CN114259229A - Multi-parameter vital sign monitoring device and method - Google Patents
Multi-parameter vital sign monitoring device and method Download PDFInfo
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Abstract
The invention discloses a multi-parameter vital sign monitoring device and a method, which are used for detecting vital sign parameters and comprise the following steps: a contact part which is arc-shaped and corresponds to the head or four limbs of a living body; the light source emitting module is used for alternately emitting detection light to irradiate the surface of the life body; the wide-spectrum photoelectric detector is used for receiving reflected light reflected when the detection light is projected to a living body and generating an electric signal; the multi-channel optical filter is used for filtering ambient light when the wide-spectrum photoelectric detector receives reflected light; the mainboard is used for sending out detection light within a preset signal range when the light source emission module is triggered, and sending a calculation result to external equipment in real time in a wired or wireless mode. The invention provides a multi-parameter vital sign monitoring device and method, which can obtain multi-parameter vital sign indexes in real time, so that the blue light treatment process has quantitative basis.
Description
Technical Field
The invention relates to the technical field of detection, in particular to a multi-parameter vital sign monitoring device and method.
Background
Neonatal Jaundice (Neonatal Jaundice) is a phenomenon that the skin, mucous membrane and sclera of the whole body are yellow due to the increase of bilirubin concentration caused by the abnormal bilirubin metabolism in the body, and is one of the common diseases of the newborn, and about 85% of term infants and most premature infants have temporary bilirubin increase in the period of the newborn. Clinically, neonatal jaundice is classified into physiological jaundice and pathological jaundice. Pathological jaundice can cause high bilirubin encephalopathy (kernal jaundice), symptoms are more serious than physiological jaundice, such as anorexia, edema, dyspnea and the like, free bilirubin has lipophilicity, and can enter nerve cells of a newborn to cause dysfunction of a nervous system, a motor system, a hearing system and a kidney system, the death rate is up to 80%, the probability of sequelae after healing is 100%, and common sequelae such as hyperkinetic hand-foot syndrome, hearing loss, dull eyesight, dysplasia and the like are caused.
The neonatal with serious jaundice symptoms needs blue light treatment, the blue light treatment for the neonatal jaundice is generally carried out for about 1-4 days, and different diseases and required time are different. The phototherapy time for jaundice with severe jaundice is long, generally 48-72 hours, and the phototherapy time for hyperbilirubinemia is generally 24-48 hours. In general, the continuous light exposure time cannot exceed 4 days. The phototherapy for neonatal jaundice is a simple, safe and effective method, and is divided into single-side irradiation and double-side irradiation, and the double-side irradiation is generally considered to have a better effect than the single-side irradiation. Phototherapy is divided into continuous irradiation and intermittent irradiation, and the effects of continuous irradiation and intermittent irradiation are generally considered to be similar, but the side effects of intermittent irradiation are obviously small. Continuous irradiation is generally carried out for more than 24 hours, the serious disease condition can be continuously irradiated for 48-72 hours, and the children need to be closely concerned about whether adverse reactions exist in the irradiation process. The intermittent irradiation can be 8-12 hours in one day at intervals of 16-12 hours; the irradiation can also be carried out for 6 to 12 hours, and the irradiation can be carried out at intervals of 2 to 4 hours. The irradiation time is determined according to the change of the irradiation condition, and the total irradiation time does not exceed 4 days generally.
Currently, hospitals generally determine neonatal jaundice by using bilirubin concentration measured by a venous blood test method or bilirubin concentration measured by trace blood as a main index. The venous blood and trace blood test belongs to invasive test process, which needs to take the heel blood or venous blood of the newborn, and obtains the serum bilirubin concentration by a diazo reagent method, an oxidase method, a chemical oxidation method and the like, and the test method has the advantages that the precision is very high, about +/-5.13 mu mol/L, but the risk of newborn infection is increased due to the need of blood collection. Therefore, a noninvasive percutaneous jaundice meter is developed, which can rapidly detect bilirubin concentration in a newborn infant and has a great role in clinical jaundice diagnosis.
However, both of the above methods do not allow real-time detection of changes in bilirubin levels in neonates. Clinically, the basis for diagnosing neonatal jaundice and distinguishing whether it is pathological is: bilirubin concentration and bilirubin concentration change over a given period of time. The traditional venous blood test method has higher precision, but is not suitable for detecting the change of bilirubin concentration in a newborn infant. The percutaneous jaundice instrument needs medical care personnel to detect regularly at intervals, thus increasing workload invisibly and failing to achieve the effect of real-time monitoring. Especially for the infants who are treated by blue light, the real-time change of the bilirubin content in the infant body in the treatment process can not be obtained in real time, the dose irradiated by the blue light is difficult to be reasonably judged, and the treatment effect and the safety can not be ensured.
Disclosure of Invention
In view of the above technical problems, the present invention provides a multi-parameter vital sign monitoring device and method, which can obtain a real-time content value of bilirubin in infant blood in a blue light treatment process in real time, and obtain a multi-parameter vital sign index at the same time, so that the blue light treatment process has a quantitative basis, and the problems of large workload and incapability of obtaining a detection result in real time in the existing neonatal jaundice detection are solved.
Additional features and advantages of the disclosure will be set forth in the detailed description which follows, or in part will be obvious from the description, or may be learned by practice of the disclosure.
According to an aspect of the invention, a multi-parameter vital signs monitoring device is disclosed for detecting vital signs parameters, comprising:
the contact part is arc-shaped, corresponds to the head or four limbs of a living body, and is provided with a first hollow area at the center;
the light source emitting module is used for alternately emitting detection light, and the detection light irradiates the surface of the living body after passing through the first hollow area;
the wide-spectrum photoelectric detector is isolated from the light source emission module and is used for receiving reflected light reflected when the detection light is projected to a living body and generating an electric signal;
a multi-channel optical filter for filtering ambient light when the wide spectrum photodetector receives the reflected light;
the mainboard is used for triggering the light source emitting module to emit the detection light within a preset signal range, receiving and calculating the electric signal and sending a calculation result to external equipment in real time in a wired or wireless mode.
Furthermore, the contact part is made of soft materials, and the surface of the contact part is provided with a detachable silica gel pad.
Further, the light source emission module and the wide-spectrum photodetector are arranged on the main board, the light source emission module comprises a plurality of LED light sources which are used for emitting the detection light and are distributed around the wide-spectrum photodetector in an equidistant circumferential manner, and the detection light emitted by the LED light sources comprises fluorescence used for exciting the surface of the living body or/and monochromatic light absorbed by living body tissues.
Further, be provided with a light path on the mainboard and separate the subassembly, the light path is separated the subassembly and is formed with through the baffle with different the LED light source sends detect the corresponding light-emitting channel of light, and with the corresponding leaded light passageway of wide spectrum photoelectric detector, leaded light passageway with the light-emitting channel mutual isolation.
Furthermore, a light-tight cover body is surrounded at the periphery of the light path separation component, through holes corresponding to the partition plates are formed in the hollow upper surface of the cover body respectively, the upper surface of the cover body is made of a light-transmitting material, the multi-channel optical filter is arranged in the cover body at a position corresponding to the light guide channel, or the multi-channel optical filter is formed on the surface of the wide-spectrum photoelectric detector in a film covering mode.
Furthermore, the device also comprises a shell, wherein the wide-spectrum photoelectric detector, the light source emission module, the multi-channel optical filter, the main board and the light path separation component are all contained in the shell, a second hollow area corresponding to the first hollow area and provided with the contact part is arranged at the lower part of the shell, the light path separation component penetrates through the second hollow area and then reaches the first central control area, and the contact part is detachably connected with the lower part of the shell.
Furthermore, the multichannel optical filter is formed on the surface of the wide-spectrum photoelectric detector in a film covering mode.
Further, the mainboard includes host system, DAC module, light source drive module, signal reading module, ADC module, the mainboard still is connected with power module, host system with DAC module ADC module is connected, DAC module with light source drive module connects, light source drive module with the light source emission module is connected, ADC module with signal reading module connects, signal reading module with wide spectrum photoelectric detector connects, wherein, host system is used for:
controlling the DAC module to perform a current scanning program on the light source driving module so that an output signal of each LED light source in the light source emitting module is within a preset signal range, and storing working parameters of each LED light source;
sending a trigger signal according to the working parameters, wherein the trigger signal is subjected to digital-to-analog conversion by the DAC module and then drives the light source emitting module to work through the light source driving module;
and calculating the electric signal read by the signal reading module and then transmitting the electric signal to the external equipment through wireless/wired transmission, or directly transmitting the read electric signal to the external equipment through wireless/wired transmission.
Furthermore, the main board is further connected with a temperature measurement module, the temperature measurement module comprises a first temperature sensor and a second temperature sensor which are respectively arranged in different hollow first copper pipes and second copper pipes and are in contact with each other, one end of each first copper pipe is in contact with the contact part, one end of each second copper pipe is in contact with the main board, the first temperature sensor and the second temperature sensor respectively generate a first temperature signal and a second temperature signal after detecting the temperature of the first copper pipe and the temperature of the second copper pipe and transmit the first temperature signal and the second temperature signal to the main board, and the main board adjusts a preset signal range of output signals of the LED light source according to the second temperature signal and transmits the first temperature signal to the external equipment in real time.
According to a second aspect of the present disclosure, there is provided a multi-parameter vital signs monitoring method, which can be applied to the above apparatus, comprising the following steps:
placing the contact part on the head or the limbs of the detected person;
the control main board triggers a plurality of LED light sources of the light source emitting module to alternately emit detection light to irradiate the surface of the life body within a preset signal range;
receiving reflected light reflected when the detection light is projected to a living body by using a wide-spectrum photoelectric detector to generate a corresponding electric signal;
measuring the temperature of a detected person and the mainboard by using a temperature measuring module, respectively generating a first temperature signal and a second temperature signal, and adjusting a preset signal range of an output signal of the LED light source according to the second temperature signal;
and receiving and calculating the electric signal and the temperature signal by using the mainboard through a preset algorithm, and sending a calculation result to external equipment in a wired or wireless manner in real time so that the external equipment displays the calculation result in real time.
Further, the method further comprises performing absorbance calibration for eliminating optical path difference on the LED light source, and performing operation compensation on the optical signal intensity of the detection light emitted by the LED light source.
The technical scheme of the disclosure has the following beneficial effects:
according to the multi-parameter vital sign monitoring device and method provided by the invention, medical care personnel can obtain the real-time content value of the bilirubin in the blood of the infant in the blue light treatment process in real time and obtain vital sign indexes such as body temperature, heart rate, blood oxygen, respiration rate and the like at the same time, so that the blue light treatment process has quantitative basis and the treatment effect and safety are ensured. The invention adopts the combined LED light source as the light source, effectively reduces the interference of the ambient light to the detection by combining the multichannel light filter with the wide-spectrum photoelectric detector, and eliminates the detection consistency error caused by the inconsistency of the light intensity of the LED light source and the central wavelength by utilizing the current scanning program, thereby realizing the spectrum signal acquisition device with small volume, compact light path structure and good consistency.
Drawings
FIG. 1 is an exploded view of a monitoring device according to an embodiment of the present disclosure;
FIG. 2 is a diagram illustrating the spectral relationship between a multi-channel filter and a wide-spectrum photodetector in an embodiment of the present disclosure;
FIG. 3 is a schematic structural diagram of an optical path separating assembly in an embodiment of the present disclosure;
FIG. 4 is a schematic structural diagram of a cover in an embodiment of the present disclosure;
fig. 5 is a block diagram of a motherboard according to an embodiment of the present disclosure;
FIG. 6 is a schematic diagram of another exploded structure of the monitoring device in the embodiment of the present disclosure;
FIG. 7 is an exemplary flow chart of a monitoring method in an embodiment of the present description;
FIG. 8 is an exemplary diagram of a signal spectrum in an example of the present specification;
FIG. 9 is a flowchart of an embodiment of the method for calibrating absorbance in the examples of the present specification.
Reference numerals:
1. a contact portion; 101. a first hollow region; 102. a silica gel pad;
2. a light source emitting module;
3. a broad spectrum photodetector;
4. a multi-channel optical filter;
5. a main board; 501. a main control module; 502. a DAC module; 503. a light source driving module; 504. a signal reading module; 205. an ADC module; 506. a temperature measuring module;
6. an optical path separation element; 601, performing heat treatment on the mixture; a partition plate; 602. a light exit channel; 603. a light guide channel;
7. a light source lens; 701. through hole
8. A housing; 801. a second hollow region;
9. a first copper tube;
10. a second copper tube;
11. a first temperature sensor;
12. a second temperature sensor;
13. and (4) an external device.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Translation of characters
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in fig. 1, embodiments of the present specification provide a multi-parameter vital signs monitoring device for detecting vital signs parameters, including:
the contact part 1 is arc-shaped, corresponds to the head or four limbs of a living body, and is provided with a first hollow area 101 at the center;
in this case, the two ends of the contact part 1 may be bent inward by 10 to 60 degrees, such that it can be smoothly prevented from being placed on the head or limbs of the infant, and the first hollow region 101 is provided to detect the skin in contact with the contact part 1.
The light source emitting module 2 is used for alternately emitting detection light, and the detection light irradiates the surface of a living body after passing through the first hollow area 101;
wherein the light source emitting module 2 emits detection light to detect the skin in the first hollow area 101.
The wide-spectrum photoelectric detector 3 is isolated from the light source emission module 2, and the wide-spectrum photoelectric detector 3 is used for receiving reflected light reflected when the detection light is projected to a living body and generating an electric signal;
in order to avoid cross contamination between the detection light and the emission light, the detection light and the emission light should be isolated from each other, that is, the light source emitting module 2 and the wide spectrum photodetector 3 should be isolated from each other by a light-tight material, and the light-tight material should extend all the way to the skin surface of the person to be detected to prevent light contamination, and in addition, in other embodiments, the wide spectrum photodetector 3 may be replaced by one of a silicon-based photodiode or a silicon-based CMOS array detector.
A multi-channel optical filter 4, wherein the multi-channel optical filter 4 is configured to filter ambient light when the wide-spectrum photodetector 3 receives the reflected light;
exemplarily, the multi-channel optical filter 4 may be a multi-channel optical filter 4, the number of channels corresponds to the wavelength and the number of the LED light sources, if the LED light sources are four, the multi-channel optical filter 4 is a four-channel multi-channel optical filter 4, the communication passing wavelength of each channel corresponds to the center wavelength of each light-emitting LED chip, for example, the spectral bandwidth of each channel is 10nm, the cut-off depth is greater than od3 °, the narrow spectral bandwidth and the large cut-off depth effectively suppress the interference of the ambient light to the detection, especially, during the treatment process when the infant enters the blue light room, a large amount of ambient light interference exists, and the multi-channel optical filter 4 can effectively prevent the interference.
The mainboard 5 is used for triggering the light source emitting module 2 to emit the detection light within a preset signal range, receiving and calculating the electric signal, and sending a calculation result to the external equipment 13 in real time in a wired or wireless mode.
Exemplarily, when the trigger light source emitting module 2 emits the detection light within the preset signal range, the main board 5 should adopt a manner of time-sharing illumination of the LED light source and multiplexing of the multi-channel light splitting optical path. That is, the LED light source only lights a specific wavelength at a time, correspondingly collects the output signal of the wide spectrum photodetector 3 to obtain a path of electrical signal, collects the ambient light background signal value when all the LED light sources are off, lights all the LED light sources in sequence to complete a signal collection period, and then the main board 5 calculates the collected electrical signal according to a preset calculation model to calculate the corresponding detection result.
When calculating, the main board 5 may control part of the LED light sources to be alternately turned on, and calculate the electrical signals in the corresponding electrical signals at corresponding time points, so as to obtain a group of signal spectrograms including parameters representing vital signs, as shown in fig. 2.
In the above calculation, the main board 5 may also control another part of the LED light sources to be alternately turned on after the calculation is completed, repeat the above operations, obtain another group of signal spectrograms including parameters representing vital signs of the other group of signal spectrograms, and then take an average value of the two groups of signal spectrograms.
In one embodiment, please continue to refer to fig. 1, the contact portion 1 is made of a soft material, and a detachable silicone pad 102 is disposed on a surface thereof.
Wherein, because the person being detected in this disclosure is mostly the baby, the baby is good and dynamic and the skin is tender, and the silica gel pad 102 that sets up can protect baby's skin, and the detachable installation of silica gel pad 102 can be convenient for change silica gel pad 102, prevents that silica gel pad 102 from using repeatedly and causing the pollution.
In an embodiment, please continue to refer to fig. 1, the light source emitting module 2 and the wide spectrum photodetector 3 are disposed on the main board 5, the light source emitting module 2 includes a plurality of LED light sources for emitting the detection light, and the LED light sources are distributed around the wide spectrum photodetector 3 in an equidistant manner, and the detection light emitted by the LED light sources includes fluorescence for exciting a surface of a living body or/and includes monochromatic light absorbed by a tissue of the living body.
Wherein, in order to reduce the volume of the device and make it convenient for being suitable for infant group, the light source emitting module 2 and the light source receiving module are directly arranged on the main board 5, and simultaneously, in order to improve the detection precision, the LED light sources are arranged around the circumference of the wide spectrum photoelectric detector 3.
In an embodiment, referring to fig. 3, a light path separating element 6 is disposed on the main board 5, the light path separating element 6 forms, through a partition 601, a light emitting channel 602 corresponding to the detection light emitted by different LED light sources and a light guiding channel 603 corresponding to the wide-spectrum photodetector 3, and the light guiding channel 603 and the light emitting channel 602 are isolated from each other.
It should be explained that the optical path separating component 6 is disposed on the main board 5, and may be fixed by adhesion, or indirectly fixed on the main board 5 by other devices such as the housing 8 and the fixing frame, or fastened to the main board 5 by the fixing column. The light path separating assembly 6 should be provided with a plurality of opaque partition boards 601 inside, and the partition boards 601 divide the space inside the light path separating assembly 6 into a light guide channel 603 and a light emitting channel 602 to realize the isolation between the detection light and the reflected light.
In the above embodiment, as a supplement, please refer to fig. 1 and 4, a light-tight cover body is surrounded at the periphery of the light path separating component 6, through holes 701 corresponding to the partition boards 601 are formed in a hollow manner on the upper surface of the cover body, and the upper surface of the cover body is made of a light-transmitting material, wherein the multi-channel optical filter 4 is disposed in the cover body at a position corresponding to the light-guiding channel 603, or the multi-channel optical filter 4 is formed on the surface of the broad spectrum photodetector 3 in a film covering manner.
In this case, since the optical path separation member 6 is disposed on the main board 5 in order to reduce the volume of the apparatus, the volume of the optical path separation member 6 cannot be too large due to stability of use, and therefore, a cover is disposed to separate ambient light to a greater extent, and it should be noted that the surface of the cover and the opening of the optical path separation member 6 should be flush.
As a supplement, in order to facilitate installation, the multi-channel optical filter 4 may be tiled on the light guide channel 603, or the entire hollow surface of the cover body may be the multi-channel optical filter 4, and a through hole 701 for detecting light emission is provided on the hollow surface, that is, the through hole 701 corresponds to the light exit channel 602.
Additionally, in order to reduce the assembly steps and improve the stability, i.e. to prevent the multi-channel filter 4 from loosening during the use of the device, the multi-channel filter 4 may be formed on the surface of the wide-spectrum photodetector 3 by chemical coating, i.e. the coating is formed on the surface of the photosensitive array of the detector.
In an embodiment, please refer to fig. 1 again, the apparatus further includes a housing 8, the wide-spectrum photodetector 3, the light source emitting module 2, the multi-channel filter 4, the main board 5 and the optical path separating element 6 are all accommodated in the housing 8, a second hollow region 801 corresponding to the first hollow region 101 of the contact portion 1 is disposed at a lower portion of the housing 8, the optical path separating element 6 penetrates through the second hollow region 801 and reaches the first central control region, and the contact portion 1 is detachably connected to the lower portion of the housing 8.
The device is not too large in size because most of the users use the device, otherwise, the load of the baby is large easily, the detection result is affected, and a plurality of components are accommodated in the oblate casing 8, so that the size is small. The contact part 1 can be connected with the housing 8 by means of a snap or a bolt, facilitating the replacement of the contact part 1.
Additionally, when the device is installed, the cover body should pass through the second hollow area 801 and the first hollow area 101, and the surface (hollow surface) of the cover body provided with the through hole 701 should be flush with the edge surface of the first hollow area 101, so as to prevent discomfort of the baby.
In an embodiment, referring to fig. 5, the main board 5 includes a main control module 501, a DAC module 502, a light source driving module 503, a signal reading module 504, and an ADC module 205, the main board 5 is further connected to a power supply module, the main control module 501 is connected to the DAC module 502 and the ADC module 205, the DAC module 502 is connected to the light source driving module 503, the light source driving module 503 is connected to the light source emitting module 2, the ADC module 205 is connected to the signal reading module 504, and the signal reading module 504 is connected to the wide-spectrum photodetector 3, where the main control module 501 is configured to:
controlling the DAC module 502 to perform a current scanning procedure on the light source driving module 503, so that the output signal of each LED light source in the light source emitting module 2 is within a preset signal range, and storing the operating parameter of each LED light source;
sending a trigger signal according to the working parameter, wherein the trigger signal is digital-to-analog converted by the DAC module 502 and then drives the light source emitting module 2 to work through the light source driving module 503;
the electric signal read by the signal reading module 504 is calculated and then transmitted to the external device 13 through wireless/wired transmission, or the read electric signal is directly transmitted to the external device 13 through wireless/wired transmission.
Wherein, the main control chip can be the MCU chip, the MCU chip is through being connected with wired interface module or wireless connection module, with calculation result real-time transmission to external equipment 13, exemplary, in order to reduce cost and mainboard 5's volume, the main control chip can also be the bluetooth SOC chip, through bluetooth SOC chip, directly realize the wireless connection of this device, owing to the mobility of the group of being used, after having reduced the constraint of cable, can greatly improve the practicality of this device, external equipment 13 can be all electronic equipment that have bluetooth wireless function such as cell-phone, flat panel, computer.
When the mainboard 5 is triggered to work and calculate, firstly, due to natural limitation of a manufacturing process, the difference of luminous power among LED light sources of the same type is eliminated in application of adopting light intensity as a detection signal; and secondly, due to the difference of human tissue parameters, the absorption and scattering coefficients of the detection light with different wavelengths in the human body have larger difference. To eliminate the above-mentioned difference, an optimal detection signal value can be realized by a design program without changing the parameters of the signal reading module 504. Specifically, an optimal signal range is preset for a specific LED light source, the signal range is determined by a LOW threshold LED1_ LOW and a HIGH threshold LED1_ HIGH, and each LED light source corresponds to a different LOW threshold and a different HIGH threshold respectively; after the device contacts a human body, the Bluetooth SOC chip controls the DAC module 502 to perform an accurate ground current scanning program, so that the output signal of each LED light source enters a set threshold range, and corresponding working parameters at the moment are determined; and driving the LED light source to work according to the determined working parameters, and then acquiring signals by the wide-spectrum photoelectric detector 3 to obtain expected electric signals.
By the method, the detection is standardized in amplitude, hardware does not need to be calibrated and parameter adjusted, and accurate real-time detection can be realized by combining a preset detection algorithm.
In one embodiment, with continuing reference to fig. 5 and with reference to fig. 6, the motherboard 5 is further connected to a temperature measurement module 506, the temperature measuring module 506 comprises a first temperature sensor 11 and a second temperature sensor 12 which are respectively arranged in contact with a first copper pipe 9 and a second copper pipe 10 which are different and hollow, one end of the first copper pipe 9 is in contact connection with the contact part 1, one end of the second copper pipe 10 is in contact connection with the main board 5, the first temperature sensor 11 and the second temperature sensor 12 respectively generate a first temperature signal and a second temperature signal after detecting the temperatures of the first copper pipe 9 and the second copper pipe 10, respectively, and transmit the first temperature signal and the second temperature signal to the main board 5, the main board 5 adjusts a preset signal range of the output signal of the LED light source according to the second temperature signal, and transmits the first temperature signal to the external device 13 in real time.
The first temperature sensor 11 and the second temperature sensor 12 can be thermistors, the negative electrode of the LED light source is connected with one electrode of the second temperature sensor 12 in circuit connection, reliable and rapid heat conduction is ensured through continuous large-area copper coating on the wiring board of the main board 5, and after the second temperature signal is collected by the Bluetooth SOC, the constant-current luminous power change of the LED light source can be compensated according to the second temperature signal.
According to the multi-parameter vital sign monitoring device provided by the embodiment, medical staff can acquire the real-time content value of the bilirubin in the blood of the infant in the blue light treatment process in real time and acquire vital sign indexes such as body temperature, heart rate, blood oxygen and respiration rate at the same time, so that the blue light treatment process has quantitative basis, and the treatment effect and safety are ensured. The invention adopts the combined LED light source as the light source, effectively reduces the interference of the ambient light to the detection by combining the multichannel optical filter 4 with the wide-spectrum photoelectric detector 3, and eliminates the detection consistency error caused by the inconsistency of the light intensity of the LED light source and the central wavelength by utilizing the current scanning program, thereby realizing the spectrum signal acquisition device with small volume, compact light path structure and good consistency.
Based on the same idea, the exemplary embodiment of the present disclosure further provides a multi-parameter vital sign monitoring method, as shown in fig. 7, the method includes the following steps S1 to S5:
in step S1, the contact part is placed on the head or the limbs of the detected person;
in step S2, the main board is controlled to trigger a plurality of LED light sources of the light source emitting module to alternately emit detection light to irradiate the surface of the living body within a preset signal range;
in step S3, a broad spectrum photodetector is used to receive the reflected light from the detected light when it is projected onto the living body, and generate a corresponding electrical signal;
in step S4, a temperature measuring module is used for measuring the temperature of the detected person and the mainboard, a first temperature signal and a second temperature signal are respectively generated, and the preset signal range of the output signal of the LED light source is adjusted according to the second temperature signal;
in step S5, the motherboard receives and calculates the electrical signal and the temperature signal through a preset algorithm, and sends the calculation result to an external device in a wired or wireless manner in real time, so that the external device displays the calculation result in real time.
In an embodiment, a calculation method and an algorithm for a physical sign parameter are provided, which specifically include the following steps:
the number of LED light sources is exemplarily set to four, and the wavelengths thereof are 650nm, 850nm, 550nm, and 460nm, respectively, wherein:
by controlling the 650nm LED light source and the 850nm LED light source to be alternately lightened and passing through respective electric signals of the main board at corresponding time points, the signal acquisition frequency is between 1K and 2K, and the acquisition time is between 10 and 20s, a group of signal spectrograms containing heart rate changes is obtained, as shown in FIG. 3:
blood oxygen and heart rate calculations are performed from the signals:
the blood oxygen calculation mode is as follows:
wherein AC _650nm is the difference between the peak and the valley of the signal of the LED light source of 650nm, specifically the arithmetic mean of the difference of each peak and valley signal; DC _650nm is the average of the signal intensities of 650nm LED light sources;
wherein AC _850nm is the difference between the peaks and the valleys of the signal of the LED light source with 850nm, specifically the arithmetic mean of the difference of each peak and valley signal; DC _850nm is the average of the signal intensity of LED 2;
epsilon-hb-650 nm is the absorptivity of deoxyhemoglobin at 650nm, epsilon-hbo 2-650 nm is the absorptivity of oxygen and hemoglobin at 650 nm;
the epsilon-hb-850 nm is the absorptivity of deoxyhemoglobin to 850nm, and the epsilon-hbo 2-850 nm is the absorptivity of oxygen and hemoglobin to 850 nm;
and A is a correction coefficient which is obtained through limited times of experiments.
The heart rate is calculated in the following way:
the waveform signal of the wavelength can be obtained by carrying out the same data acquisition on the 550nm LED light source, and then the waveform period is calculated to obtain the heart rate value.
The jaundice value calculation mode is as follows:
the same set of signal values is obtained by data acquisition for a 460nm LED light source, and the average of the set of signal values is calculated. The average of the LED light source signal at 550nm was calculated accordingly.
Then, the jaundice value is calculated by the following formula.
Wherein I _550nm is the average value of the signal intensity of the LED light source with the wavelength of 550 nm; wherein I _460nm is the average value of the signal intensity of the LED light source of 460 nm; E. alpha and D are correction coefficients obtained through limited times of experiments.
By the method, a plurality of human health parameters can be rapidly and stably obtained; the sensor has small volume and can be applied to a human body.
In an embodiment, the multi-parameter vital sign monitoring method further includes performing an absorbance calibration for eliminating the optical path difference on the LED light source, and performing an operation compensation on the intensity of the optical signal of the detection light emitted by the LED light source.
In this embodiment, an exemplary method for compensating for temperature variation of constant-current optical power of an LED light source is provided, which includes:
because the luminous efficiency of the LED light emitting chip is greatly affected by temperature, in the application of using light intensity as a detection signal, for example, the detection of jaundice value in the present case, it is necessary to ensure that the luminous power of the LED light emitting source is continuously stable in the signal acquisition period. In practical applications, however, the LED chip emitting light continuously generates a large amount of heat at the same time, and the junction temperature of the LED chip continuously increases, so that the light emission efficiency continuously decreases. A relative value method based on experimental data is provided for temperature compensation of the constant current luminous power of the LED. The specific method comprises the following steps of S201-S205:
in step S201, a specific white board (teflon material) is fixed in front of the light source in the apparatus embodiment.
In step S202, the device in the above embodiment is placed in a thermostat control box whose temperature can be adjusted.
In step S203, the main board controls to light one of the LED light sources with a very short pulse (0-10ms), and controls to collect an output signal of the wide-spectrum detector and an output signal of the second temperature sensor; the above process is repeated with the unit of second as the period.
In step S204, the temperature of the incubator is adjusted, and temperature scanning is performed at 0-50 ℃ at intervals of 5 ℃.
In step S205, the above process is repeated to acquire data of other LED light sources.
The following temperature compensation methods were derived from experimental data:
Vactis the current directly collected LED light source signal voltage value, and the unit of the voltage is millivolt mv.
VcalIs the corrected LED signal voltage value.
K is 100 times the amount of relative change with respect to a voltage value of 25 degrees celsius.
According to the formula K ═ b0+b1T+b2T2+b3T3And T is 100 times of the actual temperature.
Taking an 469nm LED light source as an example, 3-degree polynomial fitting is performed according to formula 1 based on the data obtained in steps S203 to S204 to obtain the following coefficients:
b0＝4.48746；
b1＝-0.00292；
b2＝4.57625E-7；
b3＝-3.91797E-12；
according to the coefficient, the proportion of temperature compensation on the constant-current luminous power of the LED can be obtained.
Additionally, the absorbance calibration may be performed on the LED light source, and the optical path difference between the LED light source and the light source lens, the multi-channel optical filter, the optical path separation component, and the wide-spectrum detector in the device embodiment due to the processing and manufacturing tolerance and the assembly error is specifically calibrated according to the absorbance of each LED light source in the following method, so as to eliminate the inter-platform difference and improve the precision of the device, and specifically, a flow chart of the calibration and calibration method is provided through experimental data, as shown in fig. 9.
It should be noted that in the above embodiment, in the method for calibrating the absorbance of the LED light source to eliminate the optical path difference, a two-point linear calibration method is adopted to obtain the standard absorbance curve of the specific LED, and the light source driving module is ensured to output the current of 20ma by default at the ambient temperature of 25 ℃.
It is noted that in fig. 9, the ADC corresponds to an ADC module in the device embodiment, and the light source driving corresponds to a light source driving module.
The specific details of the above method have been described in detail in the embodiment of the apparatus part, and the details that are not disclosed can be referred to the embodiment of the apparatus part, and thus are not described again.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention. Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features included in other embodiments, rather than other features, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the claims above, any of the claimed embodiments may be used in any combination. The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Claims (10)
1. A multi-parameter vital sign monitoring device for detecting vital sign parameters, comprising:
the contact part is arc-shaped, corresponds to the head or four limbs of a living body, and is provided with a first hollow area at the center;
the light source emitting module is used for alternately emitting detection light, and the detection light irradiates the surface of the living body after passing through the first hollow area;
the wide-spectrum photoelectric detector is isolated from the light source emission module and is used for receiving reflected light reflected when the detection light is projected to a living body and generating an electric signal;
the multi-channel optical filter is used for filtering ambient light when the wide-spectrum photoelectric detector receives the reflected light and separating an optical signal with a preset wavelength from the reflected light;
the mainboard is used for triggering the light source emitting module to emit the detection light within a preset signal range, receiving and calculating the electric signal and sending a calculation result to external equipment in real time in a wired or wireless mode.
2. The multi-parameter vital signs monitoring device of claim 1, wherein the contact portion is made of a soft material and has a detachable silicone pad disposed on a surface thereof.
3. The multi-parameter vital signs monitoring device of claim 1, wherein the light source emitting module and the broad spectrum photodetector are disposed on the motherboard, wherein the light source emitting module comprises a plurality of LED light sources arranged to emit the detection light and circumferentially distributed at equal intervals around the broad spectrum photodetector, and wherein the detection light emitted by the LED light sources comprises fluorescence for exciting a surface of a living body or/and comprises monochromatic light absorbed by tissue of the living body.
4. The multi-parameter vital sign monitoring device according to claim 3, wherein a light path separating assembly is disposed on the main board, and the light path separating assembly forms an outgoing light channel corresponding to the detection light emitted from the different LED light sources and a light guiding channel corresponding to the broad-spectrum photodetector through a partition plate, wherein the light guiding channel and the outgoing light channel are isolated from each other.
5. The multi-parameter vital sign monitoring device according to claim 4, wherein a light-tight cover is surrounded around the light path separation assembly, through holes corresponding to the partition plates are formed in a hollow manner in an upper surface of the cover, and the upper surface of the cover is made of a light-transmitting material, wherein the multi-channel optical filter is disposed in the cover at a position corresponding to the light-transmitting channel, or the multi-channel optical filter is formed on the surface of the broad-spectrum photodetector by means of a film coating.
6. The multi-parameter vital signs monitoring device according to claim 4, further comprising a housing, wherein the broad spectrum photodetector, the light source emitting module, the multi-channel filter, the main board, and the optical path separating assembly are all received in the housing, a second hollow region corresponding to the first hollow region is provided with the contact portion at a lower portion of the housing, the optical path separating assembly penetrates the second hollow region and then reaches the first central control region, and the contact portion is detachably connected to the lower portion of the housing.
7. The multi-parameter vital sign monitoring device according to claim 1, wherein the main board includes a main control module, a DAC module, a light source driving module, a signal reading module, and an ADC module, the main board is further connected to a power supply module, the main control module is connected to the DAC module and the ADC module, the DAC module is connected to the light source driving module, the light source driving module is connected to the light source emitting module, the ADC module is connected to the signal reading module, the signal reading module is connected to the wide-spectrum photodetector, wherein the main control module is configured to:
controlling the DAC module to perform a current scanning program on the light source driving module so that an output signal of each LED light source in the light source emitting module is within a preset signal range, and storing working parameters of each LED light source;
sending a trigger signal according to the working parameters, wherein the trigger signal is subjected to digital-to-analog conversion by the DAC module and then drives the light source emitting module to work through the light source driving module;
and calculating the electric signal read by the signal reading module and then transmitting the electric signal to the external equipment through wireless/wired transmission, or directly transmitting the read electric signal to the external equipment through wireless/wired transmission.
8. The multi-parameter vital sign monitoring device according to claim 7, wherein the main board is further connected to a temperature measurement module, the temperature measurement module includes a first temperature sensor and a second temperature sensor respectively disposed in contact with a first copper tube and a second copper tube that are hollow and different from each other, one end of the first copper tube is in contact with the contact portion, one end of the second copper tube is in contact with the main board, the first temperature sensor and the second temperature sensor respectively generate a first temperature signal and a second temperature signal after detecting the temperatures of the first copper tube and the second copper tube, and transmit the first temperature signal and the second temperature signal to the main board, and the main board adjusts a preset signal range of the output signal of the LED light source according to the second temperature signal and transmits the first temperature signal to the external device in real time.
9. A multi-parameter vital signs monitoring method, applicable to the device of any one of claims 1-9, comprising the steps of:
placing the contact portion according to any one of claims 1 to 9 on the head or the limbs of the subject;
the control main board triggers a plurality of LED light sources of the light source emitting module to alternately emit detection light to irradiate the surface of the life body within a preset signal range;
receiving reflected light reflected when the detection light is projected to a living body by using a wide-spectrum photoelectric detector to generate a corresponding electric signal;
measuring the temperature of a detected person and the mainboard by using a temperature measuring module, respectively generating a first temperature signal and a second temperature signal, and adjusting a preset signal range of an output signal of the LED light source according to the second temperature signal;
and receiving and calculating the electric signal and the temperature signal by using the mainboard through a preset algorithm, and sending a calculation result to external equipment in a wired or wireless manner in real time so that the external equipment displays the calculation result in real time.
10. The multi-parameter vital signs monitoring method of claim 9, further comprising performing an absorbance calibration to the LED light source to eliminate optical path differences and performing an operational compensation to the optical signal intensity of the detected light emitted by the LED light source.
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