CN114323899A - Detector and detection method for treating bone joint inflammation by estrogen receptor modulator - Google Patents
Detector and detection method for treating bone joint inflammation by estrogen receptor modulator Download PDFInfo
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- CN114323899A CN114323899A CN202210001404.7A CN202210001404A CN114323899A CN 114323899 A CN114323899 A CN 114323899A CN 202210001404 A CN202210001404 A CN 202210001404A CN 114323899 A CN114323899 A CN 114323899A
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Abstract
The invention relates to the technical field of reagent detection, in particular to an estrogen receptor modulator-based bone joint inflammation detector, which comprises a detection box, wherein a vibration table is slidably connected in the middle of the lower end of the detection box, a connecting table is arrayed at the upper end of the vibration table, a placing cavity is formed in the upper end surface of the connecting table, two extrusion plates are arranged on two sides of the placing cavity, the two extrusion plates are symmetrically arranged by taking the placing cavity as a center, rubber bulges are arrayed on the inner walls of the two extrusion plates, the placing cavity is of an arc-shaped structure, a connecting plate is fixedly connected in the middle of the detection box, a mounting cavity is arrayed in the middle of the connecting plate, a vibration block is slidably connected in the mounting cavity, the vibration block and the placing cavity are in one-to-one correspondence, a mounting through hole is formed in the middle of the vibration block, a detection test tube is arranged in the middle of the mounting through hole, the lower end of the detection test tube is positioned in the placing cavity, and drive plates are slidably connected on two sides of the vibration block, the invention can uniformly shake a plurality of detection test tubes at the same time, the reagent can be fully and uniformly mixed, and meanwhile, the use is simple and the adaptability is stronger.
Description
Technical Field
The invention relates to the technical field of reagent detection, in particular to a detector and a detection method for treating bone joint inflammation by an estrogen receptor modulator.
Background
Arthritis generally refers to inflammatory diseases caused by inflammation, infection, degeneration, trauma or other factors, and can be classified into bone, rheumatoid, ankylosis, reactivity, gout, rheumatism, suppuration, etc. according to the cause. According to statistics, half of people who are over 50 years old in China suffer from osteoarthritis, which is a very common disease in China. It has been found from the literature that estrogen can affect many organ systems. There are several ways in which estrogen acts on tissues, the most characteristic of which is that it interacts with estrogen receptors, resulting in changes in gene transcription. The use of estrogen receptors to treat osteoarthritis has begun in the clinic. When detecting the result, need add various reagents to shake it evenly, it is even that testing personnel shakes hand now mainly, shakes even effect relatively poorly, and the reagent in the test tube mixes inhomogeneously, influences the experimental result, and does not have among the current device and can make the test tube shake even and heat the many test tubes of hand shake even again automatically.
Disclosure of Invention
The invention aims to provide an estrogen receptor modulator-treated bone joint inflammation detector and a detection method thereof. To solve the problems set forth in the background art described above.
In order to achieve the purpose, the invention provides the following technical scheme: an inflammation detector for treating osteoarthrosis by estrogen receptor regulator comprises a detection box, wherein a vibration table is connected in the middle of the lower end of the detection box in a sliding manner, a connecting table is arranged at the upper end of the vibration table in an array manner, a placing cavity is arranged on the upper end face of the connecting table, extruding plates are arranged on two sides of the placing cavity, the two extruding plates are symmetrically arranged by taking the placing cavity as a center, rubber bulges are arranged on the inner walls of the two extruding plates in an array manner, the placing cavity is of an arc-shaped structure, a connecting plate is fixedly connected in the middle of the detection box, a mounting cavity is arranged in the middle of the connecting plate in an array manner, vibration blocks are connected in the mounting cavity in a sliding manner, the vibration blocks correspond to the placing cavity one by one, a mounting through hole is arranged in the middle of the vibration blocks, a detection test tube is arranged in the middle of the mounting through hole, the lower end of the detection test tube is positioned in the placing cavity, and drive plates are connected in the two sides of the vibration blocks in a sliding manner, vibrate the fixed slat of the lower extreme both sides of piece fixedly connected with all, the lower extreme and the connection platform fixed connection of fixed slat, two fixed slat uses the mounting hole to set up as central symmetry, the side of fixed slat is equipped with locking adjustment mechanism, locking adjustment mechanism's top and the side fixed connection of stripper plate.
Preferably, the upper side of the fixed slat is of a V-shaped structure, the lower end of the fixed slat is of an L-shaped structure, and the corners of the V-shaped structure at the upper end of the fixed slat are vertical structures.
Preferably, locking adjustment mechanism is by mounting panel, lock plate, pressure regulating plate and reset spring, the intermediate position sliding connection of mounting panel and fixed slat, lock plate fixed connection is in the middle of the upper end of mounting panel, the lock plate is just to the vertical structure department of fixed slat, reset spring fixed connection is between lock plate and fixed slat, pressure regulating plate is located the upper end of mounting panel.
Preferably, the pressure regulating plate is of a V-shaped structure, the corners of the pressure regulating plate are hinged to the side ends of the fixed slats, the upper side of the pressure regulating plate is of a horizontal structure, the lower side of the pressure regulating plate is of an inclined structure, the top end of the lower side of the pressure regulating plate is of a hook-shaped structure, and the top end of the lower side of the pressure regulating plate abuts against the side end of the locking plate.
Preferably, the upper end of the drive plate is a pressing head, the lower end of the drive plate abuts against the upper side of the adjusting pressure plate, a fixing ring is fixedly connected between the two drive plates, and the axis of the fixing ring and the axis of the mounting through hole are on the same straight line.
Preferably, the middle array of shaking the platform has the connector, connect platform and connector one-to-one, connect in the middle of the left side of platform and connector rotation connection, fixedly connected with electric putter on the left side inner wall of detection case, shake the left side and the power take off end fixed connection of platform.
Preferably, the installation intracavity wall all is the arc structure with the lateral wall that vibrates the piece, be equipped with the spacing groove on the inside wall of installation chamber, vibrate the both sides of piece all fixedly connected with stopper, stopper sliding connection is in the spacing inslot.
Preferably, both sides of the lower end of the extrusion plate are fixedly connected with auxiliary plates, the upper end of the connecting table is provided with a sliding groove, and the auxiliary plates are slidably connected in the sliding groove.
A method for detecting estrogen receptor modulators for treating inflammation of bone joints comprising:
the method comprises the following steps: pressing the driving plate, driving the extrusion plate to move by the driving plate, placing the test tube added with the reagent in the mounting through hole, and limiting and fixing the test tube by the extrusion plate;
step two: after the detection test tube is installed, the electric push rod drives the oscillating table to reciprocate back and forth, and when the oscillating table moves, the oscillating block is limited in the installation cavity, so that the connecting table rotates and inclines;
step three: the oscillating block is fixedly connected with the connecting table through the fixed strip plate, the oscillating block rotates along with the connecting table when the connecting table rotates, the connecting table and the oscillating block keep a horizontal state in the rotating process, and the reagents in the test tube are oscillated in reciprocating movement, so that the reagents can be fully fused;
step four: vibrate the completion back, vibrate the platform and connect the platform and all keep the horizontality, conveniently take out the detection test tube.
Compared with the prior art, the invention has the beneficial effects that:
firstly, a plurality of connecting tables are arranged on a vibration table, a plurality of test tubes are shaken up at one time, the test tubes with different diameters are clamped and fixed through an extrusion plate, the adaptability is stronger, and the test tubes are prevented from being collided and damaged in the shaking up process;
second, drive through the electric push rod and vibrate platform reciprocating motion that makes a round trip, shake even processing to the test tube, guarantee the abundant mixture of reagent for testing result is more accurate.
Drawings
FIG. 1 is a schematic view of the connection structure inside the detection box;
FIG. 2 is a schematic view of a three-dimensional connection structure of the oscillating block and the connection table;
FIG. 3 is an enlarged view of point A;
FIG. 4 is a schematic view of a connection structure of the oscillating table.
In the figure: 1 detection case, 2 connecting plates, 21 installation cavity, 3 detection test tubes, 4 vibrate the piece, 5 installation through-holes, 6 spacing grooves, 7 spacing blocks, 8 connection platforms, 9 fixed slat, 10 drive plates, 101 solid fixed ring, 11 stripper plate, 12 rubber bulge, 13 accessory plate, 14 spouts, 15 place the chamber, 16 locking adjustment mechanism, 161 mounting panel, 162 locking plate, 163 pressure regulating plate, 164 reset spring, 17 vibrate platform, 18 connector.
Detailed Description
In order to further understand and appreciate the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described and illustrated in the drawings in the embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments, and do not limit the embodiments in any way. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a technical solution: an estrogen receptor modulator treatment bone joint inflammation detector comprises a detection box 1, wherein the middle of the lower end of the detection box 1 is slidably connected with a vibration table 17, the upper end array of the vibration table 17 is provided with a connecting table 8, the upper end surface of the connecting table 8 is provided with a placing cavity 15, two sides of the placing cavity 15 are respectively provided with a squeezing plate 11, the two squeezing plates 11 are symmetrically arranged by taking the placing cavity 15 as a center, the inner walls of the two squeezing plates 11 are respectively provided with a rubber bulge 12 in an array mode, the placing cavity 15 is of an arc-shaped structure, the middle of the detection box 1 is fixedly connected with a connecting plate 2, the middle of the connecting plate 2 is provided with a mounting cavity 21, a vibration block 4 is slidably connected in the mounting cavity 21, the vibration block 4 corresponds to the placing cavity 15 one by one, the middle of the vibration block 4 is provided with a mounting through hole 5, a detection test tube 3 is arranged in the middle of the mounting through hole 5, the lower end of the detection test tube 3 is positioned in the placing cavity 15, two side driving plates 10 of the vibration block 4 are slidably connected, vibrate the fixed slat 9 of the lower extreme both sides of piece 4 all fixedly connected with, the lower extreme of fixed slat 9 with connect 8 fixed connection of platform, two fixed slats 9 use mounting hole 5 to set up as central symmetry, the side of fixed slat 9 is equipped with locking adjustment mechanism 16, locking adjustment mechanism 16's top and stripper plate 11's side fixed connection.
The upside of fixed slat 9 is the V-arrangement structure, and the lower extreme of fixed slat 9 is the L shape structure, and the corner of fixed slat 9 upper end V-arrangement structure is vertical structure, connects platform 8 to carry out fixed connection through fixed slat 9 and shock piece 4, connects platform 8 to drive when rotatory to vibrate piece 4 and rotate together through fixed slat 9, guarantees that the two is in the horizontality, avoids colliding detection test tube 3.
The adjusting pressure plate 163 is of a V-shaped structure, the corners of the adjusting pressure plate 163 are hinged to the side ends of the fixing strips 9, the upper side of the adjusting pressure plate 163 is of a horizontal structure, the lower side of the adjusting pressure plate 163 is of an inclined structure, the top end of the lower side of the adjusting pressure plate 163 is of a hook-shaped structure, the top end of the lower side of the adjusting pressure plate 163 abuts against the side end of the locking plate 162, when the driving plate 10 is pressed, the upper end of the adjusting pressure plate 163 is pressed by the lower end of the driving plate 10, the adjusting pressure plate 163 rotates, the locking plate 162 is pressed by the lower end of the adjusting pressure plate 163, the mounting plate 161 and the pressing plate 11 are pushed to move, and the detection test tube 3 can be conveniently inserted.
The upper end of drive plate 10 is for pressing the head for press more comfortable, the lower extreme of drive plate 10 supports and leans on adjusting pressure plate 163 upside, the solid fixed ring 101 of fixedly connected with between two drive plates 10, gu fixed ring 101's axis and mounting hole 5's axis are on same straight line, gu fixed ring 101 can prescribe a limit to the position of drive plate 10, avoid drive plate 10 and shock piece 4 to drop when shaking even reagent.
Vibrate platform 17's middle array has connector 18, connect platform 8 and connector 18 one-to-one, rotate with connector 18 in the middle of connecting platform 8's the left side and connect, fixedly connected with electric push rod on the left side inner wall of detection case 1, vibrate platform 17's left side and power take off end fixed connection, electric push rod drives and vibrates platform 17 reciprocating motion that makes a round trip, vibrate platform 17 when removing, vibrate piece 4 by the restriction in installation cavity 21, make and connect platform 8 to take place the rotation slope.
The lateral wall of installation cavity 21 inner wall and shock piece 4 all is the arc structure, is equipped with spacing groove 6 on the inside wall of installation cavity 21, vibrates the both sides of piece 4 all fixedly connected with stopper 7, and stopper 7 sliding connection is in spacing groove 6, and spacing groove 6 restricts the displacement who vibrates piece 4 and stopper 7, carries out spacing fixed to vibrating piece 4 simultaneously, avoids shaking even in-process, vibrates piece 4 and takes place to drop.
All fixedly connected with accessory plate 13 in the lower extreme both sides of stripper plate 11, the upper end of connecting table 8 is equipped with spout 14, and accessory plate 13 sliding connection restricts the distance that stripper plate 11 removed in spout 14, and when avoiding not having centre gripping detection test tube 3, stripper plate 11 takes place to drop.
A method for detecting estrogen receptor modulators for treating inflammation of bone joints comprising:
the method comprises the following steps: pressing the driving plate 10, driving the extrusion plate 11 to move by the driving plate 10, placing the test tube 3 added with the reagent in the installation through hole 5, and limiting and fixing the test tube by the extrusion plate 11;
step two: after the detection test tube 3 is installed, the electric push rod drives the oscillating table 17 to reciprocate back and forth, and when the oscillating table 17 moves, the oscillating block 4 is limited in the installation cavity 21, so that the connecting table 8 rotates and inclines;
step three: the oscillating block 4 is fixedly connected with the connecting table 8 through the fixed strip plate 9, the oscillating block 4 rotates along with the connecting table 8 when the connecting table 8 rotates, the connecting table 8 and the oscillating block 4 keep a horizontal state in the rotating process, and the reagents in the detection test tube 3 are oscillated in the reciprocating movement, so that the reagents can be fully fused;
step four: vibrate the completion back, vibrate platform 17 and connect platform 8 and all keep the horizontality, conveniently take out test tube 3.
While embodiments of the invention have been shown and described, it is emphasized that: the above description is presented only by way of example of use of an embodiment of the invention and is not intended to limit the invention in any way. It will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. An inflammation detector for treating bone joints by estrogen receptor modulators comprises a detection box (1), and is characterized in that: sliding connection has vibration platform (17) in the middle of the lower extreme of detection case (1), the upper end array of vibrating platform (17) has connection platform (8), the up end of connecting platform (8) is equipped with places chamber (15), the both sides of placing chamber (15) all are equipped with stripper plate (11), two stripper plate (11) are used to place chamber (15) and are set up as central symmetry, two all the array has rubber bulge (12) on the inner wall of stripper plate (11), place chamber (15) and be the arc structure, the centre fixedly connected with connecting plate (2) of detection case (1), the centre array of connecting plate (2) has installation cavity (21), sliding connection has vibration piece (4) in installation cavity (21), vibrate piece (4) and place chamber (15) one-to-one, the centre of vibrating piece (4) is equipped with mounting hole (5), be equipped with in the middle of installation through-hole (5) and detect test tube (3), the lower extreme of detecting test tube (3) is located places chamber (15), the both sides sliding connection who vibrates piece (4) has drive plate (10), vibrate the fixed slat of all fixedly connected with (9) in lower extreme both sides of piece (4), the lower extreme and the connection platform (8) fixed connection of fixed slat (9), two fixed slat (9) set up as central symmetry with installation through-hole (5), the side of fixed slat (9) is equipped with locking adjustment mechanism (16), the top of locking adjustment mechanism (16) and the side fixed connection of stripper plate (11).
2. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: the upside of fixed slat (9) is the V-arrangement structure, the lower extreme of fixed slat (9) is the L-arrangement structure, the corner of fixed slat (9) upper end V-arrangement structure is vertical structure.
3. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: locking adjustment mechanism (16) is by mounting panel (161), lock plate (162), adjusting pressure plate (163) and reset spring (164), the intermediate position sliding connection of mounting panel (161) and fixed slat (9), lock plate (162) fixed connection is in the middle of the upper end of mounting panel (161), lock plate (162) just are fixed slat (9) vertical structure department, reset spring (164) fixed connection is between lock plate (162) and fixed slat (9), adjusting pressure plate (163) is located the upper end of mounting panel (161).
4. The apparatus for detecting inflammation in bone joints according to claim 3, wherein the apparatus comprises: the adjusting pressure plate (163) is of a V-shaped structure, the corners of the adjusting pressure plate (163) are hinged to the side ends of the fixing strips (9), the upper side of the adjusting pressure plate (163) is of a horizontal structure, the lower side of the adjusting pressure plate (163) is of an inclined structure, the top end of the lower side of the adjusting pressure plate (163) is of a hook-shaped structure, and the top end of the lower side of the adjusting pressure plate (163) abuts against the side end of the locking plate (162).
5. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: the upper end of drive plate (10) is the press head, the lower extreme of drive plate (10) supports and leans on regulation pressure plate (163) upside, two fixedly connected with solid fixed ring (101) between drive plate (10), the axis of gu fixed ring (101) and the axis of installation through-hole (5) are on same straight line.
6. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: vibrate the middle array of platform (17) and have connector (18), connect platform (8) and connector (18) one-to-one, connect in the middle of the left side of platform (8) and connector (18) rotate the connection, fixedly connected with electric putter on the left side inner wall of detection case (1), vibrate the left side and the power take off end fixed connection of platform (17).
7. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: installation cavity (21) inner wall and the lateral wall that vibrates piece (4) all are the arc structure, be equipped with spacing groove (6) on the inside wall of installation cavity (21), vibrate all fixedly connected with stopper (7) in both sides of piece (4), stopper (7) sliding connection is in spacing groove (6).
8. The apparatus for detecting inflammation in bone joints according to claim 1, wherein the apparatus comprises: both sides of the lower end of the extrusion plate (11) are fixedly connected with auxiliary plates (13), the upper end of the connecting table (8) is provided with a sliding groove (14), and the auxiliary plates (13) are connected in the sliding groove (14) in a sliding manner.
9. An assay method according to any one of claims 1 to 8 for the treatment of inflammation of a bone joint with an estrogen receptor modulator, wherein:
the method comprises the following steps: pressing the driving plate (10), driving the extrusion plate (11) to move by the driving plate (10), placing the test tube (3) added with the reagent in the installation through hole (5), and limiting and fixing the test tube by the extrusion plate (11);
step two: after the detection test tube (3) is installed, the electric push rod drives the vibration table (17) to reciprocate back and forth, and when the vibration table (17) moves, the vibration block (4) is limited in the installation cavity (21), so that the connection table (8) rotates and inclines;
step three: the oscillating block (4) is fixedly connected with the connecting table (8) through the fixing strip plate (9), the oscillating block (4) rotates along with the connecting table (8) when the connecting table (8) rotates, the connecting table (8) and the oscillating block (4) keep a horizontal state in the rotating process, and reagents in the detection test tube (3) are oscillated in reciprocating movement, so that the reagents can be fully fused;
step four: vibrate the completion back, vibrate platform (17) and connect platform (8) and all keep the horizontality, conveniently take out test tube (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210001404.7A CN114323899B (en) | 2022-01-04 | 2022-01-04 | Oscillation device for estrogen receptor modulator-treated osteoarticular inflammation detector and oscillation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210001404.7A CN114323899B (en) | 2022-01-04 | 2022-01-04 | Oscillation device for estrogen receptor modulator-treated osteoarticular inflammation detector and oscillation method thereof |
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| Publication Number | Publication Date |
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| CN114323899A true CN114323899A (en) | 2022-04-12 |
| CN114323899B CN114323899B (en) | 2022-12-30 |
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| CN202210001404.7A Active CN114323899B (en) | 2022-01-04 | 2022-01-04 | Oscillation device for estrogen receptor modulator-treated osteoarticular inflammation detector and oscillation method thereof |
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2022
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Patent Citations (6)
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| CN207756072U (en) * | 2018-02-02 | 2018-08-24 | 宋亚兵 | A kind of test tube rotation rocking equipment |
| CN208757450U (en) * | 2018-05-15 | 2019-04-19 | 新昌县科畅科技咨询有限公司 | A kind of adjustable test tube rocking equipment of chemistry teaching bore |
| CN210187028U (en) * | 2019-06-20 | 2020-03-27 | 北京物资学院 | Laboratory chemical reagent vibrates device |
| CN211487441U (en) * | 2019-12-13 | 2020-09-15 | 上海膳生生物科技有限公司 | Test tube vibration device for food detection |
| CN214183235U (en) * | 2020-12-25 | 2021-09-14 | 哈尔滨钜仁生物科技有限公司 | Reagent pipe heat preservation strorage device |
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