CN220275597U - Blood glucose detecting system and blood glucose meter based on laser transmission type - Google Patents
Blood glucose detecting system and blood glucose meter based on laser transmission type Download PDFInfo
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Abstract
The utility model provides a laser transmission-based blood glucose detection system and a blood glucose meter, comprising an optical path module, a circuit module, a display module and a microprocessor module; the first end of the optical path module is connected with the microprocessor module through the circuit module, the second end of the optical path module is connected with the microprocessor module, and the microprocessor module is connected with the display module; the optical path module comprises a first laser, a second laser, an optical coupler and a contact device, wherein the first laser and the second laser are used for transmitting laser signals with different wave bands; the contact device is used for contacting a preset acquisition part of an object; the display module is used for receiving basic information of an object; the microprocessor module is used for detecting the blood sugar of the subject based on the laser signal information and the basic information. The system is favorable for reducing the complexity of blood glucose detection and improving the efficiency of blood glucose detection. The utility model can be widely applied to the technical field of detection.
Description
Technical Field
The utility model relates to the technical field of detection, in particular to a laser transmission-based blood glucose detection system and a blood glucose meter.
Background
Blood sugar detection is required to be carried out frequently on patients with related diseases, and in the related technology, venous blood extraction detection, electrochemical blood sugar detection and the like belong to invasive or minimally invasive detection methods, so that the risk of infection of the patients is increased easily, and the psychological burden of the patients is increased simultaneously; and the detection process is complex, and the patient is required to wait for the detection result.
In view of the above, there is a need to solve the problems of the related art.
Disclosure of Invention
The present utility model aims to solve at least one of the technical problems existing in the related art to a certain extent.
It is therefore an object of embodiments of the present utility model to provide an efficient laser-based transmission type blood glucose detection system, comprising:
the embodiment of the utility model provides a laser transmission-based blood glucose detection system, which comprises: the display device comprises an optical path module, a circuit module, a display module and a microprocessor module; the first end of the optical path module is connected with the microprocessor module through the circuit module, the second end of the optical path module is connected with the microprocessor module, and the microprocessor module is connected with the display module; the optical path module comprises a first laser, a second laser, an optical coupler and a contact device, wherein the first laser is connected with the second laser through the optical coupler, the first end of the optical coupler is connected with the first end of a first optical detector, the second end of the optical coupler is connected with the first end of the contact device, the second end of the contact device is connected with the first end of a second optical detector, and the second end of the contact device is connected with the first end of a third optical detector; the second end of the first optical detector, the second end of the second optical detector and the second end of the third optical detector are all connected with the microprocessor module through the circuit module; the first laser and the second laser are used for transmitting laser signals with two different wave bands; the contact device is used for contacting a preset acquisition part of an object; the display module is used for receiving basic information of an object; the microprocessor module is used for detecting the blood sugar of the subject based on the laser signal information and the basic information. Therefore, the embodiment of the application realizes noninvasive blood glucose detection through the combined action of the laser and the detector; and the second detector and the third detector receive the transmission laser signals, so that blood glucose detection based on the transmission laser signals is realized. Therefore, the embodiment of the application is beneficial to reducing the complexity of blood glucose detection and improving the efficiency of blood glucose detection.
In addition, the laser transmission-based blood glucose detection system according to the above embodiment of the present utility model may further have the following additional technical features:
further, in an embodiment of the utility model, the basic information comprises age, height, weight, meal time of the subject.
Further, in an embodiment of the present utility model, the circuit module includes an amplifying unit, and the second end of the first photodetector is connected to the microprocessor module through the circuit module includes: the second end of the first light detector is connected with the microprocessor module through the amplifying unit.
Further, in an embodiment of the present utility model, the circuit module includes a constant current driving unit, and the constant current driving unit is connected to the first laser.
Further, in one embodiment of the present utility model, the circuit module includes a temperature control unit, and the temperature control unit is connected to the second laser; the temperature control unit comprises a MAX1978 chip.
Further, in one embodiment of the present utility model, the system further comprises a memory module, the memory module comprising an SD card.
Further, in one embodiment of the present utility model, the system further comprises a timing module:
the second end of the light path module is connected with the microprocessor module through the timing module.
Further, in an embodiment of the present utility model, the predetermined collection site includes a finger, and the contacting means for contacting the predetermined collection site of the subject includes: the contact device is used for placing a finger part of a subject.
Further, in one embodiment of the present utility model, the first laser comprises a DFB laser.
In another aspect, the present utility model provides a blood glucose meter comprising any of the above laser-based transmission-type blood glucose detection systems.
The advantages and benefits of the utility model will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the utility model.
The embodiment of the application discloses a blood sugar detecting system based on laser transmission, which comprises: the display device comprises an optical path module, a circuit module, a display module and a microprocessor module; the first end of the optical path module is connected with the microprocessor module through the circuit module, the second end of the optical path module is connected with the microprocessor module, and the microprocessor module is connected with the display module; the optical path module comprises a first laser, a second laser, an optical coupler and a contact device, wherein the first laser is connected with the second laser through the optical coupler, the first end of the optical coupler is connected with the first end of a first optical detector, the second end of the optical coupler is connected with the first end of the contact device, the second end of the contact device is connected with the first end of a second optical detector, and the second end of the contact device is connected with the first end of a third optical detector; the second end of the first optical detector, the second end of the second optical detector and the second end of the third optical detector are all connected with the microprocessor module through the circuit module; the first laser and the second laser are used for transmitting laser signals with two different wave bands; the contact device is used for contacting a preset acquisition part of an object; the display module is used for receiving basic information of an object; the microprocessor module is used for detecting the blood sugar of the subject based on the laser signal information and the basic information. Therefore, the embodiment of the application realizes noninvasive blood glucose detection through the combined action of the laser and the detector; and the second detector and the third detector receive the transmission laser signals, so that blood glucose detection based on the transmission laser signals is realized. Therefore, the embodiment of the application is beneficial to reducing the complexity of blood glucose detection and improving the efficiency of blood glucose detection.
Drawings
FIG. 1 is a schematic diagram of an embodiment of a laser-based transmission type blood glucose testing system according to an embodiment of the present application;
FIG. 2 is a schematic diagram of another embodiment of a laser-based transmission type blood glucose testing system according to an embodiment of the present application;
fig. 3 is an electrical schematic diagram of an embodiment of a temperature control unit according to an embodiment of the present application.
Detailed Description
Embodiments of the present utility model are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the utility model.
In the description of the present utility model, it should be understood that the terms "length," "upper," "lower," "front," "rear," "left," "right," "top," "inner," "outer," "axial," "radial," "circumferential," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present utility model and simplify description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be configured and operated in a particular orientation, and thus should not be construed as limiting the present utility model. Furthermore, features defining "first", "second" may include one or more such features, either explicitly or implicitly. In the description of the present utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present utility model, it should be noted that, unless explicitly stated and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
The current and more conventional blood sugar detection modes are as follows: venous blood extraction detection, electrochemical blood glucose detection, and the like. The venous blood detection method needs to measure blood sugar by extracting venous blood detection, the method is limited to hospitals in use, and the measurement time is long, so that the method is not suitable for the situation that the blood sugar of a human body needs to be frequently detected in daily life of an individual; the electrochemical detection method is to apply a certain voltage to blood, the current of the blood increases along with the increase of the blood glucose concentration in the blood, precisely measure the weak currents, and reversely calculate the corresponding blood glucose concentration according to the relation between the current value and the blood glucose concentration. The detection method has the characteristics of portability, small volume, relatively simplified operation and the like, but the measurement still needs to collect blood samples, pain is brought to patients, risks of other diseases are caused, and psychological pressure is caused to users during the measurement. However, these invasive or minimally invasive methods of detection on the one hand place a physiological and psychological burden on the tester and also increase the risk of unwanted infections. Therefore, research and application of noninvasive blood glucose detection technology are becoming more and more widespread, such as blood substitution method, biosensor method, conservation of energy metabolism method, etc. The blood substitute method mainly comprises saliva, sweat and urine of a human body, and the concentration of blood sugar of the human body is estimated by calculating the concentration of glucose in the substitute, so that model research analysis of the saliva, sweat and urine of the human body is established; but the correlation between the surrogate and blood was found to be insignificant in the experiments, and the study method required further investigation. The biosensor method measures physical quantities of a human body using an external sensor or an implantable subcutaneous sensor and has a strong correlation with blood glucose of the human body, but the measuring method may cause harmful radiation to skin tissues of the human body, so the technical method has not been widely used. The energy conservation method is based on the energy conservation method of human body in daily metabolism, namely, the heat generated by glucose in human body during consumption, oxygen consumption and the like are related to the blood sugar concentration of human body, but in practical clinical research, parameters such as the temperature of human body, the temperature and the humidity of environment and the like need to be measured, so that a large number of sensors are needed, and the influence of errors of the specification and the precision of each sensor is easy to be caused, and therefore, the noninvasive detection method based on the energy conservation method needs further research and improvement.
Accordingly, the present application proposes a laser transmission type blood glucose detection system, and the laser transmission type blood glucose detection system proposed in the present application will be described in detail with reference to a schematic structural diagram of the laser transmission type blood glucose detection system shown in fig. 1.
The application provides a blood sugar detecting system based on laser transmission formula includes: an optical path module 110, a circuit module 120, a display module 140, and a microprocessor module 130; the first end of the optical path module is connected with the microprocessor module through the circuit module, the second end of the optical path module is connected with the microprocessor module, and the microprocessor module is connected with the display module;
the optical path module comprises a first laser, a second laser, an optical coupler and a contact device, wherein the first laser is connected with the second laser through the optical coupler, the first end of the optical coupler is connected with the first end of the first optical detector, the second end of the optical coupler is connected with the first end of the contact device, the second end of the contact device is connected with the first end of the second optical detector, and the second end of the contact device is connected with the first end of the third optical detector; the second end of the first optical detector, the second end of the second optical detector and the second end of the third optical detector are all connected with the microprocessor module through the circuit module;
the first laser and the second laser are used for transmitting laser signals with two different wave bands; the contact device is used for contacting a preset acquisition part of an object;
the display module is used for receiving basic information of the object;
the microprocessor module is used for detecting the blood sugar of the subject based on the laser signal information and the basic information. Specifically, the microprocessor module can input laser signal information and basic information as characteristics, and the artificial intelligence model is used for detecting the blood sugar of the subject.
In some possible embodiments, the optical path module is used for generating laser for blood glucose detection, the circuit module is used for converting a laser signal into an electrical signal, the display module is used for interacting information with a user, and the microprocessor module is used for acquiring laser signals and object basic information required for blood glucose detection and processing the signals and the information to obtain a blood glucose value of the object. Specifically, the microprocessor module can perform blood glucose detection in a logic operation mode, and can also perform blood glucose detection in an artificial intelligence mode. The present application is not limited. In some possible implementations, as shown in fig. 2, the optical path module includes a first laser, which may be a 1310nm laser light source, and a second laser, which may be a 1550nm laser light source. It can be understood that the near infrared spectroscopy irradiates the parts of the human body with abundant capillaries and less other tissues by using infrared light, obtains the spectral information carrying detection information, correlates with the detected blood sugar concentration, establishes a correction model by using a mathematical method, and finally predicts the blood sugar concentration according to the model. Human blood is a red opaque liquid which is generated by the heart and circulates in human blood vessels, and mainly consists of blood plasma and blood cells, wherein the blood plasma contains glucose, inorganic salt and a large amount of water, the glucose concentration in the blood refers to blood glucose concentration, the chemical molecular formula of the glucose contains a plurality of methyl (O-H) and hydroxyl (C-H), and the functional groups are hydrogen-containing functional groups which are strong in absorption to near infrared spectrum, and the research finds that the absorption to glucose molecules is small but the absorption to water molecules is large in the wavelength range of 1000-1400 nm; in the wavelength range of 1400-1800nm, the absorption of glucose molecules is strong, but the absorption of water molecules is weak, so that the system selects proper wavelengths in two wave band ranges as a measuring light source and a reference light source of the system respectively, and a reference light source is selected because the content specific gravity of water molecules in blood is high, so that the influence of water molecules on the measurement of the system should be considered to be avoided when the wavelength is selected. Therefore, the first laser and the second laser emit laser signals with different wave bands, and blood sugar detection is carried out on the object. And the light is received and converted into a laser signal by the light detector. Illustratively, referring to fig. 2, the first light detector may be the photodetector 1 of fig. 2 for receiving the direct signals of the first and second lasers; the second light detector may be 1310 detector 3 of fig. 2 for receiving the transmission signal of the first laser; the third light detector may be 1550 detector 2 of fig. 2 for receiving the transmission signal of the second laser. Specifically, light sources of 1550nm and 1310nm are used as a measuring light source and a reference light source of the system, wherein the 1550nm measuring light source is used for detecting glucose molecules in blood, and the 1310nm reference light source is used for measuring water molecules in blood and removing background noise during blood glucose detection. Two paths of laser light source signals are connected to the input end of the coupler, two paths of laser light source signals are output by the coupler, one path of laser light source signals are connected to the photoelectric detector with the collimator, and the other path of laser light source signals are used for probing fingers. The system uses a photodetector with low dark current, high sensitivity and responsiveness for receiving the direct near infrared light signal and transmitting the near infrared light signal of the finger. It can be understood that the signals received by the three light detectors are converted into electric signals which can be identified by the microprocessor module through the signal conversion of the circuit module, and the electric signals are sent to the microprocessor module for signal processing. Meanwhile, the display module receives basic information of the object and transmits the basic information to the microprocessor module for auxiliary detection of blood sugar. According to the embodiment of the application, noninvasive blood glucose detection is realized through the combined action of the laser and the detector; and the second detector and the third detector receive the transmission laser signals, so that blood glucose detection based on the transmission laser signals is realized. Therefore, the embodiment of the application is beneficial to reducing the complexity of blood glucose detection and improving the efficiency of blood glucose detection.
Optionally, the basic information of the laser transmission-based blood glucose detection system provided by the application comprises age, height, weight and meal time of the subject.
In some possible embodiments, background noise information of the blood glucose test is obtained from the basic information of the subject, and is used to optimize the blood glucose test result based on the laser signal. Specifically, the basic information can be formed into an array, and the array is sent to the microprocessor module for signal and data processing to obtain the blood glucose detection result.
Optionally, the application provides a blood sugar detecting system based on laser transmission formula, and the circuit module includes the amplification unit, and the second end of first light detector passes through circuit module and links to each other with microprocessor module and includes: the second end of the first light detector is connected with the microprocessor module through the amplifying unit.
In some possible embodiments, the OPA131 photovoltaic mode based I/V conversion circuit is designed such that when near infrared light impinges on the photodetector surface, the photodiode will generate a current proportional to the intensity of the light, but the current is relatively weak. The current passes through the feedback resistor RF, converting the voltage. Because noise such as 50Hz power frequency interference exists in the signal acquisition process, a two-stage amplifying circuit is designed, a low-pass filter circuit is also introduced, namely, a low-frequency effective signal is reserved, high-frequency noise is filtered, and the effective signal is amplified. The laser signal measured by the light detector is amplified by the amplifying unit, so that the signal processing of the microprocessor module is facilitated. It is understood that the second end of the second light detector is connected to the microprocessor module through the amplifying unit, and the second end of the third light detector is connected to the microprocessor module through the amplifying unit.
Optionally, the laser transmission-based blood glucose detection system provided by the application comprises a circuit module, wherein the circuit module comprises a constant current driving unit, and the constant current driving unit is connected with the first laser.
In some possible embodiments, using FP7103 based constant current drive units/circuits, the constant current regulation formula for the circuit output is: i F =v FB R, wherein V FB The constant output current can be obtained by adjusting R with a fixed output of 0.25V. And stable output of the laser is realized through the constant circuit driving unit. It will be appreciated that the constant current drive unit is also connected to the second laser.
Optionally, the circuit module of the blood glucose detection system based on laser transmission provided by the application comprises a temperature control unit, wherein the temperature control unit is connected with the second laser; the temperature control unit comprises a MAX1978 chip.
In some possible embodiments, referring to fig. 3, a temperature control circuit with MAX1978 as a core is adopted, a thermal bridge circuit is externally connected, a thermistor is used for detecting the surface temperature of the laser in real time, if the temperature fluctuation is relatively large, a designed H-bridge circuit and a PID regulating circuit are used for regulating the current of the circuit, so that the power of heating or refrigerating the TEC is regulated, the laser is maintained at a constant surface temperature, the stability of the laser is improved, and the accuracy of the system is further improved.
Optionally, the laser transmission-based blood glucose detection system provided by the application further comprises a storage module, wherein the storage module comprises an SD card.
In some possible embodiments, the storage module is used for storing blood glucose detection data of the subject, or storing blood glucose detection intermediate data, so that the subject can conveniently call and check, and a blood glucose change trend is generated for reference.
Optionally, the system for detecting blood glucose based on laser transmission provided by the application further comprises a timing module:
the second end of the optical path module is connected with the microprocessor module through the timing module.
In some possible embodiments, the timing module may be implemented by a microprocessor module. Specifically, the embedded microcontroller realizes time-sharing multiplexing of two lasers, and two ends of the coupler respectively emit near infrared light sources with enough power and stability of 1550nm and 1310nm at intervals of 15 s; the two paths of photoelectric detectors collect direct photoelectric signals and transmitted photoelectric signals, the embedded microcontroller adjusts the two-channel ADC to collect signals, and the collected two paths of signals are stored in an SD card of the system board, so that the microprocessor module is convenient for calling and processing data; in addition, the system wirelessly transmits the acquired two-channel data to the display module in real time, and the display module displays the acquired two-channel signals in real time and stores the acquired two-channel signals in a local path.
In some possible embodiments, the measuring light source 1550 and the reference light source 1310 are independently operated in a time-division multiplexing mode, so that mutual interference is avoided. The driving light source circuit is designed by using a transistor, the driving IO is connected to the GPIO control end of the embedded microprocessor, and the microcontroller controls the high and low level of the GPIO control end and uses a timer to time, so that the time-sharing multiplexing function of two paths of light sources of the system is realized.
In some possible embodiments, the timing module is further configured to increase a time attribute, and periodically detect a blood glucose condition of the subject to form blood glucose change trend data for reference by the subject.
Optionally, the blood sugar detecting system based on laser transmission that this application provided, predetermine the collection position and include the finger, and the contact device is used for contacting the preset collection position of object and includes: the contact device is used for placing the finger part of the object.
In some possible embodiments, in order to obtain an optimal detection result, a suitable detection site needs to be selected, which needs to be satisfied: (1) the exposed part of the human body is selected, so that the detection is convenient; (2) selecting a location of less individual variability of the user; (3) Selecting a measurement environment (4) with weak external interference, and selecting a detection part with rich capillary vessels and less other tissue components; in addition, the selected part should avoid being interfered by factors of human body surface, such as body temperature, sweat, etc., and the above factors are combined, and the selected detection part can be selected from finger, ear, etc., and the proposed system is to select finger tip as detection part. The near infrared light with fixed wavelength is irradiated at one end of the finger, the other end of the finger is provided with a high-sensitivity photoelectric detector, the near infrared light is received by the photoelectric detector after penetrating through blood in the skin, and the light intensity is detected to be minimum because the absorption of the light by skeletal tissues and the like in the skin is constant all the time and the blood volume is changed in a pulsation mode, namely, when the heart contracts, the peripheral blood volume is the largest, and the light absorption amount is the largest; when the heart is relaxed, the peripheral blood volume is minimized, the light absorption is minimized, and the intensity of the detected light is maximized. Thus, embodiments of the present application may perform blood glucose testing by a finger.
Optionally, the laser transmission-based blood glucose detection system provided in the present application, the first laser comprises a DFB laser.
In some possible embodiments, a two-band DFB laser is used as the light source for the illumination. The DFB laser has the characteristics of high output light power, good light source stability, good monochromaticity and the like, and the laser diode can work in a stable and good state by designing a peripheral constant current driving circuit and a temperature control circuit.
As can be seen from the above description, the embodiments of the present application realize noninvasive blood glucose detection through the combined action of the laser and the detector; and the second detector and the third detector receive the transmission laser signals, so that blood glucose detection based on the transmission laser signals is realized. Therefore, the embodiment of the application is beneficial to reducing the complexity of blood glucose detection and improving the efficiency of blood glucose detection.
On the other hand, the embodiment of the application provides a blood glucose meter, which comprises the laser transmission-based blood glucose detection system.
In the description of the present specification, reference to the term "one embodiment," "another embodiment," or "certain embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present utility model have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the utility model, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. A laser transmission-based blood glucose testing system, comprising: the display device comprises an optical path module, a circuit module, a display module and a microprocessor module; the first end of the optical path module is connected with the microprocessor module through the circuit module, the second end of the optical path module is connected with the microprocessor module, and the microprocessor module is connected with the display module;
the optical path module comprises a first laser, a second laser, an optical coupler and a contact device, wherein the first laser is connected with the second laser through the optical coupler, the first end of the optical coupler is connected with the first end of a first optical detector, the second end of the optical coupler is connected with the first end of the contact device, the second end of the contact device is connected with the first end of a second optical detector, and the second end of the contact device is connected with the first end of a third optical detector; the second end of the first optical detector, the second end of the second optical detector and the second end of the third optical detector are all connected with the microprocessor module through the circuit module;
the first laser and the second laser are used for transmitting laser signals with two different wave bands; the contact device is used for contacting a preset acquisition part of an object;
the display module is used for receiving basic information of an object;
the microprocessor module is used for detecting the blood sugar of the subject based on the laser signal information and the basic information.
2. The laser transmission-based blood glucose testing system of claim 1, wherein the basic information includes age, height, weight, meal time of the subject.
3. The laser-based transmission blood glucose testing system of claim 1, wherein the circuit module includes an amplifying unit, and wherein the second end of the first photodetector is coupled to the microprocessor module via the circuit module comprises: the second end of the first light detector is connected with the microprocessor module through the amplifying unit.
4. The laser-based blood glucose testing system of claim 1, wherein the circuit module includes a constant current drive unit coupled to the first laser.
5. The laser-based transmission blood glucose testing system of claim 1, wherein the circuit module comprises a temperature control unit, the temperature control unit being coupled to the second laser; the temperature control unit comprises a MAX1978 chip.
6. The laser transmission-based blood glucose testing system of claim 1, further comprising a memory module, wherein the memory module comprises an SD card.
7. The laser transmission-based blood glucose testing system of claim 1, further comprising a timing module:
the second end of the light path module is connected with the microprocessor module through the timing module.
8. The laser transmission-based blood glucose testing system of claim 1, wherein the predetermined collection site comprises a finger, and wherein the contacting means for contacting the predetermined collection site of the subject comprises: the contact device is used for placing a finger part of a subject.
9. The laser based blood glucose testing system of claim 1, wherein the first laser comprises a DFB laser.
10. A blood glucose meter comprising a laser transmission-based blood glucose detection system according to any one of claims 1 to 9.
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