CN114302734A - PnPP-19用于预防和治疗眼病的方法和用途 - Google Patents

PnPP-19用于预防和治疗眼病的方法和用途 Download PDF

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Publication number
CN114302734A
CN114302734A CN202080061721.7A CN202080061721A CN114302734A CN 114302734 A CN114302734 A CN 114302734A CN 202080061721 A CN202080061721 A CN 202080061721A CN 114302734 A CN114302734 A CN 114302734A
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CN
China
Prior art keywords
pnpp
eye
glaucoma
peptide
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080061721.7A
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English (en)
Chinese (zh)
Inventor
A·达·席尔瓦·库尼亚·朱尼尔
M·E·德·利马·佩雷斯·加西亚
C·努内斯·达·席尔瓦
L·费尔南达·努内斯·杜拉多
P·维拉尼·博尔赫斯·达·席尔瓦
P·古斯塔沃·圣保罗·拉卡蒂瓦
G·麦克斯·格罗斯
I·弗朗西斯科·德·保拉·朱尼尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomedical Product Development Co
Universidade Federal de Minas Gerais
Original Assignee
Biomedical Product Development Co
Universidade Federal de Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomedical Product Development Co, Universidade Federal de Minas Gerais filed Critical Biomedical Product Development Co
Publication of CN114302734A publication Critical patent/CN114302734A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN202080061721.7A 2019-09-03 2020-09-01 PnPP-19用于预防和治疗眼病的方法和用途 Pending CN114302734A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962895252P 2019-09-03 2019-09-03
US62/895,252 2019-09-03
PCT/BR2020/050349 WO2021042193A1 (en) 2019-09-03 2020-09-01 Method and use of pnpp-19 for preventing and treating eye diseases

Publications (1)

Publication Number Publication Date
CN114302734A true CN114302734A (zh) 2022-04-08

Family

ID=74682721

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080061721.7A Pending CN114302734A (zh) 2019-09-03 2020-09-01 PnPP-19用于预防和治疗眼病的方法和用途

Country Status (8)

Country Link
US (1) US20210060125A1 (https=)
EP (1) EP4025234A4 (https=)
JP (1) JP2022547231A (https=)
KR (1) KR20220084011A (https=)
CN (1) CN114302734A (https=)
BR (1) BR112022003759A2 (https=)
CA (1) CA3147704A1 (https=)
WO (1) WO2021042193A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024168415A1 (en) * 2023-02-17 2024-08-22 Biozeus Biopharmaceutical S.A. Topical peptide formulation for the treatment of sexual dysfunction
WO2025133214A1 (en) 2023-12-21 2025-06-26 Novaliq Gmbh Ophthalmic polypeptide compositions for the treatment of posterior eye disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068388A2 (pt) * 2015-09-18 2017-04-27 Universidade Federal De Minas Gerais - Ufmg Uso do peptideo sintetico pntx-19 para tratamento de dor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005097137A (ja) * 2003-09-22 2005-04-14 Tokyoto Igaku Kenkyu Kiko 糖尿病性網膜症の予防又は治療剤
JP2011219412A (ja) * 2010-04-09 2011-11-04 Saisentan Igaku Kenkyusho:Kk 緑内障の視野改善治療薬
US8759298B2 (en) * 2010-05-03 2014-06-24 Scott & White Healthcare Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration
MX362058B (es) * 2012-08-20 2019-01-07 Univ Federal De Minas Gerais Ufmg Péptido pntx(19) sintético, composición farmacéutica y uso.
GB201401453D0 (en) * 2014-01-28 2014-03-12 Univ Birmingham Transmucosal and transepithelial drug delivery system
BR102014010268B1 (pt) * 2014-04-29 2021-12-28 Universidade Federal De Minas Gerais - Ufmg Uso do peptídeo sintético pntx-19 para tratamento de dor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068388A2 (pt) * 2015-09-18 2017-04-27 Universidade Federal De Minas Gerais - Ufmg Uso do peptideo sintetico pntx-19 para tratamento de dor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAROLINA NUNES SILVA ET AL.: "PnPP-19, a synthetic and nontoxic peptide designed from a phoneutria nigriventer toxin, potentiates erectile function via NO/cGMP", 《THE JOURNAL OF UROLOGY》, vol. 194, no. 5, 30 November 2015 (2015-11-30), pages 1481 - 1490, XP055402767, DOI: 10.1016/j.juro.2015.06.081 *
RAFAEL SIMÓ ET AL.: "Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives", 《TRENDS ENDOCRINOL METABOLISM:TEM》, vol. 25, no. 1, 31 January 2014 (2014-01-31), pages 23 - 33, XP055252443, DOI: 10.1016/j.tem.2013.09.005 *

Also Published As

Publication number Publication date
BR112022003759A2 (pt) 2022-05-31
JP2022547231A (ja) 2022-11-10
US20210060125A1 (en) 2021-03-04
CA3147704A1 (en) 2021-03-11
EP4025234A1 (en) 2022-07-13
WO2021042193A1 (en) 2021-03-11
KR20220084011A (ko) 2022-06-21
EP4025234A4 (en) 2023-09-20

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