modules 5 may be composed of 2 electrode needles, including one electrode needle having a high potential and one electrode needle having a low potential. In another example, the electrode module 5 may consist of 4, 6 or 10 electrode needles, and the potential of each electrode needle may be different.
According to another embodiment of the first aspect of the present invention, the high voltage high frequency steep pulse generating module 3 comprises: the high-voltage power supply generation module 31 is connected with the control module 2 and is used for generating a required high-voltage power supply according to the control information received from the control module 2; high frequency steep pulse signal produces module 32, respectively with control module 2 high voltage power supply produces module 31, current signal acquisition module 4 and electrode module 5 is connected for follow the control information that control module 2 received will the high pressure that high voltage power supply produced module 31 converts required high frequency steep pulse signal into, and with high frequency steep pulse signal transmission to current signal acquisition module 4 is convenient for its detection current signal and with high frequency steep pulse signal transmission to electrode module 5 and is convenient for its implementation high frequency steep pulse ablation operation. Referring to fig. 1 and fig. 3, in order to output high-voltage high-frequency steep pulses in the embodiment of the present invention, a high-voltage power supply generating module 31 for outputting a high-voltage signal and a high-frequency steep pulse signal generating module 32 for outputting a high-frequency steep pulse signal must be provided, and the control module 2 controls the voltage power supply generating module 31 and the high-frequency steep pulse signal generating module 32 respectively to obtain a required high-voltage electrical signal and high-voltage high-frequency steep pulses respectively.
In practice, ablation parameters may also be set based on factors such as the type of tumor to be treated, shape, size, malignancy, and the like. For example, in one example, the ablation parameter may be set to a high voltage, such as 100V, in which case the output voltage of the high voltage power generation module 31 may be adjusted; in another example, the ablation parameters may be set to the pulse frequency, in which case the output frequency of the high frequency steep pulse signal generation module 32 may be adjusted, for example, to 100 GHz; in yet another example, the ablation parameters may also be set as a combination of voltage and pulse frequency, in which case the high voltage power generation module 31 and the high frequency steep pulse signal generation module 32 need to be adjusted separately.
According to an embodiment of the first aspect of the present invention, the control information of the control module 2 includes a voltage control signal and a pulse control signal, and the control module 2 is configured to output the voltage control signal to control the voltage value output by the high voltage power supply generating module 31; the control module 2 is configured to output a pulse control signal for controlling the high-frequency steep pulse signal generating module 32 to output the high-frequency steep pulse.
According to another embodiment of the first aspect of the present invention, referring to fig. 4, the current signal collecting module 4 includes a current sensor 41 for collecting a current value of the high-frequency steep pulse output by the high-frequency steep pulse signal generating module 32 and sending the current value to the upper computer 1 via the control module 2. In the embodiment of the invention, in order to collect the current conveniently, the current sensor 41 is adopted for collection, so that the current collecting device has the advantages of convenience, reliability and convenience in implementation, the current sensor 41 can be in a specification and a model which are common in the market, and the specific type of the current sensor 41 does not limit the application on the premise of meeting the functions of the application.
According to another embodiment of the first aspect of the present invention, the current signal collecting module 4 further collects a first current value of the high-frequency steep pulse signal generating module 32 before the ablation operation and a second current value of the high-frequency steep pulse signal generating module 32 after the ablation operation, and compares a variation value of the first current value and the second current value with the input current variation threshold, if the variation value of the first current value and the second current value is smaller than the input current variation threshold, the ablation parameter needs to be adjusted. For example, the input current change threshold for ablation may be defined as: after the transmission of 5 pulses, the rising change in the required current value reaches 10A. In this case, if the rising change of the current value does not reach 5A after the 5 pulses are emitted, the upper computer 1 judges that the ablation target is not reached, otherwise, judges that the ablation target is reached. In another alternative embodiment, the ablation targets are set to: when the first current value before the ablation operation is not 10A and the second current value after the ablation operation is 12A, and the change value of the first current value and the change value of the second current value are smaller than the input current change threshold (assumed to be 5A) by comparing the change value (2A) of the first current value 10A and the second current value 12A with the input current change threshold, the ablation parameters need to be adjusted.
According to an embodiment of the first aspect of the present invention, an analog signal amplifying module 8 is further disposed between the high-voltage high-frequency steep pulse generating module 3 and the current signal collecting module 4, and is configured to amplify the current signal collected by the current signal collecting module 4. Referring to fig. 5, this is because, in practical use, the high-voltage high-frequency steep pulse generating module 3 outputs a high-voltage high-frequency steep pulse signal, that is, an analog signal, and the current signal collecting module 4 generally collects an analog signal, but the current signal output by the high-voltage high-frequency steep pulse generating module 3 is generally small, for example, 0.1A, 1A, or 5A, and after the analog signal amplifying module 8 is adopted, the current signal collecting module 4 can obtain a current value amplified by a certain multiple, so that the collection is more convenient. Certainly, the analog signal amplification module 8 can be selected from the specifications and models common in the market, and on the premise of meeting the functions of the application, the specific type of the analog signal amplification module 8 should not form the limitation of the application.
According to another embodiment of the first aspect of the present invention, an analog-to-digital conversion module 9 is further disposed between the current signal collection module 4 and the control module 2, and is configured to convert the signal transmitted from the current signal collection module 4 to the control module 2 into a digital signal. Referring to fig. 6 to 7, this is because, in practical use, the current signal collection module 4 outputs an analog signal, and the control module 2 generally collects a digital signal, so the analog-to-digital conversion module 9 must be used to convert the analog signal into a digital signal for the control module 2 to receive. Certainly, the analog-to-digital conversion module 9 may be a standard type commonly found in the market, and on the premise of satisfying the functions of the present application, the specific type of the analog-to-digital conversion module 9 should not form a limitation to the present application.
According to another embodiment of the first aspect of the present invention, the image capturing module 6 is a high definition camera. The high-definition camera is convenient for catch the abluent tumour cell image, and the change condition of tumour cell when melting is observed at touch display screen 11 one side to the doctor of being convenient for, technical staff or other people.
According to an embodiment of the first aspect of the present invention, the memory module 7 may be a memory with a circular overlay type body storage, and the data storage duration is t, where t is more than 30 days and less than 60 days. For example, the data storage period is 32 days.
Referring to fig. 8, an embodiment of the second aspect of the present invention provides a method for evaluating high-voltage high-frequency steep-pulse ablated tumor cells of a high-voltage high-frequency steep-pulse ablated tumor cell device based on image visualization according to any one of the first aspects of the present invention, comprising the following steps:
acquiring medical images through the image acquisition module 6, marking tumor targets in the acquired medical images, and establishing three-dimensional image data containing tumor target treatment target areas, wherein the dimensionality of the three-dimensional image data is mxnxh, m is the length of the three-dimensional image data, n is the width of the three-dimensional image data, and h is the spectral dimensionality of the three-dimensional image data; carrying out normalization processing on the three-dimensional image data: x = [ (X) m -X m0 )/(X m0 ),(X n -X n0 )/(X n0 ),(X h -X h0 )/(X h0 )]Wherein X is m ，X m0 Length coordinate, X, of three-dimensional image data n ，X n0 Is the width coordinate, X, of the three-dimensional image data h ，X h0 Spectral dimension coordinates of the three-dimensional image data;
generating a needle distribution area enveloping a tumor target treatment target area in a three-dimensional image, performing binarization operation on data after normalization processing of three-dimensional image data, and enabling X and a set threshold value X 0 Comparing when X is larger than X 0 The pixel becomes 1; when X is less than X 0 The pixel becomes 0, and the region where the pixel becomes 1 is defined as the binary imageThe needle distribution area is provided with the electrode module 5 to carry out high-voltage high-frequency steep pulse ablation tumor cell operation;
establishing an electromagnetic field distribution model, and calculating the electromagnetic field distribution of the high-voltage high-frequency steep pulse:
wherein, ω δ is k Δ xsin θ δ, ω σ is k Δ ysin θ σ, Δ x is the x-direction array unit interval, Δ y is the y-direction pixel interval, θ δ and θ σ are the scanning angle coordinates of the pixel point relative to the pixel center, M and N are the serial numbers of the pixel point in the x direction and the y direction, k is the wave number, k =2 pi/λ, M is the number of the pixel points in the x direction, N is the number of the pixel points in the y direction, (δ, σ) is the coordinate of the pixel point, a is the coordinate of the pixel point, and x is the scanning angle coordinate of the pixel point in the x direction and the y direction mn Is the amplitude weighting coefficient of the pixel point,
as a function of the distribution of the electromagnetic field,
target signals received by the pixel points;
in order to focus the phase weighting coefficients,
weighting coefficients for the scanning phases;
according to the electromagnetic field distribution, calculating the temperature field of the tumor cells, setting a temperature threshold value, obtaining isothermal surface envelopes of the temperature threshold value in the three-dimensional image, sequentially traversing coordinates (X, Y, Z) of the isothermal surface envelopes, and calculating an ablation volume:
；
setting ablation parameters through the upper computer 1, wherein the ablation parameters represent the degree of conformity between an ablation volume and a tumor target treatment target area;
recalculating the ablation volume to satisfy the ablation parameters.
In the embodiment of the present invention, the image acquired by the image acquisition module 6 can be used by a doctor, a technician or others to observe the change condition of the tumor cells during ablation on one side of the touch display screen 11, but the image acquired by the image acquisition module 6 also records the change condition of the tumor cells in real time, and if the change condition of the cells can be directly analyzed, the arrangement of the electrode module 5 and the setting of the high-voltage high-frequency steep pulse signal parameters are further guided, so that the ablation quality can be further improved. In view of this, in the embodiment of the present invention, first, the image acquisition module 6 acquires a medical image, marks a tumor target in the acquired medical image, and establishes a three-dimensional image including a treatment target region of the tumor target; then, generating a needle distribution area enveloping a tumor target treatment target area in the three-dimensional image, and arranging the electrode module 5 in the needle distribution area to implement high-voltage high-frequency steep pulse ablation tumor cell operation; then, calculating the electromagnetic field distribution of the high-voltage high-frequency steep pulse, calculating the temperature field of tumor cells according to the electromagnetic field distribution, setting a temperature threshold value, obtaining isothermal surface envelopes of the temperature threshold value in the three-dimensional image, sequentially traversing coordinates (X, Y, Z) of the isothermal surface envelopes, and calculating the ablation volume:
(ii) a Then, setting ablation parameters through the upper computer 1, wherein the ablation parameters represent the degree of conformity between the ablation volume and the tumor target treatment target area; finally, the ablation volume is recalculated to meet the ablation parameters.
That is to say, the embodiment of the present invention also records the change condition of tumor cells in real time through the images acquired by the image acquisition module 6, marks the tumor target according to the acquired images by using the control module 2, the upper computer 1, etc., and then establishes a three-dimensional image including the tumor target treatment target area, so that the tumor target is clearly exposed in the upper computer 1 or the touch display screen 11; then, according to the exposed tumor target, the electrode module 5 is arranged at the position to perform the operation of ablating tumor cells by high-voltage high-frequency steep pulses, and according to the change of current in the operation process of ablating tumor cells, the voltage and the pulse value of the high-voltage high-frequency steep pulses are adjusted by adopting the mode of adjusting ablation parameters in the first aspect of the embodiment of the invention to realize the optimal ablation operation. And finally, analyzing the survival condition of the tumor cells after ablation on the image acquired by the image acquisition module 6, and then re-ablating according to the analysis result.
In conclusion, the evaluation method for ablating the tumor cells by the high-voltage high-frequency steep pulse provided by the embodiment of the invention can accurately analyze and evaluate the tumor cells and then accurately ablate the tumor cells by virtue of the image acquisition module 6, and has a good use effect.
It should be clear that the embodiments in this specification are described in a progressive manner, and the same or similar parts in the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. For embodiments of the method, reference is made to the description of the apparatus embodiments in part. The present invention is not limited to the specific steps and structures described above and shown in the drawings. Also, a detailed description of known process techniques is omitted herein for the sake of brevity.
The above description is only an example of the present application and is not limited to the present application. Numerous modifications and variations could be made to the present disclosure by those skilled in the art without departing from the scope of the present disclosure. Any modification, equivalent replacement, improvement or the like made within the spirit and principle of the present application shall be included in the scope of the claims of the present application.
Claims (1)
1. An image-visualized high-voltage high-frequency steep pulse tumor cell ablation system, which is characterized by comprising:
the upper computer (1) is used for inputting a current change threshold, judging whether ablation parameters need to be adjusted or not, and sending an adjustment instruction when the ablation parameters need to be adjusted; the upper computer (1) further comprises a touch display screen (11), and the touch display screen (11) is used for observing the image change condition of the ablation target in real time;
the control module (2) is connected with the upper computer (1) and used for receiving an instruction of the upper computer (1) to generate control information and transmitting the image change condition of the ablation target to the touch display screen (11) in real time;
the high-voltage high-frequency steep pulse generating module (3) is connected with the control module (2) and is used for generating or adjusting a high-voltage high-frequency steep pulse signal by the control information of the control module (2);
the current signal acquisition module (4) is respectively connected with the control module (2) and the high-voltage high-frequency steep pulse generation module (3) and is used for acquiring a current signal generated by the high-voltage high-frequency steep pulse generation module (3) in real time during ablation operation and transmitting the acquired current signal to the control module (2);
the electrode module (5) is connected with the high-voltage high-frequency steep pulse generating module (3) and is used for receiving a high-voltage high-frequency steep pulse signal generated by the high-voltage high-frequency steep pulse generating module (3) and sending the signal to a tissue area to be ablated;
the image acquisition module (6) is connected with the control module (2) and is used for acquiring image information of a tissue area to be ablated and transmitting the acquired image information to the touch display screen (11) through the control module (2);
the memory module (7) is respectively connected with the control module (2) and the current signal acquisition module (4) and is used for storing the image information acquired by the image acquisition module (6), the operation information of the upper computer (1) and the current signal acquired by the current signal acquisition module (4);
the high-voltage high-frequency steep pulse generation module (3) comprises:
the high-voltage power supply generation module (31) is connected with the control module (2) and is used for generating a required high-voltage power supply according to the control information received from the control module (2);
the high-frequency steep pulse signal generating module (32) is respectively connected with the control module (2), the high-voltage power supply generating module (31), the current signal collecting module (4) and the electrode module (5) and is used for converting high voltage generated by the high-voltage power supply generating module (31) into required high-voltage high-frequency steep pulse signals according to control information received from the control module (2), transmitting the high-voltage high-frequency steep pulse signals to the current signal collecting module (4) so as to facilitate the detection of the current signals and transmitting the high-voltage high-frequency steep pulse signals to the electrode module (5) so as to facilitate the implementation of high-voltage high-frequency steep pulse ablation operation;
the control information of the control module (2) comprises a voltage control signal and a pulse control signal, and the control module (2) is used for outputting the voltage control signal to control the voltage value output by the high-voltage power supply generation module (31); the control module (2) is used for outputting a pulse control signal for outputting a high-frequency steep pulse output by the high-frequency steep pulse signal generation module (32);
the current signal acquisition module (4) comprises a current sensor (41) which is used for acquiring the current value of the high-frequency steep pulse output by the high-frequency steep pulse signal generation module (32) and sending the current value to the upper computer (1) through the control module (2);
the current signal acquisition module (4) is also used for acquiring a first current value of the high-frequency steep pulse signal generation module (32) before ablation operation and a second current value of the high-frequency steep pulse signal generation module after ablation operation, comparing the change values of the first current value and the second current value with the input current change threshold value, and if the change values of the first current value and the second current value are smaller than the input current change threshold value, adjusting ablation parameters;
an analog signal amplification module (8) is also arranged between the high-voltage high-frequency steep pulse generation module (3) and the current signal acquisition module (4) and is used for amplifying and processing the current signals acquired by the current signal acquisition module (4);
an analog-to-digital conversion module (9) is further arranged between the current signal acquisition module (4) and the control module (2) and is used for converting signals transmitted to the control module (2) from the current signal acquisition module (4) into digital signals;
the image acquisition module (6) is a high-definition camera;
the memory module (7) is a memory stored by a circulating covering type body, the data storage time is t, and t is more than 30 days and less than 60 days;
medical images are acquired through the image acquisition module (6), tumor targets are marked in the acquired medical images, and the medical images are acquiredThree-dimensional image data including a tumor target treatment target area is established, the dimensionality of the three-dimensional image data is mxnxh, wherein m is the length of the three-dimensional image data, n is the width of the three-dimensional image data, and h is the spectral dimensionality of the three-dimensional image data; carrying out normalization processing on the three-dimensional image data: x ═ X [ (X) m -X m0 )/(X m0 ),(X n -X n0 )/(X n0 ),(X h -X h0 )/(X h0 )]Wherein X is m ，X m0 Length coordinate, X, of three-dimensional image data n ，X n0 Is the width coordinate, X, of the three-dimensional image data h ，X h0 Spectral dimension coordinates of the three-dimensional image data;
generating a needle distribution area enveloping a tumor target treatment target area in a three-dimensional image, performing binarization operation on data after normalization processing of three-dimensional image data, and enabling X and a set threshold value X 0 Comparing when X is larger than X 0 The pixel becomes 1; when X is less than X 0 The pixel is changed into 0, according to the binary image, the area where the pixel is changed into 1 is the needle distribution area, and the electrode module (5) is arranged in the needle distribution area to implement high-voltage high-frequency steep pulse ablation tumor cell operation;
establishing an electromagnetic field distribution model, and calculating the electromagnetic field distribution of the high-voltage high-frequency steep pulse:
wherein, ω δ is k Δ xsin θ δ, ω σ is k Δ ysin θ σ, Δ x is the array unit interval in the x direction, Δ y is the pixel interval in the y direction, θ δ and θ σ are the scanning angle coordinates of the pixel points relative to the pixel center, M and N are the serial numbers of the pixel points in the x direction and the y direction, k is the wave number, k is 2 pi/λ, M is the number of the pixel points in the x direction, N is the number of the pixel points in the y direction, (δ, σ) is the coordinates of the pixel points, a is the coordinate of the pixel points, and x is the scanning angle coordinates of the pixel points in the x direction and the y direction mn Is the amplitude weighting coefficient of the pixel point,
as a function of the distribution of the electromagnetic field,
target signals received by the pixel points;
in order to focus the phase weighting factors,
weighting coefficients for the scanning phases;
according to the electromagnetic field distribution, calculating the temperature field of the tumor cells, setting a temperature threshold value, obtaining isothermal surface envelopes of the temperature threshold value in the three-dimensional image, sequentially traversing coordinates (X, Y, Z) of the isothermal surface envelopes, and calculating an ablation volume:
setting ablation parameters through the upper computer (1), wherein the ablation parameters represent the degree of conformity between an ablation volume and a tumor target treatment target area;
recalculating the ablation volume to satisfy the ablation parameters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210029099.2A CN114343820B (en) | 2022-01-12 | 2022-01-12 | Visual high-voltage high-frequency steep pulse of image melts tumour cell system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210029099.2A CN114343820B (en) | 2022-01-12 | 2022-01-12 | Visual high-voltage high-frequency steep pulse of image melts tumour cell system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114343820A CN114343820A (en) | 2022-04-15 |
| CN114343820B true CN114343820B (en) | 2022-09-20 |
Family
ID=81108497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210029099.2A Active CN114343820B (en) | 2022-01-12 | 2022-01-12 | Visual high-voltage high-frequency steep pulse of image melts tumour cell system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114343820B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848133B (en) * | 2022-04-22 | 2022-11-18 | 天津市鹰泰利安康医疗科技有限责任公司 | Tumor cell ablation system based on image visualization |
| CN115227379A (en) * | 2022-06-17 | 2022-10-25 | 江苏邦士医疗科技有限公司 | Six-phase steep pulse electric field tumor ablation system |
| CN115670639B (en) * | 2022-11-13 | 2023-06-30 | 天津市鹰泰利安康医疗科技有限责任公司 | High-voltage steep pulse treatment control system |
| CN116026625B (en) * | 2023-02-20 | 2023-08-18 | 天津市鹰泰利安康医疗科技有限责任公司 | Electroporation ablation performance detection device and method using high-frequency bidirectional pulse |
| CN116509534A (en) * | 2023-03-13 | 2023-08-01 | 浙江伽奈维医疗科技有限公司 | IGBT current detection and control device, system and method for steep pulse therapy |
| CN116077178B (en) * | 2023-04-04 | 2023-06-27 | 浙江伽奈维医疗科技有限公司 | Needle distribution simulating method and system for steep pulse tumor therapeutic apparatus and therapeutic apparatus |
| CN116458993A (en) * | 2023-04-19 | 2023-07-21 | 上海玮启医疗器械有限公司 | Pulse ablation control system |
| CN118058828B (en) * | 2024-04-17 | 2024-06-18 | 天津市鹰泰利安康医疗科技有限责任公司 | Bimodal composite pancreatic cancer tumor ablation method and bimodal composite pancreatic cancer tumor ablation system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394334A (en) * | 2018-11-23 | 2019-03-01 | 刘海鹰 | A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system |
| CN210408587U (en) * | 2018-11-23 | 2020-04-28 | 刘海鹰 | High-voltage bipolar steep pulse group tumor treatment system |
| CN113576652A (en) * | 2021-06-04 | 2021-11-02 | 上海睿刀医疗科技有限公司 | Composite steep pulse treatment equipment for automatically monitoring and adjusting ablation parameters |
| CN113633370B (en) * | 2021-08-18 | 2023-04-11 | 上海交通大学 | High-frequency composite electric field ablation system |
-
2022
- 2022-01-12 CN CN202210029099.2A patent/CN114343820B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN114343820A (en) | 2022-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114343820B (en) | Visual high-voltage high-frequency steep pulse of image melts tumour cell system | |
| JP4450622B2 (en) | Impedance-controlled tissue peeling device and method | |
| EP2684534B1 (en) | Electrosurgical systems including heat-distribution indicators | |
| US9439712B2 (en) | Heat-distribution indicators, thermal zone indicators, electrosurgical systems including same and methods of directing energy to tissue using same | |
| US8114070B2 (en) | Methods and systems for treating BPH using electroporation | |
| US9005193B2 (en) | Multichannel ablation with frequency differentiation | |
| US20080015571A1 (en) | Methods and systems for treating tumors using electroporation | |
| US8706258B2 (en) | Method and apparatus for treating cancer | |
| JP2004520865A (en) | Apparatus for tumor detection and treatment using localized impedance measurements | |
| CN101919728B (en) | Warm and hot therapeutic device | |
| US7662099B2 (en) | Method and instrumentation to sense thermal lesion formation by ultrasound imaging | |
| CN116687545A (en) | Tumor ablation system adopting pulsed electric field | |
| Gao et al. | Photoacoustic necrotic region mapping for radiofrequency ablation guidance | |
| CN113100917B (en) | Hybrid IRE and RF ablation using a sine wave generator | |
| KR20120074496A (en) | Apparatus for treatment and driving method thereof | |
| US20110071514A1 (en) | Method and system for controlling radio frequency output according to change in impedance of biological cells | |
| Zhang et al. | Biological current source imaging method based on acoustoelectric effect: A systematic review | |
| CN115737111A (en) | Energy control method and system based on wall thickness and impedance and ablation system | |
| KR101944436B1 (en) | The beauty mediacl device using a radio frequency that can control the high frequency irradiation and humidity adjustment amount | |
| Gao et al. | Miniaturized catheter-integrated photoacoustic ablation monitoring system: A feasibility study | |
| CN114788729A (en) | Catheter integrating ultrasonic imaging and radio frequency ablation | |
| US20190307333A1 (en) | Acoustoelectric image-guided therapy | |
| CN114052886B (en) | Control method of adaptive ablation device | |
| CN114847972B (en) | Transcranial brain stimulation multichannel data acquisition system and method | |
| KR20120117510A (en) | Apparatus for ultrasound treatment and driving method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |