CN114247012A - Remaining needle film capable of inducing drug extravasation - Google Patents

Remaining needle film capable of inducing drug extravasation Download PDF

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Publication number
CN114247012A
CN114247012A CN202111517086.1A CN202111517086A CN114247012A CN 114247012 A CN114247012 A CN 114247012A CN 202111517086 A CN202111517086 A CN 202111517086A CN 114247012 A CN114247012 A CN 114247012A
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layer
value
sensing
color development
medicine
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黄妹妹
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Wuhan University WHU
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Wuhan University WHU
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1588Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body having means for monitoring, controlling or visual inspection, e.g. for patency check, avoiding extravasation

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The application relates to a needle pad pasting is kept somewhere of response medicine exosmosis belongs to medical appliances technical field, includes: the pH value sensing color development layer contains a pH indicator for detecting and displaying the pH value of the extravasated drug; the external protective layer is made of transparent materials and is mutually overlapped with the pH value induction color development layer, and a coating for indicating the pH value is arranged on the external protective layer. The pH value induction color development layer of the indwelling needle film has the pH value according to each medicine, and the medicine with peracid or over-alkali can influence the permeability of the blood vessel intima to cause blood vessel injury. When the medicine exosmosis occurs, the exudation medicine is soaked on the surface of the skin, the indwelling needle film can be changed into different colors according to different PH values of the medicine, the early recognition of medical care personnel is facilitated, the self observation of patients and family members is also facilitated, and the safety of nursing infusion is improved.

Description

Remaining needle film capable of inducing drug extravasation
Technical Field
The application relates to the technical field of medical appliances, in particular to an indwelling needle film for inducing drug extravasation.
Background
The medicine extravasation refers to the entry of corrosive liquid medicine into peripheral tissues outside the lumen of a vein in the process of intravenous infusion. It is a common adverse reaction after intravenous infusion, and mild patients can cause the phenomena of swelling and pain of local tissues, and severe patients can cause the necrosis of local skin tissues and even damage of neuromuscular joints to cause tissue dysfunction. Drug extravasation was classified into grades 0-IV according to INS guidelines, with the extent of skin whitening, subcutaneous edema, cooling of the skin and with or without pain in the drug extravasation area.
Although intravenous infusion guidelines suggest the use of central venous catheters for infusion to avoid damage to blood vessels when infusing certain high risk drugs, such as chemotherapeutic drugs, vasoactive drugs, etc. However, some patients select the peripheral venous catheter for infusing high-risk medicines due to factors such as economic conditions and blood coagulation dysfunction, and the infusion process needs frequent patrol of nurses, so that the workload of the nurses is increased, and the working efficiency is also reduced. Furthermore, signs and symptoms of early drug extravasation are not always evident on the day, and inflammation may appear days or weeks later, possibly evolving into ulcers or necrosis.
There are studies that suggest that nearly half of drug extravasation is found as a result of patient complaints, which, while important in identifying extravasation, consider that the patient's extravasation experience can be affected by a number of factors, including individual pain tolerance, loss of sensation, and the like. In addition, it is difficult to determine whether the pain at the site is the result of extravasation or the irritation of the vessel wall by the drug. Therefore, it is particularly important to identify early onset of drug extravasation in patients.
In summary, there is a need for an indwelling needle patch capable of automatically sensing drug extravasation, timely discovering the occurrence of drug extravasation of a patient, reducing the severity of drug extravasation, alleviating the pain of the patient, and improving the working efficiency of nurses.
Disclosure of Invention
The embodiment of the application provides a needle pad pasting is kept somewhere to response medicine extravasation to take place medicine extravasation and can not effectively detect in solving patient's venous transfusion in the correlation technique, increase the problem of patient's pain and medical personnel work load.
The embodiment of the application provides a needle pad pasting is kept somewhere of response medicine extravasation includes:
the pH value sensing color development layer contains a pH indicator for detecting and displaying the pH value of the extravasated drug;
the external protective layer is made of transparent materials and is mutually overlapped with the pH value induction color development layer, and a coating for indicating the pH value is arranged on the external protective layer.
In some embodiments: the temperature-sensitive color-developing layer is mutually overlapped with the external protective layer, and the temperature-sensitive color-developing layer is provided with a temperature-sensitive color-developing material for sensing the temperature of the extravasated drug.
In some embodiments: the temperature sensing color development layer is positioned inside or around the pH value sensing color development layer, and the temperature sensing color development layer and the pH value sensing color development layer are not overlapped with each other.
In some embodiments: the temperature-sensitive color-changing material is made of any one of an inorganic temperature-sensitive color-changing material, an organic temperature-sensitive color-changing material or an inorganic-organic temperature-sensitive color-changing composite material.
In some embodiments: still include the water response discoloration layer with the mutual coincide of outside protective layer, the coating has the water that detects and show the exosmosis medicine on the water response discoloration layer and meets water color changing printing ink.
In some embodiments: the water-sensitive color-changing layer is positioned inside or around the pH value sensitive color-developing layer, and the water-sensitive color-changing layer and the pH value sensitive color-developing layer are not overlapped with each other.
In some embodiments: the outer protective layer is a PET layer or a nylon layer.
In some embodiments: an adhesive layer is coated on the outer protective layer.
In some embodiments: the water absorption layer is positioned around the pH value induction color development layer, and the water absorption layer and the pH value induction color development layer are not overlapped with each other.
In some embodiments: the pH value induction color development layer is positioned between the release paper and the external protective layer.
The beneficial effect that technical scheme that this application provided brought includes:
the embodiment of the application provides a remaining needle film for sensing drug extravasation, which is provided with a pH value sensing color development layer, wherein the pH value sensing color development layer contains a pH indicator for detecting and displaying the pH value of an extravasation drug; and the external protective layer is made of transparent material and is mutually overlapped with the pH value induction color development layer, and a coating for indicating the pH value is arranged on the external protective layer.
Therefore, the pH value induction color development layer of the indwelling needle film has the pH value according to each medicine, and the medicine with over-acid or over-alkali can influence the permeability of the vascular intima to cause vascular injury. When the medicine exosmosis occurs, the exudation medicine is soaked on the surface of the skin, the indwelling needle film can be changed into different colors according to different PH values of the medicine, the early recognition of medical care personnel is facilitated, the self observation of patients and family members is also facilitated, and the safety of nursing infusion is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is an exploded view of the structure of a first embodiment of the present application;
FIG. 2 is an exploded view of a second embodiment of the present application;
FIG. 3 is an exploded view of a third embodiment of the present application;
FIG. 4 is an exploded view of the structure of a fourth embodiment of the present application;
fig. 5 is an exploded view of the fifth embodiment of the present application.
Reference numerals:
1. a pH value induction color development layer; 2. an outer protective layer; 3. coating; 4. a temperature-sensitive color development layer; 5. a water-sensitive color-changing layer; 6. a water-absorbing layer; 7. and (4) release paper.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the application provides a needle pad pasting is kept somewhere to response medicine extravasation, and it can solve and take place medicine extravasation and can not effectively detect in the patient venous transfusion among the correlation technique, increases the problem of patient's pain and medical personnel work load.
Example 1
Referring to fig. 1, an embodiment of the present application provides an indwelling needle patch for sensing drug extravasation, including:
the pH value sensing color development layer 1 is provided with a pH value indicator for detecting and displaying the pH value of the extravasated drug, and the pH value indicator can detect and display the pH value of the extravasated drug. The acid-base indicator is preferably, but not limited to, a mixture of a methyl red indicator, a polyvinylidene fluoride binder and a non-woven fabric.
And the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value sensing color development layer 1, and a coating 3 for indicating the pH value on the pH value sensing color development layer 1 is arranged on the external protective layer 2. Coating 3 is a color marking indicating different pH pH values.
The pH value induction color development layer 1 of the indwelling needle film disclosed by the embodiment of the application is utilized and has a pH value according to each medicine, and the permeability of the intima of a blood vessel can be influenced by the medicine of peracid or over-alkali, so that the blood vessel is damaged.
When medicine exosmosis occurs, exuded medicine is soaked on the surface of skin, the pH value induction color development layer 1 can be changed into different colors according to different pH values of the medicine, so that the early recognition of medical care personnel is facilitated, the self observation of patients and family members is facilitated, and the safety of nursing infusion is improved.
The outer protective layer 2 is preferably a PET layer or a nylon layer, and can prevent the acid-base indicator from being damaged by oxygen, water vapor, carbon dioxide, and the like in the air. An adhesive layer is coated on the outer protective layer 2, and the pH value induction color development layer 1 and the outer protective layer 2 are applied on the skin of a patient.
Example 2
Referring to fig. 2, an embodiment of the present application provides an indwelling needle patch for sensing drug extravasation, including:
the pH value sensing color development layer 1 is provided with a pH value indicator for detecting and displaying the pH value of the extravasated drug, and the pH value indicator can detect and display the pH value of the extravasated drug. The acid-base indicator is preferably, but not limited to, a mixture of a methyl red indicator, a polyvinylidene fluoride binder and a non-woven fabric.
And the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value sensing color development layer 1, and a coating 3 for indicating the pH value on the pH value sensing color development layer 1 is arranged on the external protective layer 2. Coating 3 is a color marking indicating different pH pH values.
And the temperature sensing color development layer 4 is mutually overlapped with the external protective layer 2, and the temperature sensing color development layer 4 is provided with a temperature-sensitive color change material for sensing the temperature of the extravasated medicine. The temperature-sensitive color-changing material is made of any one of an inorganic temperature-sensitive color-changing material, an organic temperature-sensitive color-changing material or an inorganic-organic temperature-sensitive color-changing composite material.
The temperature sensing color development layer 4 is positioned around the pH value sensing color development layer 1, and the temperature sensing color development layer 4 and the pH value sensing color development layer 1 are not overlapped with each other. When drug extravasation occurs, subcutaneous edema occurs and the temperature of the skin vessels in the edema area will exhibit a low temperature distribution pattern. The temperature-sensitive color development layer 4 can be colored at low temperature and can be identified by naked eyes.
The pH value induction color development layer 1 of the indwelling needle film disclosed by the embodiment of the application is utilized and has a pH value according to each medicine, and the permeability of the intima of a blood vessel can be influenced by the medicine of peracid or over-alkali, so that the blood vessel is damaged.
When medicine exosmosis occurs, exudation medicine is soaked on the surface of the skin, the pH value induction color development layer 1 can change into different colors according to different pH values of the medicine, the temperature induction color development layer 4 can be colored at low temperature, the early recognition of medical care personnel is facilitated, the self-observation of patients and family members is facilitated, and the safety of nursing infusion is improved.
The outer protective layer 2 is preferably a PET layer or a nylon layer, and can prevent the acid-base indicator from being damaged by oxygen, water vapor, carbon dioxide, and the like in the air. An adhesive layer is coated on the outer protective layer 2, and the pH value induction color development layer 1 and the outer protective layer 2 are applied on the skin of a patient.
Example 3
Referring to fig. 3, an embodiment of the present application provides an indwelling needle patch for sensing drug extravasation, including:
the pH value sensing color development layer 1 is provided with a pH value indicator for detecting and displaying the pH value of the extravasated drug, and the pH value indicator can detect and display the pH value of the extravasated drug. The acid-base indicator is preferably, but not limited to, a mixture of a methyl red indicator, a polyvinylidene fluoride binder and a non-woven fabric.
And the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value sensing color development layer 1, and a coating 3 for indicating the pH value on the pH value sensing color development layer 1 is arranged on the external protective layer 2. Coating 3 is a color marking indicating different pH pH values.
And the water-encountering induction color-changing layer 5 is mutually overlapped with the external protective layer 2, and water-encountering color-changing ink for detecting and displaying the externally-permeated medicine is coated on the water-encountering induction color-changing layer 5. The ink capable of changing color when meeting water is water-based screen printing ink without harmful materials, is white, becomes transparent when meeting water, and is reduced after being dried.
The water-contact induction color-changing layer 5 is positioned inside or around the pH induction color-developing layer 1, and the water-contact induction color-changing layer and the pH induction color-developing layer are not overlapped with each other. When the medicine is leaked, the discoloring layer 5 can fade when meeting water, and can be identified by naked eyes.
The pH value induction color development layer 1 of the indwelling needle film disclosed by the embodiment of the application is utilized and has a pH value according to each medicine, and the permeability of the intima of a blood vessel can be influenced by the medicine of peracid or over-alkali, so that the blood vessel is damaged.
When the medicine exosmosis takes place, ooze the medicine and soak on the skin surface, pH value response color development layer 1 can become different colours according to the different pH value of medicine, meets water response color development layer 5 and can appear fading, makes things convenient for medical personnel early stage to discern, also makes things convenient for patient and family members' self-observation, improves the security of nursing infusion.
The outer protective layer 2 is preferably a PET layer or a nylon layer, and can prevent the acid-base indicator from being damaged by oxygen, water vapor, carbon dioxide, and the like in the air. An adhesive layer is coated on the outer protective layer 2, and the pH value induction color development layer 1 and the outer protective layer 2 are applied on the skin of a patient.
Example 4
Referring to fig. 4, an embodiment of the present application provides an indwelling needle patch for sensing drug extravasation, including:
the pH value sensing color development layer 1 is provided with a pH value indicator for detecting and displaying the pH value of the extravasated drug, and the pH value indicator can detect and display the pH value of the extravasated drug. The acid-base indicator is preferably, but not limited to, a mixture of a methyl red indicator, a polyvinylidene fluoride binder and a non-woven fabric.
And the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value sensing color development layer 1, and a coating 3 for indicating the pH value on the pH value sensing color development layer 1 is arranged on the external protective layer 2. Coating 3 is a color marking indicating different pH pH values.
And the water absorbing layer 6 is mutually overlapped with the external protective layer 2, the water absorbing layer 6 is positioned at the periphery of the pH value induction color development layer 1, and the water absorbing layer 6 and the pH value induction color development layer 1 are not overlapped with each other. The water absorption layer 6 can absorb the exosmotic medicine, and prevent the exosmotic medicine from expanding and polluting the skin area of a patient.
The pH value induction color development layer 1 of the indwelling needle film disclosed by the embodiment of the application is utilized and has a pH value according to each medicine, and the permeability of the intima of a blood vessel can be influenced by the medicine of peracid or over-alkali, so that the blood vessel is damaged.
When medicine exosmosis takes place, ooze the medicine and soak on the skin surface, pH value response color development layer 1 can become different colours according to the different pH value changes of medicine, and layer 6 that absorbs water can adsorb the exosmosis medicine, makes things convenient for medical personnel early stage to discern, also makes things convenient for patient and family members' self-observation, improves the security of nursing infusion.
The outer protective layer 2 is preferably a PET layer or a nylon layer, and can prevent the acid-base indicator from being damaged by oxygen, water vapor, carbon dioxide, and the like in the air. An adhesive layer is coated on the outer protective layer 2, and the pH value induction color development layer 1 and the outer protective layer 2 are applied on the skin of a patient.
Example 5
Referring to fig. 5, an embodiment of the present application provides an indwelling needle patch for sensing drug extravasation, including:
the pH value sensing color development layer 1 is provided with a pH value indicator for detecting and displaying the pH value of the extravasated drug, and the pH value indicator can detect and display the pH value of the extravasated drug. The acid-base indicator is preferably, but not limited to, a mixture of a methyl red indicator, a polyvinylidene fluoride binder and a non-woven fabric.
And the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value sensing color development layer 1, and a coating 3 for indicating the pH value on the pH value sensing color development layer 1 is arranged on the external protective layer 2. Coating 3 is a color marking indicating different pH pH values.
And the release paper 7 is mutually bonded with the external protective layer 2, and the pH value induction color development layer 1 is positioned between the release paper 7 and the external protective layer 2. The release paper 7 is adhered on the external protective layer 2 to protect the pH value induction color development layer 1, and the release paper 7 is peeled off from the external protective layer 2 and then is pasted on the skin in the pinhole area when in use.
Principle of operation
The embodiment of the application provides a remaining needle film for sensing drug extravasation, and the remaining needle film is provided with a pH value sensing color development layer 1, and the pH value sensing color development layer 1 is provided with a pH indicator for detecting and displaying the pH value of an extravasation drug; and the external protective layer 2 is made of transparent material and is mutually overlapped with the pH value induction color development layer, and a coating 3 for indicating the pH value is arranged on the external protective layer 2.
Therefore, the pH value induction color development layer 1 of the indwelling needle film has own pH value according to each medicine, and the medicine with peracid or over-alkali can influence the permeability of the vascular intima to cause vascular injury. When the medicine exosmosis occurs, the exudation medicine is soaked on the surface of the skin, the indwelling needle film can be changed into different colors according to different PH values of the medicine, the early recognition of medical care personnel is facilitated, the self observation of patients and family members is also facilitated, and the safety of nursing infusion is improved.
In the description of the present application, it should be noted that the terms "upper", "lower", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only for convenience in describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present application. Unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
It is noted that, in the present application, relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above description is merely exemplary of the present application and is presented to enable those skilled in the art to understand and practice the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. An indwelling needle patch for sensing drug extravasation, comprising:
the pH value sensing color development layer (1) is provided with a pH indicator for detecting and displaying the pH value of the extravasated drug;
the outer protective layer (2) is made of transparent materials and is mutually overlapped with the pH value induction color development layer (1), and a coating (3) for indicating the pH value is arranged on the outer protective layer (2).
2. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
the temperature-sensitive color-developing layer (4) is mutually overlapped with the external protective layer (2), and the temperature-sensitive color-developing layer (4) is provided with a temperature-sensitive color-changing material for sensing the temperature of the extravasated medicament.
3. The indwelling needle patch for sensing drug extravasation according to claim 2, wherein:
the temperature sensing color development layer (4) is positioned inside or around the pH value sensing color development layer (1), and the temperature sensing color development layer (4) and the pH value sensing color development layer (1) are not overlapped with each other.
4. The indwelling needle patch for sensing drug extravasation according to claim 2, wherein:
the temperature-sensitive color-changing material is made of any one of an inorganic temperature-sensitive color-changing material, an organic temperature-sensitive color-changing material or an inorganic-organic temperature-sensitive color-changing composite material.
5. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
still include the water response discoloration layer (5) of meeting with the mutual coincide of external protection layer (2), it has the water that detects and show the exosmosis medicine to meet the water color change printing ink on water response discoloration layer (5).
6. The indwelling needle patch according to claim 5, which senses drug extravasation, comprising:
the water-sensitive color-changing layer (5) is positioned inside or around the pH value sensitive color-developing layer (1), and the water-sensitive color-changing layer (5) and the pH value sensitive color-developing layer (1) are not overlapped with each other.
7. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
the external protection layer (2) is a PET layer or a nylon layer.
8. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
and an adhesive layer is coated on the outer protective layer (2).
9. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
the water absorption layer (6) is overlapped with the external protective layer (2), the water absorption layer (6) is positioned around the pH value induction color development layer (1), and the water absorption layer (6) and the pH value induction color development layer (1) are not overlapped with each other.
10. The indwelling needle patch for sensing drug extravasation according to claim 1, wherein:
the environment-friendly color developing paper is characterized by further comprising release paper (7) mutually bonded with the external protective layer (2), and the pH value induction color developing layer (1) is located between the release paper (7) and the external protective layer (2).
CN202111517086.1A 2021-12-07 2021-12-07 Remaining needle film capable of inducing drug extravasation Pending CN114247012A (en)

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