CN114342826B - Electric shock device and application - Google Patents

Electric shock device and application Download PDF

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Publication number
CN114342826B
CN114342826B CN202111499619.8A CN202111499619A CN114342826B CN 114342826 B CN114342826 B CN 114342826B CN 202111499619 A CN202111499619 A CN 202111499619A CN 114342826 B CN114342826 B CN 114342826B
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electric shock
animal
cage
rotor
metal
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CN202111499619.8A
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CN114342826A (en
Inventor
孟志强
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Publication of CN114342826B publication Critical patent/CN114342826B/en
Priority to PCT/CN2022/137520 priority patent/WO2023104149A1/en
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K15/00Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
    • A01K15/02Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals
    • A01K15/029Electric or similar shock devices, e.g. prods
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K15/00Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
    • A01K15/02Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals
    • A01K15/021Electronic training devices specially adapted for dogs or cats

Abstract

The application belongs to the technical field of biomedicine, and particularly relates to an electric shock device and application. The existing animal models mainly adopt rodents, such as rats and mice. There are no relevant devices in large animals (e.g., pigs, dogs, monkeys, etc.). The application provides an electric shock device, including electric shock stimulator, circuit protection subassembly and the animal protection clothing that connects gradually, the animal protection clothing is including inlayer and the skin that stacks gradually, the inlayer is the metal level. The electric shock device is not interfered by external environment and equipment.

Description

Electric shock device and application
Technical Field
The application belongs to the technical field of biomedicine, and particularly relates to an electric shock device and application.
Background
In biomedical research, electric shocks are commonly used as an induction method in animal models. The principle is to utilize the natural fear and avoidance characteristics of animals (including humans) to electric shock, i.e., uncomfortable feeling such as pain is generated when receiving electric shock, and the animals naturally dislike the feeling and try to escape the electric shock. First, this sensation causes a learning of the surrounding scene upon shock and is therefore commonly used to study learning memory and associated post-traumatic stress syndrome. Secondly, when conditions are set such that the animal is highly likely to receive food or water, but is highly likely to receive an electric shock, the animal is in an anxious state and is therefore also used to study anxiety disorders. Again, when the animal is not able to escape from the shock anyway, the animal will give rise to a behavior of giving up escape, i.e. despair or similar depressive states, which are used to study depression. At present, rodent animals such as rats and mice are mainly adopted as the animal models. The experimental device is also special for small animals, is usually carried out by adopting a fear conditioning behavior box, the animals are placed into the behavior box, the lamp on the box wall is lightened or a special sound is played, meanwhile, a certain current is applied to the metal strip at the bottom of the box and lasts for a certain time, and therefore, the animals are shocked by electricity. There is no relevant device or method in large animals (e.g., pigs, dogs, monkeys, etc.), especially in monkeys, because they can climb up the side walls and top of the behavioral box or cage, and it is not feasible to apply an electric shock only at the bottom of the box.
The existing electric shock device is implemented in a behavior box mode, the bottom of the behavior box is composed of metal strips with alternate positive and negative electrodes and mutually insulated, when four limbs of an animal step on the positive and negative metal strips at the same time, if current is applied to the metal strips, a current loop can be formed to generate electric shock to the animal, and the current technology has the following defects: (1) The electric shock in the prior art is carried out by applying positive and negative electrodes to alternate electric shock metal strips, and one of the defects of the technology is that when the four limbs of an animal are just at the positive electrode or the negative electrode, a current loop cannot be formed, so that the electric shock cannot be generated. (2) The prior art is not suitable for animals which can climb or stand with two feet, such as monkeys, dogs and the like, and when the animals climb to the side wall or the top and leave the electric shock metal strip, electric shock cannot be generated; when the animal stands on both feet, there is a high probability that the animal will stand on the metal strip connected with the same pole, and electric shock may not be generated. (3) Unlike large and small animals, it is difficult for large animals to transfer the animals frequently, and particularly, the animals have a large response to re-entering the behavior box after the previous shock stimulation.
Disclosure of Invention
1. Technical problem to be solved
Based on the existing animal models, rodents such as rats and mice are mainly adopted. However, no relevant device problems exist in large animals (such as pigs, dogs, monkeys and the like), and the electric shock device and the application are provided.
2. Technical scheme
In order to achieve the above object, the present application provides an electric shock device, including electric shock stimulator, circuit protection subassembly and the animal protection clothing that connects gradually, the animal protection clothing is including the inlayer and the skin that stack gradually, the inlayer is the metal level.
Another embodiment provided by the present application is: the circuit protection assembly is a rotor, and the rotor is connected with the metal protection hose.
Another embodiment provided by the present application is: the electric shock stimulator comprises a positive electrode and a negative electrode, the rotor comprises an external connector and an internal connector, and the positive electrode is connected with the external connector.
Another embodiment provided by the present application is: the electric shock stimulator is connected with the intelligent terminal or the controller.
Another embodiment provided by the present application is: the rotor inner joint is connected with the metal layer through a lead, and the metal protection hose is arranged on the outer side of the lead.
Another embodiment provided by the present application is: the output current of the electric shock stimulator is adjustable constant direct current.
The application also provides an application of the electric shock device, which is characterized in that: the electric shock device is applied to a fear conditioning learning memory model, a post-traumatic stress syndrome animal model, an anxiety disorder animal model, a depression animal model or a drug addiction animal model of a large animal.
Another embodiment provided by the present application is: the electric shock stimulator is arranged above the rearing cage or the action cage, the circuit protection assembly is arranged above the rearing cage or the action cage, and the rearing cage or the action cage is a metal cage.
Another embodiment provided by the present application is: the electric shock stimulator generates stimulation current, the stimulation current reaches the skin of the trunk of the animal through the circuit protection component and the metal layer, and the stimulation current returns to the electric shock stimulator through the metal cage to form a current loop so as to form electric shock stimulation on the animal.
Another embodiment provided by the present application is: and the electric shock stimulator is used for adjusting the current and the stimulation time to set stimulation parameters.
3. Advantageous effects
Compared with the prior art, the electric shock device that this application provided's beneficial effect lies in:
the electric shock device provided by the application is an electric shock device which is not interfered by external environment and equipment.
The application provides an electric shock device, the wire passes through metal protection hose connection animal protection clothing, prevents that the animal from grabbing the wire of stinging.
The application of the electric shock device that this application provided, electric shock stimulator passes through circuit protection subassembly and links to each other with the wire, and the electric wire winding when can preventing the animal from rotating.
According to the application of the electric shock device, the metal layer of the animal protection coat is connected with the lead and is in contact with the skin to form a current loop, so that the animal can be guaranteed to be stimulated by electric shock at any position.
The application of the electric shock device provided by the application can give electric shock stimulation through operational behaviors (such as pressing rods, drinking water and the like) or at artificially set time, so that an animal model of diseases is established in large animals.
The application of the electric shock device provided by the application can be used for establishing animal models such as electric shock related learning memory, electric shock related anxiety, depression, drug addiction and the like in large animals (such as pigs, dogs, monkeys and the like) to carry out biomedical research.
Drawings
Fig. 1 is a schematic view of the structure of the electric stun device of the present application.
Detailed Description
Hereinafter, specific embodiments of the present application will be described in detail with reference to the accompanying drawings, and it will be apparent to those skilled in the art from this detailed description that the present application can be practiced. Features from different embodiments may be combined to yield new embodiments, or certain features may be substituted for certain embodiments to yield yet further preferred embodiments, without departing from the principles of the present application.
Referring to fig. 1, the present application provides an electric shock device, including electric shock stimulator 1, circuit protection subassembly 2 and animal protection clothing 3 that connect gradually, animal protection clothing 3 includes the inlayer and the skin that stack gradually, the inlayer is the metal level.
The electric shock stimulator 1 may adopt an existing commercial electric shock stimulator. Compared with the existing mode of applying positive and negative electrodes by adopting alternate electric shock metal strips, the metal layer of the animal protection coat 3 designed by the invention can ensure that no matter where the four limbs of the animal step on, even when the animal climbs to the top of the cage, electric shock stimulation can still be applied.
The metal layer may be any material with better conductivity.
Further, the circuit protection component 2 is a rotor, and the rotor is connected with the metal protection hose 4.
A rotor is any device that can remain conductive when a wire at one end is rotated.
Further, the electric shock stimulator 1 includes a positive electrode and a negative electrode, and the rotor includes an external connector, and the positive electrode is connected to the external connector. The situation that the bodies of the animals are in the same pole can not be generated.
Further, the electric shock stimulator 1 is connected with an intelligent terminal or a controller.
Further, the rotor is connected with the metal layer through a wire, and the metal protection hose 4 is arranged outside the wire. The special animal protective clothing 3 is closely attached to the trunk of an animal, the inner layer is a metal layer which can be in close contact with the body and conducts current, the outer layer is a nylon layer which is firm and durable, and the animal protective clothing 3 is connected with the rotor through a metal protective hose.
The metal protective hose 4 can be any material having a strength that prevents an animal from biting.
Further, the output current of the electric shock stimulator 1 is an adjustable constant direct current.
The application also provides an application of the electric shock device, and the electric shock device is applied to a fear conditioning learning memory model, a post-traumatic stress syndrome animal model, an anxiety disorder animal model, a depression animal model or a drug addiction animal model of a large animal. Can be used for large animals including monkeys, dogs, pigs, etc., and can be used with visual or sound stimulation to establish animal models such as electric shock-related learning memory, electric shock-related anxiety, depression, drug addiction, etc. for biomedical research.
Further, the electric shock stimulator 1 is arranged above the rearing cage or the action cage 5, the circuit protection component 2 is arranged above the rearing cage or the action cage 5, and the rearing cage or the action cage 5 is a metal cage. The electric shock stimulator 1 is fixed above the behavior cage or the rearing cage 5, and a partition board is arranged at the bottom to place the animal to touch and grasp. The electric wire is connected out from the electric shock stimulator 1 and then reaches the top or the side surface of the behavior cage or the feeding cage 5 through a sealed metal protection pipe 4, wherein the negative pole is directly connected with the cage through a metal joint, and the positive pole is connected through a rotor fixed on the cage.
The shock test can be performed in a rearing cage without having to transfer the animal to a behavior cage.
The positive pole is connected to the external joint of the rotor, and the rotor is fixed on the cage. The other end of the rotor extends into the cage and is connected with the metal layer on the inner side of the animal protection clothes 3 through a lead, and the lead is protected through a metal protection hose 4. Due to the adoption of the rotor, the circuit can still be kept conductive even when the animal rotates.
Furthermore, the electric shock stimulator is turned on manually or by signals of a computer, a controller and the like, the electric shock stimulator 1 is turned on, stimulation current is generated and reaches the skin of the trunk of the animal through the circuit protection component 2 and the metal layer, and the stimulation current returns to the electric shock stimulator 1 through the metal cage to form a current loop so as to form electric shock stimulation on the animal.
The positive electrode and the negative electrode of the electric shock stimulator 1 are respectively connected to the metal behavior cage (or rearing cage) 5 and the animal protective clothing 3, the interior of the animal protective clothing 3 is in contact with the skin through the metal layer, when electric stimulation is applied, current can pass through the metal layer of the animal protective clothing 3, pass through the body of an animal and then return to the electric shock stimulator 1 through the metal cage in contact with the limbs of the animal, so that a current loop is formed, and electric shock is formed on the animal. By combining visual stimulation and sound stimulation, animal models such as electric shock related learning memory, electric shock related anxiety, depression, drug addiction and the like can be established in the large animals so as to carry out related biomedical research.
Furthermore, the electric shock stimulator 1 adjusts the current and the stimulation time to set the stimulation parameters.
The complete set of devices can be mounted on any housing for holding or temporarily viewing animals.
Although the present application has been described above with reference to specific embodiments, those skilled in the art will recognize that many changes may be made in the configuration and details of the present application within the principles and scope of the present application. The scope of protection of the application is determined by the appended claims, and all changes that come within the meaning and range of equivalency of the technical features are intended to be embraced therein.

Claims (6)

1. An electric stun device, characterized by: the animal protection garment comprises an electric shock stimulator, a circuit protection assembly and an animal protection garment which are sequentially connected, wherein the animal protection garment comprises an inner layer and an outer layer which are sequentially stacked, the inner layer is a metal layer, and the metal layer is made of a conductive material; the circuit protection assembly is a rotor, and the rotor is connected with a metal protection hose;
the electric shock stimulator comprises a positive electrode and a negative electrode, the rotor comprises an external joint, and the positive electrode is connected with the external joint; the positive electrode is connected to an external joint of the rotor, and the rotor is fixed on a feeding cage or a behavior cage; the other end of the rotor extends into the cage and is connected with the metal layer on the inner side of the animal protection coat through a lead, and the lead is protected through the metal protection hose;
the electric shock stimulator is arranged above the feeding cage or the behavior cage, the circuit protection assembly is arranged above the feeding cage or the behavior cage, and the feeding cage or the behavior cage is a metal cage; the electric shock stimulator generates stimulation current, the stimulation current reaches the skin of the trunk of the animal through the circuit protection component and the metal layer, and the stimulation current returns to the electric shock stimulator through the metal cage to form a current loop so as to form electric shock stimulation on the animal.
2. The electric stun apparatus of claim 1, wherein: the electric shock stimulator is connected with the intelligent terminal or the controller.
3. The electric stun apparatus of claim 1, wherein: the rotor is connected with the metal layer through a lead, and the metal protection hose is arranged on the outer side of the lead.
4. The electric stun apparatus of any one of claims 1-3 wherein: the output current of the electric shock stimulator is adjustable constant direct current.
5. Use of an electric stun device as claimed in any one of claims 1 to 4, wherein: the electric shock device is applied to a fear conditioning learning memory model, a post-traumatic stress syndrome animal model, an anxiety disorder animal model, a depression animal model or a drug addiction animal model of a large animal.
6. Use of the electric stun apparatus of claim 5 wherein: and the electric shock stimulator is used for adjusting the current and the stimulation time to set stimulation parameters.
CN202111499619.8A 2021-12-09 2021-12-09 Electric shock device and application Active CN114342826B (en)

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Application Number Priority Date Filing Date Title
CN202111499619.8A CN114342826B (en) 2021-12-09 2021-12-09 Electric shock device and application
PCT/CN2022/137520 WO2023104149A1 (en) 2021-12-09 2022-12-08 Electric shock apparatus and use thereof

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Application Number Priority Date Filing Date Title
CN202111499619.8A CN114342826B (en) 2021-12-09 2021-12-09 Electric shock device and application

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CN114342826A CN114342826A (en) 2022-04-15
CN114342826B true CN114342826B (en) 2022-11-29

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CN114342826B (en) * 2021-12-09 2022-11-29 深圳先进技术研究院 Electric shock device and application
CN115474556B (en) * 2022-10-26 2024-02-02 浙江大学医学院附属第一医院 Experimental device and experimental method for rat depression model

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CN102499109A (en) * 2011-10-20 2012-06-20 上海移数信息科技有限公司 High-grade intelligent scene fear analysis system
CN106455523A (en) * 2014-10-31 2017-02-22 深圳市大疆创新科技有限公司 Systems and methods for walking pets
CN205378675U (en) * 2016-03-15 2016-07-13 何田田 Pet dog coat
CN111280129A (en) * 2020-02-26 2020-06-16 重庆医科大学 Construction method of young-stage cynomolgus monkey depression model

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