CN114246333A - Health-care composition with functions of resisting aging and improving immunity - Google Patents
Health-care composition with functions of resisting aging and improving immunity Download PDFInfo
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- CN114246333A CN114246333A CN202111611960.8A CN202111611960A CN114246333A CN 114246333 A CN114246333 A CN 114246333A CN 202111611960 A CN202111611960 A CN 202111611960A CN 114246333 A CN114246333 A CN 114246333A
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- astaxanthin
- lycopene
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the technical field of health products, and discloses a health composition with anti-aging and immunity-improving functions, which comprises a compound consisting of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, wherein the compound comprises the following raw materials in parts by weight: 3.5-4.5 parts of nicotinamide mononucleotide, 2-4 parts of albumin titanium powder, 0.5-1.5 parts of lycopene and 1.5-2.5 parts of astaxanthin, wherein the health-care composition consists of nicotinamide mononucleotide, albumin peptide powder, lycopene and astaxanthin in a certain proportion, the nicotinamide mononucleotide can restore the DNA cell damage of a human body and activate the function of the DNA cell of the human body and the astaxanthin can enhance the regeneration capability of cells, and the life of the DNA cell of the human body is prolonged, so that the life of the human body is prolonged.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to a health care composition with functions of resisting aging and improving immunity.
Background
The immunity is a defense mechanism of a human body, is the capability of the human body to recognize and eliminate any foreign matters invaded from the outside, is the capability of treating aged, damaged, dead and denatured self cells and recognizing and treating in-vivo tapered and virus infected cells, modern immunology considers that the immunity is physiological reaction for recognizing and eliminating the foreign matters of the human body, an immune system is used for executing the function in the human body, the human lives in an environment which is suitable for living and full of danger for millions of years, the human can survive and obtains extraordinary immunity, so the immunity is a product in a biological evolution process, the immunity is low in epidemic force, the immune system cannot normally play a protection role, under the condition, the infection of bacteria, viruses, fungi and the like is extremely easy to cause diseases, and the disease can quickly cause the decline of the body mechanism, causing the body to show signs of aging.
Disclosure of Invention
The invention aims to provide a health-care composition with functions of resisting aging and improving immunity, so as to solve the problems in the background technology.
Technical scheme
The invention provides the following technical scheme: a health-care composition with anti-aging and immunity-improving functions comprises a compound consisting of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, wherein the compound comprises the following raw materials in parts by weight: 3.5-4.5 parts of nicotinamide mononucleotide, 2-4 parts of albumin titanium powder, 0.5-1.5 parts of lycopene and 1.5-2.5 parts of astaxanthin.
Preferably, the feed comprises the following raw materials in parts by weight: 3.5-4 parts of nicotinamide mononucleotide, 2-3 parts of albumin titanium powder, 0.5-1 part of lycopene and 1.5-2 parts of astaxanthin.
Preferably, the feed comprises the following raw materials in parts by weight: 4-4.5 parts of nicotinamide mononucleotide, 3-4 parts of albumin titanium powder, 1-1.5 parts of lycopene and 2-2.5 parts of astaxanthin.
Preferably, the purity of the nicotinamide mononucleotide, the purity of the albumin peptide powder, the purity of the lycopene and the purity of the astaxanthin are not lower than 90%.
Nicotinamide mononucleotide: nicotinamide Mononucleotide (NMN) is an important substance, the molecular weight of NMN is 334.2192, which is one of substances inherent in the human body, NMN plays an important role in energy generation of human cells, is involved in synthesis of intracellular NAD (Nicotinamide adenine dinucleotide, an important coenzyme for cellular energy conversion), plays a key role in energy metabolism of cells, and has great application value in the field of medicine, and NAD is involved in a number of important signaling pathways in mammalian cells, including poly ADP-ribosylation in DNA repair, mono ADP ribosylation in immune response and G protein-coupled signaling, and synthesis of cyclic ADP ribose and Nicotinamide adenine dinucleotide phosphate (NAADP) in intracellular calcium signaling, so Nicotinamide mononucleotide can increase the lifespan of human body.
Albumin polypeptide powder: the amino acid required by the human body is provided, which is the material basis of positive balance of the amino acid of the human body, promotes the absorption of nucleic acid in food in intestinal tracts and regulates the distribution of the nucleic acid in liver and thymus so as to improve the immune function; protecting liver, and improving liver detoxification function; the proliferation of probiotics in the intestinal tract is enhanced, and the intestinal mucosa tissue is shielded to prevent the implantation and the attack of harmful bacteria in the intestinal tract.
And (3) lycopene: the lycopene is also called as a natural antioxidant, has a color range from yellow to red, has high activity under a fat-soluble condition, has the main functions of tonifying qi and producing blood, strengthening spleen and stomach, strengthening heart and refreshing, and can also improve senile macular degeneration, wherein the higher the content of the lycopene in human plasma is, the lower the incidence rate of cancers and coronary heart diseases is. It also has anticancer and tumor inhibiting effects, and has special therapeutic effect on prostatitis.
Astaxanthin: astaxanthin is a chain-breaking antioxidant. The product has strong oxidation resistance, can remove nitrogen dioxide, sulfide, disulfide and the like, can reduce lipid peroxidation, effectively inhibit lipid peroxidation caused by free radicals, has various physiological effects of inhibiting tumorigenesis, enhancing immunity, removing free radicals in vivo and the like, has a good treatment effect on skin cancer caused by ultraviolet rays, and also has a prevention and treatment effect on eye diseases caused by diabetes.
A health-care composition with the functions of delaying sanility and improving immunity can be prepared into different dosage forms, such as oral liquid, capsule, etc.
A health composition with antiaging and immunity enhancing effects is used in preparation of health medicine or health food.
A preparation method of a health care capsule with functions of resisting aging and improving immunity comprises the following steps:
(I): selecting high-quality and pollution-free raw materials;
(II): mixing nicotinamide mononucleotide, titanium albumin powder, lycopene and astaxanthin according to a part ratio under the conditions of drying and sterility respectively, and uniformly stirring;
(III): and filling the powder after being uniformly stirred into capsules.
Advantageous effects
Compared with the prior art, the invention provides a health-care composition with anti-aging and immunity-improving functions, which has the following beneficial effects:
the health-care composition with the functions of resisting aging and improving immunity comprises nicotinamide mononucleotide, albumin peptide powder, lycopene and astaxanthin according to a certain proportion, wherein the nicotinamide mononucleotide can restore the damage of human DNA cells and activate the functions of the human DNA cells and the astaxanthin can enhance the regeneration capacity of the cells, and the service life of the human DNA cells is prolonged, so that the service life of a human body is prolonged.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
the invention provides a technical scheme that: a health capsule with anti-aging and immunity improving functions comprises a compound consisting of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, wherein the compound comprises the following raw materials in parts by weight: 3.5 parts of nicotinamide mononucleotide, 2 parts of albumin titanium powder, 0.5 part of lycopene and 1.5 parts of astaxanthin.
In this example, the purity of nicotinamide mononucleotide, the purity of albumin peptide powder, the purity of lycopene and the purity of astaxanthin are not less than 90%.
A preparation method of a health care capsule with functions of resisting aging and improving immunity comprises the following steps:
(I): selecting high-quality and pollution-free raw materials;
(II): mixing nicotinamide mononucleotide, titanium albumin powder, lycopene and astaxanthin according to a part ratio under the conditions of drying and sterility respectively, and uniformly stirring;
(III): and filling the powder after being uniformly stirred into capsules.
Example two:
the invention provides a technical scheme that: a health capsule with anti-aging and immunity improving functions comprises a compound consisting of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, wherein the compound comprises the following raw materials in parts by weight: 4 parts of nicotinamide mononucleotide, 3 parts of albumin titanium powder, 1 part of lycopene and 2 parts of astaxanthin.
In this example, the purity of nicotinamide mononucleotide, the purity of albumin peptide powder, the purity of lycopene and the purity of astaxanthin are not less than 90%.
A preparation method of a health care capsule with functions of resisting aging and improving immunity comprises the following steps:
(I): selecting high-quality and pollution-free raw materials;
(II): mixing nicotinamide mononucleotide, titanium albumin powder, lycopene and astaxanthin according to a part ratio under the conditions of drying and sterility respectively, and uniformly stirring;
(III): and filling the powder after being uniformly stirred into capsules.
Example three:
the invention provides a technical scheme of a health-care capsule with anti-aging and immunity-improving functions, which comprises a compound consisting of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, wherein the compound comprises the following raw materials in parts by weight: 4.5 parts of nicotinamide mononucleotide, 4 parts of albumin titanium powder, 1.5 parts of lycopene and 2.5 parts of astaxanthin.
In this example, the purity of nicotinamide mononucleotide, the purity of albumin peptide powder, the purity of lycopene and the purity of astaxanthin are not less than 90%.
A preparation method of a health care capsule with functions of resisting aging and improving immunity comprises the following steps:
(I): selecting high-quality and pollution-free raw materials;
(II): mixing nicotinamide mononucleotide, titanium albumin powder, lycopene and astaxanthin according to a part ratio under the conditions of drying and sterility respectively, and uniformly stirring;
(III): and filling the powder after being uniformly stirred into capsules.
Experimental data
Selecting a model: mouse model with anti-aging effect of metformin
The mouse model feed with the melbine anti-aging effect is characterized in that melbine with the mass ratio of 0.035-0.06% is added on the basis of feed raw materials for ensuring the normal growth of a mouse, C57BL/6 mice are fed freely without gastric lavage, the animal ethics are met, the reasonable dosage of melbine is controlled, the body health of the mice is ensured, the survival rate of the mice is improved, the service life of the mice is prolonged, the cataract index of the mice of 105 weeks old is remarkably reduced, and the aging is remarkably delayed. The invention also provides a preparation method of the mouse model feed, which is simple and convenient to operate, low in production cost and capable of realizing batch production. In addition, when the model feed added with 0.035% of metformin by mass ratio is fed to C57BL/6 mice to 100 weeks old, the glycosylated hemoglobin level value in the mice is lower, and the serum metabolite level related to diabetes is improved, so that the mouse model feed provided by the invention can improve the insulin sensitivity of the mice while delaying the aging of the mice, and has positive effect on preventing metabolic syndrome.
The invention selects the D-galactose to replicate the aging mouse model, the model has simple and convenient manufacturing method, obvious aging characteristics and lower experimental cost, and the model is widely applied to the research of the aging mechanism and the action mechanism of the anti-aging drug.
The experimental contents are as follows: selecting 60 male mice of the same species 90-110g, randomly dividing the mice into 5 groups (12 mice in each group), wherein the first group and the second group are not taken with the health powder, the third group, the fourth group and the fifth group are all taken with the health powder, the third group is taken with the dosage of the health powder in the first embodiment, the fourth group is taken with the dosage of the health powder in the second embodiment, the fifth group is taken with the dosage of the three health powders in the first embodiment, each group of mice is taken with the health powder once, each time each group is taken with one gram of the health powder, one week is taken with one cycle, four cycles are taken, after the taking is finished, the mice are subjected to blood drawing detection, and the blood drawing detection result is obtained as a next table;
as can be seen from the above table, the composition can restore the functions of DNA cell damage, activating DNA cells and enhancing cell regeneration, and the proportion in the fourth group (i.e., example two) is the optimal proportion.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A health care composition with anti-aging and immunity improving functions is characterized in that: the compound consists of nicotinamide mononucleotide, albumin titanium powder, lycopene and astaxanthin, and comprises the following raw materials in parts by weight: 3.5-4.5 parts of nicotinamide mononucleotide, 2-4 parts of albumin titanium powder, 0.5-1.5 parts of lycopene and 1.5-2.5 parts of astaxanthin.
2. The health composition with anti-aging and immunity-improving effects according to claim 2, wherein the composition comprises: comprises the following raw materials in parts by weight: 3.5-4 parts of nicotinamide mononucleotide, 2-3 parts of albumin titanium powder, 0.5-1 part of lycopene and 1.5-2 parts of astaxanthin.
3. The health composition with anti-aging and immunity-improving effects according to claim 2, wherein the composition comprises: comprises the following raw materials in parts by weight: 4-4.5 parts of nicotinamide mononucleotide, 3-4 parts of albumin titanium powder, 1-1.5 parts of lycopene and 2-2.5 parts of astaxanthin.
4. The health composition with anti-aging and immunity-improving effects according to claim 2, wherein the composition comprises: the purity of the nicotinamide mononucleotide, the purity of the albumin peptide powder, the purity of the lycopene and the purity of the astaxanthin are not lower than 90%.
5. A health care oral preparation with functions of resisting aging and improving immunity is characterized in that: comprising the compound of claim 1.
6. A health care capsule with functions of resisting aging and improving immunity is characterized in that: comprising the compound of claim 1.
7. The use of the health composition with anti-aging and immunity-enhancing effects according to claims 5 and 6 in the preparation of health drugs or health foods.
8. The method for preparing the health capsule with the functions of resisting aging and improving immunity according to claim 1, which is characterized in that: the method comprises the following steps:
(I): selecting high-quality and pollution-free raw materials;
(II): mixing nicotinamide mononucleotide, titanium albumin powder, lycopene and astaxanthin according to a part ratio under the conditions of drying and sterility respectively, and uniformly stirring;
(III): and filling the powder after being uniformly stirred into capsules.
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