CN114288056A - Auxiliary device for detecting physiological indexes of small animals and using method thereof - Google Patents
Auxiliary device for detecting physiological indexes of small animals and using method thereof Download PDFInfo
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- CN114288056A CN114288056A CN202111493097.0A CN202111493097A CN114288056A CN 114288056 A CN114288056 A CN 114288056A CN 202111493097 A CN202111493097 A CN 202111493097A CN 114288056 A CN114288056 A CN 114288056A
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Abstract
The invention relates to an auxiliary device for detecting physiological indexes of small animals and a using method thereof, the auxiliary device comprises a supporting structure, a device main body, an elastic tail root fixing component and a tail sleeve pipe, wherein the device main body, the elastic tail root fixing component and the tail sleeve pipe are supported on the supporting structure, the device main body is made of transparent materials and can be used for conveniently observing and recording the real-time state of the small animals from multiple angles, the device main body is also provided with a bottom opening, the tail of the small animals can be conveniently stretched out naturally, and the excrement of the small animals can be conveniently collected in real time, the elastic tail root fixing component is used for fixing the small animals in an open elastic fixing mode, so that the small animals can be kept in a quiet and stable state in the device main body, the small animals are prevented from generating stress reaction and free rotation, further, various equipment connecting lines connected to the small animals are prevented from being wound or disconnected, and the tail sleeve pipe can be kept in a certain temperature range, not only the tail of the small animal is convenient to place comfortably, but also the experiment sampling operation is convenient.
Description
Technical Field
The invention relates to the technical field of animal nerve function research, in particular to an auxiliary device for detecting physiological indexes of small animals and a using method thereof.
Background
In animal nerve function research, animal physiological index changes need to be detected frequently. However, in the process of detecting the physiological indexes of the animals, the grasping operation of researchers often causes stress reaction of the animals, so that the measurement result is inaccurate, and particularly, the stress reaction is easy to occur in small animals such as experimental mice. In addition, in neuroscience research, an external device is often required to be connected to a conscious animal for wired stimulation or detection, the animal moves around after being connected with the wired device, external wires are easy to be wound and even the connection is interrupted, and the animal generates stress reaction such as tension after the animal is wound by the wires.
In the field, there are also some devices for fixing small animals when detecting the change of the physiological index of the animals, such as a binder device and a light-controlled animal blood sugar real-time monitoring device, wherein the binder device is used for fixing the small animals for intravenous injection and blood collection, however, the device is used for experimental operation and detection by completely binding the small animals, and obviously, the device can cause the stress of the small animals. The real-time monitoring device for the blood sugar of the light-regulated animal is used for real-time detection of the blood sugar concentration of the tail vein of the light-genetic-stimulated animal. Specifically, the real-time light-control animal blood sugar monitoring device buckles an animal in a lower-opening opaque cylinder with the volume twice that of the animal, and a plurality of small holes are formed in the top and the periphery of the lower end of the cylinder so as to facilitate light stimulation and tail detection of blood sugar. Under this kind of environment, the toy is faced what is a confined hood of few light, can't satisfy the needs of observing the overall state in real time, and the toy can freely be swung in addition, makes the equipment line take place to twine or break very easily when being connected with lighter fragile equipment line on the toy.
Generally, the device for fixing the small animal to assist the change detection of the physiological indexes of the animal at present has the problems that the animal easily generates stress reaction, is inconvenient to observe and the like, and the problem that the animal can freely move and rotate to cause the equipment wire connected with the animal body to be wound or broken due to poor animal fixing effect, so that the accuracy of the change detection of the physiological indexes of the animal cannot be ensured.
Disclosure of Invention
Based on this, an object of the present invention is to provide an auxiliary device for detecting physiological indexes of small animals and a method for using the same, wherein the device can open elastically fix the small animals, so that the small animals have loose and half free bodies and wide visual fields, can stay in place naturally and quietly after being adapted for a short time, can avoid the small animals from generating stress reactions and beating, and is beneficial to accurately detect the physiological index changes of the small animals.
An auxiliary device for detecting physiological indexes of small animals comprises a supporting structure, a device main body, an elastic tail root fixing component and a tail sleeve pipe, wherein the device main body is supported on the supporting structure;
the device main body comprises a supporting part movably supported on the supporting structure and a funnel part extending from the supporting part, wherein the funnel part is used for accommodating the small animal, the bottom of the funnel part is provided with a bottom opening, and the bottom opening is used for enabling the tail of the small animal to naturally fall and extend out and facilitating the collection of excrement of the small animal;
wherein the elastic tail root fixing component is arranged between the bottom opening and the tail sleeve pipe and is used for fixing the tail root of the small animal;
wherein the tail sleeve pipe is used for fixing the tail rear portion of the small animal, and the temperature of the tail sleeve pipe is set to be kept in a certain temperature range, so that the tail of the small animal can be comfortably placed and the experiment sampling operation is convenient.
In an embodiment of the invention, the device body is made of transparent material, and the inner surface and the outer surface are smooth surfaces, so that the small animals are prevented from being shielded, and the real-time state of the small animals can be observed and recorded conveniently.
In an embodiment of the invention, the elastic tail root fixing component comprises an adhesive tape, a clip, an elastic member and a tail root fixing ring, wherein the adhesive tape is used for adhering a tail root extending from the bottom opening, the clip is used for clamping a clamping part of the adhesive tape, the elastic member is used for binding and fixing the clip on the tail root fixing ring, so that the small animal can be kept in an autonomous elastic range, and the head of the small animal can face the fixing surface of the funnel part without rotating, and the various connecting lines on the small animal can be kept in quiet and stable connection.
In an embodiment of the invention, the tail root fixing ring has two fixing lugs, and the two ends of the clip are respectively fixed to the corresponding fixing lugs after the clip is bound and fixed by the elastic piece.
In an embodiment of the invention, the supporting structure includes a supporting base, an L-shaped bracket connected to the supporting base, and a supporting ring connected to the L-shaped bracket, the supporting portion of the device main body is a cylindrical structure, and an extending flange is formed at the top of the supporting portion in an extending manner, the supporting portion is movably sleeved in the supporting ring, and a state that the bottom surface of the extending flange is supported against the top surface of the supporting ring can be formed, so that the state of the device main body can be adjusted by lifting the supporting portion, and thus the small animal can be induced to actively climb to extend its tail out of the bottom opening of the funnel portion.
In an embodiment of the invention, the support part has a top opening, so that a connection wire of an external detection device can be led into the funnel part from the top opening and connected to the small animal body.
In an embodiment of the present invention, the supporting structure further includes a first supporting column connecting the supporting base and the tail fixing ring, and a second supporting column connecting the supporting base and the tail sleeving tube.
A use method of an auxiliary device for detecting a physiological index of a small animal comprises the following steps:
s1, placing the small animal on a funnel part of the auxiliary device, so that the tail of the small animal naturally extends out of the funnel part;
s2, sticking the tail root of the small animal by using an adhesive tape, clamping the clamping part of the adhesive tape by using a clip, binding the clip by using an elastic piece, and fixing the two ends of the elastic piece on a tail root fixing ring;
s3, inserting the tail back part of the small animal into the tail sleeve pipe, and keeping the tail sleeve pipe at a preset temperature; and
and S4, connecting the connecting wire of the detection device to the connecting end of the small animal.
In an embodiment of the present invention, the step S1 includes the steps of:
placing small animals into the funnel part for a plurality of times, and enabling the small animals to freely move to be familiar with the environment of the funnel part; and
the device body is lifted up at an incline so that the small animal actively climbs to induce it to project a tail out through the bottom opening of the funnel.
In an embodiment of the present invention, the method for using the auxiliary device for detecting a physiological index of a small animal further includes the steps of: s5, after the small animal is adaptively connected with a connecting line of the detection equipment, carrying out any one or more experimental operations of optogenetic stimulation, electrical stimulation, catheter administration, catheter body fluid collection, tail blood collection and myoelectricity and electroencephalogram collection on the small animal.
The auxiliary device for detecting the physiological indexes of the small animals fixes the small animals in an open elastic fixing mode, so that the small animals can be naturally and elastically kept in a quiet and stable state, stress reaction and free rotation of the small animals can be avoided, winding or disconnection of various equipment connecting lines connected to the small animals is avoided, particularly, light thin wire electric wires cannot be bitten by the small animals or pulled apart due to the fact that the small animals rotate and wind, and foreign body sensation on the small animals can be relieved to smoothly connect various precise detection equipment.
The device main body of the auxiliary device for detecting the physiological indexes of the small animals is made of transparent materials, so that the real-time state of the small animals in the device main body can be conveniently observed by eyes at multiple angles or recorded by a camera, and the requirement of observing the full state in real time is met.
The device main body of the auxiliary device for detecting the physiological indexes of the small animals is provided with the bottom opening, so that the tail of the small animals can be conveniently and naturally extended out, and meanwhile, the excrement of the small animals can be conveniently collected in real time.
The tail sleeving pipe adopted by the auxiliary device for detecting the physiological indexes of the small animals can be kept within a certain temperature range, such as 25-37 ℃, namely within a more comfortable temperature range of the small animals, so that the tails of the small animals can be placed comfortably, and meanwhile, the auxiliary device is convenient for experiment adoption operation, such as blood sampling operation on the tails of the small animals.
Further objects and advantages of the invention will be fully apparent from the ensuing description and drawings.
Drawings
Fig. 1 is a schematic structural diagram of the auxiliary device for detecting a physiological index of a small animal according to a preferred embodiment of the present invention.
Fig. 2 is a flow chart of a method for using the auxiliary device for detecting a physiological index of a small animal according to the above-mentioned selected embodiment of the present invention.
The reference numbers illustrate: a support structure 10; a support base 11; an L-shaped bracket 12; a support ring 13; a first support column 14; a second support column 15; a device main body 20; a support portion 21; an extension flange 211; a top opening 212; a funnel part 22; a bottom opening 221; an elastic tail root fixing component 30; an adhesive tape 31; a clip 32; an elastic member 33; a heel securing ring 34; a fixing lug 341; the tail is sleeved with a tube 40.
Detailed Description
The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art. The basic principles of the invention, as defined in the following description, may be applied to other embodiments, variations, modifications, equivalents, and other technical solutions without departing from the spirit and scope of the invention.
It will be understood by those skilled in the art that in the present disclosure, the terms "vertical," "lateral," "up," "down," "front," "back," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for ease of description and simplicity of description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus, the above terms should not be construed as limiting the present invention.
It is understood that the terms "a" and "an" should be interpreted as meaning that a number of one element or element is one in one embodiment, while a number of other elements is one in another embodiment, and the terms "a" and "an" should not be interpreted as limiting the number.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; may be mechanically connected, may be electrically connected or may be in communication with each other; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The invention provides the open type auxiliary device for elastically fixing the small animal, so that the small animal is loose and semi-free in body and wide in visual field, can naturally and quietly stay in place after being adapted for a short time, can avoid the small animal from generating stress reaction and free spin, ensures that the physiological index change of the small animal is accurately detected, and provides an accurate experimental basis for the animal nerve function research.
As shown in fig. 1, a specific structure of an auxiliary device for detecting a physiological index of a small animal according to the present invention is illustrated. The auxiliary device for detecting the physiological indexes of the small animals comprises a supporting structure 10, a device main body 20 supported on the supporting structure 10, an elastic tail root fixing component 30 and a tail sleeve pipe 40; the device main body 20 comprises a support part 21 movably supported on the support structure 10 and a funnel part 22 extending from the support part 21, the funnel part 22 is used for accommodating the small animal, the bottom of the funnel part 22 is provided with a bottom opening 221, the bottom opening 221 is used for allowing the tail of the small animal to naturally fall and extend out and facilitating the collection of excrement of the small animal; wherein the elastic tail root fixation assembly 30 is disposed between the bottom opening 221 and the tail sleeve tube 40 for fixation of the tail root of the small animal; wherein the tail sleeve pipe 40 is used for fixing the tail rear part of the small animal, and the temperature of the tail sleeve pipe 40 is set and kept in a certain temperature range, so as to ensure that the tail of the small animal can be comfortably placed and facilitate the experiment sampling operation.
Particularly, the device main body 20 is made of transparent materials, the inner surface and the outer surface of the device main body are smooth surfaces, so that the small animals are prevented from being shielded, most bodies of the small animals can be seen by eyes from multiple angles, the real-time state of the small animals in the device main body 20 can be conveniently observed by eyes from multiple angles or recorded by a camera, and the requirement of observing the full state in real time is met.
Preferably, the device body 20 is made of acrylic material.
It should be noted that the tail sleeve 40 may be connected to an external heating device or covered with a thermal bag to maintain the temperature within a certain temperature range, and the specific temperature maintaining manner of the tail sleeve 40 is not limited in the present invention.
In addition, it is worth mentioning that the temperature of the tail sleeving tube 40 is preferably kept at 25-37 ℃ to be close to the body temperature of the small animal and kept in a temperature range in which the small animal is comfortable, so that the tail of the small animal can be comfortably placed, and the experimental sampling operation can be facilitated, for example, the blood sampling operation is performed on the tail of the small animal.
Further, the elastic tail fixing assembly 30 comprises an adhesive tape 31, a clip 32, an elastic member 33 and a tail fixing ring 34, wherein the adhesive tape 31 is used for adhering the tail root extending from the bottom opening 221, the clip 32 is used for clamping the grippable part of the adhesive tape 31, and the elastic member 33 is used for binding and fixing the clip 32 on the tail fixing ring 34, so that the small animal can be kept in an autonomous elastic range, and the head of the small animal can face the fixed side of the funnel part 22 without rotating, thereby keeping various connecting lines on the small animal quiet and stable.
It is worth mentioning that the adhesive tape 31 is preferably a medical adhesive tape, the grippable portion of the adhesive tape 31 is a portion of the adhesive tape 31 other than the root of the tail of the small animal, and the elastic member 33 is preferably a rubber band.
Further, the tail fixing ring 34 has two fixing lugs 341, and the elastic member 33 fastens the clip 32 and then fixes the two ends to the corresponding fixing lugs 341.
It will be appreciated that by elastically fixing only the tail of the small animal by the elastic tail root fixing member 30, the small animal can be in a loose, semi-free state, and since the device body 20 is a transparent device, the small animal has a wide field of view, and after a short period of semi-free activity, the small animal can adapt to naturally and quietly stay in place, naturally and elastically remain in a quiet and stable state, avoiding the generation of stress reaction. Meanwhile, the tail root of the small animal is fixed on the tail root fixing ring 34 through the clamp 32 and the elastic piece 33, so that the head of the small animal can be kept towards the fixing surface of the funnel without rotating within an autonomous elastic range, and the connection of various detection devices is kept quiet and stable.
That is to say, the auxiliary device for detecting the physiological indexes of the small animals fixes the small animals in an open elastic fixing mode, so that the small animals can be naturally and elastically kept in a quiet and stable state, stress reaction and free rotation of the small animals can be avoided, winding or disconnection of various equipment connecting lines connected to the small animals can be avoided, particularly, light thin wire electric wires cannot be bitten by the small animals or pulled apart due to the fact that the small animals rotate and wind, and foreign body sensation on the small animals can be relieved to smoothly connect various precision detection equipment.
It should be mentioned that the supporting structure 10 includes a supporting base 11, an L-shaped support 12 connected to the supporting base 11, and a supporting ring 13 connected to the L-shaped support 12, the supporting portion 21 of the device main body 20 is a cylindrical structure and has an extending flange 211 formed at the top thereof, the supporting portion 21 is movably sleeved in the supporting ring 13, and can form a state that the bottom surface of the extending flange 211 supports against the top surface of the supporting ring 13, so that the device main body 20 can be movably supported on the supporting structure 10.
It will be appreciated that, with the device body 20 movably supported on the L-shaped bracket 12, the condition of the device body 20 can be adjusted by lifting the support 21 when the tail tray of the small animal is inside the funnel, for example, the device body 20 can be lifted obliquely, so as to facilitate the small animal to be induced to actively climb up to project its tail from the bottom opening 221 of the funnel portion 22.
In other words, by arranging the device main body 20 to be movably supported on the supporting structure 10, the posture of the small animal inside the device main body 20 can be adjusted by adjusting the posture of the device main body 20, so as to meet the requirements of different experiments, and simultaneously avoid the stress reaction of the small animal caused by adopting an adjusting mode such as direct grabbing.
It is worth mentioning that the support 21 has a top opening 212, so that the connection wires of the external detection device can be led into the funnel 22 from the top opening 212 and connected to the small animal.
Further, the supporting structure 10 further includes a first supporting column 14 connecting the supporting base 11 and the tail fixing ring 34, and a second supporting column 15 connecting the supporting base 11 and the tail sleeving tube 40.
It is worth mentioning that the tail root fixing ring 34, the tail sleeve pipe 40 and the support structure 10 are preferably made of stainless steel.
In addition, it is worth mentioning that the small animal used for auxiliary detection by the auxiliary device of the present invention is a mouse, and may also be other small animals, and the present invention does not limit the specific type of the experimental small animal.
In this embodiment of the present invention, the specific dimensions of the auxiliary device for detecting the physiological index of the small animal are as follows: support base 11 for long be 50cm, wide 30cm, high 8 cm's cuboid structure, device main part 20 open-top 212's diameter is 13cm, the degree of depth of supporting part 21 is 6.5cm, the degree of depth of funnel portion 22 is 12.5cm, be fan-shaped after funnel portion 22 expandes, sectorial radius is 15cm, bottom opening 221's diameter is 1cm, bottom opening 221 with support the distance between the base 11 and be 15 cm.
It should be understood that the auxiliary device for detecting the physiological index of the small animal may have other sizes according to different experimental requirements, and the invention is not limited thereto.
In this embodiment of the present invention, the specific steps of using the auxiliary device for detecting a physiological index of a small animal are as follows:
first, the small animal needs to move freely in the funnel 22 of the device body 20 to become familiar with the environment of the funnel 22 for three consecutive days, about one hour per day.
It is worth mentioning that the small animal, when familiar with the device body 20, will remain in a quiet climbing position at the bottom of the funnel portion 22, some will actively extend the tail out of the funnel bottom opening 221, some will tray the tail in the funnel, and the device body 20 can be lifted alone and tilted slightly to actively climb the small animal to induce its tail out of the funnel bottom opening 221.
Next, the root of the tail is stuck with a small piece of medical adhesive tape, the tape is additionally provided with a shank portion for a small clip to be clipped, the small clip is bound with an elastic member 33 and both ends of the elastic member 33 are fixed to tail fixing rings 34, respectively.
Again, after the tail exits the tail securing ring 34, the tail is inserted into the tail sleeve tube 40 and a heat-retaining pouch is attached to the tail sleeve tube 40 to maintain a temperature preferably near the body temperature of the small animal.
Finally, the equipment which needs to be connected to the small animal is connected to the small animal connecting end in a connecting line, and the small animal can carry out specific experimental operations after adapting for 40 minutes, such as: optogenetic stimulation, electrical stimulation, catheter administration, catheter body fluid collection, tail blood collection, myoelectricity brain electricity collection and the like.
That is, as shown in fig. 2, the invention also provides in another aspect a method for using the auxiliary device for detecting a physiological index of a small animal, comprising the steps of:
s1, placing the small animal on the funnel part 22 of the auxiliary device, so that the tail of the small animal naturally extends out of the funnel part 22;
s2, sticking the tail root of the small animal by using the adhesive tape 31, clamping the clampable part of the adhesive tape 31 by using a clip, binding the clip 32 by using the elastic piece 33, and fixing the two ends of the elastic piece 33 on the tail root fixing ring 34;
s3, inserting the tail back part of the small animal into the tail sleeve pipe 40, and keeping the tail sleeve pipe 40 at a preset temperature; and
and S4, connecting the connecting wire of the detection device to the connecting end of the small animal.
Specifically, the step S1 includes the steps of:
placing small animals in the funnel part 22 for a plurality of times to freely move so as to be familiar with the environment of the funnel part 22; and
the device body 20 is lifted up at an incline so that the small animal actively climbs to induce it to project its tail through the bottom opening 221 of the funnel 22.
Further, the use method of the auxiliary device for detecting the physiological indexes of the small animals further comprises the following steps: s5, after the small animal is adaptively connected with a connecting line of the detection equipment, carrying out any one or more experimental operations of optogenetic stimulation, electrical stimulation, catheter administration, catheter body fluid collection, tail blood collection and myoelectricity and electroencephalogram collection on the small animal.
In general, the auxiliary device for detecting the physiological indexes of the small animals has the following advantages:
(1) the small animal is fixed in an open elastic fixing mode, so that the small animal can be naturally and elastically kept in a quiet and stable state, and stress reaction and free rotation of the small animal can be avoided;
(2) the connection lines of various devices connected to the small animals cannot be wound or disconnected, particularly the light thin-wire type electric wires cannot be wound, pulled apart and bitten apart by the small animals, and the foreign body sensation on the small animals can be reduced to smoothly connect various precision devices;
(3) the device main body 20 made of transparent material is adopted, so that the real-time state of the small animal can be observed and recorded in multiple angles through naked eyes or a common camera;
(4) the tail of the small animal can be elastically and stably arranged in the tail sleeving pipe 40 which is kept in a certain temperature range, and the tail can be placed comfortably and is convenient for experiment sampling operation;
(5) the bottom opening 221 of the device main body 20 can facilitate the tail of the small animal to naturally fall and extend, and can collect the excrement of the small animal in real time.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above examples only express preferred embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. An auxiliary device for detecting physiological indexes of small animals is characterized by comprising a supporting structure, a device main body, an elastic tail root fixing component and a tail sleeve pipe, wherein the device main body is supported on the supporting structure;
the device main body comprises a supporting part movably supported on the supporting structure and a funnel part extending from the supporting part, wherein the funnel part is used for accommodating the small animal, the bottom of the funnel part is provided with a bottom opening, and the bottom opening is used for enabling the tail of the small animal to naturally fall and extend out and facilitating the collection of excrement of the small animal;
wherein the elastic tail root fixing component is arranged between the bottom opening and the tail sleeve pipe and is used for fixing the tail root of the small animal;
wherein the tail sleeve pipe is used for fixing the tail rear portion of the small animal, and the temperature of the tail sleeve pipe is set to be kept in a certain temperature range, so that the tail of the small animal can be comfortably placed and the experiment sampling operation is convenient.
2. The device as claimed in claim 1, wherein the device body is made of transparent material and has smooth inner and outer surfaces.
3. The auxiliary device for small animal physiological index detection according to claim 1 or 2, wherein the elastic tail fixing component comprises an adhesive tape, a clip, an elastic member and a tail fixing ring, wherein the adhesive tape is used for adhering a tail root extending from the bottom opening, the clip is used for clamping a clamping part of the adhesive tape, and the elastic member is used for binding and fixing the clip on the tail fixing ring.
4. The auxiliary device for detecting the physiological indexes of the small animals as claimed in claim 3, wherein the tail root fixing ring is provided with two fixing ears, and the two ends of the clip are respectively fixed on the corresponding fixing ears after the clip is bound and fixed by the elastic piece.
5. The auxiliary device for detecting the physiological index of the small animal as claimed in claim 3, wherein the supporting structure comprises a supporting base, an L-shaped bracket connected to the supporting base, and a supporting ring connected to the L-shaped bracket, the supporting portion of the device body is a cylindrical structure, and an extending flange is formed at the top of the supporting portion in an extending manner, the supporting portion is movably sleeved in the supporting ring, and a state that the bottom surface of the extending flange is supported against the top surface of the supporting ring can be formed.
6. An aid for the detection of a physiological index of a small animal according to claim 5, wherein the support portion has a top opening through which a connection cord of an external detection device can be introduced into the funnel portion and connected to the small animal.
7. The aid device for small animal physiological index detection according to claim 5, wherein the support structure further comprises a first support column connecting the support base and the tail root fixing ring and a second support column connecting the support base and the tail sleeve.
8. A use method of an auxiliary device for detecting a physiological index of a small animal is characterized by comprising the following steps:
s1, placing the small animal on a funnel part of the auxiliary device, so that the tail of the small animal naturally extends out of the funnel part;
s2, sticking the tail root of the small animal by using an adhesive tape, clamping the clamping part of the adhesive tape by using a clip, binding the clip by using an elastic piece, and fixing the two ends of the elastic piece on a tail root fixing ring;
s3, inserting the tail back part of the small animal into the tail sleeve pipe, and keeping the tail sleeve pipe at a preset temperature; and
and S4, connecting the connecting wire of the detection device to the connecting end of the small animal.
9. The method for using the auxiliary device for detecting the physiological index of small animals as claimed in claim 8, wherein said step S1 includes the steps of:
placing small animals into the funnel part for a plurality of times, and enabling the small animals to freely move to be familiar with the environment of the funnel part; and
the device body is lifted up at an incline so that the small animal actively climbs to induce it to project a tail out through the bottom opening of the funnel.
10. The method of using the auxiliary device for detecting the physiological index of the small animal as claimed in claim 8, further comprising the steps of: s5, after the small animal is adaptively connected with a connecting line of the detection equipment, carrying out any one or more experimental operations of optogenetic stimulation, electrical stimulation, catheter administration, catheter body fluid collection, tail blood collection and myoelectricity and electroencephalogram collection on the small animal.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023102772A1 (en) * | 2021-12-08 | 2023-06-15 | 中国科学院深圳先进技术研究院 | Apparatus for facilitating detection of physiological indicators of small animals and use method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023102772A1 (en) * | 2021-12-08 | 2023-06-15 | 中国科学院深圳先进技术研究院 | Apparatus for facilitating detection of physiological indicators of small animals and use method thereof |
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