CN114305538A - Tissue defect plugging device and tissue defect plugging device - Google Patents

Abstract

The invention relates to a tissue defect plugging device and a tissue defect plugging device. The tissue defect occluder comprises an occluder body which is made of memory material. When the occluder body is in the state of natural extension, all clamping rings are on the coplanar, perhaps, two adjacent clamping rings are equipped with the clearance on the straight line direction of its plane of perpendicular to, can produce and resume original shape moment of torsion for first room interval and second room interval produce the trend that is close to each other, and then make first room interval and second room interval between them close to each other and paste tightly, finally reach the purpose of sealing the oval hole, the shutoff effect is better, the operation is comparatively simple simultaneously. In addition, the calibers of the clamping rings are different, so that the flow-resistant membrane can be eliminated, the structure is simple, and the effect of plugging the oval hole is also obtained; in addition, by adopting the structural design form, the metal material implanted into the body is less, so that the complication of thrombosis can be avoided, namely adverse reaction is not easy to cause.

Description

Tissue defect plugging device and tissue defect plugging device

Technical Field

The invention relates to the technical field of medical suturing instruments, in particular to a tissue defect plugging device and a tissue defect plugging device.

Background

The foramen ovale is a physiological pathway in the embryonic stage of the atrial septum of the heart. The fetus has no pulmonary circulation and oxygenated blood from the umbilical cord flows from the right atrium of the fetus through the foramen ovale into the left atrium. After birth, with the establishment of pulmonary circulation, the pressure in the left atrium increases, and the secondary septum and the primary septum approach each other and are cohered and fused to gradually form a permanent atrial septum. However, if some people still do not fuse, patent foramen ovale (PFO for short) is formed. In most cases, the pressure in the left atrium of the human heart is greater than in the right atrium, the PFO being in a closed state. In certain circumstances, the PFO tunnel may be pushed open such that a passageway is formed between the left and right atria. Emboli from the venous system, which may enter the systemic circulation through PFO channels, appear as strokes or Transient Ischemic Attacks (TIA) if the cerebral arterial system becomes embolized.

The patent foramen ovale is common, the PFO occluder is implanted through catheter intervention, so that the secondary septum and the primary septum are close to and fused with each other, after the instrument is implanted, the endothelium gradually grows, and finally the whole PFO occluder is wrapped to form thorough occlusion. PFO occluders, among other things, typically comprise two occluding disks and a waist connecting the two occluding disks. PFO occluders are typically made of a superelastic metallic material, such as nitinol, and are compressible into an elongated configuration for delivery through a delivery catheter from outside the body along a vascular path to a site in the atrial septum. After delivery to the desired location, the PFO stopper is released from the delivery catheter, restoring its original two-disc-waist configuration. The waist is arranged in the PFO tunnel, and the two plugging disks are respectively tightly attached to the left atrium side and the right atrium side and are respectively clamped at openings at two ends of the tunnel. The blocking disk is formed by weaving nickel-titanium alloy wires into two side faces, the two side faces are connected with each other and form a certain inner space in the middle, the flow blocking film needs to be sewn in the inner space between the two side faces, the flow blocking film plays a role in blocking the oval hole tunnel, the operation of sewing the flow blocking film is complex, and the complexity of the manufacturing process is high.

Disclosure of Invention

The invention provides a tissue defect plugging device and a tissue defect plugging device, which are used for solving one or more technical problems in the prior art.

The technical scheme is as follows: a tissue defect occluder comprises an occluder body, wherein the occluder body is made of memory materials;

the occluder body comprises a filament body, the filament body is spirally arranged and is provided with at least two clamping and closing rings, at least one clamping and closing ring is used for abutting against the side surface of the first atrial septum deviating from the second atrial septum, and at least another clamping and closing ring is used for abutting against the side surface of the second atrial septum deviating from the first atrial septum; when the occluder body is in a natural extension state, all the clamping rings are positioned on the same plane, or gaps are arranged on the two adjacent clamping rings in the linear direction perpendicular to the plane where the clamping rings are positioned.

In one embodiment, the occluder body comprises a first clamping disk for abutting the first atrial septum and a second clamping disk for abutting the second atrial septum, the first clamping disk being connected to the second clamping disk; the first clamping disc comprises at least two clamping and closing rings which are different in caliber and connected in sequence, and the second clamping disc comprises at least two clamping and closing rings which are different in caliber and connected in sequence.

In one embodiment, at least one of the clamping loops in the first clamping disk and/or the second clamping disk is adapted to be disposed in an foramen ovale tunnel.

In one embodiment, all the clamping rings of the first clamping disk are coaxially arranged, and the calibers of all the clamping rings of the first clamping disk are gradually increased or decreased according to the arrangement sequence; all the clamping rings of the second clamping disc are coaxially arranged, and the calibers of all the clamping rings of the second clamping disc gradually increase or gradually decrease according to the arrangement sequence.

In one embodiment, the gripping loops of the first clamping disk alternate with the gripping loops of the second clamping disk when the occluder body is in a naturally expanded state.

In one embodiment, all the occluding rings of the occluding device body are coaxially arranged, and the calibers of all the occluding rings of the occluding device body are gradually increased or decreased according to the arrangement sequence.

In one embodiment, one end of the first clamping disk is one of the free ends of the tissue defect occluder, one end of the second clamping disk is the other free end of the tissue defect occluder, and the other end of the first clamping disk is connected with the other end of the second clamping disk.

In one embodiment, when the occluder body is in a natural extension state, the first clamping disk and the second clamping disk are on the same plane, or the first clamping disk and the second clamping disk are provided with gaps in a linear direction perpendicular to the plane of the first clamping disk and the second clamping disk.

In one embodiment, the first clamping disk and the second clamping disk are connected to form an integrated structure; the first clamping disc and the second clamping disc are made of the same memory material.

In one embodiment, the clasping loops are circular, oval, star-shaped, petal-shaped, triangular or polygonal.

In one embodiment, the filament is provided as a spring in a helically extending arrangement.

In one embodiment, the filaments are at least two; one of the silk bodies is provided with a spring which extends spirally around a first direction, the other silk body is provided with a spring which extends spirally around a second direction opposite to the first direction, and the spiral coils of the two springs are abutted in a one-to-one correspondence mode.

In one embodiment, the occluder body is stretched into an elongated strip shape when the occluder body is in a fully stretched state.

In one embodiment, the occluder body is made of a memory alloy or a memory metal.

A tissue defect occluding device, which comprises the tissue defect occluding device.

In one embodiment, the tissue defect occlusion device further comprises a sheath and a pushing assembly, and the occluder body is connected with the pushing assembly and arranged inside the sheath.

When the oval hole is closed, the occluder body is compressed and placed in the conveying device, the occluder is conveyed into the right atrium through a blood vessel, the conveying device penetrates through the oval hole tunnel, and the conveying device gradually releases the clamping and closing ring so that at least one clamping and closing ring is arranged outside the first atrial septum of the left atrium; withdrawing the delivery device from the foramen ovale tunnel, while the occlusive loop abutting against the outside of the septum primum remains stationary, thereby releasing, for example, at least one other occlusive loop and placing it in the foramen ovale tunnel; the delivery device is further withdrawn, releasing the remaining occlusive devices, and allowing the remaining occlusive devices to cling to the outside of the septum secundum of the right atrium. Wherein, because the occluder body is the memory material, when the occluder body is in the natural state of stretching out, all clamping ring are in the coplanar, perhaps, there are two adjacent clamping ring and be equipped with the clearance on the linear direction of its plane of perpendicular to, can produce and resume original shape moment of torsion, make first room interval and second room interval produce the trend that is close to each other, and then make first room interval and second room interval between them be close to each other and paste tightly, finally reach the purpose of sealing the oval hole, the shutoff effect is better, the operation is comparatively simple simultaneously. In addition, the calibers of the clamping rings are different, so that the flow-resistant membrane can be eliminated, the structure is simple, and the effect of plugging the oval hole is also obtained; in addition, by adopting the structural design form, the metal material implanted into the body is less, so that the complication of thrombosis can be avoided, namely adverse reaction is not easy to cause.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention.

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic structural view of a tissue defect occluder in accordance with an embodiment of the present invention;

FIG. 2 is a schematic structural view of the tissue defect occluder shown in FIG. 1 installed in the oval hole in an operating state;

FIG. 3 is a schematic structural view of a tissue defect occluder in accordance with another embodiment of the present invention;

FIG. 4 is a structural diagram of the tissue defect occluder shown in FIG. 3 in an operating state mounted in the foramen ovale;

FIG. 5 is a schematic structural view of a tissue defect occluder in accordance with a further embodiment of the present invention;

FIG. 6 is a schematic structural view of the tissue defect occluder shown in FIG. 5 in an operating state mounted in the foramen ovale;

FIG. 7 is a schematic structural view of a tissue defect occluder in accordance with an embodiment of the present invention in a natural extension state;

FIG. 8 is a schematic view of a tissue defect occluder in accordance with a further embodiment of the present invention;

FIG. 9 is a schematic view of a tissue defect occluder according to yet another embodiment of the present invention;

FIG. 10 is a schematic view of a tissue defect occluder in accordance with a further embodiment of the present invention;

fig. 11 is a schematic view of another view structure of a tissue defect occluder in accordance with yet another embodiment of the present invention.

10. A stopper body; 11. a filament body; 111. clamping and closing the ring; 112. a first clamping disk; 113. a second clamping disk; 114. a waist part; 20. a first room; 30. a second atrial septum; 40. an oval hole tunnel.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Referring to fig. 1, fig. 1 is a schematic structural view of a tissue defect occluder according to an embodiment of the present invention, which is suitable for suturing patent foramen ovale, blood vessel, atrial septal defect, ventricular septal defect, etc., and the tissue defect occluder according to an embodiment of the present invention.

Referring to fig. 1 and 2, fig. 2 is a structural schematic view of the tissue defect occluder shown in fig. 1 installed in the oval hole in an operating state; in one embodiment, the tissue defect occluder comprises an occluder body 10, the occluder body 10 being a memory material. The occluder body 10 comprises a filament body 11, the filament body 11 is spirally arranged and is formed with at least two clamping and closing rings 111, at least one clamping and closing ring 111 is used for abutting against the side surface of the first room 20, which is far away from the second room interval 30, and at least another clamping and closing ring 111 is used for abutting against the side surface of the second room interval 30, which is far away from the first room 20. When the occluder body 10 is in a natural extension state, all the clamping rings 111 are in the same plane, or two adjacent clamping rings 111 are provided with gaps in a straight line direction perpendicular to the plane of the clamping rings.

It should be noted that the clipping ring 111 refers to a structure formed by winding the filament 11 for one circle, for example, as shown in fig. 1, the occluder body 10 includes 9 clipping rings 111 with successively increasing diameters, and when the occluder body 10 is installed at the foramen ovale, the clipping ring 111 abuts against the wall of the atrial septum to fix the atrial septum.

When the above-mentioned tissue defect occluder is used for closing a foramen ovale, for example, the occluder body 10 is compressed and placed in a delivery device, the occluder device is sent to the right atrium through a blood vessel, the delivery device passes through a tunnel 40 of the foramen ovale, and the delivery device gradually releases the clamping and closing rings 111, so that at least one clamping and closing ring 111 is arranged outside the first room 20 of the left atrium; withdrawing the delivery device from the tunnel 40, while the gripping loop 111 abutting against the external side of the first room 20 remains stationary, and releasing, for example, at least one other gripping loop 111 and placing it in the tunnel 40; the delivery device is further withdrawn, releasing the remaining gripping and closure loops 111, and allowing the remaining gripping and closure loops 111 to fit snugly outside the septum secundum 30 of the right atrium. Because the occluder body 10 is made of memory materials, when the occluder body 10 is in a natural extension state, all the clamping rings 111 are on the same plane, or gaps are arranged on two adjacent clamping rings 111 in the linear direction perpendicular to the plane, the original shape restoring torque can be generated, so that the first room 20 and the second room 30 are close to each other, the first room 20 and the second room 30 are close to each other and attached tightly, and finally the purpose of sealing the oval hole is achieved, the occlusion effect is good, and the operation is simple. In addition, the calibers of the clamping rings 111 are different, so that the flow-resistant membrane can be eliminated, the structure is simple, and the effect of plugging the oval hole is also obtained; in addition, by adopting the structural design form, the metal material implanted into the body is less, so that the complication of thrombosis can be avoided, namely adverse reaction is not easy to cause.

Further, there are at least three clamping loops 111, and at least one clamping loop 111 is used to be disposed in the foramen ovale tunnel 40.

The number of the clipping rings 111 provided in the foramen ovale tunnel 40 may be one, two, three or other numbers, which is not limited herein, as long as the clipping rings 111 for abutting against the first room 20 partition and the clipping rings 111 for abutting against the second room partition 30 can be connected to each other to better block the defect site, so long as the specific foramen ovale structure can be adapted, and specifically, the number of the clipping rings 111 can be automatically adjusted to be suitable one or more layers according to parameters such as the depth and the length of the foramen ovale tunnel 40.

Referring to fig. 1 and 2, in one embodiment, the occluder body 10 includes a first clamping disk 112 for abutting the first room 20 compartment, and a second clamping disk 113 for abutting the second room compartment 30. The first clamping disk 112 is connected to a second clamping disk 113. The first clamping disk 112 includes at least two clamping rings 111 with different calibers and connected in sequence, and the second clamping disk 113 includes at least two clamping rings 111 with different calibers and connected in sequence. Thus, after the oval hole is blocked by the tissue defect blocking device, the first clamping disk 112 abuts against the first room 20, and the second clamping disk 113 abuts against the second room 30, namely, the first clamping disk 112 and the second clamping disk 113 can realize that the first room 20 and the second room 30 are close to each other and abut against each other, and finally the aim of closing the oval hole is achieved, and the blocking effect is better. In addition, the first clamping disk 112 comprises at least two clamping and closing rings 111 which are different in caliber and are arranged in sequence, and the second clamping disk 113 comprises at least two clamping and closing rings 111 which are different in caliber and are arranged in sequence, so that a good plugging effect can be achieved, a flow-resistant film can be eliminated, and the structure is simple.

Referring to fig. 1 and 2 or fig. 5 and 6, further, at least one clamping ring 111 of the first clamping disk 112 and/or the second clamping disk 113 is disposed in the foramen ovale tunnel 40. At least one clamping ring 111 of the first clamping disk 112 and/or the second clamping disk 113 is arranged in the foramen ovale tunnel 40 and corresponds to the waist 114.

In order to adapt to a specific oval hole structure and achieve better defect occlusion during the oval hole occlusion operation by using the tissue defect occluding device, according to specific conditions, at least one clamping ring 111 of the first clamping disk 112 may be placed in the oval hole tunnel 40 as a waist portion 114, at least one clamping ring 111 of the second clamping disk 113 may be placed in the oval hole tunnel 40 as a waist portion 114, and at least one clamping ring 111 of the first clamping disk 112 and at least one clamping ring 111 of the second clamping disk 113 may be placed in the oval hole tunnel 40 as a waist portion 114.

Referring to fig. 3 and 4, of course, as an alternative, a waist portion 114 may also be disposed between the first clamping disk 112 and the second clamping disk 113, the first clamping disk 112 is connected to the second clamping disk 113 through the waist portion 114, and the shape of the waist portion 114 is not limited, for example, the shape of the clamping ring 111 is a combination of one or more of a straight line segment, an arc segment and a broken line segment. After adopting the defective plugging device of tissue to block the foramen ovale like this, first clamp plate 112 butts in first room 20 separates, second clamp plate 113 butts in second room interval 30 for waist 114 is in foramen ovale tunnel 40, and first clamp plate 112 need not to set up in foramen ovale tunnel 40 with the clamping ring 111 of second clamp plate 113, and then first clamp plate 112 and second clamp plate 113 both can realize separating first room 20 and close to each other with second room interval 30 and paste tightly, finally reach the purpose of sealing the foramen ovale, the shutoff effect is better.

Specifically, the larger the number of the clamping rings 111 of the first clamping disk 112, the better, the at least two clamping rings 111 of the first clamping disk 112 with different calibers respectively abut against the first room 20 from inside to outside in sequence, so that the fixing effect on the first room 20 is better; similarly, the larger the number of the clamping rings 111 of the second clamping disk 113, the better, the at least two clamping rings 111 of the second clamping disk 113 with different calibers respectively abut against the second room partition 30 from inside to outside in sequence, so that the second room partition 30 is better fixed, the flow-blocking film can be eliminated, and the structure is simple.

Referring to fig. 1 to 6, in one embodiment, all the clamping rings 111 of the first clamping disk 112 are coaxially arranged, and the calibers of all the clamping rings 111 of the first clamping disk 112 are gradually increased or decreased in the order of their arrangement. In this way, all the clamping rings 111 of the first clamping disk 112 are sequentially arranged from inside to outside or from outside to inside, and abut against at least two different positions of the first room 20, so that a good plugging effect can be achieved, the flow-blocking film can be eliminated, and the structure is simple.

It should be noted that the setting order of all the locking rings 111 of the first clamping disk 112 is also the sequential connection order of all the locking rings 111 of the first clamping disk 112. Of course, in the present embodiment, it is not necessary to limit the calibers of all the clamping rings 111 of the first clamping disk 112 to be sequentially changed in the order of their arrangement. For example, as an alternative, at least two clamping rings 111 with the same diameter can be allowed to exist in all clamping rings 111 of the first clamping disk 112.

Referring to fig. 1 to 6, in one embodiment, all the clamping rings 111 of the second clamping disk 113 are coaxially arranged, and the calibers of all the clamping rings 111 of the second clamping disk 113 are gradually increased or decreased in the order of their arrangement. Similarly, all the clamping rings 111 of the second clamping disk 113 are arranged in sequence from inside to outside or from outside to inside, and abut against at least two different positions of the second chamber partition 30, so that a good plugging effect can be achieved, a flow-blocking film can be eliminated, and the structure is simple.

It should be noted that the setting order of all the locking rings 111 of the second clamping disk 113 is also the sequential connection order of all the locking rings 111 of the second clamping disk 113. Of course, in this embodiment, it is not necessary to limit the calibers of all the clamping rings 111 of the second clamping disk 113 to be sequentially changed in the order of their arrangement. Likewise, as an alternative, it is also possible to allow at least two snap rings 111 of the same diameter to be present in all the snap rings 111 of the second clamping disk 113.

As an example, when the occluder body 10 is in a natural extension state, all the clamping rings 111 of the first clamping disk 112 are arranged at equal intervals from inside to outside, and when the occluder body abuts against the partition of the first room 20, the effect of pressing the partition of the first room 20 is stable; when the occluder body 10 is in a natural extension state, all the clamping rings 111 of the second clamping disk 113 are arranged at equal intervals from inside to outside, and when the occluder body abuts against the second room interval 30, the compression effect on the second room interval 30 is stable. Of course, when the occluder body 10 is in a natural extension state, all the clamping rings 111 of the first clamping disk 112 are not limited to be arranged at equal intervals from inside to outside, and may be arranged at intervals in other manners; likewise, all the clamping rings 111 of the second clamping disk 113 are not limited to be arranged at equal intervals from inside to outside, and may be arranged at intervals in other manners, and are not limited herein.

Referring to fig. 7, in one embodiment, the occluding device body 10 is in a natural expanded state with the occluding rings 111 of the first clamping disk 112 alternating with the occluding rings 111 of the second clamping disk 113. In this way, when the occluder body 10 is in a natural extended state, the clamping loops 111 of the first clamping disk 112 and the clamping loops 111 of the second clamping disk 113 are arranged alternately, so as to avoid overlapping, so that on the one hand, they are arranged on the same plane as much as possible, and on the other hand, the occluder body 10 has a better flow blocking effect.

It should be noted that the arrangement of the clamping loops 111 of the first clamping disk 112 and the clamping loops 111 of the second clamping disk 113 alternately means that the clamping loops 111 of the first clamping disk 112 are located between two adjacent clamping loops 111 of the second clamping disk 113, and the clamping loops 111 of the second clamping disk 113 are located between two adjacent clamping loops 111 of the first clamping disk 112.

Of course, as an alternative, when the occluder body 10 is in a natural extension state, the clamping ring 111 of the first clamping disk 112 and the clamping ring 111 of the second clamping disk 113 are not limited to the alternate arrangement in the above-mentioned embodiments, for example, the clamping ring 111 of the first clamping disk 112 and the clamping ring 111 of the second clamping disk 113 are in contact with each other when the calibers of the clamping ring 111 are the same, and other arrangements are also possible, as long as the elastic force provided by deformation is enough to make the first room 20 and the second room 30 close to each other when closing the foramen ovale, and the specific structural form is not limited herein.

Referring to fig. 5 and 6, in one embodiment, all the occluding rings 111 of the occluding device body 10 are coaxially arranged, and the calibers of all the occluding rings 111 of the occluding device body 10 are gradually increased or decreased according to the arrangement sequence. Thus, according to the specific features of the foramen ovale, the clamping and closing ring 111 with a relatively small caliber can be sent into and abutted against the first room 20 partition, and the clamping and closing ring 111 with a relatively large caliber can be abutted against the second room partition 30, so that the foramen ovale can be better plugged. Of course, the relatively large-diameter clipping and closing ring 111 may be fed into the first room 20 to abut against the first room, and the relatively small-diameter clipping and closing ring 111 may abut against the second room 30, so as to achieve a good sealing effect on the foramen ovale.

Referring to fig. 1 to 6, in one embodiment, one end of the first clamping disk 112 is one of the free ends of the tissue defect occluder, one end of the second clamping disk 113 is the other free end of the tissue defect occluder, and the other end of the first clamping disk 112 is connected to the other end of the second clamping disk 113.

In one embodiment, the first clamping disk 112 is in the same plane as the second clamping disk 113 when the occluding device body 10 is in a natural, expanded state. So, can produce and resume original shape moment of torsion for first room 20 separates and produces the trend that is close to each other with second room interval 30, and then makes first room 20 between them separate and closely paste with second room interval 30 is close to each other, finally reaches the purpose of closed oval hole, and the shutoff effect is better, and the operation is comparatively simple simultaneously.

In another embodiment, the first clamping disk 112 and the second clamping disk 113 are provided with a gap in a linear direction perpendicular to the plane in which they lie. Where the gap is defined as d, d is set to be, for example, less than 1 mm. So, because clearance d is less, can produce the original shape moment of torsion of recovering equally for first room 20 separates and produces the trend that is close to each other with second room interval 30, and then makes first room 20 between them separate and second room interval 30 is close to each other and pastes closely, finally reaches the purpose of closed oval hole, and the shutoff effect is better, and the operation is comparatively simple simultaneously.

In one embodiment, the first clamping disk 112 is connected to the second clamping disk 113 to form a unitary structure. The first clamping plate 112 and the second clamping plate 113 are made of the same memory material. Therefore, the same memory wire can be respectively processed to form the first clamping disk 112 and the second clamping disk 113, the processing and forming speed is high, the production efficiency is high, the material consumption is low, and the damage to the body is extremely small.

Of course, as an alternative, the first clamping disk 112 and the second clamping disk 113 are not limited to be formed by processing and molding the filament 11 in the above embodiment, and may be manufactured in other manners, for example, the first clamping disk 112 and the second clamping disk 113 may be processed independently, and then combined to form an integrated structure by, for example, melting and connecting.

In one embodiment, the pinching collar 111 is circular (as shown in fig. 1-6), oval, star-shaped, petal-shaped, triangular, or polygonal. Thus, when the contour of the clamping ring 111 is designed to be regular, the first clamping disk 112 and the second clamping disk 113 can be conveniently machined and molded, and the production efficiency is high.

It should be noted that the outline of the clipping and closing ring 111 can be flexibly set and adjusted arbitrarily according to the size and shape of the foramen ovale, and may be regular or irregular, as long as it can press the atrial septum when abutting against the outer sidewall of the atrial septum.

Referring to fig. 8-11, in one embodiment, the filament 11 is provided as a spring in a helically extending arrangement. So, the silk body 11 is set up to the spring that the spiral extension was arranged, can corresponding stretch and compression when local atress to make occluder body 10 to not equidimension, the oval hole homoenergetic of shape can obtain good adaptability, thereby install the position at oval hole department and stabilize and be difficult for droing, and is better to the shutoff effect of oval hole, and the tissue damage that arouses simultaneously is less.

Referring to fig. 10 and 11, in one embodiment, the number of the filaments 11 is at least two. One of the filament bodies 11 is provided as a spring extending spirally around a first direction, the other filament body 11 is provided as a spring extending spirally around a second direction opposite to the first direction, and the spiral coils of the two springs are abutted in one-to-one correspondence. Thus, the two wires 11 extend in opposite directions, i.e. the two wires 11 have opposite unwinding forces and cancel each other out, so that any one wire 11 can be prevented from unwinding, and the fixing effect is better. Of course, as shown in fig. 8 and 9, the number of the filament 11 may be one, and the specific number is not limited herein and is set according to actual requirements.

In one embodiment, the occluding device body 10 is stretched into an elongated strip shape when the occluding device body 10 is in a fully stretched state. In this way, when the occluder body 10 needs to be transported to a surgical site, the occluder body 10 can be stretched into a slender strip shape, placed in a sheath tube with a small size specification, and transported to the right atrium through the sheath tube via a blood vessel to reach a tissue defect position.

It should be noted that the occluder body 10 is in a fully stretched state, that is, the occluder body 10 is stretched to a limit position.

In one embodiment, the occluding device body 10 is a memory alloy or memory metal. Therefore, the memory alloy or the memory metal is adopted, so that the damage to human tissues is small, and the memory alloy or the memory metal is durable, long in service life and low in cost. The memory alloy includes, but is not limited to, a titanium-nickel alloy, an aluminum alloy, a titanium alloy, and a nickel alloy, and may be selected according to actual requirements.

In one embodiment, the tissue defect occluding device further comprises a sheath and a pushing assembly, and the occluder body 10 is connected with the pushing assembly and arranged inside the sheath. Therefore, the sheath tube penetrates through the blood vessel to establish an operation channel, and the pushing assembly and the occluder body 10 are conveyed to the position near the foramen ovale. The pushing assembly is, for example, a steel cable, the stopper body 10 is further provided with a threaded connection portion connected with the wire body 11, the steel cable is provided with a threaded hole adapted to the threaded connection portion, the threaded connection portion is unlocked by rotating the steel cable, the clamping ring 111 of the wire body 11 is gradually released to the outside of the sheath tube, the wire body 11 is made of a memory material, when each clamping ring 111 is gradually released, the original shape restoring torque can be generated, the first room 20 and the second room 30 are close to each other and attached to each other, the goal of closing the oval hole is finally achieved, and the plugging effect is good.

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Claims (16)

1. A tissue defect occluder is characterized by comprising an occluder body, wherein the occluder body is made of memory material;

the occluder body comprises a filament body, the filament body is spirally arranged and is provided with at least two clamping and closing rings, at least one clamping and closing ring is used for abutting against the side surface of the first atrial septum deviating from the second atrial septum, and at least another clamping and closing ring is used for abutting against the side surface of the second atrial septum deviating from the first atrial septum; when the occluder body is in a natural extension state, all the clamping rings are positioned on the same plane, or gaps are arranged on the two adjacent clamping rings in the linear direction perpendicular to the plane where the clamping rings are positioned.

2. The tissue defect occluder of claim 1, wherein said occluder body comprises a first clamping disk for abutting said first atrial septum and a second clamping disk for abutting said second atrial septum, said first clamping disk being connected to said second clamping disk; the first clamping disc comprises at least two clamping and closing rings which are different in caliber and connected in sequence, and the second clamping disc comprises at least two clamping and closing rings which are different in caliber and connected in sequence.

3. The tissue defect occluder of claim 2, wherein at least one of said first clamping disk and/or said second clamping disk is adapted to be disposed in an foramen ovale tunnel.

4. The tissue defect occluder of claim 2, wherein all said occluding rings of said first clamping disk are coaxially arranged and the calibers of all said occluding rings of said first clamping disk are gradually increased or decreased in the order of their arrangement; all the clamping rings of the second clamping disc are coaxially arranged, and the calibers of all the clamping rings of the second clamping disc gradually increase or gradually decrease according to the arrangement sequence.

5. The tissue defect occluder of claim 4, wherein said gripping loops of said first clamping disk alternate with said gripping loops of said second clamping disk when said occluder body is in a naturally expanded state.

6. The tissue defect occluder of claim 2, wherein all said occluding rings of said occluding device body are coaxially arranged, and wherein the calibers of all said occluding rings of said occluding device body are gradually increased or decreased in the order of their arrangement.

7. The tissue defect occluder of claim 2, wherein one end of said first clamping disk is one of the free ends of said tissue defect occluder, one end of said second clamping disk is the other of the free ends of said tissue defect occluder, and the other end of said first clamping disk is connected to the other end of said second clamping disk.

8. The tissue defect occluder of claim 2, wherein the first clamping disk and the second clamping disk are in the same plane when the occluder body is in a natural expanded state, or wherein the first clamping disk and the second clamping disk are provided with gaps in a linear direction perpendicular to the plane in which the first clamping disk and the second clamping disk are located.

9. The tissue defect occluder of claim 2, wherein said first clamping disk is connected to said second clamping disk to form a unitary structure; the first clamping disc and the second clamping disc are made of the same memory material.

10. The tissue defect occluder of claim 1, wherein said clamping ring is circular, oval, star-shaped, petal-shaped, triangular or polygonal.

11. The tissue defect occluder of claim 1, wherein said filament is provided as a spring in a helically extending arrangement.

12. The tissue defect occluder of claim 11, wherein said filaments are at least two; one of the silk bodies is provided with a spring which extends spirally around a first direction, the other silk body is provided with a spring which extends spirally around a second direction opposite to the first direction, and the spiral coils of the two springs are abutted in a one-to-one correspondence mode.

13. The tissue defect occluder of claim 1, wherein said occluder body is stretched into an elongated strip when said occluder body is in a fully stretched state.

14. The tissue defect occluder of claim 1, wherein said occluder body is a memory alloy or a memory metal.

15. A tissue defect occlusion device, characterized in that it comprises a tissue defect occluder according to any of claims 1 to 14.

16. The tissue defect closure device of claim 15, further comprising a sheath and a pusher assembly, wherein said occluder body is connected to said pusher assembly and disposed inside said sheath.

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