CN114305555A - Tissue defect plugging device and operation suture line - Google Patents

Abstract

The invention relates to a tissue defect plugging device and an operation suture, wherein a far end is pushed out from the interior of a conveying sheath, so that the far end simultaneously pierces a first atrial septum and a second atrial septum at an oval hole; under the elastic force of the memory material body, the distal end can reversely pierce the septum secundum and the septum primum; when the distal end reversely pierces the atrial septum, the barbs on the side wall of the distal end synchronously pierce the second atrial septum and the first atrial septum, and can prevent the distal end from moving towards the direction far away from the proximal end, namely when the pushing assembly continues to push out the suture line body, the distal end can continuously move forwards and pierce the second atrial septum and the first atrial septum; finally, the proximal end of the suture is tied off and separated from the pushing assembly. At this time, the knotted point at the proximal end of the suture and the barb at the distal end of the suture fix the suture on the septum primum and the septum secundum as a whole, and the tissues of the septum primum and the septum secundum are tightly attached together.

Description

Tissue defect plugging device and operation suture line

Technical Field

The invention relates to the technical field of medical suturing instruments, in particular to a tissue defect plugging device and an operation suture.

Background

The foramen ovale is a physiological pathway in the embryonic stage of the atrial septum of the heart. The fetus has no pulmonary circulation and oxygenated blood from the umbilical cord flows from the right atrium of the fetus through the foramen ovale into the left atrium. After birth, with the establishment of pulmonary circulation, the pressure in the left atrium increases, and the secondary septum and the primary septum approach each other and are cohered and fused to gradually form a permanent atrial septum. However, if some people still do not fuse, patent foramen ovale (PFO for short) is formed. In most cases, the pressure in the left atrium of the human heart is greater than in the right atrium, the PFO being in a closed state. In certain circumstances, the PFO tunnel may be pushed open such that a passageway is formed between the left and right atria. Emboli from the venous system, which may enter the systemic circulation through PFO channels, appear as strokes or Transient Ischemic Attacks (TIA) if the cerebral arterial system becomes embolized.

Patent foramen ovale is common, and a PFO (Perfluorooctane phosphate) occluder is implanted through a catheter intervention occlusion method. PFO occluders typically include two disc surfaces (defined as the left and right disc surfaces, respectively) and a thin waist connecting the two disc surfaces. Occluders are typically made from superelastic metallic materials such as: nickel titanium alloy. Can be compressed into an elongated strip form for delivery from outside the body to the interatrial site along a vascular pathway through a delivery catheter. After delivery to the desired location, the PFO stopper is released from the delivery catheter, restoring its original two-disc-waist configuration. The two disc surfaces are respectively attached to the left atrium side and the right atrium side, and the waist part is arranged in the PFO channel. Thereby leading the secondary septum and the primary septum to be close to and fused with each other. After the device is implanted, endothelium gradually grows, and finally the whole PFO occluder is wrapped to form complete occlusion.

In the traditional technology, a PFO (Perfluorooctane phosphate) plugging device is used for plugging holes at two ends of a foramen ovale so as to play a role in closing the foramen ovale and blocking blood flow. However, because the PFO has its own pathophysiological structure, the primary septum and the parasitic septum are in a tunnel shape, and some complex PFOs are accompanied by interatrial septum tumors or multiple atrial septal defects, and have various shapes and sizes, if the form of the PFO occluder is not a real form suitable for the human pathophysiological structure, the PFO occluder brings risks to the operation, including the problems of the PFO occluder falling off, the blood flow insufficiency, the poor occlusion effect, and the complex operation.

Disclosure of Invention

The invention provides a tissue defect blocking device and a surgical suture line, which aim to solve one or more technical problems in the prior art.

The technical scheme is as follows: a surgical suture, comprising: the suture line body is a memory material body, and the suture line body is a bent line body in a natural stretching state; the suture body is provided with a far end and a near end which are opposite; the distal end is provided with a pointed shape capable of piercing target tissues, and barbs are arranged on the side wall of the distal end; the tip of the barb being closer to the distal head than the muzzle of the barb; the near end is used for being connected with the pushing assembly.

In one embodiment, the bent line body includes at least three straight line segments connected in sequence, or includes at least one arc-shaped line segment, or includes a combination of at least one straight line segment and at least one arc-shaped line segment.

In one embodiment, the suture body further comprises a mid-section connecting the distal end and the proximal end; when the suture line body is in a natural extension state, the middle section comprises a straight line section and/or an arc line section.

In one embodiment, the extension direction of the proximal end is defined as a first direction, the extension direction of the distal end is defined as a second direction, the first direction and the second direction form an included angle a, and a is 120-180 °.

In one embodiment, the proximal end and the distal end are each set to a straight line segment; the distal end is parallel to the proximal end when the suture body is in a naturally extended state.

In one embodiment, the middle section is provided as a straight line section, and the suture body further comprises a first arc-shaped line section connecting one end of the middle section with the distal end, and a second arc-shaped line section connecting the other end of the middle section with the proximal end.

In one embodiment, the suture body has a length of 1mm to 10mm at the distal end, a length of 5mm to 10mm at the middle section, and a length of 5mm to 20mm at the proximal end in a natural extension state.

In one embodiment, the number of the barbs is at least two, and all the barbs are arranged in sequence along the extending direction of the distal end.

In one embodiment, the suture body is a memory alloy or memory metal; the barb with the stylolite body is the integral structure.

In one embodiment, the proximal end is provided with a detent in a naturally extended state.

In one embodiment, the positioning part is a spiral structure or a folding structure or a positioning ring.

In one embodiment, the proximal tail portion is provided with a threaded connector that is rotatably coupled to the pusher assembly.

A tissue defect occluding device comprising said surgical suture.

In one embodiment, the tissue defect occlusion device further comprises a delivery sheath and a pusher assembly disposed within the delivery sheath; the suture line body is connected with the pushing assembly and arranged inside the conveying sheath.

When the tissue defect plugging device and the surgical suture are used, the tissue defect plugging device is conveyed to the position near the foramen ovale through a blood vessel by virtue of the conveying sheath, and the distal end is pushed out from the inside of the conveying sheath by virtue of the pushing assembly, so that the distal end simultaneously pierces the first atrial septum and the second atrial septum at the position of the foramen ovale; the pushing assembly is utilized to continuously push out the suture line body, so that the suture line body is exposed outside the delivery sheath and can naturally relax, at the moment, because the suture line body is a bent line body in a natural stretching state, the orientation of the distal end of the suture line is turned, and the distal end can reversely pierce the septum secundum and the septum primum under the elastic force action of the memory material body; the barbs on the side wall of the distal end of the; finally, the proximal end of the suture is tied off and separated from the pushing assembly. At this time, the knotted point at the proximal end of the suture and the barb at the distal end of the suture fix the suture on the septum primum and the septum secundum as a whole, and the tissues of the septum primum and the septum secundum are tightly attached together.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention.

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic structural view of a tissue defect occluding device according to an embodiment of the invention in operation;

FIG. 2 is a schematic structural view of a tissue defect occluding device according to another embodiment of the invention in operation;

FIG. 3 is a schematic structural view of a tissue defect occluding device according to another embodiment of the invention in a working state;

FIG. 4 is a schematic structural view of a tissue defect occluding device according to another embodiment of the invention in operation;

FIG. 5 is a schematic structural view of a tissue defect occluding device according to another embodiment of the invention in operation;

FIG. 6 is a schematic structural view showing a state in which a tissue defect occluding device according to still another embodiment of the present invention is operated;

FIG. 7 is a schematic structural view showing a state in which a tissue defect occluding device according to still another embodiment of the present invention is operated;

fig. 8 is a structural diagram illustrating a state in which a tissue defect occluding device according to still another embodiment of the present invention is operated.

10. A suture body; 11. a distal end; 111. a barb; 1111. a tip of the umbrella; 1112. an umbrella opening; 12. a proximal end; 121. a positioning part; 13. a middle section; 14. a first arc-shaped line segment; 15. a second arc-shaped line segment; 20. a push assembly; 30. a septum primum; 40. a second atrial septum; 50. a delivery sheath; 60. the foramen ovale.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Herein, it is noted that proximal refers to the end of the suture body that is closer to the operator, and distal refers to the end of the suture body that is further from the operator, i.e., earlier in contact with and piercing the atrial septum relative to the proximal end.

Referring to fig. 1, fig. 1 is a schematic structural view showing a state in which a tissue defect occluding device according to an embodiment of the present invention is operated, and the tissue defect occluding device according to an embodiment of the present invention includes a surgical suture. It is suitable for suturing patent foramen ovale 60, blood vessel, atrial septal defect, ventricular septal defect, etc. In one embodiment, the surgical suture includes a suture body 10. The suture body 10 is made of memory material, and the suture body 10 is a bent line body (as shown in fig. 1) in a natural extension state. Suture body 10 has opposite distal and proximal ends 11 and 12. The distal end 11 is provided with a pointed shape capable of piercing the target tissue, and barbs 111 are provided on the side wall of the distal end 11. The tip 1111 of the barb 111 is closer to the head of the distal end 11 than the gore 1112 of the barb 111. The proximal end 12 is adapted to be coupled to a pusher assembly 20.

It should be noted that the head of the distal end 11 refers to the end point of the distal end 11 that is farthest from the proximal end 12 in the direction along the extending path of the suture body 10; conversely, the trailing end 11 refers to the end point on the distal end 11 closest to the proximal end 12 along the path of the suture body 10.

It should be noted that, because the tip 1111 of the barb 111 is closer to the head of the distal end 11 than the nozzle 1112 of the barb 111, the barb 111 will pierce the interatrial septum smoothly and simultaneously when the distal end 11 pierces the interatrial septum, and after the barb 111 pierces the interatrial septum, the barb 111 will prevent the distal end 11 from moving back out of the interatrial septum and only continue to move forward under the pushing force of the pushing assembly 20.

When the surgical suture is used, the distal end 11 is pushed out from the inside of the delivery sheath 50 through the delivery sheath 50 and the delivery sheath 50 is conveyed to the vicinity of the foramen ovale 60 through the blood vessel by the delivery sheath 50, so that the distal end 11 simultaneously pierces the septum primum 30 and the septum secundum 40 at the position of the foramen ovale 60; the pushing assembly 20 is used for continuously pushing out the suture line body 10, so that the suture line body 10 is exposed outside the delivery sheath 50 and can naturally relax, at the moment, because the suture line body 10 is a bent line body in a natural stretching state, the orientation of the distal end 11 of the suture line is turned, and the distal end 11 can reversely pierce the septum secundum 40 and the septum primum 30 under the elastic force of the memory material body; while distal end 11 is piercing the atrial septum in the opposite direction, barbs 111 on the sidewall of distal end 11 simultaneously pierce septum secundum 40 and septum primum 30 and prevent distal end 11 from moving in a direction away from proximal end 12, i.e., while pusher assembly 20 continues to push out suture body 10, further forward movement of distal end 11 (i.e., in a direction closer to proximal end 12) is achieved and second atrial septum 40 and septum primum 30 are pierced; finally, the proximal end 12 of the suture is tied off and separated from the pusher assembly 20. At this point, the knotted point at proximal end 12 of the suture and barbs 111 at distal end 11 of the suture hold the suture together at septum primum 30 and septum secundum 40 and hold the tissue of septum primum 30 and septum secundum 40 snugly together.

It should be noted that the "barb 111" may be "a portion of the distal end 11", that is, the "barb 111" is integrally formed with "the other portion of the distal end 11"; or a separate member that is separable from the rest of the distal end 11, i.e., the barbs 111, may be separately formed and then integrated with the rest of the distal end 11. As shown in FIG. 1, in one embodiment, the "barb 111" is a part of the "distal end 11" that is integrally formed.

Referring to fig. 1 to 5, fig. 1 to 5 illustrate surgical sutures with different shapes, in an embodiment, the bent wire body includes at least three straight line segments (as shown in fig. 1), or includes at least one arc-shaped line segment (as shown in fig. 2), or includes a combination of at least one straight line segment and at least one arc-shaped line segment (as shown in fig. 3). Thus, referring to fig. 1, when the bent wire body adopts at least three straight line segments connected in sequence, that is, the distal end 11 is set as the first straight line segment, thus, during the process of first delivering the distal end 11 out of the delivery sheath 50, and puncturing the septum primum 30 and septum secundum 40, because the distal end 11 is a straight line segment which vertically acts on the septum primum 30 and the septum secundum 40, the stress is concentrated, it is easier to pierce septum primum 30 and septum secundum 40, after the straight line segment has pierced the septum from the right atrium into the left atrium, the other straight line segments enter the left atrium in sequence, and in the process of recovering the shape to the bent line body under the action of the self elastic force of the memory material body, the far end 11 can realize 180-degree turning, and can reverse pierce septum secundum 40 and septum primum 30 again until it returns to the right atrium.

Referring to fig. 4, as an alternative, the bent line body includes three linear segments connected in sequence, and an arc segment serially disposed between two adjacent linear segments. When the arc-shaped line segments are arranged between two adjacent straight line segments in series, the transition effect is achieved, and the two adjacent straight line segments can smoothly puncture the first atrial septum 30 and the second atrial septum 40.

As an alternative, when the bent wire body adopts an arc-shaped line segment, the arc-shaped line segment may be specifically an arc-shaped line segment or an elliptic arc-shaped line segment, or when the bent wire body adopts a combination of an arc-shaped line segment and a straight line segment, the whole puncture process can be realized.

Referring to fig. 1-5, in one embodiment, the suture body 10 further includes a middle section 13 connecting the distal end 11 and the proximal end 12. When the suture body 10 is in a natural extension state, the middle section 13 includes a straight line segment and/or an arc-shaped line segment, the extension direction of the proximal end 12 is defined as a first direction (as shown by an arrow S1 in fig. 1), the extension direction of the distal end 11 is defined as a second direction (as shown by an arrow S2 in fig. 1), and an included angle a (not shown) formed between the first direction and the second direction is 120 ° to 180 °. Thus, the pushing assembly 20 is used to continuously push out the suture body 10, so that the suture body 10 is exposed outside the delivery sheath 50, and the suture body can be naturally relaxed, and at this time, because the suture body 10 is a bent line body in a natural extension state, and the included angle a is 120 ° to 180 °, the orientation of the suture distal end 11 is turned, and the distal end 11 can reversely pierce the second atrial septum 40 and the first atrial septum 30 under the elastic force of the memory material.

Referring to fig. 1, 3-5, in one embodiment, the proximal end 12 and the distal end 11 are each defined by straight line segments. The distal end 11 is parallel to the proximal end 12 when the suture body 10 is in a naturally extended state. Thus, the angle a is 180 degrees, so that the 180 degree rotation of the distal end 11 of the suture can better make the distal end 11 penetrate the septum secundum 40 and the septum primum 30 in the opposite direction under the elastic force of the memory material.

Referring to fig. 4, in one embodiment, the middle section 13 is a straight line section, and the suture body 10 further includes a first arc-shaped line section 14 connecting one end of the middle section 13 with the distal end 11, and a second arc-shaped line section 15 connecting the other end of the middle section 13 with the proximal end 12. Thus, after the distal end 11 passes through the interatrial septum, the middle section 13 can also smoothly puncture the interatrial septum due to the connection with the middle section 13 through the first arc-shaped line section 14, and meanwhile, the first arc-shaped line section 14 is an arc chamfer and has small damage to tissues; similarly, when the middle section 13 passes through the interatrial septum, the proximal end 12 can also smoothly penetrate the interatrial septum by connecting with the proximal end 12 through the second arc-shaped line section 15, and the second arc-shaped line section 15 is a circular arc chamfer and has less damage to tissues.

In one embodiment, suture body 10 has a length of 1mm to 10mm at distal end 11, a length of 5mm to 10mm at middle section 13, and a length of 5mm to 20mm at proximal end 12 in a naturally extended state.

It should be noted that the length of the distal end 11 refers to the length of the distal end 11 after being fully stretched and straightened, the length of the middle section 13 refers to the length of the middle section 13 after being fully stretched and straightened, and the length of the proximal end 12 refers to the length of the proximal end 12 after being fully stretched and straightened.

In one embodiment, suture body 10 is a memory alloy or memory metal. Therefore, the memory alloy or the memory metal is adopted, so that the damage to human tissues is small, and the memory alloy or the memory metal is durable, long in service life and low in cost. The memory alloy includes, but is not limited to, a titanium-nickel alloy, an aluminum alloy, a titanium alloy, and a nickel alloy, and may be selected according to actual requirements.

Referring to fig. 1, in one embodiment, there are at least two barbs 111, and all barbs 111 are arranged in sequence along the extending direction of the distal end 11. Thus, the distal end 11 is fixed on the atrial septum by at least two barbs 111, so that the distal end 11 is prevented from falling off from the atrial septum, and the connecting structure is stable.

Of course, as an alternative, the barbs 111 may be provided as one, and the distal end 11 can be fixed to the atrial septum by using one barb 111 to prevent the distal end 11 from falling off the atrial septum.

In one embodiment, barbs 111 are of unitary construction with suture body 10. Thus, in the production process, the barb 111 and the suture body 10 are integrally processed and formed, and the production efficiency is high.

Referring to fig. 6-8, in one embodiment, the proximal end 12 is provided with a positioning portion 121 in a natural extension state. Thus, when the proximal end 12 is fully released, the positioning portion 121 can abut against the septum primum 30, preventing the proximal end 12 from moving forward, which is equivalent to acting as a knotting point of the proximal end 12.

Referring to fig. 6 to 8, in one embodiment, the positioning portion 121 is a spiral structure (as shown in fig. 6), a folded structure (as shown in fig. 7) or a positioning ring (as shown in fig. 8). Thus, when the retainer 121 is fully released, it can expand to form a spiral, fold or loop that is stable against septum primum 30, preventing the proximal end 12 from moving forward, which is equivalent to acting as a tie point for the proximal end 12.

Referring to FIG. 1, in one embodiment, the proximal end 12 is provided with a threaded connector (not shown) at the rear thereof, which is rotatably coupled to the pusher assembly 20. Thus, the pushing assembly 20 is correspondingly provided with a threaded hole corresponding to the threaded connector, and the pushing assembly 20 drives the threaded connector to be unscrewed by means of rotation, so that the suture body 10 is pushed out from the interior of the delivery sheath 50.

Referring to fig. 1, in one embodiment, the tissue defect occlusion device further comprises a delivery sheath 50 and a pusher assembly 20 disposed within the delivery sheath 50. The suture body 10 is connected to the pushing assembly 20 and disposed inside the delivery sheath 50. In this way, in use, the suture body 10 is gradually pushed out from the inside of the delivery sheath 50 through the delivery sheath 50 and the delivery sheath 50 is conveyed to the vicinity of the foramen ovale 60 through the blood vessel, and finally the first atrial septum 30 and the second atrial septum 40 are sutured and attached to each other.

In summary, the tissue defect blocking device and the surgical suture in the above embodiments have at least the following advantages:

1. simple structure can adopt one or more operation stylolite just can directly make the two-layer interatrial interval laminating of oval hole 60 together, compares and uses traditional occluder can obtain better sealed effect, and the choked flow effect is complete, and the while operation is comparatively simple.

2. The barbs 111 are arranged on the distal end 11, so that the distal end 11 of the suture line body 10 can be fixed more conveniently; the positioning part 121 is arranged on the near end 12, so that the near end 12 can be conveniently positioned, an auxiliary tool is not needed for knotting, and the operation difficulty is greatly reduced.

3. Less metal materials are implanted into the human body, so that the adverse effect on the human body can be reduced.

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Claims (14)

1. A surgical suture, comprising:

the suture line body is a memory material body, and the suture line body is a bent line body in a natural stretching state; the suture body is provided with a far end and a near end which are opposite; the distal end is provided with a pointed shape capable of piercing target tissues, and barbs are arranged on the side wall of the distal end; the tip of the barb being closer to the distal head than the muzzle of the barb; the near end is used for being connected with the pushing assembly.

2. The surgical suture according to claim 1, wherein the bent wire body comprises at least three straight line segments connected in series, or comprises at least one arc segment, or comprises a combination of at least one straight line segment and at least one arc segment.

3. The surgical suture of claim 2, wherein the suture body further comprises a mid-section connecting the distal end and the proximal end; when the suture line body is in a natural extension state, the middle section comprises a straight line section and/or an arc line section.

4. The surgical suture of any one of claims 1 to 3, wherein the proximal end extends in a first direction and the distal end extends in a second direction, the first direction forming an angle a with the second direction, a being 120 ° to 180 °.

5. The surgical suture of claim 4, wherein the proximal end and the distal end are each provided as a straight line segment; the distal end is parallel to the proximal end when the suture body is in a naturally extended state.

6. The surgical suture of claim 3, wherein the middle section is provided as a straight line segment, the suture body further comprising a first arc-shaped line segment connecting one end of the middle section with the distal end, and a second arc-shaped line segment connecting the other end of the middle section with the proximal end.

7. The surgical suture of claim 3, wherein the suture body has a length of 1mm to 10mm at the distal end, a length of 5mm to 10mm at the mid-section, and a length of 5mm to 20mm at the proximal end in a naturally extended state.

8. The surgical suture of claim 1, wherein the number of barbs is at least two, all of the barbs being arranged in series along the extension of the distal end.

9. The surgical suture of claim 1, wherein the suture body is a memory alloy or a memory metal; the barb with the stylolite body is the integral structure.

10. The surgical suture of claim 1, wherein the proximal end is provided with a detent when in a naturally extended state.

11. The surgical suture of claim 10, wherein the positioning portion is a spiral structure or a folded structure or a positioning loop.

12. The surgical suture of claim 1, wherein the proximal tail is provided with a threaded connector that is rotationally coupled to the pusher assembly.

13. A tissue defect closure device, characterized in that it comprises a surgical suture according to any one of claims 1 to 12.

14. The tissue defect closure device of claim 13, further comprising a delivery sheath and a pusher assembly disposed within the delivery sheath; the suture line body is connected with the pushing assembly and arranged inside the conveying sheath.

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