CN114271492A - High-content rutin powder raw material composition, rutin powder, and preparation method and application thereof - Google Patents
High-content rutin powder raw material composition, rutin powder, and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a raw material composition with high-content rutin powder, a preparation method and application thereof. The product has the characteristics of high solubility, high content and the like, has excellent stability, and is particularly suitable for carbonated beverages, fruit juice beverages, functional beverages, milk beverages, solid beverages, tablet candies and other products with high requirements on clarity. The product can be in a state of no precipitation, no precipitation and clear solution in the liquid beverage, and the stability is excellent; the solid beverage has good dissolving property, and can be quickly dispersed and dissolved in cold water; the pressure resistance is good and the stability is good in tabletting.
Description
Technical Field
The invention relates to a high-content rutin powder raw material composition, rutin powder, a preparation method and application thereof, belonging to the technical field of microcapsules.
Background
Rutin, also known as rutin, is a flavonoid compound widely existing in nature, and is a natural antioxidant. Rutin has various physiological effects, can scavenge free radicals, absorb ultraviolet rays, has certain effects on protecting gastric mucosa and resisting osteoporosis, can also reduce blood sugar, and also has the effects of resisting cancer cells, resisting viruses, resisting bacteria, resisting inflammation, relieving pain, enhancing immunity and the like. The main effects of rutin are most clinically applied, namely the function of improving blood vessels, and the rutin can improve the elasticity of the blood vessels, reduce the permeability and fragility of the blood vessels and has the effects on cerebral hemorrhage, hypertension, retinal hemorrhage, purpura and the like. Because the rutin has various biological activities, no obvious side effect and high safety, the rutin is applied as a health-care product or food beneficial to health in foreign countries.
Although rutin has various health-beneficial effects, because rutin is insoluble in water, the dissolution rate of gastrointestinal tracts is low, and the oral bioavailability is low, so that the application of rutin is greatly limited. How to improve the water solubility of rutin and ensure the stable release of rutin, and further improve the bioavailability becomes a main direction for solving the application of rutin. In recent years, with the progress of research, a plurality of methods for solving the application of rutin are also proposed, such as preparation of rutin inclusion compounds, liposomes, self-microemulsion drug delivery systems and the like, but the methods have some problems respectively, such as the inclusion compounds use organic solvents with toxic and side effects, the liposomes are expensive and lack application prospects, and the microemulsion drug delivery systems need to use a large amount of surfactants and the like.
Based on the above factors, the microcapsule technology is a technology very suitable for solving the problem of rutin application, and the microcapsule technology is a technology that solid, liquid or gas is embedded in a tiny and sealed capsule and can be released under specific conditions. It features that the reaction of external factors to active matter is reduced, the physical state of active matter is changed, the taste of active matter is improved, and the utilization rate is raised. The preparation process does not use organic solvent and other substances with toxic and side effects, and is simple and easy to obtain, and the production cost is low.
The prior art describes some research results about improving the stability and water solubility of rutin: EP3453766a1 discloses a method for producing a flavone inclusion compound: the insoluble flavone with rhamnoside is treated with rhamnosidase in the presence of cyclodextrin to remove rhamnose in the flavone structure, and inclusion is performed, so that the solubility of the inclusion compound can be improved. CN201810525567.9 discloses a rutin-entrapped polymer micelle and a preparation method thereof: rutin and a rutin-coated carrier are mixed according to the proportion of 1: 3-100, dissolving rutin and a carrier in an organic solvent according to a ratio, and then dropwise adding the mixture into distilled water, wherein the volume ratio of the organic solvent to the distilled water is 1: 2-10. Volatilizing the organic solvent from the obtained solution, filtering, and collecting filtrate, namely the rutin-entrapped polymer micelle solution. EP3082728B1 discloses a method for the compatibilization of rutin with a polyhydroxy alkyl alcohol: the solubility of rutin in toothpaste is improved by adding polyhydroxy alkyl alcohol, specifically the rutin toothpaste is prepared by mixing a mixture consisting of rutin dissolved in one or more polyhydroxy alkyl alcohols and other toothpaste matrixes, wherein the weight ratio of the polyhydroxy alkyl alcohol to the rutin is 10: 1, the weight of rutin in the composition is 0.5 percent. CN113304113A discloses a co-amorphous solid dispersion for improving dissolution of quercetin and a preparation method thereof: adding quercetin into methanol or ethanol, heating in water bath, stirring, and dissolving completely to obtain quercetin alcoholic solution; adding lysine into methanol or pure water, stirring, and heating in water bath until the lysine is completely dissolved to obtain lysine alcohol solution; pouring the lysine alcohol solution into the quercetin alcohol solution according to the molar ratio of 1:1.5-2 of the quercetin to the lysine, heating in a water bath and stirring; filtering the mixed solution containing quercetin-lysine, stirring in water bath until the filtrate is completely evaporated, and drying the precipitate in a vacuum drying oven at 40 deg.C to obtain the final product, i.e. quercetin-lysine co-amorphous solid dispersion.
The preparation method of the currently disclosed technology cannot be simply and easily obtained, meanwhile, a solvent with toxic and side effects can be used in the preparation process, and further optimization is expected for the content and solubility of rutin in the obtained product.
Disclosure of Invention
The invention discloses a raw material composition with high-content rutin powder, a preparation method and application thereof. The product has the characteristics of high solubility, high content and the like, has excellent stability, and can be widely applied to solid beverages, liquid beverages, capsules, tablets and the like.
The invention provides a raw material composition of rutin powder, which comprises the following components in parts by weight:
wherein, the embedding wall material is prepared from cyclodextrin and Arabic gum according to the weight ratio of 1-20: 1, preparing a composition;
the mixture I is prepared from soluble soybean polysaccharide and gellan gum according to a weight ratio of 1-10: 1, and further, the weight ratio of the soluble soybean polysaccharide to the gellan gum is 2-5: 1.
for the technical scheme, it is further preferable that the raw material composition of the rutin powder comprises the following components in parts by weight:
for the technical scheme, it is further preferable that the raw material composition of the rutin powder comprises the following components in parts by weight:
for the technical scheme, most preferably, the raw material composition of the rutin powder comprises the following components in parts by weight:
for the above-described technical solution, further, the weight ratio of cyclodextrin to gum arabic is 4-10: 1;
with respect to the above-mentioned technical solution, further, the cyclodextrin is at least one of α -cyclodextrin, β -cyclodextrin, γ -cyclodextrin, wherein γ -cyclodextrin is preferred.
For the above technical solution, further, the weight ratio of the chelating agent to the gellan gum is 1 to 8: 1, furthermore, the weight ratio of the chelating agent to the gellan gum is 4-7: 1;
for the technical scheme, further, the alkali regulator is at least one of sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; among them, sodium hydroxide is preferred.
For the technical scheme described above, further, the acid regulator is at least one of citric acid, malic acid, tartaric acid, phosphoric acid and acetic acid; among them, citric acid is preferable.
For the technical scheme, further, the antioxidant is one or more of tea polyphenol, water-soluble rosemary extract, sodium ascorbate, calcium ascorbate, ascorbic acid and phytic acid; among them, sodium ascorbate and calcium ascorbate are preferable.
For the above technical solution, further, the chelating agent is one or more of sodium citrate, sodium hexametaphosphate, sodium gluconate, and sodium tartrate. Among them, sodium citrate is preferable.
For the technical scheme, the detergent further comprises 0.1-5.0 parts by weight of alkali regulator; 0.1-5.0 parts by weight of an acid regulator; 0-1.5 parts by weight of an anticaking agent.
The second aspect of the invention provides a preparation method of rutin powder, which comprises the following steps:
(1) under the condition of keeping out of the sun, putting the alkali regulator into water to be completely dissolved, wherein the preferable temperature is 30-35 ℃;
(2) adding rutin into the solution (1), controlling the temperature at 30-55 ℃, preferably 30-35 ℃, stirring until the rutin is dissolved, adding the embedding wall material, and stirring and dispersing uniformly;
(3) adding an acid regulator into the solution (2), regulating the pH to 2-8, controlling the temperature to be 30-55 ℃, immediately adding glycerol after stirring and dissolving, and uniformly stirring and dispersing; the preferred temperature is controlled to 30-35 ℃.
(4) Adding a mixed reagent I into water, wherein the material-liquid ratio is 1: 40-65, stirring and dispersing, adding the antioxidant and the chelating agent until the antioxidant and the chelating agent are completely dissolved, adding the solution (3), stirring uniformly, and homogenizing at 20-30 MPa;
the technical scheme further comprises the step of drying after homogenizing, adding an anticaking agent into the dried powder, and then screening and packaging to obtain the product.
For the technical scheme described above, further, the pH adjustment in the step (4) is preferably carried out at a pH of 4-7;
with respect to the above technical solution, further, the drying in the step (5) is preferably one of spray drying and freeze drying.
The third aspect of the invention provides rutin powder obtained by the preparation method, and the fourth aspect provides application of the rutin powder. Further, the application comprises the fields of food, beverage, health care products and the like, and is particularly suitable for carbonated beverages, fruit juice beverages and functional beverages with high requirements on clarity, and products such as milk beverages, solid beverages, tablet candies and the like. The product can be in a state of no precipitation, no precipitation and clear solution in the liquid beverage, and the stability is excellent; the solid beverage has good dissolving property, and can be quickly dispersed and dissolved in cold water; the pressure resistance is good and the stability is good in tabletting.
Compared with the prior art, the invention has the following beneficial effects:
according to the high-content rutin powder, a specific solution preparation method and a special mixture I are adopted to be matched with a microencapsulation means, so that a very high-content rutin powder product can be obtained, the solubility of rutin can be effectively improved, and the high-content rutin powder has good product stability and brewing stability; the rutin powder product obtained by the invention has the content of 35-80 percent, the product has high solubility, the solubility in cold water is more than 5 percent and greatly exceeds the solubility of the rutin raw material in the cold water, the solution is clear after the product is prepared, the turbidity of a1 percent concentration water solution is less than 10NTU, and the product has excellent stability. More excellent, when the content reaches 45-70%, the high solubility and the high stability of the product can still be maintained. The product has simple preparation process, can be applied to various terminal environments, and can be widely used for solid beverages, liquid beverages, capsules, tablets and the like.
Detailed Description
The present invention is further illustrated by the following examples, but it should be understood that the scope of the present invention is not limited by the examples.
In the present invention, percentages and percentages are by mass unless otherwise specifically indicated. Unless otherwise specified, the experimental methods used are conventional methods, and the materials, reagents and the like used are commercially available.
Example 1
Under the condition of keeping out of the light, 170g of water is weighed into a beaker, the temperature is kept at 32 ℃, 4.5g of potassium hydroxide is added, and the mixture is stirred until the potassium hydroxide is completely dissolved.
Weighing 35g of rutin, adding into the solution, keeping the temperature at 32 ℃, stirring until the rutin is completely dissolved, adding 35g of alpha-cyclodextrin and 5g of Arabic gum, and stirring and dispersing uniformly.
After the pH of the solution was adjusted to 5.2 with tartaric acid, 8g of glycerin was immediately added, and the mixture was uniformly stirred and dispersed.
Weighing 40g of deionized water in a beaker, controlling the temperature at 32 ℃, adding 0.6g of soybean polysaccharide and 0.2g of gellan gum, stirring and dispersing uniformly, adding 3.2g of calcium ascorbate and 1.2g of sodium citrate, stirring until the calcium ascorbate and the sodium citrate are completely dissolved, adding the solution, stirring uniformly, and homogenizing once under the condition of 25 MPa.
And (3) freeze-drying the obtained emulsion, adding 0.8g of silicon dioxide into the dried powder, screening and packaging to obtain the product. Designated sample 1.
Example 2
570g of water are weighed into a beaker under the condition of keeping out of light, the temperature is kept at 34 ℃, 17.6g of sodium hydroxide is added, and the mixture is stirred until the sodium hydroxide is completely dissolved.
Weighing 230g of rutin, adding into the solution, keeping the temperature at 34 ℃, stirring until the rutin is completely dissolved, adding 153g of gamma-cyclodextrin and 24g of Arabic gum, and stirring and dispersing uniformly.
After the solution was adjusted to pH 4.7 with citric acid, 42g of glycerin was immediately added, and the mixture was uniformly stirred and dispersed.
325g of deionized water is weighed in a beaker, the temperature is controlled to be 34 ℃, 4.4g of soybean polysaccharide and 1.6g of gellan gum are added into the beaker, after the mixture is stirred and dispersed evenly, 18.5g of sodium ascorbate and 6.5g of sodium tartrate are added into the beaker, the mixture is stirred until the mixture is completely dissolved, the solution is added into the beaker, the mixture is stirred evenly, and the mixture is homogenized once under the condition of 28 MPa.
And (3) freeze-drying the obtained emulsion, adding 4.1g of silicon dioxide into the dried powder, screening and packaging to obtain the product. Designated sample 2.
Example 3
1200g of water was weighed into a beaker under the protection from light, the temperature was kept at 31 ℃, 42.0g of sodium hydroxide was added, and the mixture was stirred until the sodium hydroxide was completely dissolved.
Weighing 532g of rutin, adding into the solution, keeping the temperature at 31 ℃, stirring until the rutin is completely dissolved, adding 245.8g of gamma-cyclodextrin and 35.4 g of acacia, and stirring and dispersing uniformly.
After the solution was adjusted to pH 5.1 with citric acid, 62g of glycerin was immediately added, and uniformly dispersed with stirring.
Weighing 620g of deionized water in a beaker, controlling the temperature at 31 ℃, adding 7.8g of soybean polysaccharide and 2.1g of gellan gum, stirring and dispersing uniformly, adding 32g of ascorbic acid and 12g of sodium tripolyphosphate, stirring until the ascorbic acid and the sodium tripolyphosphate are completely dissolved, adding the solution, stirring uniformly, and homogenizing at 27MPa for one time.
And (3) freeze-drying the obtained emulsion, adding 8.8g of silicon dioxide into the dried powder, screening and packaging to obtain the product. And recorded as sample 3.
Example 4
820g of water are weighed out in a beaker in the dark, the temperature is kept at 32 ℃, 30.5g of sodium hydroxide is added, and the mixture is stirred until the sodium hydroxide is completely dissolved.
Weighing 518g of rutin, adding the rutin into the solution, keeping the temperature at 32 ℃, stirring until the rutin is completely dissolved, adding 105g of alpha-cyclodextrin and 22.8g of Arabic gum, and stirring and dispersing uniformly.
After the pH of the solution was adjusted to 6.2 with malic acid, 45g of glycerin was immediately added, and the mixture was uniformly stirred and dispersed.
440g of deionized water is weighed in a beaker, the temperature is controlled at 32 ℃, 5.6g of soybean polysaccharide and 2.4g of gellan gum are added into the beaker, after the mixture is stirred and dispersed evenly, 14.5g of ascorbic acid and 12g of sodium gluconate are added into the beaker, the mixture is stirred until the mixture is completely dissolved, the solution is added into the beaker, the mixture is stirred evenly, and the mixture is homogenized once under the condition of 30 MPa.
And (3) freeze-drying the obtained emulsion, adding 7.6g of silicon dioxide into the dried powder, screening and packaging to obtain the product. And recorded as sample 4.
Example 5
The rutin raw materials used in the samples 1, 2, 3 and 4 are subjected to solubility test, and the results are shown in the table 1:
TABLE 1
| Name (R) | Appearance of the product | Solubility in water |
| Rutin raw material | Light yellow-green powder | ＜0.005％ |
The results show that the tested rutin raw material has extremely low water solubility, and the application of the rutin raw material is greatly limited.
Example 6
The content detection, the reconstitution evaluation and the turbidity test were carried out on the samples 1, 2, 3 and 4, and the results are shown in table 2:
TABLE 2
The results show that the rutin powder product obtained by the process disclosed by the invention has the characteristics of high content, high solubility, good reconstitution property, uniform and precipitate-free solution after reconstitution and clarified solution.
The brewing evaluation method comprises the following steps: measuring 100g of water at room temperature from a beaker, weighing 5.0g of sample, putting the sample into the water, stirring for 45s, and observing whether the solution has undissolved sediment, floating objects, surface froth and the like after the stirring is finished, wherein the phenomenon is qualified.
Example 7
Putting the sample 1, the sample 2, the sample 3, the sample 4 and the rutin raw materials into an accelerating oven at 60 ℃, and carrying out destructive accelerated experiment evaluation on the four groups of samples for 20 days, wherein the results are shown in tables 3-1-3-5:
TABLE 3-1
TABLE 3-2
Tables 3 to 3
Tables 3 to 4
Tables 3 to 5
As can be seen from 20-day destructive acceleration experiments, after the acceleration of 20 days at 60 ℃, the appearance, the reconstitution property and the turbidity of three groups of samples are not obviously changed, the content retention rate is slightly reduced, but the product is generally considered to be qualified when the content retention rate is more than or equal to 90% after the acceleration of 20 days.
Example 8
Putting the sample 1, the sample 2, the sample 3 and the sample 4 into an accelerated oven with the temperature of 40 ℃ and the RH of 75 percent, and carrying out accelerated stability experimental evaluation on the three groups of samples, wherein the results are shown in tables 4-1-4:
TABLE 4-1
TABLE 4-2
Tables 4 to 3
Tables 4 to 4
As can be seen from the 40 ℃ accelerated stability experiment, after three months of acceleration, the three groups of samples have no obvious change in the aspects of appearance, reconstitution property and turbidity, and the content retention rate is slightly reduced, but the product is qualified when the three months of acceleration is carried out, wherein the content retention rate is more than or equal to 90%. After the product is accelerated for three months, various physical and chemical indexes are not obviously changed, and the stability is qualified. The rutin powder prepared by the process has excellent stability.
Example 9 influence of the order of the treatment modes on the product
Based on the process of example 1, the effect of the treatment mode sequence on the product performance in the invention is mainly examined, and the results are shown in Table 5
Mode 1: alkali regulator-rutin-embedding wall material-acid regulator-glycerin-stabilizer-antioxidant and chelating agent; the process of example 1;
mode 2: alkali regulator-rutin-embedding wall material-glycerin-acid regulator-stabilizer-antioxidant and chelating agent;
mode 3: alkali regulator-rutin-acid regulator-embedding wall material-glycerin-stabilizer-antioxidant and chelating agent;
mode 4: alkali regulator-rutin-acid regulator-glycerin-embedding wall material-stabilizing agent-antioxidant and chelating agent;
mode 5: alkali regulator-rutin-glycerol-acid regulator-embedding wall material-stabilizing agent-antioxidant and chelating agent;
mode 6: alkali regulator-rutin-glycerin-embedding wall material-acid regulator-stabilizer-antioxidant and chelating agent;
mode 7: rutin-alkali regulator-embedding wall material-acid regulator-glycerin-stabilizer-antioxidant and chelating agent;
TABLE 5
From the results, it can be seen that the order of the treatment modes in example 1 of the present invention has a great influence on the final quality of the product. Only the product prepared according to the sequence of the invention has high content, high stability and clear effect after brewing.
Example 10 (. about.inventive Mixed reagent I)
Based on the process of example 1, the effect of the mixed reagent I on the product performance in the invention is mainly examined: the results are shown in Table 6:
TABLE 6
| Mixing reagent I | Brewing evaluation | Encapsulation efficiency | Turbidity (1%) | Three month accelerated retention |
| Soluble soybean polysaccharide and gellan gum | Qualified | 99.1％ | 3.7 | 98.76％ |
| Soluble soybean polysaccharide and xanthan gum | Fail to be qualified and not completely dissolved | 82.3％ | 28.6 | 87.23％ |
| Soluble soybean polysaccharide and carrageenan | Fail to be qualified and not completely dissolved | 81.4％ | 19.6 | 77.93％ |
| Soluble soybean polysaccharide and HPMC | Fail to be qualified and not completely dissolved | 79.3％ | 16.8 | 74.65％ |
| Soluble soybean polysaccharide and pectin | Fail to be qualified and not completely dissolved | 82.6％ | 15.7 | 71.83％ |
| Xanthan gum and gellan gum | Fail to qualify and unclarified | 65.6％ | 31.5 | 63.78％ |
| Carrageenan and gellan gum | Fail to qualify and unclarified | 64.8％ | 32.6 | 59.39％ |
| HPMC, gellan gum | Fail to qualify and unclarified | 59.7％ | 41.6 | 67.21％ |
| Pectin and gellan gum | Fail to qualify and unclarified | 54.2％ | 21.7 | 70.34％ |
From the results, the combination of stabilizers has a great influence on the product. Only by the mixture I, the product has excellent embedding rate and stability.
Example 11 ratio of soluble Soy polysaccharide to Gellan Gum in mixture I
Based on the process of example 1, the effect of the ratio of soluble soybean polysaccharide to gellan gum in mixture I on product stability was examined with emphasis on the results shown in Table 7:
TABLE 7
From the results, when the ratio of soluble soybean polysaccharide to gellan gum in mixture I was 2 to 5: 1, the product has excellent reconstitution, encapsulation and stability.
Example 12 (. chelating agent to gellan gum ratio)
Based on the process of example 1, the effect of the ratio of chelating agent to gellan gum on product stability was examined with emphasis on the results shown in Table 8:
TABLE 8
From the results, when the ratio of the chelating agent to the gellan gum is 4 to 7: 1, the product is excellent in quality in all aspects.
Example 13 stability of product in beverage
Adding the sample 1, the sample 2, the sample 3 and the sample 4 into a beverage formula in an amount of adding the rutin content of 1000ppm, and carrying out accelerated stability experimental evaluation on the four groups of samples, wherein the results are shown in tables 9-1-9-4:
TABLE 9-1
TABLE 9-2
Tables 9 to 3
Tables 9 to 4
It can be seen from the accelerated stability test at 40 ℃, after three months of acceleration, four groups of samples all maintain higher stability and clarity in the beverage.
Example 14 stability of product in compression
Adding the rutin content of the samples 1, 2, 3 and 4 into a tablet formula by the addition amount of 500 mg/tablet for tabletting, and carrying out accelerated stability test evaluation on the four groups of samples, wherein the results are shown in a table 10:
watch 10
It can be seen from the 40 ℃ accelerated stability test that after three months of acceleration, the three groups of samples all maintain higher stability in the tablet.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and those skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A raw material composition of rutin powder is characterized by comprising the following components in parts by weight:
the embedding wall material is prepared from cyclodextrin and Arabic gum according to the weight ratio of 1-20: 1, preparing a composition;
the mixture I is prepared from soluble soybean polysaccharide and gellan gum according to a weight ratio of 1-10: 1.
2. The raw material composition of rutin powder according to claim 1, which is characterized by comprising the following components in parts by weight:
3. the raw material composition of rutin powder of claim 1, wherein the mixture I is prepared from soluble soybean polysaccharide and gellan gum according to the weight ratio of 2-5: 1.
4. The raw material composition of rutin powder of claim 1, wherein the weight ratio of cyclodextrin to acacia gum is 4-10: 1; the cyclodextrin is at least one of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.
5. The raw material composition of rutin powder of claim 1, wherein the weight ratio of the chelating agent to gellan gum is 1-8: 1.
6. the raw material composition of rutin powder of claim 1, wherein the antioxidant is one or more of tea polyphenols, water-soluble rosemary extract, sodium ascorbate, calcium ascorbate, ascorbic acid, and phytic acid; the chelating agent is one or more of sodium citrate, sodium hexametaphosphate, sodium gluconate and sodium tartrate.
7. The raw material composition of rutin powder of claim 1, further comprising 0.1-5.0 parts by weight of an alkali regulator; 0.1-5.0 parts by weight of an acid regulator; 0-1.5 parts by weight of an anticaking agent.
8. A method for preparing rutin powder by using the composition of claim 1, comprising the following steps:
(1) under the condition of keeping out of the sun, putting the alkali regulator into water to be completely dissolved;
(2) adding rutin into the solution (1), controlling the temperature at 30-55 ℃, stirring until the rutin is dissolved, adding the embedding wall material, and stirring and dispersing uniformly;
(3) and (3) putting an acid regulator into the solution (2), regulating the pH to 2-8, controlling the temperature to be 30-55 ℃, immediately adding glycerol after stirring and dissolving, and uniformly stirring and dispersing.
(4) Adding a mixed reagent I into water, wherein the material-liquid ratio is 1: 40-65, stirring and dispersing, adding the antioxidant and the chelating agent until the antioxidant and the chelating agent are completely dissolved, adding the solution (3), stirring uniformly, and homogenizing at 20-30 MPa.
9. Rutin powder obtained by the preparation method according to claim 8.
10. The use of rutin powder of claim 9 in the fields of food, beverage, and health care products.
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| US20200288759A1 (en) * | 2017-11-02 | 2020-09-17 | San-Ei Gen F.F.I., Inc. | Method for producing water-soluble or water-dispersible microparticles, use or method for use as substitute having emulsifying function, method for producing emulsion, method for producing food and food containing emulsion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116076720A (en) * | 2022-12-21 | 2023-05-09 | 河南中大恒源生物科技股份有限公司 | Preparation method and application of water-soluble rutin powder |
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